CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJJ3_LEIDO

TriTrypDb:

LdBPK_323190.1 , LdCL_320037700 , LDHU3_32.4040

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IJJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJJ3

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	2
GO:0042592	homeostatic process	3	2
GO:0048878	chemical homeostasis	4	2
GO:0050801	monoatomic ion homeostasis	5	2
GO:0055065	obsolete metal ion homeostasis	7	2
GO:0055080	monoatomic cation homeostasis	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0072507	obsolete divalent inorganic cation homeostasis	7	2
GO:0098771	inorganic ion homeostasis	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.199
CLV_PCSK_FUR_1	30	34	PF00082	0.199
CLV_PCSK_KEX2_1	32	34	PF00082	0.199
CLV_PCSK_SKI1_1	32	36	PF00082	0.199
CLV_PCSK_SKI1_1	64	68	PF00082	0.400
CLV_PCSK_SKI1_1	88	92	PF00082	0.199
DEG_APCC_DBOX_1	31	39	PF00400	0.400
DEG_APCC_DBOX_1	63	71	PF00400	0.199
DOC_CYCLIN_RxL_1	29	39	PF00134	0.400
DOC_MAPK_DCC_7	64	72	PF00069	0.199
DOC_MAPK_gen_1	139	147	PF00069	0.199
DOC_MAPK_gen_1	30	37	PF00069	0.400
DOC_MAPK_MEF2A_6	40	48	PF00069	0.400
DOC_MAPK_MEF2A_6	64	72	PF00069	0.199
DOC_MAPK_NFAT4_5	64	72	PF00069	0.199
DOC_PP1_RVXF_1	38	44	PF00149	0.400
DOC_PP2B_PxIxI_1	103	109	PF00149	0.199
DOC_PP4_FxxP_1	101	104	PF00568	0.199
DOC_USP7_MATH_1	28	32	PF00917	0.400
DOC_WW_Pin1_4	100	105	PF00397	0.199
LIG_BIR_II_1	1	5	PF00653	0.400
LIG_BRCT_BRCA1_1	86	90	PF00533	0.199
LIG_Clathr_ClatBox_1	8	12	PF01394	0.400
LIG_FHA_1	111	117	PF00498	0.199
LIG_FHA_2	48	54	PF00498	0.199
LIG_LIR_Apic_2	99	104	PF02991	0.199
LIG_LIR_Gen_1	103	112	PF02991	0.199
LIG_LIR_Gen_1	50	59	PF02991	0.199
LIG_LIR_Gen_1	79	90	PF02991	0.199
LIG_LIR_Nem_3	103	108	PF02991	0.199
LIG_LIR_Nem_3	132	138	PF02991	0.199
LIG_LIR_Nem_3	50	54	PF02991	0.199
LIG_LIR_Nem_3	79	85	PF02991	0.199
LIG_MAD2	107	115	PF02301	0.199
LIG_NRBOX	40	46	PF00104	0.400
LIG_Pex14_2	101	105	PF04695	0.199
LIG_REV1ctd_RIR_1	133	143	PF16727	0.199
LIG_SH3_3	113	119	PF00018	0.199
LIG_SUMO_SIM_par_1	33	39	PF11976	0.400
LIG_SUMO_SIM_par_1	44	50	PF11976	0.199
LIG_SUMO_SIM_par_1	59	65	PF11976	0.199
LIG_SUMO_SIM_par_1	68	75	PF11976	0.199
LIG_UBA3_1	34	40	PF00899	0.400
MOD_CDK_SPxxK_3	100	107	PF00069	0.199
MOD_CK1_1	17	23	PF00069	0.400
MOD_CK2_1	33	39	PF00069	0.400
MOD_GlcNHglycan	16	19	PF01048	0.199
MOD_GlcNHglycan	97	101	PF01048	0.199
MOD_GSK3_1	7	14	PF00069	0.400
MOD_GSK3_1	72	79	PF00069	0.199
MOD_GSK3_1	96	103	PF00069	0.400
MOD_NEK2_1	11	16	PF00069	0.400
MOD_NEK2_1	110	115	PF00069	0.199
MOD_NEK2_1	71	76	PF00069	0.199
MOD_NEK2_1	96	101	PF00069	0.400
MOD_PIKK_1	118	124	PF00454	0.199
MOD_PK_1	33	39	PF00069	0.400
MOD_PKA_2	14	20	PF00069	0.400
MOD_Plk_1	11	17	PF00069	0.400
MOD_Plk_1	96	102	PF00069	0.400
MOD_Plk_4	33	39	PF00069	0.400
MOD_Plk_4	76	82	PF00069	0.199
MOD_ProDKin_1	100	106	PF00069	0.199
TRG_AP2beta_CARGO_1	132	142	PF09066	0.199
TRG_DiLeu_BaEn_2	96	102	PF01217	0.400
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.400
TRG_DiLeu_LyEn_5	57	62	PF01217	0.199
TRG_ER_diArg_1	30	33	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q17586	CAEEL	24%	32%
Q4V3C7	ARATH	33%	30%
Q67XQ0	ARATH	33%	30%
Q8VZI2	ARATH	35%	35%
Q9ZQR4	ARATH	33%	35%
Q9ZVS8	ARATH	35%	30%