Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJM8_LEIDO

TriTrypDb:

LdBPK_365080.1 , LdCL_360058000 , LDHU3_36.6800

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.718
CLV_NRD_NRD_1	397	399	PF00675	0.591
CLV_NRD_NRD_1	436	438	PF00675	0.488
CLV_NRD_NRD_1	441	443	PF00675	0.487
CLV_NRD_NRD_1	445	447	PF00675	0.544
CLV_PCSK_KEX2_1	397	399	PF00082	0.584
CLV_PCSK_KEX2_1	435	437	PF00082	0.499
CLV_PCSK_KEX2_1	441	443	PF00082	0.488
CLV_PCSK_KEX2_1	445	447	PF00082	0.544
CLV_PCSK_PC7_1	437	443	PF00082	0.482
CLV_PCSK_SKI1_1	222	226	PF00082	0.589
CLV_PCSK_SKI1_1	227	231	PF00082	0.502
CLV_PCSK_SKI1_1	323	327	PF00082	0.505
CLV_PCSK_SKI1_1	381	385	PF00082	0.466
CLV_PCSK_SKI1_1	437	441	PF00082	0.436
CLV_PCSK_SKI1_1	446	450	PF00082	0.679
CLV_PCSK_SKI1_1	533	537	PF00082	0.707
DEG_APCC_DBOX_1	415	423	PF00400	0.627
DEG_APCC_DBOX_1	484	492	PF00400	0.550
DOC_AGCK_PIF_2	119	124	PF00069	0.584
DOC_CKS1_1	264	269	PF01111	0.706
DOC_CYCLIN_RxL_1	216	228	PF00134	0.578
DOC_CYCLIN_RxL_1	326	338	PF00134	0.619
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.553
DOC_MAPK_gen_1	402	409	PF00069	0.483
DOC_MAPK_gen_1	441	451	PF00069	0.541
DOC_MAPK_JIP1_4	211	217	PF00069	0.590
DOC_MAPK_MEF2A_6	211	219	PF00069	0.594
DOC_PP1_RVXF_1	477	483	PF00149	0.514
DOC_PP1_RVXF_1	545	551	PF00149	0.355
DOC_PP2B_LxvP_1	303	306	PF13499	0.567
DOC_PP2B_LxvP_1	484	487	PF13499	0.522
DOC_PP2B_LxvP_1	582	585	PF13499	0.682
DOC_PP4_FxxP_1	113	116	PF00568	0.708
DOC_USP7_MATH_1	316	320	PF00917	0.466
DOC_USP7_MATH_1	344	348	PF00917	0.493
DOC_USP7_MATH_1	487	491	PF00917	0.543
DOC_USP7_MATH_1	555	559	PF00917	0.643
DOC_USP7_UBL2_3	326	330	PF12436	0.520
DOC_WW_Pin1_4	103	108	PF00397	0.703
DOC_WW_Pin1_4	263	268	PF00397	0.769
DOC_WW_Pin1_4	27	32	PF00397	0.710
DOC_WW_Pin1_4	57	62	PF00397	0.801
DOC_WW_Pin1_4	580	585	PF00397	0.751
LIG_14-3-3_CanoR_1	175	184	PF00244	0.693
LIG_14-3-3_CanoR_1	272	277	PF00244	0.685
LIG_14-3-3_CanoR_1	339	345	PF00244	0.631
LIG_14-3-3_CanoR_1	416	426	PF00244	0.528
LIG_14-3-3_CanoR_1	522	531	PF00244	0.655
LIG_14-3-3_CanoR_1	556	562	PF00244	0.619
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_Clathr_ClatBox_1	279	283	PF01394	0.554
LIG_Clathr_ClatBox_1	542	546	PF01394	0.563
LIG_FHA_1	106	112	PF00498	0.716
LIG_FHA_1	149	155	PF00498	0.586
LIG_FHA_1	264	270	PF00498	0.670
LIG_FHA_1	3	9	PF00498	0.462
LIG_FHA_1	378	384	PF00498	0.586
LIG_FHA_1	452	458	PF00498	0.643
LIG_FHA_1	524	530	PF00498	0.689
LIG_FHA_1	537	543	PF00498	0.550
LIG_FHA_1	62	68	PF00498	0.662
LIG_FHA_2	192	198	PF00498	0.563
LIG_FHA_2	359	365	PF00498	0.598
LIG_FHA_2	498	504	PF00498	0.565
LIG_GBD_Chelix_1	409	417	PF00786	0.587
LIG_GBD_Chelix_1	498	506	PF00786	0.566
LIG_LIR_Gen_1	123	130	PF02991	0.591
LIG_LIR_Gen_1	161	169	PF02991	0.690
LIG_LIR_Gen_1	453	463	PF02991	0.436
LIG_LIR_Nem_3	123	127	PF02991	0.500
LIG_LIR_Nem_3	161	165	PF02991	0.579
LIG_LIR_Nem_3	275	279	PF02991	0.537
LIG_LIR_Nem_3	453	459	PF02991	0.466
LIG_MYND_1	489	493	PF01753	0.696
LIG_MYND_1	61	65	PF01753	0.710
LIG_Pex14_1	162	166	PF04695	0.573
LIG_Rb_pABgroove_1	116	124	PF01858	0.536
LIG_SH2_NCK_1	576	580	PF00017	0.713
LIG_SH2_STAT3	392	395	PF00017	0.581
LIG_SH2_STAT5	19	22	PF00017	0.608
LIG_SH2_STAT5	357	360	PF00017	0.641
LIG_SH2_STAT5	392	395	PF00017	0.581
LIG_SH2_STAT5	483	486	PF00017	0.502
LIG_SH3_3	104	110	PF00018	0.737
LIG_SH3_3	261	267	PF00018	0.629
LIG_SH3_3	62	68	PF00018	0.672
LIG_SUMO_SIM_anti_2	138	145	PF11976	0.480
LIG_SUMO_SIM_par_1	141	147	PF11976	0.572
LIG_SUMO_SIM_par_1	275	281	PF11976	0.562
LIG_SUMO_SIM_par_1	304	311	PF11976	0.536
LIG_SUMO_SIM_par_1	447	455	PF11976	0.668
LIG_TRAF2_1	194	197	PF00917	0.554
LIG_TRAF2_1	340	343	PF00917	0.553
LIG_TRAF2_1	606	609	PF00917	0.714
LIG_TYR_ITIM	17	22	PF00017	0.380
LIG_UBA3_1	77	83	PF00899	0.608
LIG_WRC_WIRS_1	41	46	PF05994	0.568
LIG_WRC_WIRS_1	463	468	PF05994	0.604
MOD_CDC14_SPxK_1	30	33	PF00782	0.786
MOD_CDK_SPxK_1	27	33	PF00069	0.783
MOD_CK1_1	178	184	PF00069	0.784
MOD_CK1_1	2	8	PF00069	0.577
MOD_CK1_1	218	224	PF00069	0.378
MOD_CK1_1	285	291	PF00069	0.743
MOD_CK1_1	40	46	PF00069	0.789
MOD_CK1_1	415	421	PF00069	0.623
MOD_CK1_1	56	62	PF00069	0.591
MOD_CK1_1	594	600	PF00069	0.760
MOD_CK2_1	177	183	PF00069	0.705
MOD_CK2_1	191	197	PF00069	0.543
MOD_CK2_1	363	369	PF00069	0.637
MOD_CK2_1	561	567	PF00069	0.613
MOD_CK2_1	603	609	PF00069	0.735
MOD_GlcNHglycan	1	4	PF01048	0.637
MOD_GlcNHglycan	101	104	PF01048	0.697
MOD_GlcNHglycan	131	135	PF01048	0.560
MOD_GlcNHglycan	166	169	PF01048	0.615
MOD_GlcNHglycan	177	180	PF01048	0.704
MOD_GlcNHglycan	23	26	PF01048	0.598
MOD_GlcNHglycan	292	295	PF01048	0.699
MOD_GlcNHglycan	346	349	PF01048	0.578
MOD_GlcNHglycan	364	368	PF01048	0.438
MOD_GlcNHglycan	55	58	PF01048	0.657
MOD_GlcNHglycan	557	560	PF01048	0.564
MOD_GSK3_1	173	180	PF00069	0.719
MOD_GSK3_1	223	230	PF00069	0.573
MOD_GSK3_1	23	30	PF00069	0.666
MOD_GSK3_1	334	341	PF00069	0.568
MOD_GSK3_1	344	351	PF00069	0.501
MOD_GSK3_1	53	60	PF00069	0.749
MOD_GSK3_1	587	594	PF00069	0.807
MOD_GSK3_1	66	73	PF00069	0.556
MOD_GSK3_1	97	104	PF00069	0.711
MOD_LATS_1	173	179	PF00433	0.753
MOD_N-GLC_1	348	353	PF02516	0.545
MOD_N-GLC_1	37	42	PF02516	0.704
MOD_NEK2_1	12	17	PF00069	0.475
MOD_NEK2_1	130	135	PF00069	0.468
MOD_NEK2_1	21	26	PF00069	0.581
MOD_NEK2_1	215	220	PF00069	0.449
MOD_NEK2_1	412	417	PF00069	0.593
MOD_NEK2_1	587	592	PF00069	0.804
MOD_PIKK_1	391	397	PF00454	0.579
MOD_PIKK_1	464	470	PF00454	0.518
MOD_PKA_2	338	344	PF00069	0.629
MOD_PKA_2	415	421	PF00069	0.521
MOD_PKA_2	555	561	PF00069	0.614
MOD_Plk_1	227	233	PF00069	0.572
MOD_Plk_1	295	301	PF00069	0.628
MOD_Plk_1	37	43	PF00069	0.704
MOD_Plk_1	518	524	PF00069	0.725
MOD_Plk_2-3	123	129	PF00069	0.532
MOD_Plk_2-3	338	344	PF00069	0.576
MOD_Plk_4	215	221	PF00069	0.590
MOD_Plk_4	316	322	PF00069	0.494
MOD_Plk_4	37	43	PF00069	0.568
MOD_Plk_4	487	493	PF00069	0.581
MOD_Plk_4	497	503	PF00069	0.561
MOD_Plk_4	587	593	PF00069	0.710
MOD_ProDKin_1	103	109	PF00069	0.702
MOD_ProDKin_1	263	269	PF00069	0.769
MOD_ProDKin_1	27	33	PF00069	0.712
MOD_ProDKin_1	57	63	PF00069	0.801
MOD_ProDKin_1	580	586	PF00069	0.755
MOD_SUMO_for_1	403	406	PF00179	0.504
TRG_DiLeu_BaEn_1	139	144	PF01217	0.476
TRG_DiLeu_BaEn_1	429	434	PF01217	0.566
TRG_DiLeu_BaEn_1	513	518	PF01217	0.566
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.545
TRG_ENDOCYTIC_2	124	127	PF00928	0.509
TRG_ENDOCYTIC_2	19	22	PF00928	0.395
TRG_ER_diArg_1	396	398	PF00400	0.482
TRG_ER_diArg_1	422	425	PF00400	0.646
TRG_ER_diArg_1	434	437	PF00400	0.262
TRG_ER_diArg_1	440	442	PF00400	0.490
TRG_NES_CRM1_1	207	223	PF08389	0.593
TRG_NES_CRM1_1	462	473	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N7	Leptomonas seymouri	49%	98%
A4HQ02	Leishmania braziliensis	78%	100%
A4IDR3	Leishmania infantum	100%	100%
E9ATR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0S8	Leishmania major	93%	100%