Dolichol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dolichol kinase

Gene product:

dolichol kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJJ2_LEIDO

TriTrypDb:

LdBPK_352980.1 , LdCL_350034700 , LDHU3_35.3830

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0016020	membrane	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IJJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJJ2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	9
GO:0019637	organophosphate metabolic process	3	11
GO:0043048	dolichyl monophosphate biosynthetic process	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004168	dolichol kinase activity	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.626
CLV_C14_Caspase3-7	490	494	PF00656	0.343
CLV_NRD_NRD_1	207	209	PF00675	0.443
CLV_NRD_NRD_1	210	212	PF00675	0.412
CLV_NRD_NRD_1	285	287	PF00675	0.325
CLV_NRD_NRD_1	418	420	PF00675	0.402
CLV_NRD_NRD_1	66	68	PF00675	0.427
CLV_PCSK_KEX2_1	206	208	PF00082	0.471
CLV_PCSK_KEX2_1	212	214	PF00082	0.408
CLV_PCSK_KEX2_1	285	287	PF00082	0.327
CLV_PCSK_KEX2_1	418	420	PF00082	0.402
CLV_PCSK_KEX2_1	66	68	PF00082	0.425
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.408
CLV_PCSK_PC7_1	208	214	PF00082	0.385
CLV_PCSK_PC7_1	281	287	PF00082	0.358
CLV_PCSK_SKI1_1	243	247	PF00082	0.588
CLV_PCSK_SKI1_1	286	290	PF00082	0.282
CLV_PCSK_SKI1_1	423	427	PF00082	0.438
DEG_Nend_UBRbox_3	1	3	PF02207	0.452
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.282
DOC_MAPK_gen_1	206	218	PF00069	0.612
DOC_MAPK_gen_1	285	294	PF00069	0.474
DOC_MAPK_MEF2A_6	211	218	PF00069	0.537
DOC_MAPK_MEF2A_6	22	30	PF00069	0.325
DOC_MAPK_MEF2A_6	355	364	PF00069	0.447
DOC_MAPK_NFAT4_5	22	30	PF00069	0.364
DOC_MAPK_NFAT4_5	355	363	PF00069	0.434
DOC_PP2B_LxvP_1	159	162	PF13499	0.446
DOC_PP2B_LxvP_1	23	26	PF13499	0.348
DOC_PP2B_LxvP_1	495	498	PF13499	0.304
DOC_PP2B_LxvP_1	511	514	PF13499	0.447
DOC_PP4_FxxP_1	546	549	PF00568	0.714
DOC_USP7_MATH_1	13	17	PF00917	0.451
DOC_USP7_MATH_1	434	438	PF00917	0.595
DOC_USP7_MATH_1	542	546	PF00917	0.731
DOC_WW_Pin1_4	295	300	PF00397	0.335
DOC_WW_Pin1_4	41	46	PF00397	0.353
DOC_WW_Pin1_4	538	543	PF00397	0.745
DOC_WW_Pin1_4	545	550	PF00397	0.729
DOC_WW_Pin1_4	67	72	PF00397	0.676
LIG_14-3-3_CanoR_1	165	169	PF00244	0.377
LIG_14-3-3_CanoR_1	255	260	PF00244	0.344
LIG_14-3-3_CanoR_1	418	422	PF00244	0.651
LIG_14-3-3_CanoR_1	98	103	PF00244	0.330
LIG_Actin_WH2_2	265	283	PF00022	0.468
LIG_APCC_ABBAyCdc20_2	426	432	PF00400	0.713
LIG_BRCT_BRCA1_1	214	218	PF00533	0.490
LIG_BRCT_BRCA1_1	233	237	PF00533	0.386
LIG_BRCT_BRCA1_1	250	254	PF00533	0.396
LIG_BRCT_BRCA1_1	410	414	PF00533	0.447
LIG_Clathr_ClatBox_1	512	516	PF01394	0.402
LIG_EH1_1	363	371	PF00400	0.383
LIG_eIF4E_1	424	430	PF01652	0.710
LIG_FHA_1	442	448	PF00498	0.488
LIG_FHA_1	9	15	PF00498	0.387
LIG_FHA_2	299	305	PF00498	0.480
LIG_FHA_2	481	487	PF00498	0.392
LIG_GBD_Chelix_1	272	280	PF00786	0.526
LIG_HP1_1	498	502	PF01393	0.447
LIG_LIR_Apic_2	516	522	PF02991	0.667
LIG_LIR_Apic_2	545	549	PF02991	0.590
LIG_LIR_Gen_1	110	120	PF02991	0.408
LIG_LIR_Gen_1	166	176	PF02991	0.354
LIG_LIR_Gen_1	191	197	PF02991	0.598
LIG_LIR_Gen_1	304	315	PF02991	0.282
LIG_LIR_Gen_1	356	366	PF02991	0.447
LIG_LIR_Gen_1	475	484	PF02991	0.333
LIG_LIR_Gen_1	55	64	PF02991	0.343
LIG_LIR_Gen_1	80	91	PF02991	0.487
LIG_LIR_Nem_3	110	115	PF02991	0.400
LIG_LIR_Nem_3	166	171	PF02991	0.375
LIG_LIR_Nem_3	191	196	PF02991	0.571
LIG_LIR_Nem_3	304	310	PF02991	0.287
LIG_LIR_Nem_3	356	362	PF02991	0.335
LIG_LIR_Nem_3	475	479	PF02991	0.315
LIG_LIR_Nem_3	540	546	PF02991	0.722
LIG_LIR_Nem_3	55	59	PF02991	0.343
LIG_LIR_Nem_3	80	86	PF02991	0.487
LIG_NRBOX	507	513	PF00104	0.447
LIG_PALB2_WD40_1	258	266	PF16756	0.402
LIG_PCNA_TLS_4	418	426	PF02747	0.678
LIG_Pex14_1	244	248	PF04695	0.330
LIG_PTB_Apo_2	424	431	PF02174	0.607
LIG_REV1ctd_RIR_1	112	119	PF16727	0.410
LIG_SH2_CRK	83	87	PF00017	0.441
LIG_SH2_GRB2like	327	330	PF00017	0.621
LIG_SH2_NCK_1	168	172	PF00017	0.374
LIG_SH2_NCK_1	83	87	PF00017	0.441
LIG_SH2_PTP2	182	185	PF00017	0.441
LIG_SH2_STAP1	168	172	PF00017	0.374
LIG_SH2_STAP1	474	478	PF00017	0.404
LIG_SH2_STAP1	49	53	PF00017	0.347
LIG_SH2_STAT5	107	110	PF00017	0.364
LIG_SH2_STAT5	112	115	PF00017	0.349
LIG_SH2_STAT5	137	140	PF00017	0.408
LIG_SH2_STAT5	168	171	PF00017	0.351
LIG_SH2_STAT5	182	185	PF00017	0.396
LIG_SH2_STAT5	248	251	PF00017	0.336
LIG_SH2_STAT5	271	274	PF00017	0.408
LIG_SH2_STAT5	359	362	PF00017	0.335
LIG_SH2_STAT5	424	427	PF00017	0.613
LIG_SH2_STAT5	56	59	PF00017	0.355
LIG_SH3_3	377	383	PF00018	0.453
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.390
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.355
LIG_SUMO_SIM_par_1	182	188	PF11976	0.411
LIG_SUMO_SIM_par_1	271	277	PF11976	0.432
LIG_SUMO_SIM_par_1	384	389	PF11976	0.382
LIG_SUMO_SIM_par_1	459	465	PF11976	0.403
LIG_SUMO_SIM_par_1	477	483	PF11976	0.223
LIG_SUMO_SIM_par_1	5	11	PF11976	0.383
LIG_TRFH_1	263	267	PF08558	0.402
LIG_TYR_ITIM	54	59	PF00017	0.355
LIG_TYR_ITIM	81	86	PF00017	0.441
LIG_TYR_ITSM	164	171	PF00017	0.404
LIG_UBA3_1	113	117	PF00899	0.402
LIG_WRC_WIRS_1	473	478	PF05994	0.379
MOD_CDC14_SPxK_1	541	544	PF00782	0.710
MOD_CDK_SPK_2	67	72	PF00069	0.676
MOD_CDK_SPxK_1	538	544	PF00069	0.706
MOD_CDK_SPxxK_3	67	74	PF00069	0.675
MOD_CK1_1	155	161	PF00069	0.511
MOD_CK1_1	188	194	PF00069	0.553
MOD_CK1_1	202	208	PF00069	0.592
MOD_CK1_1	417	423	PF00069	0.666
MOD_CK1_1	545	551	PF00069	0.730
MOD_CK1_1	55	61	PF00069	0.349
MOD_CK2_1	480	486	PF00069	0.350
MOD_GlcNHglycan	109	112	PF01048	0.447
MOD_GSK3_1	166	173	PF00069	0.352
MOD_GSK3_1	195	202	PF00069	0.621
MOD_GSK3_1	310	317	PF00069	0.358
MOD_GSK3_1	330	337	PF00069	0.596
MOD_GSK3_1	409	416	PF00069	0.335
MOD_GSK3_1	436	443	PF00069	0.587
MOD_GSK3_1	48	55	PF00069	0.341
MOD_GSK3_1	527	534	PF00069	0.734
MOD_GSK3_1	538	545	PF00069	0.735
MOD_GSK3_1	8	15	PF00069	0.395
MOD_N-GLC_1	145	150	PF02516	0.624
MOD_N-GLC_1	434	439	PF02516	0.393
MOD_NEK2_1	129	134	PF00069	0.349
MOD_NEK2_1	218	223	PF00069	0.338
MOD_NEK2_1	231	236	PF00069	0.412
MOD_NEK2_1	249	254	PF00069	0.421
MOD_NEK2_1	310	315	PF00069	0.346
MOD_NEK2_1	364	369	PF00069	0.322
MOD_NEK2_1	413	418	PF00069	0.504
MOD_NEK2_1	48	53	PF00069	0.347
MOD_PIKK_1	522	528	PF00454	0.538
MOD_PK_1	212	218	PF00069	0.501
MOD_PK_1	373	379	PF00069	0.474
MOD_PKA_1	207	213	PF00069	0.637
MOD_PKA_2	152	158	PF00069	0.504
MOD_PKA_2	164	170	PF00069	0.242
MOD_PKA_2	207	213	PF00069	0.578
MOD_PKA_2	280	286	PF00069	0.569
MOD_PKA_2	417	423	PF00069	0.660
MOD_PKB_1	253	261	PF00069	0.328
MOD_PKB_1	371	379	PF00069	0.463
MOD_Plk_1	145	151	PF00069	0.428
MOD_Plk_1	386	392	PF00069	0.346
MOD_Plk_1	434	440	PF00069	0.597
MOD_Plk_4	129	135	PF00069	0.378
MOD_Plk_4	152	158	PF00069	0.481
MOD_Plk_4	185	191	PF00069	0.381
MOD_Plk_4	2	8	PF00069	0.364
MOD_Plk_4	298	304	PF00069	0.394
MOD_Plk_4	409	415	PF00069	0.335
MOD_Plk_4	49	55	PF00069	0.335
MOD_Plk_4	77	83	PF00069	0.402
MOD_ProDKin_1	295	301	PF00069	0.335
MOD_ProDKin_1	41	47	PF00069	0.349
MOD_ProDKin_1	538	544	PF00069	0.747
MOD_ProDKin_1	545	551	PF00069	0.730
MOD_ProDKin_1	67	73	PF00069	0.674
MOD_SUMO_for_1	62	65	PF00179	0.666
TRG_DiLeu_BaEn_1	20	25	PF01217	0.337
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.368
TRG_ENDOCYTIC_2	112	115	PF00928	0.365
TRG_ENDOCYTIC_2	168	171	PF00928	0.378
TRG_ENDOCYTIC_2	182	185	PF00928	0.348
TRG_ENDOCYTIC_2	327	330	PF00928	0.580
TRG_ENDOCYTIC_2	359	362	PF00928	0.417
TRG_ENDOCYTIC_2	56	59	PF00928	0.355
TRG_ENDOCYTIC_2	83	86	PF00928	0.399
TRG_ER_diArg_1	206	208	PF00400	0.677
TRG_ER_diArg_1	211	214	PF00400	0.602
TRG_ER_diArg_1	284	286	PF00400	0.560
TRG_ER_diArg_1	370	373	PF00400	0.389
TRG_NLS_MonoExtN_4	208	215	PF00514	0.638
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ90	Leptomonas seymouri	76%	91%
A0A1X0P5F5	Trypanosomatidae	50%	100%
A0A3R7KY54	Trypanosoma rangeli	50%	100%
A4HMW0	Leishmania braziliensis	88%	100%
A4IBI1	Leishmania infantum	100%	100%
C9ZZ59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	99%
E9AFB7	Leishmania major	95%	100%
E9B6H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BTH9	Trypanosoma cruzi	51%	100%