RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine hydrolase (FSH1)/50S ribosome-binding GTPase/GTPase of unknown function C-terminal, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJK7_LEIDO

TriTrypDb:

LdBPK_323310.1 , LdCL_320039100 , LDHU3_32.4180

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJK7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.497
CLV_C14_Caspase3-7	618	622	PF00656	0.433
CLV_C14_Caspase3-7	68	72	PF00656	0.352
CLV_MEL_PAP_1	682	688	PF00089	0.414
CLV_NRD_NRD_1	131	133	PF00675	0.352
CLV_NRD_NRD_1	422	424	PF00675	0.623
CLV_NRD_NRD_1	428	430	PF00675	0.791
CLV_NRD_NRD_1	572	574	PF00675	0.239
CLV_NRD_NRD_1	684	686	PF00675	0.428
CLV_NRD_NRD_1	936	938	PF00675	0.494
CLV_PCSK_KEX2_1	131	133	PF00082	0.352
CLV_PCSK_KEX2_1	422	424	PF00082	0.610
CLV_PCSK_KEX2_1	428	430	PF00082	0.736
CLV_PCSK_KEX2_1	572	574	PF00082	0.268
CLV_PCSK_KEX2_1	684	686	PF00082	0.428
CLV_PCSK_KEX2_1	791	793	PF00082	0.386
CLV_PCSK_KEX2_1	895	897	PF00082	0.451
CLV_PCSK_KEX2_1	955	957	PF00082	0.431
CLV_PCSK_PC1ET2_1	791	793	PF00082	0.386
CLV_PCSK_PC1ET2_1	895	897	PF00082	0.451
CLV_PCSK_PC1ET2_1	955	957	PF00082	0.431
CLV_PCSK_SKI1_1	131	135	PF00082	0.287
CLV_PCSK_SKI1_1	666	670	PF00082	0.428
CLV_PCSK_SKI1_1	805	809	PF00082	0.309
CLV_Separin_Metazoa	239	243	PF03568	0.464
CLV_Separin_Metazoa	399	403	PF03568	0.445
DEG_SPOP_SBC_1	272	276	PF00917	0.467
DEG_SPOP_SBC_1	820	824	PF00917	0.292
DEG_SPOP_SBC_1	941	945	PF00917	0.370
DOC_ANK_TNKS_1	377	384	PF00023	0.569
DOC_CDC14_PxL_1	160	168	PF14671	0.292
DOC_CYCLIN_RxL_1	101	112	PF00134	0.399
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	716	722	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	841	847	PF00134	0.328
DOC_MAPK_gen_1	322	332	PF00069	0.485
DOC_MAPK_gen_1	572	578	PF00069	0.435
DOC_MAPK_gen_1	715	724	PF00069	0.388
DOC_MAPK_gen_1	882	891	PF00069	0.418
DOC_MAPK_HePTP_8	712	724	PF00069	0.353
DOC_MAPK_MEF2A_6	363	370	PF00069	0.379
DOC_MAPK_MEF2A_6	715	724	PF00069	0.335
DOC_MAPK_MEF2A_6	754	762	PF00069	0.381
DOC_PP1_RVXF_1	292	298	PF00149	0.399
DOC_PP1_RVXF_1	713	719	PF00149	0.449
DOC_PP1_RVXF_1	752	758	PF00149	0.406
DOC_PP1_RVXF_1	880	887	PF00149	0.342
DOC_PP2B_LxvP_1	38	41	PF13499	0.352
DOC_PP4_FxxP_1	297	300	PF00568	0.404
DOC_USP7_MATH_1	150	154	PF00917	0.328
DOC_USP7_MATH_1	178	182	PF00917	0.336
DOC_USP7_MATH_1	272	276	PF00917	0.510
DOC_USP7_MATH_1	278	282	PF00917	0.504
DOC_USP7_MATH_1	385	389	PF00917	0.753
DOC_USP7_MATH_1	471	475	PF00917	0.472
DOC_USP7_MATH_1	484	488	PF00917	0.438
DOC_USP7_MATH_1	54	58	PF00917	0.328
DOC_USP7_MATH_1	565	569	PF00917	0.487
DOC_USP7_MATH_1	850	854	PF00917	0.393
DOC_WW_Pin1_4	146	151	PF00397	0.397
DOC_WW_Pin1_4	273	278	PF00397	0.505
DOC_WW_Pin1_4	672	677	PF00397	0.394
DOC_WW_Pin1_4	768	773	PF00397	0.296
DOC_WW_Pin1_4	805	810	PF00397	0.406
LIG_14-3-3_CanoR_1	298	304	PF00244	0.398
LIG_14-3-3_CanoR_1	541	547	PF00244	0.515
LIG_14-3-3_CanoR_1	652	662	PF00244	0.501
LIG_14-3-3_CanoR_1	813	819	PF00244	0.405
LIG_Actin_WH2_2	709	727	PF00022	0.328
LIG_APCC_ABBA_1	22	27	PF00400	0.341
LIG_APCC_ABBA_1	261	266	PF00400	0.488
LIG_APCC_ABBA_1	368	373	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	260	266	PF00400	0.422
LIG_BRCT_BRCA1_1	180	184	PF00533	0.292
LIG_BRCT_BRCA1_1	473	477	PF00533	0.448
LIG_BRCT_BRCA1_1	567	571	PF00533	0.487
LIG_Clathr_ClatBox_1	35	39	PF01394	0.341
LIG_Clathr_ClatBox_1	883	887	PF01394	0.328
LIG_FHA_1	12	18	PF00498	0.292
LIG_FHA_1	217	223	PF00498	0.375
LIG_FHA_1	429	435	PF00498	0.719
LIG_FHA_1	456	462	PF00498	0.442
LIG_FHA_1	654	660	PF00498	0.501
LIG_FHA_1	693	699	PF00498	0.482
LIG_FHA_1	750	756	PF00498	0.417
LIG_FHA_1	821	827	PF00498	0.305
LIG_FHA_1	857	863	PF00498	0.494
LIG_FHA_1	88	94	PF00498	0.296
LIG_FHA_1	937	943	PF00498	0.464
LIG_FHA_2	263	269	PF00498	0.450
LIG_FHA_2	46	52	PF00498	0.381
LIG_FHA_2	496	502	PF00498	0.538
LIG_FHA_2	616	622	PF00498	0.395
LIG_FHA_2	630	636	PF00498	0.373
LIG_FHA_2	675	681	PF00498	0.538
LIG_FHA_2	729	735	PF00498	0.421
LIG_GBD_Chelix_1	854	862	PF00786	0.392
LIG_Integrin_isoDGR_2	426	428	PF01839	0.528
LIG_LIR_Gen_1	181	191	PF02991	0.386
LIG_LIR_Gen_1	317	323	PF02991	0.525
LIG_LIR_Gen_1	474	485	PF02991	0.438
LIG_LIR_Gen_1	645	653	PF02991	0.342
LIG_LIR_Gen_1	756	762	PF02991	0.388
LIG_LIR_Gen_1	86	95	PF02991	0.417
LIG_LIR_Gen_1	867	878	PF02991	0.355
LIG_LIR_Nem_3	158	163	PF02991	0.386
LIG_LIR_Nem_3	181	187	PF02991	0.406
LIG_LIR_Nem_3	317	321	PF02991	0.594
LIG_LIR_Nem_3	474	480	PF02991	0.438
LIG_LIR_Nem_3	557	563	PF02991	0.439
LIG_LIR_Nem_3	645	651	PF02991	0.330
LIG_LIR_Nem_3	667	672	PF02991	0.414
LIG_LIR_Nem_3	756	760	PF02991	0.393
LIG_LIR_Nem_3	765	770	PF02991	0.316
LIG_LIR_Nem_3	867	873	PF02991	0.319
LIG_MLH1_MIPbox_1	473	477	PF16413	0.451
LIG_Pex14_2	297	301	PF04695	0.412
LIG_REV1ctd_RIR_1	801	808	PF16727	0.341
LIG_RPA_C_Fungi	945	957	PF08784	0.384
LIG_SH2_CRK	648	652	PF00017	0.349
LIG_SH2_GRB2like	648	651	PF00017	0.345
LIG_SH2_PTP2	713	716	PF00017	0.450
LIG_SH2_SRC	353	356	PF00017	0.449
LIG_SH2_STAP1	323	327	PF00017	0.419
LIG_SH2_STAT5	105	108	PF00017	0.316
LIG_SH2_STAT5	337	340	PF00017	0.438
LIG_SH2_STAT5	353	356	PF00017	0.310
LIG_SH2_STAT5	405	408	PF00017	0.434
LIG_SH2_STAT5	512	515	PF00017	0.341
LIG_SH2_STAT5	713	716	PF00017	0.361
LIG_SH2_STAT5	767	770	PF00017	0.321
LIG_SH3_3	172	178	PF00018	0.369
LIG_SH3_3	256	262	PF00018	0.350
LIG_SH3_3	477	483	PF00018	0.273
LIG_SH3_3	656	662	PF00018	0.504
LIG_SH3_3	744	750	PF00018	0.380
LIG_SH3_3	77	83	PF00018	0.406
LIG_SH3_3	924	930	PF00018	0.635
LIG_Sin3_3	414	421	PF02671	0.433
LIG_SUMO_SIM_anti_2	362	369	PF11976	0.374
LIG_TRAF2_1	177	180	PF00917	0.341
LIG_UBA3_1	720	726	PF00899	0.455
LIG_UBA3_1	888	895	PF00899	0.363
LIG_WRC_WIRS_1	800	805	PF05994	0.341
MOD_CDC14_SPxK_1	810	813	PF00782	0.296
MOD_CDK_SPxK_1	807	813	PF00069	0.296
MOD_CK1_1	149	155	PF00069	0.427
MOD_CK1_1	189	195	PF00069	0.365
MOD_CK1_1	273	279	PF00069	0.508
MOD_CK1_1	302	308	PF00069	0.577
MOD_CK1_1	57	63	PF00069	0.363
MOD_CK1_1	674	680	PF00069	0.356
MOD_CK1_1	905	911	PF00069	0.642
MOD_CK1_1	912	918	PF00069	0.698
MOD_CK1_1	932	938	PF00069	0.422
MOD_CK2_1	240	246	PF00069	0.535
MOD_CK2_1	262	268	PF00069	0.441
MOD_CK2_1	495	501	PF00069	0.312
MOD_CK2_1	628	634	PF00069	0.515
MOD_CK2_1	861	867	PF00069	0.408
MOD_Cter_Amidation	169	172	PF01082	0.316
MOD_Cter_Amidation	426	429	PF01082	0.556
MOD_GlcNHglycan	152	155	PF01048	0.455
MOD_GlcNHglycan	179	183	PF01048	0.354
MOD_GlcNHglycan	189	192	PF01048	0.296
MOD_GlcNHglycan	223	226	PF01048	0.558
MOD_GlcNHglycan	284	287	PF01048	0.454
MOD_GlcNHglycan	334	337	PF01048	0.452
MOD_GlcNHglycan	448	451	PF01048	0.574
MOD_GlcNHglycan	469	472	PF01048	0.328
MOD_GlcNHglycan	538	541	PF01048	0.341
MOD_GlcNHglycan	543	546	PF01048	0.406
MOD_GlcNHglycan	548	551	PF01048	0.406
MOD_GlcNHglycan	59	62	PF01048	0.306
MOD_GlcNHglycan	65	70	PF01048	0.348
MOD_GlcNHglycan	669	672	PF01048	0.455
MOD_GlcNHglycan	764	767	PF01048	0.242
MOD_GlcNHglycan	864	867	PF01048	0.413
MOD_GlcNHglycan	931	934	PF01048	0.478
MOD_GlcNHglycan	944	947	PF01048	0.447
MOD_GSK3_1	146	153	PF00069	0.371
MOD_GSK3_1	216	223	PF00069	0.411
MOD_GSK3_1	262	269	PF00069	0.475
MOD_GSK3_1	278	285	PF00069	0.450
MOD_GSK3_1	299	306	PF00069	0.500
MOD_GSK3_1	455	462	PF00069	0.487
MOD_GSK3_1	467	474	PF00069	0.291
MOD_GSK3_1	536	543	PF00069	0.439
MOD_GSK3_1	634	641	PF00069	0.435
MOD_GSK3_1	660	667	PF00069	0.433
MOD_GSK3_1	693	700	PF00069	0.319
MOD_GSK3_1	799	806	PF00069	0.368
MOD_GSK3_1	905	912	PF00069	0.564
MOD_GSK3_1	928	935	PF00069	0.522
MOD_GSK3_1	936	943	PF00069	0.442
MOD_N-GLC_1	254	259	PF02516	0.438
MOD_NEK2_1	221	226	PF00069	0.495
MOD_NEK2_1	240	245	PF00069	0.411
MOD_NEK2_1	270	275	PF00069	0.503
MOD_NEK2_1	282	287	PF00069	0.406
MOD_NEK2_1	697	702	PF00069	0.466
MOD_NEK2_1	73	78	PF00069	0.465
MOD_NEK2_1	760	765	PF00069	0.413
MOD_NEK2_1	803	808	PF00069	0.485
MOD_NEK2_1	814	819	PF00069	0.378
MOD_NEK2_1	821	826	PF00069	0.194
MOD_NEK2_1	87	92	PF00069	0.211
MOD_NEK2_1	902	907	PF00069	0.560
MOD_NEK2_1	93	98	PF00069	0.150
MOD_NEK2_2	138	143	PF00069	0.491
MOD_NEK2_2	155	160	PF00069	0.182
MOD_NEK2_2	278	283	PF00069	0.372
MOD_NEK2_2	472	477	PF00069	0.273
MOD_NEK2_2	514	519	PF00069	0.319
MOD_NEK2_2	775	780	PF00069	0.338
MOD_PIKK_1	11	17	PF00454	0.217
MOD_PIKK_1	385	391	PF00454	0.759
MOD_PIKK_1	93	99	PF00454	0.273
MOD_PKA_1	428	434	PF00069	0.629
MOD_PKA_2	332	338	PF00069	0.482
MOD_PKA_2	428	434	PF00069	0.764
MOD_PKA_2	540	546	PF00069	0.273
MOD_PKA_2	812	818	PF00069	0.292
MOD_PKA_2	936	942	PF00069	0.459
MOD_Plk_1	138	144	PF00069	0.398
MOD_Plk_1	254	260	PF00069	0.507
MOD_Plk_1	634	640	PF00069	0.351
MOD_Plk_1	912	918	PF00069	0.509
MOD_Plk_2-3	441	447	PF00069	0.589
MOD_Plk_4	138	144	PF00069	0.333
MOD_Plk_4	155	161	PF00069	0.185
MOD_Plk_4	20	26	PF00069	0.341
MOD_Plk_4	254	260	PF00069	0.472
MOD_Plk_4	266	272	PF00069	0.534
MOD_Plk_4	472	478	PF00069	0.317
MOD_Plk_4	642	648	PF00069	0.313
MOD_Plk_4	654	660	PF00069	0.387
MOD_Plk_4	674	680	PF00069	0.232
MOD_Plk_4	693	699	PF00069	0.293
MOD_Plk_4	799	805	PF00069	0.428
MOD_Plk_4	814	820	PF00069	0.311
MOD_ProDKin_1	146	152	PF00069	0.397
MOD_ProDKin_1	273	279	PF00069	0.501
MOD_ProDKin_1	672	678	PF00069	0.389
MOD_ProDKin_1	768	774	PF00069	0.296
MOD_ProDKin_1	805	811	PF00069	0.406
MOD_SUMO_for_1	321	324	PF00179	0.512
TRG_DiLeu_BaEn_1	345	350	PF01217	0.404
TRG_DiLeu_BaEn_1	705	710	PF01217	0.254
TRG_DiLeu_BaEn_4	246	252	PF01217	0.479
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.386
TRG_ENDOCYTIC_2	103	106	PF00928	0.356
TRG_ENDOCYTIC_2	560	563	PF00928	0.321
TRG_ENDOCYTIC_2	648	651	PF00928	0.343
TRG_ENDOCYTIC_2	713	716	PF00928	0.361
TRG_ER_diArg_1	130	132	PF00400	0.352
TRG_ER_diArg_1	422	425	PF00400	0.638
TRG_ER_diArg_1	428	430	PF00400	0.753
TRG_ER_diArg_1	571	573	PF00400	0.321
TRG_ER_diArg_1	683	685	PF00400	0.414
TRG_ER_diArg_1	714	717	PF00400	0.365
TRG_NES_CRM1_1	27	39	PF08389	0.341
TRG_NES_CRM1_1	877	890	PF08389	0.349
TRG_Pf-PMV_PEXEL_1	896	900	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP4	Leptomonas seymouri	64%	100%
A0A0S4IRQ8	Bodo saltans	35%	96%
A0A1X0NRU1	Trypanosomatidae	39%	100%
A4HKV6	Leishmania braziliensis	79%	100%
A4I8D6	Leishmania infantum	99%	100%
D0AAT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B395	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4W0	Leishmania major	93%	100%
V5BL49	Trypanosoma cruzi	43%	100%