DUF1619 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1619), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJL4_LEIDO

TriTrypDb:

LdBPK_363830.1 , LdCL_360045300 , LDHU3_36.5160

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJL4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0030030	cell projection organization	4	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.282
CLV_C14_Caspase3-7	281	285	PF00656	0.374
CLV_C14_Caspase3-7	33	37	PF00656	0.525
CLV_NRD_NRD_1	182	184	PF00675	0.374
CLV_NRD_NRD_1	395	397	PF00675	0.431
CLV_NRD_NRD_1	560	562	PF00675	0.503
CLV_PCSK_KEX2_1	101	103	PF00082	0.340
CLV_PCSK_KEX2_1	182	184	PF00082	0.407
CLV_PCSK_KEX2_1	395	397	PF00082	0.475
CLV_PCSK_KEX2_1	560	562	PF00082	0.525
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.374
CLV_PCSK_SKI1_1	106	110	PF00082	0.330
CLV_PCSK_SKI1_1	72	76	PF00082	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DEG_SPOP_SBC_1	470	474	PF00917	0.312
DOC_CKS1_1	273	278	PF01111	0.206
DOC_MAPK_FxFP_2	16	19	PF00069	0.457
DOC_MAPK_MEF2A_6	483	492	PF00069	0.280
DOC_PP1_RVXF_1	201	208	PF00149	0.230
DOC_PP1_RVXF_1	542	548	PF00149	0.385
DOC_PP4_FxxP_1	136	139	PF00568	0.228
DOC_PP4_FxxP_1	16	19	PF00568	0.457
DOC_PP4_FxxP_1	187	190	PF00568	0.242
DOC_PP4_FxxP_1	380	383	PF00568	0.288
DOC_PP4_FxxP_1	515	518	PF00568	0.273
DOC_USP7_MATH_1	274	278	PF00917	0.282
DOC_USP7_MATH_1	470	474	PF00917	0.435
DOC_WW_Pin1_4	175	180	PF00397	0.353
DOC_WW_Pin1_4	272	277	PF00397	0.329
DOC_WW_Pin1_4	31	36	PF00397	0.444
DOC_WW_Pin1_4	347	352	PF00397	0.282
DOC_WW_Pin1_4	39	44	PF00397	0.362
DOC_WW_Pin1_4	514	519	PF00397	0.417
DOC_WW_Pin1_4	579	584	PF00397	0.525
DOC_WW_Pin1_4	82	87	PF00397	0.346
LIG_14-3-3_CanoR_1	395	400	PF00244	0.452
LIG_14-3-3_CanoR_1	96	101	PF00244	0.335
LIG_BIR_III_4	259	263	PF00653	0.176
LIG_BRCT_BRCA1_1	343	347	PF00533	0.409
LIG_DLG_GKlike_1	395	403	PF00625	0.336
LIG_FHA_1	147	153	PF00498	0.393
LIG_FHA_1	252	258	PF00498	0.319
LIG_FHA_1	423	429	PF00498	0.361
LIG_FHA_1	457	463	PF00498	0.469
LIG_FHA_1	487	493	PF00498	0.407
LIG_FHA_1	51	57	PF00498	0.286
LIG_FHA_1	520	526	PF00498	0.452
LIG_FHA_1	540	546	PF00498	0.178
LIG_FHA_2	107	113	PF00498	0.386
LIG_FHA_2	190	196	PF00498	0.374
LIG_FHA_2	279	285	PF00498	0.381
LIG_FHA_2	440	446	PF00498	0.483
LIG_FHA_2	527	533	PF00498	0.518
LIG_KLC1_Yacidic_2	107	112	PF13176	0.352
LIG_LIR_Apic_2	13	19	PF02991	0.456
LIG_LIR_Apic_2	377	383	PF02991	0.347
LIG_LIR_Apic_2	81	86	PF02991	0.398
LIG_LIR_Apic_2	89	93	PF02991	0.374
LIG_LIR_Gen_1	115	124	PF02991	0.176
LIG_LIR_Gen_1	169	179	PF02991	0.252
LIG_LIR_Gen_1	26	35	PF02991	0.461
LIG_LIR_Gen_1	277	284	PF02991	0.298
LIG_LIR_Gen_1	537	545	PF02991	0.423
LIG_LIR_Nem_3	115	121	PF02991	0.452
LIG_LIR_Nem_3	130	136	PF02991	0.217
LIG_LIR_Nem_3	169	175	PF02991	0.432
LIG_LIR_Nem_3	178	184	PF02991	0.232
LIG_LIR_Nem_3	249	253	PF02991	0.302
LIG_LIR_Nem_3	26	30	PF02991	0.406
LIG_LIR_Nem_3	277	282	PF02991	0.269
LIG_LIR_Nem_3	458	464	PF02991	0.305
LIG_LIR_Nem_3	475	481	PF02991	0.354
LIG_LIR_Nem_3	537	541	PF02991	0.342
LIG_LIR_Nem_3	546	550	PF02991	0.292
LIG_LIR_Nem_3	573	579	PF02991	0.424
LIG_LIR_Nem_3	84	90	PF02991	0.372
LIG_LYPXL_yS_3	18	21	PF13949	0.528
LIG_MAD2	561	569	PF02301	0.499
LIG_MYND_1	566	570	PF01753	0.477
LIG_NRBOX	1	7	PF00104	0.605
LIG_Pex14_2	331	335	PF04695	0.246
LIG_Pex14_2	543	547	PF04695	0.289
LIG_PTAP_UEV_1	147	152	PF05743	0.368
LIG_SH2_CRK	118	122	PF00017	0.374
LIG_SH2_CRK	181	185	PF00017	0.282
LIG_SH2_CRK	232	236	PF00017	0.321
LIG_SH2_CRK	279	283	PF00017	0.273
LIG_SH2_CRK	494	498	PF00017	0.282
LIG_SH2_CRK	83	87	PF00017	0.442
LIG_SH2_CRK	90	94	PF00017	0.242
LIG_SH2_GRB2like	232	235	PF00017	0.286
LIG_SH2_NCK_1	279	283	PF00017	0.282
LIG_SH2_NCK_1	83	87	PF00017	0.282
LIG_SH2_PTP2	172	175	PF00017	0.282
LIG_SH2_PTP2	326	329	PF00017	0.282
LIG_SH2_STAT3	481	484	PF00017	0.400
LIG_SH2_STAT3	505	508	PF00017	0.464
LIG_SH2_STAT5	110	113	PF00017	0.294
LIG_SH2_STAT5	135	138	PF00017	0.321
LIG_SH2_STAT5	172	175	PF00017	0.359
LIG_SH2_STAT5	326	329	PF00017	0.267
LIG_SH2_STAT5	353	356	PF00017	0.270
LIG_SH2_STAT5	44	47	PF00017	0.362
LIG_SH2_STAT5	481	484	PF00017	0.422
LIG_SH2_STAT5	77	80	PF00017	0.374
LIG_SH2_STAT5	87	90	PF00017	0.185
LIG_SH3_3	139	145	PF00018	0.284
LIG_SH3_3	148	154	PF00018	0.272
LIG_SH3_3	18	24	PF00018	0.410
LIG_SH3_3	270	276	PF00018	0.206
LIG_SH3_3	560	566	PF00018	0.451
LIG_SH3_5	86	90	PF00018	0.374
LIG_SUMO_SIM_par_1	153	158	PF11976	0.278
LIG_SUMO_SIM_par_1	7	14	PF11976	0.553
LIG_TYR_ITIM	230	235	PF00017	0.130
LIG_TYR_ITIM	492	497	PF00017	0.254
LIG_WRC_WIRS_1	520	525	PF05994	0.305
MOD_CDK_SPxxK_3	175	182	PF00069	0.282
MOD_CDK_SPxxK_3	31	38	PF00069	0.543
MOD_CK1_1	194	200	PF00069	0.420
MOD_CK1_1	300	306	PF00069	0.340
MOD_CK1_1	402	408	PF00069	0.385
MOD_CK1_1	422	428	PF00069	0.323
MOD_CK1_1	474	480	PF00069	0.421
MOD_CK1_1	486	492	PF00069	0.450
MOD_CK1_1	554	560	PF00069	0.532
MOD_CK2_1	106	112	PF00069	0.378
MOD_CK2_1	243	249	PF00069	0.392
MOD_CK2_1	299	305	PF00069	0.352
MOD_GlcNHglycan	13	16	PF01048	0.577
MOD_GlcNHglycan	175	178	PF01048	0.461
MOD_GlcNHglycan	198	201	PF01048	0.356
MOD_GlcNHglycan	245	248	PF01048	0.374
MOD_GlcNHglycan	259	263	PF01048	0.266
MOD_GlcNHglycan	305	308	PF01048	0.374
MOD_GlcNHglycan	354	357	PF01048	0.314
MOD_GlcNHglycan	360	363	PF01048	0.399
MOD_GlcNHglycan	370	373	PF01048	0.217
MOD_GlcNHglycan	377	380	PF01048	0.343
MOD_GlcNHglycan	405	408	PF01048	0.321
MOD_GlcNHglycan	474	477	PF01048	0.448
MOD_GlcNHglycan	68	72	PF01048	0.330
MOD_GSK3_1	123	130	PF00069	0.330
MOD_GSK3_1	173	180	PF00069	0.461
MOD_GSK3_1	207	214	PF00069	0.317
MOD_GSK3_1	264	271	PF00069	0.388
MOD_GSK3_1	274	281	PF00069	0.356
MOD_GSK3_1	299	306	PF00069	0.297
MOD_GSK3_1	395	402	PF00069	0.412
MOD_GSK3_1	465	472	PF00069	0.440
MOD_GSK3_1	479	486	PF00069	0.451
MOD_GSK3_1	539	546	PF00069	0.362
MOD_N-GLC_1	243	248	PF02516	0.325
MOD_N-GLC_1	303	308	PF02516	0.248
MOD_N-GLC_1	31	36	PF02516	0.419
MOD_N-GLC_1	314	319	PF02516	0.201
MOD_N-GLC_1	338	343	PF02516	0.352
MOD_N-GLC_1	412	417	PF02516	0.457
MOD_N-GLC_1	433	438	PF02516	0.478
MOD_N-GLC_1	455	460	PF02516	0.362
MOD_N-GLC_1	486	491	PF02516	0.462
MOD_N-GLC_1	526	531	PF02516	0.436
MOD_NEK2_1	207	212	PF00069	0.359
MOD_NEK2_1	236	241	PF00069	0.303
MOD_NEK2_1	264	269	PF00069	0.286
MOD_NEK2_1	299	304	PF00069	0.313
MOD_NEK2_1	314	319	PF00069	0.242
MOD_NEK2_1	388	393	PF00069	0.475
MOD_NEK2_1	399	404	PF00069	0.321
MOD_NEK2_1	471	476	PF00069	0.443
MOD_NEK2_1	543	548	PF00069	0.321
MOD_NEK2_1	571	576	PF00069	0.442
MOD_NEK2_1	9	14	PF00069	0.584
MOD_PIKK_1	112	118	PF00454	0.337
MOD_PIKK_1	155	161	PF00454	0.282
MOD_PIKK_1	551	557	PF00454	0.435
MOD_PKA_1	395	401	PF00069	0.368
MOD_PKA_2	375	381	PF00069	0.373
MOD_PKA_2	395	401	PF00069	0.432
MOD_PKA_2	95	101	PF00069	0.342
MOD_Plk_1	106	112	PF00069	0.332
MOD_Plk_1	314	320	PF00069	0.282
MOD_Plk_1	338	344	PF00069	0.308
MOD_Plk_1	433	439	PF00069	0.442
MOD_Plk_1	456	462	PF00069	0.346
MOD_Plk_1	486	492	PF00069	0.458
MOD_Plk_1	571	577	PF00069	0.408
MOD_Plk_4	106	112	PF00069	0.374
MOD_Plk_4	268	274	PF00069	0.335
MOD_Plk_4	360	366	PF00069	0.378
MOD_Plk_4	395	401	PF00069	0.415
MOD_Plk_4	439	445	PF00069	0.526
MOD_Plk_4	457	463	PF00069	0.252
MOD_Plk_4	554	560	PF00069	0.492
MOD_Plk_4	571	577	PF00069	0.316
MOD_ProDKin_1	175	181	PF00069	0.353
MOD_ProDKin_1	272	278	PF00069	0.329
MOD_ProDKin_1	31	37	PF00069	0.445
MOD_ProDKin_1	347	353	PF00069	0.282
MOD_ProDKin_1	39	45	PF00069	0.357
MOD_ProDKin_1	514	520	PF00069	0.425
MOD_ProDKin_1	579	585	PF00069	0.528
MOD_ProDKin_1	82	88	PF00069	0.346
MOD_SUMO_rev_2	107	115	PF00179	0.432
MOD_SUMO_rev_2	283	287	PF00179	0.282
TRG_DiLeu_BaEn_1	305	310	PF01217	0.352
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.282
TRG_ENDOCYTIC_2	118	121	PF00928	0.374
TRG_ENDOCYTIC_2	133	136	PF00928	0.193
TRG_ENDOCYTIC_2	172	175	PF00928	0.282
TRG_ENDOCYTIC_2	18	21	PF00928	0.507
TRG_ENDOCYTIC_2	181	184	PF00928	0.222
TRG_ENDOCYTIC_2	232	235	PF00928	0.286
TRG_ENDOCYTIC_2	279	282	PF00928	0.273
TRG_ENDOCYTIC_2	326	329	PF00928	0.374
TRG_ENDOCYTIC_2	494	497	PF00928	0.369
TRG_ENDOCYTIC_2	538	541	PF00928	0.353
TRG_ER_diArg_1	181	183	PF00400	0.410
TRG_ER_diArg_1	394	396	PF00400	0.465
TRG_ER_diArg_1	559	561	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2E7	Leptomonas seymouri	59%	100%
A0A0S4J6N9	Bodo saltans	33%	82%
A0A1X0P3E6	Trypanosomatidae	41%	99%
A0A3R7KNL3	Trypanosoma rangeli	39%	91%
A4ID32	Leishmania infantum	99%	100%
D0A8I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ATE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q151	Leishmania major	91%	100%
Q4R9E0	Macaca fascicularis	25%	96%
Q6NUS6	Homo sapiens	24%	96%
Q8R2Q6	Mus musculus	25%	98%
V5DNN8	Trypanosoma cruzi	41%	100%