Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJI6_LEIDO

TriTrypDb:

LdBPK_171300.1 , LdCL_170019200 , LDHU3_17.1810

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IJI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.631
CLV_C14_Caspase3-7	570	574	PF00656	0.577
CLV_C14_Caspase3-7	689	693	PF00656	0.597
CLV_NRD_NRD_1	215	217	PF00675	0.735
CLV_NRD_NRD_1	224	226	PF00675	0.617
CLV_NRD_NRD_1	248	250	PF00675	0.721
CLV_NRD_NRD_1	260	262	PF00675	0.556
CLV_NRD_NRD_1	461	463	PF00675	0.721
CLV_NRD_NRD_1	598	600	PF00675	0.685
CLV_NRD_NRD_1	628	630	PF00675	0.799
CLV_NRD_NRD_1	648	650	PF00675	0.624
CLV_NRD_NRD_1	669	671	PF00675	0.761
CLV_NRD_NRD_1	675	677	PF00675	0.763
CLV_NRD_NRD_1	699	701	PF00675	0.741
CLV_NRD_NRD_1	708	710	PF00675	0.644
CLV_NRD_NRD_1	758	760	PF00675	0.759
CLV_PCSK_FUR_1	222	226	PF00082	0.603
CLV_PCSK_KEX2_1	215	217	PF00082	0.735
CLV_PCSK_KEX2_1	224	226	PF00082	0.617
CLV_PCSK_KEX2_1	248	250	PF00082	0.721
CLV_PCSK_KEX2_1	303	305	PF00082	0.543
CLV_PCSK_KEX2_1	321	323	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.644
CLV_PCSK_KEX2_1	380	382	PF00082	0.549
CLV_PCSK_KEX2_1	461	463	PF00082	0.721
CLV_PCSK_KEX2_1	597	599	PF00082	0.704
CLV_PCSK_KEX2_1	627	629	PF00082	0.656
CLV_PCSK_KEX2_1	648	650	PF00082	0.618
CLV_PCSK_KEX2_1	669	671	PF00082	0.773
CLV_PCSK_KEX2_1	675	677	PF00082	0.684
CLV_PCSK_KEX2_1	699	701	PF00082	0.741
CLV_PCSK_KEX2_1	708	710	PF00082	0.644
CLV_PCSK_KEX2_1	758	760	PF00082	0.762
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.543
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.501
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.604
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.489
CLV_PCSK_PC7_1	695	701	PF00082	0.740
CLV_PCSK_SKI1_1	318	322	PF00082	0.472
CLV_PCSK_SKI1_1	632	636	PF00082	0.677
CLV_PCSK_SKI1_1	686	690	PF00082	0.718
DEG_Nend_UBRbox_1	1	4	PF02207	0.661
DEG_SPOP_SBC_1	149	153	PF00917	0.657
DEG_SPOP_SBC_1	363	367	PF00917	0.563
DEG_SPOP_SBC_1	591	595	PF00917	0.709
DOC_CKS1_1	122	127	PF01111	0.552
DOC_CKS1_1	588	593	PF01111	0.692
DOC_MAPK_gen_1	708	716	PF00069	0.659
DOC_MIT_MIM_1	383	392	PF04212	0.541
DOC_PP1_RVXF_1	483	489	PF00149	0.655
DOC_PP2B_LxvP_1	126	129	PF13499	0.842
DOC_PP4_FxxP_1	118	121	PF00568	0.702
DOC_PP4_FxxP_1	735	738	PF00568	0.569
DOC_USP7_MATH_1	106	110	PF00917	0.588
DOC_USP7_MATH_1	149	153	PF00917	0.657
DOC_USP7_MATH_1	209	213	PF00917	0.700
DOC_USP7_MATH_1	21	25	PF00917	0.646
DOC_USP7_MATH_1	240	244	PF00917	0.694
DOC_USP7_MATH_1	35	39	PF00917	0.695
DOC_USP7_MATH_1	363	367	PF00917	0.566
DOC_USP7_MATH_1	452	456	PF00917	0.607
DOC_USP7_MATH_1	481	485	PF00917	0.660
DOC_USP7_MATH_1	500	504	PF00917	0.758
DOC_USP7_MATH_1	560	564	PF00917	0.794
DOC_USP7_MATH_1	591	595	PF00917	0.750
DOC_USP7_MATH_1	607	611	PF00917	0.576
DOC_USP7_MATH_1	634	638	PF00917	0.653
DOC_USP7_MATH_1	659	663	PF00917	0.729
DOC_USP7_MATH_1	762	766	PF00917	0.704
DOC_USP7_MATH_1	767	771	PF00917	0.680
DOC_WW_Pin1_4	116	121	PF00397	0.728
DOC_WW_Pin1_4	182	187	PF00397	0.747
DOC_WW_Pin1_4	479	484	PF00397	0.725
DOC_WW_Pin1_4	587	592	PF00397	0.693
DOC_WW_Pin1_4	66	71	PF00397	0.656
DOC_WW_Pin1_4	702	707	PF00397	0.796
DOC_WW_Pin1_4	734	739	PF00397	0.709
DOC_WW_Pin1_4	89	94	PF00397	0.651
LIG_14-3-3_CanoR_1	107	115	PF00244	0.727
LIG_14-3-3_CanoR_1	222	230	PF00244	0.740
LIG_14-3-3_CanoR_1	242	247	PF00244	0.674
LIG_14-3-3_CanoR_1	248	253	PF00244	0.729
LIG_14-3-3_CanoR_1	254	264	PF00244	0.600
LIG_14-3-3_CanoR_1	473	478	PF00244	0.586
LIG_14-3-3_CanoR_1	506	511	PF00244	0.658
LIG_14-3-3_CanoR_1	542	550	PF00244	0.708
LIG_14-3-3_CanoR_1	578	586	PF00244	0.710
LIG_14-3-3_CanoR_1	592	597	PF00244	0.597
LIG_14-3-3_CanoR_1	598	607	PF00244	0.527
LIG_14-3-3_CanoR_1	621	627	PF00244	0.698
LIG_14-3-3_CanoR_1	675	682	PF00244	0.737
LIG_14-3-3_CanoR_1	683	689	PF00244	0.746
LIG_14-3-3_CanoR_1	699	706	PF00244	0.693
LIG_14-3-3_CanoR_1	722	726	PF00244	0.666
LIG_14-3-3_CanoR_1	772	781	PF00244	0.762
LIG_14-3-3_CanoR_1	833	841	PF00244	0.635
LIG_BIR_III_2	557	561	PF00653	0.617
LIG_BIR_III_2	64	68	PF00653	0.649
LIG_BIR_III_4	633	637	PF00653	0.630
LIG_BIR_III_4	644	648	PF00653	0.625
LIG_BRCT_BRCA1_1	158	162	PF00533	0.576
LIG_FHA_1	581	587	PF00498	0.739
LIG_FHA_1	591	597	PF00498	0.638
LIG_FHA_1	677	683	PF00498	0.675
LIG_FHA_1	761	767	PF00498	0.724
LIG_FHA_1	796	802	PF00498	0.694
LIG_FHA_2	284	290	PF00498	0.495
LIG_FHA_2	403	409	PF00498	0.498
LIG_FHA_2	687	693	PF00498	0.785
LIG_Integrin_RGD_1	818	820	PF01839	0.498
LIG_LIR_Apic_2	117	121	PF02991	0.645
LIG_LIR_Apic_2	732	738	PF02991	0.575
LIG_LIR_Nem_3	84	90	PF02991	0.587
LIG_MYND_1	182	186	PF01753	0.659
LIG_SH2_NCK_1	601	605	PF00017	0.605
LIG_SH2_SRC	263	266	PF00017	0.628
LIG_SH2_STAP1	630	634	PF00017	0.604
LIG_SH2_STAT5	263	266	PF00017	0.670
LIG_SH3_2	828	833	PF14604	0.700
LIG_SH3_3	119	125	PF00018	0.631
LIG_SH3_3	573	579	PF00018	0.716
LIG_SH3_3	64	70	PF00018	0.687
LIG_SH3_3	665	671	PF00018	0.735
LIG_SH3_3	735	741	PF00018	0.646
LIG_SH3_3	825	831	PF00018	0.694
LIG_SH3_3	837	843	PF00018	0.582
LIG_SH3_3	849	855	PF00018	0.606
LIG_SH3_3	87	93	PF00018	0.577
LIG_SH3_5	83	87	PF00018	0.671
MOD_CDC14_SPxK_1	482	485	PF00782	0.664
MOD_CDC14_SPxK_1	705	708	PF00782	0.685
MOD_CDK_SPK_2	587	592	PF00069	0.693
MOD_CDK_SPxK_1	479	485	PF00069	0.716
MOD_CDK_SPxK_1	702	708	PF00069	0.689
MOD_CDK_SPxxK_3	702	709	PF00069	0.737
MOD_CK1_1	13	19	PF00069	0.723
MOD_CK1_1	151	157	PF00069	0.712
MOD_CK1_1	200	206	PF00069	0.715
MOD_CK1_1	229	235	PF00069	0.699
MOD_CK1_1	255	261	PF00069	0.695
MOD_CK1_1	266	272	PF00069	0.572
MOD_CK1_1	365	371	PF00069	0.507
MOD_CK1_1	425	431	PF00069	0.692
MOD_CK1_1	602	608	PF00069	0.728
MOD_CK1_1	610	616	PF00069	0.656
MOD_CK1_1	678	684	PF00069	0.624
MOD_CK1_1	702	708	PF00069	0.680
MOD_CK1_1	73	79	PF00069	0.732
MOD_CK1_1	737	743	PF00069	0.659
MOD_CK1_1	752	758	PF00069	0.535
MOD_CK1_1	770	776	PF00069	0.611
MOD_CK1_1	797	803	PF00069	0.662
MOD_CK1_1	832	838	PF00069	0.573
MOD_CK2_1	283	289	PF00069	0.498
MOD_CK2_1	402	408	PF00069	0.495
MOD_CK2_1	648	654	PF00069	0.697
MOD_CK2_1	89	95	PF00069	0.638
MOD_Cter_Amidation	646	649	PF01082	0.607
MOD_GlcNHglycan	12	15	PF01048	0.657
MOD_GlcNHglycan	153	156	PF01048	0.657
MOD_GlcNHglycan	158	161	PF01048	0.599
MOD_GlcNHglycan	18	21	PF01048	0.620
MOD_GlcNHglycan	211	214	PF01048	0.767
MOD_GlcNHglycan	217	220	PF01048	0.733
MOD_GlcNHglycan	241	245	PF01048	0.747
MOD_GlcNHglycan	269	272	PF01048	0.587
MOD_GlcNHglycan	344	347	PF01048	0.745
MOD_GlcNHglycan	424	427	PF01048	0.635
MOD_GlcNHglycan	450	453	PF01048	0.708
MOD_GlcNHglycan	502	505	PF01048	0.758
MOD_GlcNHglycan	522	525	PF01048	0.754
MOD_GlcNHglycan	54	57	PF01048	0.678
MOD_GlcNHglycan	562	565	PF01048	0.794
MOD_GlcNHglycan	580	583	PF01048	0.600
MOD_GlcNHglycan	611	615	PF01048	0.733
MOD_GlcNHglycan	636	639	PF01048	0.642
MOD_GlcNHglycan	650	653	PF01048	0.643
MOD_GlcNHglycan	660	664	PF01048	0.685
MOD_GlcNHglycan	665	668	PF01048	0.622
MOD_GlcNHglycan	683	686	PF01048	0.737
MOD_GlcNHglycan	701	704	PF01048	0.691
MOD_GlcNHglycan	710	713	PF01048	0.670
MOD_GlcNHglycan	727	730	PF01048	0.683
MOD_GlcNHglycan	760	763	PF01048	0.724
MOD_GlcNHglycan	772	775	PF01048	0.607
MOD_GlcNHglycan	785	788	PF01048	0.556
MOD_GlcNHglycan	79	82	PF01048	0.709
MOD_GlcNHglycan	790	793	PF01048	0.477
MOD_GlcNHglycan	804	807	PF01048	0.500
MOD_GlcNHglycan	836	839	PF01048	0.707
MOD_GSK3_1	151	158	PF00069	0.771
MOD_GSK3_1	197	204	PF00069	0.815
MOD_GSK3_1	224	231	PF00069	0.711
MOD_GSK3_1	248	255	PF00069	0.718
MOD_GSK3_1	263	270	PF00069	0.515
MOD_GSK3_1	370	377	PF00069	0.616
MOD_GSK3_1	448	455	PF00069	0.633
MOD_GSK3_1	468	475	PF00069	0.761
MOD_GSK3_1	500	507	PF00069	0.702
MOD_GSK3_1	587	594	PF00069	0.766
MOD_GSK3_1	602	609	PF00069	0.578
MOD_GSK3_1	659	666	PF00069	0.679
MOD_GSK3_1	66	73	PF00069	0.667
MOD_GSK3_1	674	681	PF00069	0.612
MOD_GSK3_1	686	693	PF00069	0.713
MOD_GSK3_1	695	702	PF00069	0.721
MOD_GSK3_1	708	715	PF00069	0.719
MOD_GSK3_1	721	728	PF00069	0.653
MOD_GSK3_1	745	752	PF00069	0.751
MOD_GSK3_1	758	765	PF00069	0.654
MOD_GSK3_1	770	777	PF00069	0.629
MOD_GSK3_1	790	797	PF00069	0.453
MOD_GSK3_1	802	809	PF00069	0.598
MOD_N-GLC_1	130	135	PF02516	0.720
MOD_N-GLC_1	201	206	PF02516	0.709
MOD_N-GLC_1	712	717	PF02516	0.612
MOD_N-GLC_1	752	757	PF02516	0.710
MOD_N-GLC_1	788	793	PF02516	0.678
MOD_N-GLC_1	806	811	PF02516	0.618
MOD_NEK2_1	162	167	PF00069	0.527
MOD_NEK2_1	252	257	PF00069	0.682
MOD_NEK2_1	364	369	PF00069	0.570
MOD_NEK2_1	422	427	PF00069	0.575
MOD_NEK2_1	567	572	PF00069	0.723
MOD_NEK2_1	721	726	PF00069	0.714
MOD_NEK2_1	834	839	PF00069	0.708
MOD_NEK2_2	767	772	PF00069	0.709
MOD_PIKK_1	130	136	PF00454	0.816
MOD_PIKK_1	162	168	PF00454	0.526
MOD_PIKK_1	197	203	PF00454	0.660
MOD_PIKK_1	255	261	PF00454	0.685
MOD_PIKK_1	567	573	PF00454	0.769
MOD_PIKK_1	602	608	PF00454	0.681
MOD_PIKK_1	690	696	PF00454	0.686
MOD_PK_1	281	287	PF00069	0.566
MOD_PK_1	473	479	PF00069	0.667
MOD_PK_1	506	512	PF00069	0.659
MOD_PK_1	669	675	PF00069	0.730
MOD_PK_1	745	751	PF00069	0.636
MOD_PKA_1	215	221	PF00069	0.722
MOD_PKA_1	224	230	PF00069	0.609
MOD_PKA_1	248	254	PF00069	0.716
MOD_PKA_1	461	467	PF00069	0.735
MOD_PKA_1	628	634	PF00069	0.689
MOD_PKA_1	648	654	PF00069	0.612
MOD_PKA_1	669	675	PF00069	0.787
MOD_PKA_1	699	705	PF00069	0.728
MOD_PKA_1	708	714	PF00069	0.651
MOD_PKA_1	758	764	PF00069	0.728
MOD_PKA_2	106	112	PF00069	0.725
MOD_PKA_2	215	221	PF00069	0.789
MOD_PKA_2	223	229	PF00069	0.680
MOD_PKA_2	248	254	PF00069	0.710
MOD_PKA_2	27	33	PF00069	0.629
MOD_PKA_2	328	334	PF00069	0.566
MOD_PKA_2	461	467	PF00069	0.735
MOD_PKA_2	472	478	PF00069	0.610
MOD_PKA_2	541	547	PF00069	0.707
MOD_PKA_2	567	573	PF00069	0.721
MOD_PKA_2	591	597	PF00069	0.741
MOD_PKA_2	628	634	PF00069	0.698
MOD_PKA_2	648	654	PF00069	0.635
MOD_PKA_2	669	675	PF00069	0.730
MOD_PKA_2	694	700	PF00069	0.771
MOD_PKA_2	708	714	PF00069	0.606
MOD_PKA_2	721	727	PF00069	0.580
MOD_PKA_2	758	764	PF00069	0.849
MOD_PKA_2	832	838	PF00069	0.653
MOD_PKB_1	222	230	PF00069	0.596
MOD_PKB_1	597	605	PF00069	0.690
MOD_Plk_1	201	207	PF00069	0.719
MOD_Plk_1	264	270	PF00069	0.594
MOD_Plk_1	288	294	PF00069	0.557
MOD_Plk_1	493	499	PF00069	0.648
MOD_Plk_1	712	718	PF00069	0.611
MOD_Plk_4	288	294	PF00069	0.557
MOD_Plk_4	425	431	PF00069	0.650
MOD_Plk_4	745	751	PF00069	0.658
MOD_Plk_4	797	803	PF00069	0.635
MOD_Plk_4	812	818	PF00069	0.530
MOD_ProDKin_1	116	122	PF00069	0.729
MOD_ProDKin_1	182	188	PF00069	0.748
MOD_ProDKin_1	479	485	PF00069	0.728
MOD_ProDKin_1	587	593	PF00069	0.693
MOD_ProDKin_1	66	72	PF00069	0.660
MOD_ProDKin_1	702	708	PF00069	0.797
MOD_ProDKin_1	734	740	PF00069	0.710
MOD_ProDKin_1	89	95	PF00069	0.649
MOD_SUMO_rev_2	391	400	PF00179	0.416
MOD_SUMO_rev_2	408	418	PF00179	0.530
TRG_DiLeu_BaEn_1	408	413	PF01217	0.535
TRG_DiLeu_BaEn_4	325	331	PF01217	0.464
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.600
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.692
TRG_DiLeu_LyEn_5	408	413	PF01217	0.535
TRG_ENDOCYTIC_2	424	427	PF00928	0.581
TRG_ENDOCYTIC_2	87	90	PF00928	0.585
TRG_ER_diArg_1	222	225	PF00400	0.644
TRG_ER_diArg_1	247	249	PF00400	0.709
TRG_ER_diArg_1	409	412	PF00400	0.538
TRG_ER_diArg_1	461	463	PF00400	0.719
TRG_ER_diArg_1	596	599	PF00400	0.792
TRG_ER_diArg_1	626	629	PF00400	0.772
TRG_ER_diArg_1	668	670	PF00400	0.807
TRG_ER_diArg_1	778	781	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.746

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H974	Leishmania braziliensis	55%	99%
A4HXJ7	Leishmania infantum	99%	100%
E9AR92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QE71	Leishmania major	86%	97%