TPR_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJJ7_LEIDO

TriTrypDb:

LdBPK_302450.1 , LdCL_300030000 , LDHU3_30.3300

Length:

781

Annotations

LeishMANIAdb annotations

Might be a conserved chaperone protein, probably not transmembrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJJ7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030544	Hsp70 protein binding	4	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.431
CLV_C14_Caspase3-7	243	247	PF00656	0.404
CLV_C14_Caspase3-7	25	29	PF00656	0.563
CLV_C14_Caspase3-7	736	740	PF00656	0.654
CLV_NRD_NRD_1	357	359	PF00675	0.601
CLV_NRD_NRD_1	513	515	PF00675	0.369
CLV_NRD_NRD_1	519	521	PF00675	0.369
CLV_NRD_NRD_1	526	528	PF00675	0.380
CLV_NRD_NRD_1	574	576	PF00675	0.407
CLV_NRD_NRD_1	677	679	PF00675	0.585

Previous1 2 3 4 5…28Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V6	Leptomonas seymouri	55%	91%
A0A0S4IQF5	Bodo saltans	29%	100%
A0A1X0P352	Trypanosomatidae	31%	100%
A0A3R7NPX7	Trypanosoma rangeli	31%	100%
A4HIH5	Leishmania braziliensis	77%	100%
A4I5S2	Leishmania infantum	99%	100%
C9ZR41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B117	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4Q749	Leishmania major	93%	99%
V5BC99	Trypanosoma cruzi	31%	100%

Previous1Next