Protein kinase domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJM9_LEIDO

TriTrypDb:

LdBPK_355160.1 , LdCL_350057400 , LDHU3_35.6880

Length:

477

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 77
NetGPI	no	yes: 0, no: 77

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJM9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	78
GO:0006793	phosphorus metabolic process	3	78
GO:0006796	phosphate-containing compound metabolic process	4	78
GO:0006807	nitrogen compound metabolic process	2	78
GO:0008152	metabolic process	1	78
GO:0009987	cellular process	1	78
GO:0016310	phosphorylation	5	78
GO:0019538	protein metabolic process	3	78
GO:0036211	protein modification process	4	78
GO:0043170	macromolecule metabolic process	3	78
GO:0043412	macromolecule modification	4	78
GO:0044237	cellular metabolic process	2	78
GO:0044238	primary metabolic process	2	78
GO:0071704	organic substance metabolic process	2	78
GO:1901564	organonitrogen compound metabolic process	3	78
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	78
GO:0003824	catalytic activity	1	78
GO:0004672	protein kinase activity	3	78
GO:0005488	binding	1	78
GO:0005524	ATP binding	5	78
GO:0016301	kinase activity	4	78
GO:0016740	transferase activity	2	78
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	78
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	78
GO:0017076	purine nucleotide binding	4	78
GO:0030554	adenyl nucleotide binding	5	78
GO:0032553	ribonucleotide binding	3	78
GO:0032555	purine ribonucleotide binding	4	78
GO:0032559	adenyl ribonucleotide binding	5	78
GO:0035639	purine ribonucleoside triphosphate binding	4	78
GO:0036094	small molecule binding	2	78
GO:0043167	ion binding	2	78
GO:0043168	anion binding	3	78
GO:0097159	organic cyclic compound binding	2	78
GO:0097367	carbohydrate derivative binding	2	78
GO:0140096	catalytic activity, acting on a protein	2	78
GO:1901265	nucleoside phosphate binding	3	78
GO:1901363	heterocyclic compound binding	2	78
GO:0004674	protein serine/threonine kinase activity	4	50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.288
CLV_NRD_NRD_1	243	245	PF00675	0.279
CLV_PCSK_KEX2_1	187	189	PF00082	0.322
CLV_PCSK_KEX2_1	245	247	PF00082	0.282
CLV_PCSK_KEX2_1	393	395	PF00082	0.287
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.310
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.292
CLV_PCSK_SKI1_1	106	110	PF00082	0.423
CLV_PCSK_SKI1_1	138	142	PF00082	0.315
CLV_PCSK_SKI1_1	153	157	PF00082	0.264
CLV_PCSK_SKI1_1	192	196	PF00082	0.300
CLV_PCSK_SKI1_1	268	272	PF00082	0.312
CLV_Separin_Metazoa	349	353	PF03568	0.383
DEG_APCC_DBOX_1	111	119	PF00400	0.408
DEG_COP1_1	424	435	PF00400	0.329
DEG_SPOP_SBC_1	293	297	PF00917	0.159
DOC_CDC14_PxL_1	235	243	PF14671	0.276
DOC_MAPK_gen_1	156	165	PF00069	0.353
DOC_MAPK_gen_1	192	201	PF00069	0.298
DOC_MAPK_MEF2A_6	134	143	PF00069	0.297
DOC_MAPK_MEF2A_6	21	28	PF00069	0.530
DOC_MAPK_MEF2A_6	439	448	PF00069	0.382
DOC_PP4_FxxP_1	200	203	PF00568	0.291
DOC_PP4_FxxP_1	270	273	PF00568	0.291
DOC_PP4_FxxP_1	290	293	PF00568	0.262
DOC_PP4_FxxP_1	430	433	PF00568	0.251
DOC_USP7_MATH_1	293	297	PF00917	0.361
DOC_USP7_MATH_1	362	366	PF00917	0.548
DOC_USP7_UBL2_3	134	138	PF12436	0.268
DOC_USP7_UBL2_3	156	160	PF12436	0.278
DOC_USP7_UBL2_3	245	249	PF12436	0.241
DOC_USP7_UBL2_3	94	98	PF12436	0.407
DOC_WW_Pin1_4	230	235	PF00397	0.298
DOC_WW_Pin1_4	340	345	PF00397	0.537
LIG_14-3-3_CanoR_1	106	111	PF00244	0.335
LIG_14-3-3_CanoR_1	313	320	PF00244	0.270
LIG_14-3-3_CanoR_1	337	344	PF00244	0.395
LIG_14-3-3_CanoR_1	404	408	PF00244	0.278
LIG_14-3-3_CanoR_1	76	84	PF00244	0.442
LIG_AP2alpha_2	288	290	PF02296	0.259
LIG_APCC_ABBAyCdc20_2	187	193	PF00400	0.298
LIG_Clathr_ClatBox_1	140	144	PF01394	0.252
LIG_deltaCOP1_diTrp_1	388	396	PF00928	0.285
LIG_deltaCOP1_diTrp_1	465	471	PF00928	0.353
LIG_eIF4E_1	168	174	PF01652	0.332
LIG_eIF4E_1	22	28	PF01652	0.411
LIG_eIF4E_1	68	74	PF01652	0.380
LIG_FHA_1	11	17	PF00498	0.559
LIG_FHA_1	202	208	PF00498	0.280
LIG_FHA_1	314	320	PF00498	0.311
LIG_FHA_1	346	352	PF00498	0.506
LIG_FHA_1	371	377	PF00498	0.479
LIG_FHA_1	69	75	PF00498	0.450
LIG_FHA_2	27	33	PF00498	0.394
LIG_FHA_2	423	429	PF00498	0.298
LIG_FHA_2	458	464	PF00498	0.292
LIG_HCF-1_HBM_1	65	68	PF13415	0.510
LIG_LIR_Apic_2	233	239	PF02991	0.298
LIG_LIR_Apic_2	288	293	PF02991	0.262
LIG_LIR_Apic_2	428	433	PF02991	0.276
LIG_LIR_Nem_3	322	327	PF02991	0.378
LIG_NRBOX	259	265	PF00104	0.241
LIG_Pex14_1	391	395	PF04695	0.267
LIG_Pex14_1	467	471	PF04695	0.326
LIG_SH2_CRK	175	179	PF00017	0.329
LIG_SH2_GRB2like	457	460	PF00017	0.153
LIG_SH2_SRC	175	178	PF00017	0.285
LIG_SH2_STAP1	19	23	PF00017	0.371
LIG_SH2_STAP1	218	222	PF00017	0.272
LIG_SH2_STAP1	247	251	PF00017	0.309
LIG_SH2_STAP1	457	461	PF00017	0.335
LIG_SH2_STAT5	22	25	PF00017	0.384
LIG_SH2_STAT5	236	239	PF00017	0.298
LIG_SH2_STAT5	327	330	PF00017	0.389
LIG_SH2_STAT5	381	384	PF00017	0.292
LIG_SH2_STAT5	395	398	PF00017	0.268
LIG_SH2_STAT5	68	71	PF00017	0.362
LIG_SH3_3	47	53	PF00018	0.589
LIG_SUMO_SIM_anti_2	135	144	PF11976	0.238
LIG_SUMO_SIM_par_1	135	144	PF11976	0.265
LIG_SUMO_SIM_par_1	177	183	PF11976	0.244
LIG_TRAF2_1	164	167	PF00917	0.363
LIG_TRFH_1	235	239	PF08558	0.264
LIG_TYR_ITIM	173	178	PF00017	0.287
LIG_TYR_ITIM	259	264	PF00017	0.314
LIG_UBA3_1	263	271	PF00899	0.280
LIG_UBA3_1	301	308	PF00899	0.308
MOD_CDK_SPxxK_3	340	347	PF00069	0.292
MOD_CK1_1	10	16	PF00069	0.516
MOD_CK1_1	345	351	PF00069	0.466
MOD_CK1_1	374	380	PF00069	0.347
MOD_CK1_1	89	95	PF00069	0.304
MOD_CK2_1	26	32	PF00069	0.384
MOD_CK2_1	271	277	PF00069	0.376
MOD_CK2_1	403	409	PF00069	0.307
MOD_GlcNHglycan	146	149	PF01048	0.260
MOD_GlcNHglycan	195	198	PF01048	0.323
MOD_GlcNHglycan	356	359	PF01048	0.568
MOD_GlcNHglycan	9	12	PF01048	0.644
MOD_GSK3_1	106	113	PF00069	0.345
MOD_GSK3_1	212	219	PF00069	0.289
MOD_GSK3_1	226	233	PF00069	0.288
MOD_GSK3_1	336	343	PF00069	0.457
MOD_GSK3_1	370	377	PF00069	0.541
MOD_NEK2_1	212	217	PF00069	0.303
MOD_NEK2_1	403	408	PF00069	0.267
MOD_NEK2_1	466	471	PF00069	0.305
MOD_NEK2_1	83	88	PF00069	0.412
MOD_PIKK_1	271	277	PF00454	0.310
MOD_PIKK_1	313	319	PF00454	0.229
MOD_PIKK_1	371	377	PF00454	0.508
MOD_PIKK_1	434	440	PF00454	0.386
MOD_PKA_1	245	251	PF00069	0.345
MOD_PKA_2	245	251	PF00069	0.311
MOD_PKA_2	312	318	PF00069	0.296
MOD_PKA_2	336	342	PF00069	0.397
MOD_PKA_2	403	409	PF00069	0.345
MOD_PKA_2	86	92	PF00069	0.408
MOD_Plk_2-3	132	138	PF00069	0.268
MOD_Plk_2-3	220	226	PF00069	0.291
MOD_Plk_4	69	75	PF00069	0.442
MOD_ProDKin_1	230	236	PF00069	0.298
MOD_ProDKin_1	340	346	PF00069	0.535
MOD_SUMO_rev_2	131	140	PF00179	0.379
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.392
TRG_ENDOCYTIC_2	175	178	PF00928	0.294
TRG_ENDOCYTIC_2	261	264	PF00928	0.290
TRG_ENDOCYTIC_2	287	290	PF00928	0.222
TRG_ENDOCYTIC_2	369	372	PF00928	0.485
TRG_ENDOCYTIC_2	395	398	PF00928	0.295
TRG_ER_diArg_1	187	189	PF00400	0.307
TRG_ER_diArg_1	244	247	PF00400	0.296
TRG_NLS_MonoExtN_4	390	396	PF00514	0.293
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	38%	100%
A0A0N0P953	Leptomonas seymouri	88%	100%
A0A0N1I9A0	Leptomonas seymouri	28%	73%
A0A0N1PD05	Leptomonas seymouri	36%	100%
A0A0S4IMB7	Bodo saltans	38%	100%
A0A0S4IQ75	Bodo saltans	30%	95%
A0A0S4IRZ7	Bodo saltans	35%	97%
A0A0S4IVW1	Bodo saltans	29%	76%
A0A0S4IX86	Bodo saltans	38%	100%
A0A0S4J804	Bodo saltans	64%	91%
A0A0S4JIJ6	Bodo saltans	25%	84%
A0A0S4JPZ1	Bodo saltans	35%	100%
A0A1X0NIA0	Trypanosomatidae	39%	100%
A0A1X0NIX2	Trypanosomatidae	34%	100%
A0A1X0NUB2	Trypanosomatidae	32%	82%
A0A1X0P527	Trypanosomatidae	38%	100%
A0A1X0P549	Trypanosomatidae	75%	100%
A0A1X0P863	Trypanosomatidae	36%	96%
A0A1X0P994	Trypanosomatidae	34%	96%
A0A3Q8IAQ1	Leishmania donovani	38%	100%
A0A3Q8IC87	Leishmania donovani	30%	100%
A0A3Q8IFW0	Leishmania donovani	38%	100%
A0A3Q8INQ4	Leishmania donovani	31%	100%
A0A3R7KCZ4	Trypanosoma rangeli	40%	100%
A0A3R7MKG5	Trypanosoma rangeli	37%	100%
A0A3R7RLL1	Trypanosoma rangeli	27%	100%
A0A3S5H5U5	Leishmania donovani	26%	100%
A0A3S7X5M4	Leishmania donovani	30%	73%
A0A3S7X6T8	Leishmania donovani	35%	100%
A0A3S7XAL3	Leishmania donovani	36%	96%
A0A3S7XAT9	Leishmania donovani	35%	95%
A0A422N701	Trypanosoma rangeli	29%	100%
A0A422NCP0	Trypanosoma rangeli	36%	96%
A0A422NH41	Trypanosoma rangeli	33%	83%
A4H4S9	Leishmania braziliensis	25%	100%
A4HED7	Leishmania braziliensis	31%	100%
A4HH03	Leishmania braziliensis	28%	100%
A4HJT5	Leishmania braziliensis	36%	100%
A4HJW2	Leishmania braziliensis	37%	100%
A4HKG9	Leishmania braziliensis	30%	100%
A4HLR0	Leishmania braziliensis	36%	100%
A4HNI1	Leishmania braziliensis	90%	100%
A4HP12	Leishmania braziliensis	35%	100%
A4HP13	Leishmania braziliensis	35%	100%
A4HZV1	Leishmania infantum	30%	100%
A4HZW8	Leishmania infantum	38%	100%
A4I1T4	Leishmania infantum	31%	100%
A4I7C4	Leishmania infantum	38%	100%
A4I7Z6	Leishmania infantum	30%	100%
A4I960	Leishmania infantum	35%	100%
A4IC37	Leishmania infantum	99%	100%
A4IDC1	Leishmania infantum	35%	100%
A4IDC2	Leishmania infantum	36%	99%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A2Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
D0A2Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	97%
D0AA64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	83%
E9AFZ2	Leishmania major	97%	100%
E9AG71	Leishmania infantum	26%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ASS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B2V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	73%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B745	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P49071	Drosophila melanogaster	28%	100%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q03428	Trypanosoma brucei brucei	38%	100%
Q08942	Trypanosoma brucei brucei	39%	100%
Q4Q1S3	Leishmania major	37%	100%
Q4Q1S4	Leishmania major	34%	100%
Q4Q2Z2	Leishmania major	27%	100%
Q4Q3Y9	Leishmania major	35%	100%
Q4Q598	Leishmania major	30%	100%
Q4Q5T9	Leishmania major	38%	100%
Q4QBQ2	Leishmania major	41%	100%
Q4QBR6	Leishmania major	30%	100%
Q4QCK0	Leishmania major	23%	100%
Q4QIV8	Leishmania major	26%	100%
V5BPJ0	Trypanosoma cruzi	36%	96%
V5D579	Trypanosoma cruzi	39%	100%
V5DFW9	Trypanosoma cruzi	32%	82%