TPR_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJJ7_LEIDO

TriTrypDb:

LdBPK_302450.1 , LdCL_300030000 , LDHU3_30.3300

Length:

781

Annotations

LeishMANIAdb annotations

Might be a conserved chaperone protein, probably not transmembrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.431
CLV_C14_Caspase3-7	243	247	PF00656	0.404
CLV_C14_Caspase3-7	25	29	PF00656	0.563
CLV_C14_Caspase3-7	736	740	PF00656	0.654
CLV_NRD_NRD_1	357	359	PF00675	0.601
CLV_NRD_NRD_1	513	515	PF00675	0.369
CLV_NRD_NRD_1	519	521	PF00675	0.369
CLV_NRD_NRD_1	526	528	PF00675	0.380
CLV_NRD_NRD_1	574	576	PF00675	0.407
CLV_NRD_NRD_1	677	679	PF00675	0.585
CLV_PCSK_FUR_1	675	679	PF00082	0.505
CLV_PCSK_KEX2_1	359	361	PF00082	0.557
CLV_PCSK_KEX2_1	513	515	PF00082	0.368
CLV_PCSK_KEX2_1	518	520	PF00082	0.371
CLV_PCSK_KEX2_1	526	528	PF00082	0.381
CLV_PCSK_KEX2_1	574	576	PF00082	0.407
CLV_PCSK_KEX2_1	675	677	PF00082	0.571
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.571
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.425
CLV_PCSK_PC7_1	514	520	PF00082	0.373
CLV_PCSK_SKI1_1	211	215	PF00082	0.460
CLV_PCSK_SKI1_1	503	507	PF00082	0.291
CLV_PCSK_SKI1_1	610	614	PF00082	0.396
CLV_Separin_Metazoa	98	102	PF03568	0.361
DEG_APCC_DBOX_1	471	479	PF00400	0.439
DEG_APCC_DBOX_1	502	510	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.454
DEG_SPOP_SBC_1	719	723	PF00917	0.789
DEG_SPOP_SBC_1	734	738	PF00917	0.581
DOC_CKS1_1	628	633	PF01111	0.631
DOC_CYCLIN_RxL_1	476	484	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	463	469	PF00134	0.460
DOC_MAPK_gen_1	112	120	PF00069	0.346
DOC_MAPK_gen_1	261	268	PF00069	0.297
DOC_MAPK_gen_1	287	295	PF00069	0.313
DOC_MAPK_gen_1	343	353	PF00069	0.455
DOC_MAPK_gen_1	763	772	PF00069	0.666
DOC_MAPK_MEF2A_6	261	268	PF00069	0.336
DOC_MAPK_MEF2A_6	485	492	PF00069	0.442
DOC_MAPK_MEF2A_6	503	511	PF00069	0.176
DOC_MAPK_MEF2A_6	766	774	PF00069	0.682
DOC_MAPK_RevD_3	504	519	PF00069	0.446
DOC_PP2B_LxvP_1	122	125	PF13499	0.308
DOC_PP2B_LxvP_1	35	38	PF13499	0.419
DOC_PP2B_LxvP_1	637	640	PF13499	0.605
DOC_PP4_FxxP_1	653	656	PF00568	0.577
DOC_PP4_MxPP_1	746	749	PF00568	0.616
DOC_USP7_MATH_1	136	140	PF00917	0.388
DOC_USP7_MATH_1	212	216	PF00917	0.328
DOC_USP7_MATH_1	227	231	PF00917	0.559
DOC_USP7_MATH_1	23	27	PF00917	0.587
DOC_USP7_MATH_1	237	241	PF00917	0.541
DOC_USP7_MATH_1	382	386	PF00917	0.388
DOC_USP7_MATH_1	549	553	PF00917	0.748
DOC_USP7_MATH_1	554	558	PF00917	0.723
DOC_USP7_MATH_1	623	627	PF00917	0.678
DOC_USP7_MATH_1	699	703	PF00917	0.700
DOC_USP7_MATH_1	705	709	PF00917	0.669
DOC_USP7_MATH_1	733	737	PF00917	0.664
DOC_USP7_MATH_1	775	779	PF00917	0.635
DOC_WW_Pin1_4	223	228	PF00397	0.463
DOC_WW_Pin1_4	375	380	PF00397	0.421
DOC_WW_Pin1_4	419	424	PF00397	0.545
DOC_WW_Pin1_4	425	430	PF00397	0.514
DOC_WW_Pin1_4	432	437	PF00397	0.485
DOC_WW_Pin1_4	559	564	PF00397	0.719
DOC_WW_Pin1_4	627	632	PF00397	0.635
DOC_WW_Pin1_4	639	644	PF00397	0.745
LIG_14-3-3_CanoR_1	112	122	PF00244	0.416
LIG_14-3-3_CanoR_1	193	198	PF00244	0.387
LIG_14-3-3_CanoR_1	290	296	PF00244	0.377
LIG_14-3-3_CanoR_1	401	409	PF00244	0.437
LIG_14-3-3_CanoR_1	460	464	PF00244	0.357
LIG_14-3-3_CanoR_1	513	521	PF00244	0.610
LIG_14-3-3_CanoR_1	610	616	PF00244	0.610
LIG_14-3-3_CanoR_1	694	701	PF00244	0.759
LIG_Actin_WH2_2	752	770	PF00022	0.643
LIG_APCC_ABBA_1	264	269	PF00400	0.381
LIG_APCC_ABBAyCdc20_2	263	269	PF00400	0.381
LIG_BIR_III_2	221	225	PF00653	0.392
LIG_BIR_III_2	246	250	PF00653	0.410
LIG_BRCT_BRCA1_1	171	175	PF00533	0.515
LIG_BRCT_BRCA1_1	261	265	PF00533	0.353
LIG_BRCT_BRCA1_1	625	629	PF00533	0.671
LIG_CtBP_PxDLS_1	494	498	PF00389	0.256
LIG_FHA_1	119	125	PF00498	0.375
LIG_FHA_1	376	382	PF00498	0.443
LIG_FHA_1	429	435	PF00498	0.576
LIG_FHA_1	487	493	PF00498	0.434
LIG_FHA_1	499	505	PF00498	0.260
LIG_FHA_1	581	587	PF00498	0.630
LIG_FHA_1	64	70	PF00498	0.345
LIG_FHA_1	662	668	PF00498	0.722
LIG_FHA_1	771	777	PF00498	0.770
LIG_FHA_2	193	199	PF00498	0.443
LIG_FHA_2	231	237	PF00498	0.471
LIG_FHA_2	241	247	PF00498	0.399
LIG_FHA_2	541	547	PF00498	0.670
LIG_FHA_2	628	634	PF00498	0.643
LIG_FHA_2	698	704	PF00498	0.656
LIG_Integrin_isoDGR_2	92	94	PF01839	0.493
LIG_LIR_Apic_2	626	631	PF02991	0.694
LIG_LIR_Apic_2	651	656	PF02991	0.589
LIG_LIR_Gen_1	135	141	PF02991	0.396
LIG_LIR_Gen_1	188	197	PF02991	0.469
LIG_LIR_Gen_1	262	271	PF02991	0.325
LIG_LIR_Gen_1	348	357	PF02991	0.345
LIG_LIR_Gen_1	614	623	PF02991	0.576
LIG_LIR_Nem_3	116	122	PF02991	0.426
LIG_LIR_Nem_3	135	140	PF02991	0.504
LIG_LIR_Nem_3	151	157	PF02991	0.496
LIG_LIR_Nem_3	188	192	PF02991	0.483
LIG_LIR_Nem_3	202	208	PF02991	0.416
LIG_LIR_Nem_3	262	268	PF02991	0.321
LIG_LIR_Nem_3	348	353	PF02991	0.435
LIG_LIR_Nem_3	462	467	PF02991	0.438
LIG_LIR_Nem_3	543	547	PF02991	0.744
LIG_LIR_Nem_3	614	618	PF02991	0.537
LIG_LIR_Nem_3	619	625	PF02991	0.519
LIG_LIR_Nem_3	626	632	PF02991	0.519
LIG_LIR_Nem_3	84	90	PF02991	0.339
LIG_LYPXL_yS_3	87	90	PF13949	0.386
LIG_MLH1_MIPbox_1	625	629	PF16413	0.585
LIG_PDZ_Class_3	776	781	PF00595	0.723
LIG_Pex14_1	288	292	PF04695	0.326
LIG_Pex14_2	205	209	PF04695	0.371
LIG_Rb_LxCxE_1	368	385	PF01857	0.388
LIG_RPA_C_Fungi	508	520	PF08784	0.461
LIG_SH2_CRK	137	141	PF00017	0.596
LIG_SH2_CRK	154	158	PF00017	0.678
LIG_SH2_CRK	598	602	PF00017	0.403
LIG_SH2_CRK	622	626	PF00017	0.444
LIG_SH2_NCK_1	137	141	PF00017	0.586
LIG_SH2_NCK_1	670	674	PF00017	0.552
LIG_SH2_SRC	219	222	PF00017	0.533
LIG_SH2_SRC	622	625	PF00017	0.392
LIG_SH2_SRC	654	657	PF00017	0.523
LIG_SH2_STAP1	321	325	PF00017	0.550
LIG_SH2_STAT5	119	122	PF00017	0.531
LIG_SH2_STAT5	219	222	PF00017	0.463
LIG_SH2_STAT5	292	295	PF00017	0.382
LIG_SH2_STAT5	337	340	PF00017	0.543
LIG_SH2_STAT5	350	353	PF00017	0.307
LIG_SH2_STAT5	452	455	PF00017	0.483
LIG_SH2_STAT5	624	627	PF00017	0.414
LIG_SH2_STAT5	628	631	PF00017	0.423
LIG_SH2_STAT5	654	657	PF00017	0.459
LIG_SH2_STAT5	658	661	PF00017	0.468
LIG_SH2_STAT5	670	673	PF00017	0.552
LIG_SH3_3	130	136	PF00018	0.400
LIG_SH3_3	221	227	PF00018	0.558
LIG_SH3_3	34	40	PF00018	0.566
LIG_SH3_3	560	566	PF00018	0.656
LIG_SH3_3	637	643	PF00018	0.691
LIG_SUMO_SIM_anti_2	754	760	PF11976	0.567
LIG_SUMO_SIM_par_1	630	636	PF11976	0.494
LIG_SUMO_SIM_par_1	751	757	PF11976	0.623
LIG_SUMO_SIM_par_1	772	779	PF11976	0.613
LIG_TRAF2_1	679	682	PF00917	0.555
LIG_TYR_ITIM	596	601	PF00017	0.437
MOD_CK1_1	113	119	PF00069	0.480
MOD_CK1_1	127	133	PF00069	0.457
MOD_CK1_1	230	236	PF00069	0.736
MOD_CK1_1	240	246	PF00069	0.734
MOD_CK1_1	648	654	PF00069	0.519
MOD_CK1_1	680	686	PF00069	0.591
MOD_CK1_1	693	699	PF00069	0.705
MOD_CK1_1	709	715	PF00069	0.690
MOD_CK1_1	717	723	PF00069	0.777
MOD_CK2_1	192	198	PF00069	0.540
MOD_CK2_1	212	218	PF00069	0.522
MOD_CK2_1	401	407	PF00069	0.700
MOD_CK2_1	676	682	PF00069	0.657
MOD_CK2_1	697	703	PF00069	0.601
MOD_GlcNHglycan	150	153	PF01048	0.749
MOD_GlcNHglycan	229	232	PF01048	0.709
MOD_GlcNHglycan	243	246	PF01048	0.687
MOD_GlcNHglycan	25	28	PF01048	0.637
MOD_GlcNHglycan	417	420	PF01048	0.747
MOD_GlcNHglycan	515	518	PF01048	0.563
MOD_GlcNHglycan	552	555	PF01048	0.588
MOD_GlcNHglycan	625	628	PF01048	0.508
MOD_GlcNHglycan	681	685	PF01048	0.792
MOD_GlcNHglycan	83	86	PF01048	0.516
MOD_GlcNHglycan	95	98	PF01048	0.437
MOD_GSK3_1	100	107	PF00069	0.410
MOD_GSK3_1	123	130	PF00069	0.435
MOD_GSK3_1	223	230	PF00069	0.672
MOD_GSK3_1	237	244	PF00069	0.765
MOD_GSK3_1	368	375	PF00069	0.598
MOD_GSK3_1	415	422	PF00069	0.652
MOD_GSK3_1	428	435	PF00069	0.744
MOD_GSK3_1	437	444	PF00069	0.721
MOD_GSK3_1	451	458	PF00069	0.469
MOD_GSK3_1	477	484	PF00069	0.514
MOD_GSK3_1	550	557	PF00069	0.574
MOD_GSK3_1	623	630	PF00069	0.626
MOD_GSK3_1	639	646	PF00069	0.476
MOD_GSK3_1	676	683	PF00069	0.720
MOD_GSK3_1	693	700	PF00069	0.517
MOD_GSK3_1	705	712	PF00069	0.568
MOD_GSK3_1	714	721	PF00069	0.766
MOD_GSK3_1	77	84	PF00069	0.628
MOD_LATS_1	538	544	PF00433	0.561
MOD_N-GLC_1	363	368	PF02516	0.414
MOD_N-GLC_1	81	86	PF02516	0.499
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	118	123	PF00069	0.422
MOD_NEK2_1	42	47	PF00069	0.523
MOD_NEK2_1	481	486	PF00069	0.500
MOD_NEK2_1	507	512	PF00069	0.320
MOD_NEK2_1	555	560	PF00069	0.644
MOD_NEK2_1	63	68	PF00069	0.587
MOD_NEK2_1	690	695	PF00069	0.670
MOD_NEK2_1	83	88	PF00069	0.274
MOD_NEK2_2	382	387	PF00069	0.532
MOD_NEK2_2	498	503	PF00069	0.387
MOD_OFUCOSY	123	128	PF10250	0.462
MOD_OFUCOSY	163	170	PF10250	0.560
MOD_PIKK_1	337	343	PF00454	0.469
MOD_PIKK_1	455	461	PF00454	0.508
MOD_PIKK_1	54	60	PF00454	0.480
MOD_PIKK_1	555	561	PF00454	0.677
MOD_PIKK_1	616	622	PF00454	0.483
MOD_PIKK_1	74	80	PF00454	0.273
MOD_PK_1	235	241	PF00069	0.512
MOD_PKA_1	513	519	PF00069	0.475
MOD_PKA_1	676	682	PF00069	0.766
MOD_PKA_2	100	106	PF00069	0.447
MOD_PKA_2	192	198	PF00069	0.571
MOD_PKA_2	459	465	PF00069	0.432
MOD_PKA_2	513	519	PF00069	0.504
MOD_PKA_2	676	682	PF00069	0.741
MOD_PKA_2	693	699	PF00069	0.629
MOD_PKA_2	709	715	PF00069	0.513
MOD_PKA_2	93	99	PF00069	0.415
MOD_PKB_1	675	683	PF00069	0.526
MOD_Plk_1	143	149	PF00069	0.566
MOD_Plk_1	363	369	PF00069	0.604
MOD_Plk_1	42	48	PF00069	0.671
MOD_Plk_1	569	575	PF00069	0.599
MOD_Plk_2-3	697	703	PF00069	0.727
MOD_Plk_4	104	110	PF00069	0.473
MOD_Plk_4	368	374	PF00069	0.521
MOD_Plk_4	382	388	PF00069	0.399
MOD_Plk_4	459	465	PF00069	0.459
MOD_Plk_4	63	69	PF00069	0.529
MOD_Plk_4	648	654	PF00069	0.553
MOD_Plk_4	754	760	PF00069	0.745
MOD_ProDKin_1	223	229	PF00069	0.598
MOD_ProDKin_1	375	381	PF00069	0.526
MOD_ProDKin_1	419	425	PF00069	0.707
MOD_ProDKin_1	432	438	PF00069	0.634
MOD_ProDKin_1	559	565	PF00069	0.665
MOD_ProDKin_1	627	633	PF00069	0.550
MOD_ProDKin_1	639	645	PF00069	0.705
MOD_SUMO_for_1	605	608	PF00179	0.535
MOD_SUMO_rev_2	592	597	PF00179	0.506
MOD_SUMO_rev_2	599	607	PF00179	0.478
TRG_ENDOCYTIC_2	119	122	PF00928	0.523
TRG_ENDOCYTIC_2	137	140	PF00928	0.517
TRG_ENDOCYTIC_2	154	157	PF00928	0.705
TRG_ENDOCYTIC_2	292	295	PF00928	0.387
TRG_ENDOCYTIC_2	350	353	PF00928	0.459
TRG_ENDOCYTIC_2	464	467	PF00928	0.540
TRG_ENDOCYTIC_2	598	601	PF00928	0.410
TRG_ENDOCYTIC_2	615	618	PF00928	0.370
TRG_ENDOCYTIC_2	622	625	PF00928	0.389
TRG_ENDOCYTIC_2	87	90	PF00928	0.389
TRG_ER_diArg_1	260	263	PF00400	0.323
TRG_ER_diArg_1	357	360	PF00400	0.510
TRG_ER_diArg_1	513	515	PF00400	0.479
TRG_ER_diArg_1	519	521	PF00400	0.487
TRG_ER_diArg_1	573	575	PF00400	0.511
TRG_ER_diArg_1	675	678	PF00400	0.750
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	527	532	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V6	Leptomonas seymouri	55%	91%
A0A0S4IQF5	Bodo saltans	29%	100%
A0A1X0P352	Trypanosomatidae	31%	100%
A0A3R7NPX7	Trypanosoma rangeli	31%	100%
A4HIH5	Leishmania braziliensis	77%	100%
A4I5S2	Leishmania infantum	99%	100%
C9ZR41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B117	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4Q749	Leishmania major	93%	99%
V5BC99	Trypanosoma cruzi	31%	100%