Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJL1_LEIDO

TriTrypDb:

LdBPK_180100.1 , LdCL_180005900 , LDHU3_18.0110

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.699
CLV_NRD_NRD_1	177	179	PF00675	0.648
CLV_NRD_NRD_1	237	239	PF00675	0.459
CLV_NRD_NRD_1	276	278	PF00675	0.456
CLV_NRD_NRD_1	290	292	PF00675	0.611
CLV_NRD_NRD_1	359	361	PF00675	0.405
CLV_NRD_NRD_1	451	453	PF00675	0.658
CLV_PCSK_FUR_1	136	140	PF00082	0.574
CLV_PCSK_KEX2_1	138	140	PF00082	0.717
CLV_PCSK_KEX2_1	177	179	PF00082	0.647
CLV_PCSK_KEX2_1	237	239	PF00082	0.473
CLV_PCSK_KEX2_1	276	278	PF00082	0.421
CLV_PCSK_KEX2_1	290	292	PF00082	0.611
CLV_PCSK_KEX2_1	451	453	PF00082	0.638
CLV_PCSK_KEX2_1	66	68	PF00082	0.481
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.717
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.579
CLV_PCSK_SKI1_1	237	241	PF00082	0.509
CLV_PCSK_SKI1_1	245	249	PF00082	0.536
CLV_PCSK_SKI1_1	31	35	PF00082	0.525
CLV_PCSK_SKI1_1	330	334	PF00082	0.347
DEG_APCC_DBOX_1	236	244	PF00400	0.522
DOC_CDC14_PxL_1	334	342	PF14671	0.408
DOC_CKS1_1	48	53	PF01111	0.568
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.494
DOC_MAPK_gen_1	109	118	PF00069	0.441
DOC_MAPK_gen_1	360	368	PF00069	0.385
DOC_MAPK_gen_1	66	73	PF00069	0.538
DOC_MAPK_HePTP_8	358	370	PF00069	0.371
DOC_MAPK_HePTP_8	63	75	PF00069	0.489
DOC_MAPK_MEF2A_6	208	216	PF00069	0.622
DOC_MAPK_MEF2A_6	360	368	PF00069	0.551
DOC_MAPK_MEF2A_6	383	392	PF00069	0.586
DOC_MAPK_MEF2A_6	66	75	PF00069	0.542
DOC_MAPK_NFAT4_5	383	391	PF00069	0.595
DOC_PP1_RVXF_1	261	268	PF00149	0.508
DOC_PP1_RVXF_1	328	334	PF00149	0.482
DOC_PP2B_LxvP_1	26	29	PF13499	0.476
DOC_PP2B_LxvP_1	390	393	PF13499	0.554
DOC_PP4_FxxP_1	216	219	PF00568	0.663
DOC_USP7_MATH_1	130	134	PF00917	0.735
DOC_USP7_MATH_1	33	37	PF00917	0.544
DOC_WW_Pin1_4	188	193	PF00397	0.623
DOC_WW_Pin1_4	19	24	PF00397	0.503
DOC_WW_Pin1_4	300	305	PF00397	0.743
DOC_WW_Pin1_4	47	52	PF00397	0.471
LIG_14-3-3_CanoR_1	112	117	PF00244	0.587
LIG_14-3-3_CanoR_1	131	135	PF00244	0.673
LIG_14-3-3_CanoR_1	164	168	PF00244	0.624
LIG_14-3-3_CanoR_1	177	186	PF00244	0.662
LIG_14-3-3_CanoR_1	206	212	PF00244	0.692
LIG_14-3-3_CanoR_1	345	349	PF00244	0.559
LIG_14-3-3_CanoR_1	438	443	PF00244	0.537
LIG_APCC_ABBA_1	116	121	PF00400	0.501
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_BRCT_BRCA1_1	240	244	PF00533	0.516
LIG_CSL_BTD_1	26	29	PF09270	0.391
LIG_EVH1_2	212	216	PF00568	0.639
LIG_FHA_1	113	119	PF00498	0.597
LIG_FHA_1	124	130	PF00498	0.700
LIG_FHA_1	170	176	PF00498	0.638
LIG_FHA_1	193	199	PF00498	0.672
LIG_FHA_1	23	29	PF00498	0.471
LIG_FHA_1	365	371	PF00498	0.407
LIG_FHA_1	397	403	PF00498	0.505
LIG_FHA_1	405	411	PF00498	0.459
LIG_FHA_1	41	47	PF00498	0.396
LIG_FHA_1	413	419	PF00498	0.446
LIG_FHA_1	57	63	PF00498	0.470
LIG_FHA_1	82	88	PF00498	0.549
LIG_FHA_2	221	227	PF00498	0.584
LIG_FHA_2	246	252	PF00498	0.591
LIG_FHA_2	301	307	PF00498	0.731
LIG_FHA_2	321	327	PF00498	0.478
LIG_FHA_2	441	447	PF00498	0.534
LIG_FHA_2	55	61	PF00498	0.610
LIG_LIR_Nem_3	25	30	PF02991	0.418
LIG_LIR_Nem_3	326	332	PF02991	0.380
LIG_LIR_Nem_3	335	340	PF02991	0.434
LIG_LYPXL_yS_3	337	340	PF13949	0.424
LIG_MAD2	330	338	PF02301	0.375
LIG_NRP_CendR_1	451	454	PF00754	0.509
LIG_PCNA_PIPBox_1	394	403	PF02747	0.513
LIG_Pex14_2	329	333	PF04695	0.407
LIG_Rb_LxCxE_1	1	22	PF01857	0.573
LIG_SH2_STAT3	120	123	PF00017	0.421
LIG_SH2_STAT5	268	271	PF00017	0.454
LIG_SH2_STAT5	346	349	PF00017	0.598
LIG_SH2_STAT5	444	447	PF00017	0.449
LIG_SH3_3	45	51	PF00018	0.526
LIG_SH3_3	84	90	PF00018	0.566
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.720
LIG_SUMO_SIM_anti_2	367	373	PF11976	0.373
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.254
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.441
LIG_SUMO_SIM_par_1	367	373	PF11976	0.373
LIG_SUMO_SIM_par_1	42	47	PF11976	0.471
LIG_SUMO_SIM_par_1	50	57	PF11976	0.417
LIG_SUMO_SIM_par_1	59	65	PF11976	0.503
LIG_SUMO_SIM_par_1	82	89	PF11976	0.529
LIG_TRAF2_1	248	251	PF00917	0.628
LIG_TRAF2_1	304	307	PF00917	0.673
LIG_WRC_WIRS_1	321	326	PF05994	0.473
LIG_WRC_WIRS_1	397	402	PF05994	0.455
MOD_CDK_SPK_2	188	193	PF00069	0.648
MOD_CK1_1	132	138	PF00069	0.686
MOD_CK1_1	163	169	PF00069	0.720
MOD_CK1_1	191	197	PF00069	0.655
MOD_CK1_1	22	28	PF00069	0.534
MOD_CK1_1	220	226	PF00069	0.552
MOD_CK1_1	246	252	PF00069	0.558
MOD_CK1_1	253	259	PF00069	0.512
MOD_CK1_1	344	350	PF00069	0.570
MOD_CK1_1	373	379	PF00069	0.426
MOD_CK2_1	220	226	PF00069	0.552
MOD_CK2_1	245	251	PF00069	0.559
MOD_CK2_1	300	306	PF00069	0.743
MOD_CK2_1	320	326	PF00069	0.544
MOD_CK2_1	8	14	PF00069	0.488
MOD_Cter_Amidation	107	110	PF01082	0.628
MOD_GlcNHglycan	179	182	PF01048	0.624
MOD_GlcNHglycan	245	248	PF01048	0.575
MOD_GlcNHglycan	372	375	PF01048	0.393
MOD_GSK3_1	125	132	PF00069	0.680
MOD_GSK3_1	145	152	PF00069	0.704
MOD_GSK3_1	188	195	PF00069	0.658
MOD_GSK3_1	197	204	PF00069	0.666
MOD_GSK3_1	228	235	PF00069	0.482
MOD_GSK3_1	246	253	PF00069	0.537
MOD_GSK3_1	275	282	PF00069	0.565
MOD_GSK3_1	296	303	PF00069	0.757
MOD_GSK3_1	344	351	PF00069	0.538
MOD_GSK3_1	366	373	PF00069	0.393
MOD_GSK3_1	396	403	PF00069	0.473
MOD_GSK3_1	4	11	PF00069	0.529
MOD_GSK3_1	419	426	PF00069	0.593
MOD_GSK3_1	54	61	PF00069	0.568
MOD_N-GLC_1	123	128	PF02516	0.603
MOD_N-GLC_1	144	149	PF02516	0.771
MOD_N-GLC_1	364	369	PF02516	0.504
MOD_N-GLC_1	405	410	PF02516	0.539
MOD_N-GLC_1	438	443	PF02516	0.549
MOD_NEK2_1	129	134	PF00069	0.651
MOD_NEK2_1	137	142	PF00069	0.711
MOD_NEK2_1	154	159	PF00069	0.665
MOD_NEK2_1	198	203	PF00069	0.571
MOD_NEK2_1	366	371	PF00069	0.446
MOD_NEK2_1	386	391	PF00069	0.276
MOD_NEK2_1	405	410	PF00069	0.448
MOD_NEK2_1	54	59	PF00069	0.506
MOD_NEK2_2	396	401	PF00069	0.456
MOD_PIKK_1	13	19	PF00454	0.502
MOD_PIKK_1	192	198	PF00454	0.675
MOD_PIKK_1	207	213	PF00454	0.714
MOD_PKA_1	177	183	PF00069	0.627
MOD_PKA_2	101	107	PF00069	0.548
MOD_PKA_2	130	136	PF00069	0.626
MOD_PKA_2	163	169	PF00069	0.685
MOD_PKA_2	177	183	PF00069	0.627
MOD_PKA_2	192	198	PF00069	0.684
MOD_PKA_2	207	213	PF00069	0.730
MOD_PKA_2	275	281	PF00069	0.577
MOD_PKA_2	344	350	PF00069	0.570
MOD_PKA_2	423	429	PF00069	0.594
MOD_PKB_1	277	285	PF00069	0.549
MOD_Plk_1	144	150	PF00069	0.747
MOD_Plk_1	220	226	PF00069	0.591
MOD_Plk_1	348	354	PF00069	0.506
MOD_Plk_1	364	370	PF00069	0.288
MOD_Plk_1	386	392	PF00069	0.565
MOD_Plk_1	405	411	PF00069	0.535
MOD_Plk_1	438	444	PF00069	0.508
MOD_Plk_1	8	14	PF00069	0.498
MOD_Plk_1	81	87	PF00069	0.540
MOD_Plk_2-3	320	326	PF00069	0.470
MOD_Plk_2-3	8	14	PF00069	0.494
MOD_Plk_4	112	118	PF00069	0.473
MOD_Plk_4	163	169	PF00069	0.682
MOD_Plk_4	22	28	PF00069	0.567
MOD_Plk_4	220	226	PF00069	0.591
MOD_Plk_4	366	372	PF00069	0.372
MOD_Plk_4	386	392	PF00069	0.267
MOD_Plk_4	396	402	PF00069	0.483
MOD_Plk_4	405	411	PF00069	0.362
MOD_Plk_4	440	446	PF00069	0.569
MOD_Plk_4	58	64	PF00069	0.571
MOD_Plk_4	82	88	PF00069	0.558
MOD_ProDKin_1	188	194	PF00069	0.616
MOD_ProDKin_1	19	25	PF00069	0.497
MOD_ProDKin_1	300	306	PF00069	0.743
MOD_ProDKin_1	47	53	PF00069	0.462
MOD_SUMO_for_1	313	316	PF00179	0.630
MOD_SUMO_rev_2	408	416	PF00179	0.502
MOD_SUMO_rev_2	441	450	PF00179	0.551
TRG_DiLeu_BaEn_1	307	312	PF01217	0.588
TRG_DiLeu_BaEn_4	308	314	PF01217	0.436
TRG_ENDOCYTIC_2	337	340	PF00928	0.466
TRG_ER_diArg_1	139	142	PF00400	0.756
TRG_ER_diArg_1	177	179	PF00400	0.648
TRG_ER_diArg_1	205	208	PF00400	0.514
TRG_ER_diArg_1	237	239	PF00400	0.468
TRG_ER_diArg_1	275	277	PF00400	0.425
TRG_ER_diArg_1	450	452	PF00400	0.624
TRG_NLS_MonoExtC_3	137	143	PF00514	0.702
TRG_NLS_MonoExtN_4	106	113	PF00514	0.579
TRG_NLS_MonoExtN_4	136	142	PF00514	0.715
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P518	Leptomonas seymouri	59%	100%
A0A1X0P854	Trypanosomatidae	26%	100%
A0A3R7KLI0	Trypanosoma rangeli	29%	100%
A4H9B5	Leishmania braziliensis	77%	99%
A4HXN6	Leishmania infantum	100%	100%
D0A013	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ARE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QE32	Leishmania major	91%	99%
V5APZ6	Trypanosoma cruzi	27%	100%