Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJM4_LEIDO

TriTrypDb:

LdBPK_180280.1 , LdCL_180007700 , LDHU3_18.0360

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.530
CLV_C14_Caspase3-7	536	540	PF00656	0.563
CLV_C14_Caspase3-7	684	688	PF00656	0.423
CLV_NRD_NRD_1	11	13	PF00675	0.565
CLV_NRD_NRD_1	157	159	PF00675	0.550
CLV_NRD_NRD_1	367	369	PF00675	0.577
CLV_PCSK_KEX2_1	11	13	PF00082	0.565
CLV_PCSK_KEX2_1	367	369	PF00082	0.504
CLV_PCSK_KEX2_1	471	473	PF00082	0.544
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.544
CLV_PCSK_SKI1_1	472	476	PF00082	0.464
CLV_PCSK_SKI1_1	479	483	PF00082	0.397
CLV_PCSK_SKI1_1	57	61	PF00082	0.553
CLV_PCSK_SKI1_1	689	693	PF00082	0.599
DOC_CDC14_PxL_1	189	197	PF14671	0.470
DOC_CKS1_1	361	366	PF01111	0.525
DOC_CKS1_1	454	459	PF01111	0.548
DOC_MAPK_DCC_7	583	592	PF00069	0.498
DOC_MAPK_gen_1	429	438	PF00069	0.542
DOC_MAPK_gen_1	471	477	PF00069	0.558
DOC_MAPK_gen_1	545	554	PF00069	0.420
DOC_MAPK_gen_1	583	592	PF00069	0.560
DOC_MAPK_gen_1	672	681	PF00069	0.317
DOC_MAPK_HePTP_8	550	562	PF00069	0.483
DOC_MAPK_HePTP_8	580	592	PF00069	0.461
DOC_MAPK_HePTP_8	686	698	PF00069	0.424
DOC_MAPK_MEF2A_6	138	146	PF00069	0.493
DOC_MAPK_MEF2A_6	201	210	PF00069	0.465
DOC_MAPK_MEF2A_6	431	440	PF00069	0.526
DOC_MAPK_MEF2A_6	545	554	PF00069	0.398
DOC_MAPK_MEF2A_6	583	592	PF00069	0.577
DOC_MAPK_MEF2A_6	689	698	PF00069	0.553
DOC_MAPK_NFAT4_5	545	553	PF00069	0.464
DOC_PP4_FxxP_1	485	488	PF00568	0.474
DOC_PP4_FxxP_1	541	544	PF00568	0.501
DOC_USP7_MATH_1	315	319	PF00917	0.648
DOC_USP7_MATH_1	330	334	PF00917	0.432
DOC_USP7_MATH_1	522	526	PF00917	0.496
DOC_USP7_MATH_1	98	102	PF00917	0.657
DOC_USP7_UBL2_3	467	471	PF12436	0.526
DOC_WW_Pin1_4	116	121	PF00397	0.514
DOC_WW_Pin1_4	175	180	PF00397	0.560
DOC_WW_Pin1_4	360	365	PF00397	0.535
DOC_WW_Pin1_4	405	410	PF00397	0.595
DOC_WW_Pin1_4	419	424	PF00397	0.676
DOC_WW_Pin1_4	453	458	PF00397	0.525
DOC_WW_Pin1_4	540	545	PF00397	0.446
LIG_14-3-3_CanoR_1	230	237	PF00244	0.388
LIG_14-3-3_CanoR_1	272	278	PF00244	0.653
LIG_14-3-3_CanoR_1	510	516	PF00244	0.442
LIG_14-3-3_CanoR_1	52	58	PF00244	0.620
LIG_14-3-3_CanoR_1	521	530	PF00244	0.449
LIG_14-3-3_CanoR_1	534	542	PF00244	0.424
LIG_14-3-3_CanoR_1	658	667	PF00244	0.524
LIG_Actin_WH2_2	42	59	PF00022	0.570
LIG_APCC_ABBA_1	552	557	PF00400	0.396
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BIR_III_4	371	375	PF00653	0.575
LIG_Clathr_ClatBox_1	325	329	PF01394	0.442
LIG_CSL_BTD_1	176	179	PF09270	0.556
LIG_FHA_1	102	108	PF00498	0.626
LIG_FHA_1	137	143	PF00498	0.387
LIG_FHA_1	230	236	PF00498	0.451
LIG_FHA_1	255	261	PF00498	0.411
LIG_FHA_1	329	335	PF00498	0.428
LIG_FHA_1	45	51	PF00498	0.571
LIG_FHA_1	454	460	PF00498	0.545
LIG_FHA_1	503	509	PF00498	0.406
LIG_FHA_1	511	517	PF00498	0.334
LIG_FHA_1	568	574	PF00498	0.436
LIG_FHA_1	690	696	PF00498	0.481
LIG_FHA_2	265	271	PF00498	0.469
LIG_FHA_2	322	328	PF00498	0.490
LIG_FHA_2	446	452	PF00498	0.411
LIG_FHA_2	512	518	PF00498	0.392
LIG_FHA_2	534	540	PF00498	0.567
LIG_FHA_2	664	670	PF00498	0.431
LIG_FHA_2	682	688	PF00498	0.343
LIG_GBD_Chelix_1	365	373	PF00786	0.542
LIG_Integrin_RGD_1	495	497	PF01839	0.471
LIG_LIR_Apic_2	539	544	PF02991	0.512
LIG_LIR_Gen_1	32	40	PF02991	0.536
LIG_LIR_Gen_1	434	445	PF02991	0.545
LIG_LIR_Gen_1	44	53	PF02991	0.434
LIG_LIR_Gen_1	513	523	PF02991	0.411
LIG_LIR_LC3C_4	557	560	PF02991	0.509
LIG_LIR_Nem_3	32	38	PF02991	0.597
LIG_LIR_Nem_3	434	440	PF02991	0.487
LIG_LIR_Nem_3	44	49	PF02991	0.619
LIG_LIR_Nem_3	513	518	PF02991	0.422
LIG_LIR_Nem_3	561	566	PF02991	0.351
LIG_PCNA_yPIPBox_3	603	613	PF02747	0.496
LIG_PTB_Apo_2	197	204	PF02174	0.473
LIG_PTB_Apo_2	517	524	PF02174	0.424
LIG_PTB_Phospho_1	197	203	PF10480	0.474
LIG_SH2_SRC	697	700	PF00017	0.430
LIG_SH2_STAP1	89	93	PF00017	0.555
LIG_SH2_STAT3	356	359	PF00017	0.476
LIG_SH2_STAT3	609	612	PF00017	0.464
LIG_SH2_STAT5	356	359	PF00017	0.531
LIG_SH2_STAT5	382	385	PF00017	0.441
LIG_SH2_STAT5	437	440	PF00017	0.488
LIG_SH2_STAT5	609	612	PF00017	0.521
LIG_SH2_STAT5	697	700	PF00017	0.439
LIG_SH3_1	585	591	PF00018	0.448
LIG_SH3_2	120	125	PF14604	0.546
LIG_SH3_3	117	123	PF00018	0.502
LIG_SH3_3	141	147	PF00018	0.433
LIG_SH3_3	274	280	PF00018	0.501
LIG_SH3_3	329	335	PF00018	0.445
LIG_SH3_3	358	364	PF00018	0.493
LIG_SH3_3	451	457	PF00018	0.509
LIG_SH3_3	559	565	PF00018	0.368
LIG_SH3_3	581	587	PF00018	0.628
LIG_SUMO_SIM_anti_2	139	146	PF11976	0.489
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.340
LIG_SUMO_SIM_anti_2	513	520	PF11976	0.469
LIG_SUMO_SIM_par_1	324	329	PF11976	0.450
LIG_SUMO_SIM_par_1	594	601	PF11976	0.501
LIG_TYR_ITIM	695	700	PF00017	0.405
LIG_WRPW_2	563	566	PF00400	0.321
MOD_CDK_SPK_2	540	545	PF00069	0.450
MOD_CDK_SPxK_1	175	181	PF00069	0.509
MOD_CDK_SPxxK_3	360	367	PF00069	0.426
MOD_CDK_SPxxK_3	405	412	PF00069	0.549
MOD_CDK_SPxxK_3	419	426	PF00069	0.574
MOD_CDK_SPxxK_3	540	547	PF00069	0.437
MOD_CK1_1	101	107	PF00069	0.500
MOD_CK1_1	132	138	PF00069	0.511
MOD_CK1_1	163	169	PF00069	0.524
MOD_CK1_1	184	190	PF00069	0.575
MOD_CK1_1	239	245	PF00069	0.521
MOD_CK1_1	249	255	PF00069	0.440
MOD_CK1_1	273	279	PF00069	0.546
MOD_CK1_1	289	295	PF00069	0.482
MOD_CK1_1	418	424	PF00069	0.650
MOD_CK1_1	533	539	PF00069	0.530
MOD_CK1_1	543	549	PF00069	0.443
MOD_CK2_1	264	270	PF00069	0.466
MOD_CK2_1	321	327	PF00069	0.556
MOD_CK2_1	511	517	PF00069	0.449
MOD_CK2_1	663	669	PF00069	0.587
MOD_GlcNHglycan	1	4	PF01048	0.583
MOD_GlcNHglycan	126	129	PF01048	0.562
MOD_GlcNHglycan	134	137	PF01048	0.471
MOD_GlcNHglycan	238	241	PF01048	0.476
MOD_GlcNHglycan	248	251	PF01048	0.553
MOD_GlcNHglycan	277	280	PF01048	0.572
MOD_GlcNHglycan	290	294	PF01048	0.454
MOD_GlcNHglycan	338	341	PF01048	0.592
MOD_GlcNHglycan	689	692	PF01048	0.580
MOD_GlcNHglycan	80	83	PF01048	0.552
MOD_GSK3_1	124	131	PF00069	0.558
MOD_GSK3_1	132	139	PF00069	0.327
MOD_GSK3_1	159	166	PF00069	0.511
MOD_GSK3_1	266	273	PF00069	0.469
MOD_GSK3_1	275	282	PF00069	0.597
MOD_GSK3_1	315	322	PF00069	0.578
MOD_GSK3_1	407	414	PF00069	0.626
MOD_GSK3_1	415	422	PF00069	0.657
MOD_GSK3_1	44	51	PF00069	0.608
MOD_GSK3_1	498	505	PF00069	0.530
MOD_GSK3_1	506	513	PF00069	0.424
MOD_GSK3_1	529	536	PF00069	0.552
MOD_GSK3_1	69	76	PF00069	0.658
MOD_GSK3_1	98	105	PF00069	0.551
MOD_N-GLC_1	132	137	PF02516	0.585
MOD_N-GLC_1	273	278	PF02516	0.405
MOD_N-GLC_1	316	321	PF02516	0.559
MOD_N-GLC_1	502	507	PF02516	0.564
MOD_NEK2_1	129	134	PF00069	0.586
MOD_NEK2_1	229	234	PF00069	0.400
MOD_NEK2_1	246	251	PF00069	0.421
MOD_NEK2_1	256	261	PF00069	0.433
MOD_NEK2_1	264	269	PF00069	0.359
MOD_NEK2_1	336	341	PF00069	0.455
MOD_NEK2_1	87	92	PF00069	0.504
MOD_PIKK_1	69	75	PF00454	0.614
MOD_PKA_2	124	130	PF00069	0.708
MOD_PKA_2	137	143	PF00069	0.371
MOD_PKA_2	229	235	PF00069	0.368
MOD_PKA_2	51	57	PF00069	0.569
MOD_PKA_2	533	539	PF00069	0.590
MOD_Plk_1	132	138	PF00069	0.462
MOD_Plk_1	212	218	PF00069	0.552
MOD_Plk_1	273	279	PF00069	0.400
MOD_Plk_1	328	334	PF00069	0.446
MOD_Plk_1	502	508	PF00069	0.509
MOD_Plk_1	98	104	PF00069	0.578
MOD_Plk_4	102	108	PF00069	0.477
MOD_Plk_4	321	327	PF00069	0.486
MOD_Plk_4	511	517	PF00069	0.398
MOD_ProDKin_1	116	122	PF00069	0.519
MOD_ProDKin_1	175	181	PF00069	0.566
MOD_ProDKin_1	360	366	PF00069	0.532
MOD_ProDKin_1	405	411	PF00069	0.598
MOD_ProDKin_1	419	425	PF00069	0.675
MOD_ProDKin_1	453	459	PF00069	0.535
MOD_ProDKin_1	540	546	PF00069	0.442
MOD_SUMO_for_1	59	62	PF00179	0.547
MOD_SUMO_for_1	93	96	PF00179	0.485
MOD_SUMO_rev_2	421	430	PF00179	0.539
MOD_SUMO_rev_2	465	473	PF00179	0.625
MOD_SUMO_rev_2	629	639	PF00179	0.544
TRG_DiLeu_BaEn_1	434	439	PF01217	0.398
TRG_DiLeu_BaEn_2	634	640	PF01217	0.498
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.533
TRG_DiLeu_BaLyEn_6	691	696	PF01217	0.487
TRG_ENDOCYTIC_2	203	206	PF00928	0.508
TRG_ENDOCYTIC_2	437	440	PF00928	0.440
TRG_ENDOCYTIC_2	697	700	PF00928	0.380
TRG_ER_diArg_1	10	12	PF00400	0.601
TRG_ER_diArg_1	367	369	PF00400	0.434
TRG_NES_CRM1_1	290	303	PF08389	0.433
TRG_NES_CRM1_1	441	453	PF08389	0.457
TRG_NES_CRM1_1	48	62	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ9	Leptomonas seymouri	55%	100%
A0A0S4JE75	Bodo saltans	25%	87%
A0A1X0P6Q4	Trypanosomatidae	31%	100%
A0A3R7NYR2	Trypanosoma rangeli	33%	100%
A4H9D2	Leishmania braziliensis	77%	100%
A4HXQ4	Leishmania infantum	99%	100%
D0A034	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QE14	Leishmania major	90%	97%
V5DMZ5	Trypanosoma cruzi	31%	100%