Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prolyl endopeptidase

Species:

Leishmania donovani

UniProt:

A0A3Q8IJI4_LEIDO

TriTrypDb:

LdBPK_367060.1 , LdCL_360083200 , LDHU3_36.9430

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005829	cytosol	2	1

Expansion

Sequence features

A0A3Q8IJI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJI4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0070012	oligopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.543
CLV_NRD_NRD_1	309	311	PF00675	0.333
CLV_NRD_NRD_1	358	360	PF00675	0.409
CLV_NRD_NRD_1	9	11	PF00675	0.326
CLV_PCSK_KEX2_1	274	276	PF00082	0.274
CLV_PCSK_KEX2_1	9	11	PF00082	0.326
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.274
CLV_PCSK_SKI1_1	10	14	PF00082	0.369
CLV_PCSK_SKI1_1	336	340	PF00082	0.402
CLV_PCSK_SKI1_1	482	486	PF00082	0.328
DEG_Kelch_Keap1_1	157	162	PF01344	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.512
DEG_SCF_FBW7_1	472	479	PF00400	0.368
DOC_CDC14_PxL_1	186	194	PF14671	0.545
DOC_CYCLIN_yClb5_NLxxxL_5	484	493	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.482
DOC_MAPK_gen_1	274	282	PF00069	0.474
DOC_MAPK_gen_1	310	318	PF00069	0.514
DOC_MAPK_gen_1	368	374	PF00069	0.571
DOC_MAPK_gen_1	385	391	PF00069	0.487
DOC_MAPK_MEF2A_6	106	114	PF00069	0.560
DOC_MAPK_MEF2A_6	310	318	PF00069	0.570
DOC_MAPK_MEF2A_6	341	349	PF00069	0.545
DOC_PP1_RVXF_1	165	171	PF00149	0.570
DOC_PP1_RVXF_1	273	280	PF00149	0.668
DOC_PP1_RVXF_1	480	486	PF00149	0.345
DOC_PP2B_LxvP_1	226	229	PF13499	0.527
DOC_PP2B_LxvP_1	370	373	PF13499	0.546
DOC_PP2B_LxvP_1	493	496	PF13499	0.367
DOC_PP2B_PxIxI_1	620	626	PF00149	0.367
DOC_PP4_FxxP_1	113	116	PF00568	0.514
DOC_PP4_FxxP_1	396	399	PF00568	0.546
DOC_PP4_FxxP_1	669	672	PF00568	0.482
DOC_USP7_MATH_1	399	403	PF00917	0.537
DOC_USP7_MATH_1	410	414	PF00917	0.527
DOC_USP7_MATH_1	636	640	PF00917	0.349
DOC_USP7_MATH_1	678	682	PF00917	0.315
DOC_USP7_MATH_1	73	77	PF00917	0.545
DOC_USP7_UBL2_3	671	675	PF12436	0.349
DOC_WW_Pin1_4	454	459	PF00397	0.437
DOC_WW_Pin1_4	472	477	PF00397	0.418
DOC_WW_Pin1_4	535	540	PF00397	0.367
DOC_WW_Pin1_4	606	611	PF00397	0.349
LIG_14-3-3_CanoR_1	65	72	PF00244	0.555
LIG_14-3-3_CanoR_1	9	17	PF00244	0.533
LIG_APCC_ABBA_1	345	350	PF00400	0.545
LIG_APCC_ABBA_1	414	419	PF00400	0.436
LIG_FHA_1	109	115	PF00498	0.544
LIG_FHA_1	12	18	PF00498	0.609
LIG_FHA_1	122	128	PF00498	0.486
LIG_FHA_1	341	347	PF00498	0.510
LIG_FHA_1	520	526	PF00498	0.334
LIG_FHA_1	539	545	PF00498	0.363
LIG_FHA_1	65	71	PF00498	0.572
LIG_FHA_1	671	677	PF00498	0.345
LIG_FHA_2	19	25	PF00498	0.545
LIG_FHA_2	266	272	PF00498	0.592
LIG_FHA_2	318	324	PF00498	0.595
LIG_FHA_2	647	653	PF00498	0.337
LIG_HCF-1_HBM_1	243	246	PF13415	0.595
LIG_LIR_Apic_2	111	116	PF02991	0.527
LIG_LIR_Apic_2	394	399	PF02991	0.514
LIG_LIR_Apic_2	591	596	PF02991	0.349
LIG_LIR_Gen_1	148	158	PF02991	0.527
LIG_LIR_Gen_1	24	32	PF02991	0.528
LIG_LIR_Gen_1	243	252	PF02991	0.532
LIG_LIR_Gen_1	268	277	PF02991	0.624
LIG_LIR_Gen_1	278	287	PF02991	0.517
LIG_LIR_Gen_1	387	396	PF02991	0.609
LIG_LIR_Gen_1	428	437	PF02991	0.458
LIG_LIR_Gen_1	563	572	PF02991	0.482
LIG_LIR_Gen_1	681	691	PF02991	0.352
LIG_LIR_Nem_3	148	153	PF02991	0.504
LIG_LIR_Nem_3	24	29	PF02991	0.546
LIG_LIR_Nem_3	243	249	PF02991	0.532
LIG_LIR_Nem_3	268	273	PF02991	0.610
LIG_LIR_Nem_3	278	282	PF02991	0.506
LIG_LIR_Nem_3	3	8	PF02991	0.507
LIG_LIR_Nem_3	378	384	PF02991	0.587
LIG_LIR_Nem_3	387	391	PF02991	0.547
LIG_LIR_Nem_3	428	433	PF02991	0.479
LIG_LIR_Nem_3	46	51	PF02991	0.561
LIG_LIR_Nem_3	503	507	PF02991	0.362
LIG_LIR_Nem_3	563	568	PF02991	0.367
LIG_LIR_Nem_3	599	605	PF02991	0.352
LIG_LIR_Nem_3	606	611	PF02991	0.405
LIG_LYPXL_S_1	4	8	PF13949	0.370
LIG_LYPXL_yS_3	189	192	PF13949	0.545
LIG_LYPXL_yS_3	5	8	PF13949	0.404
LIG_LYPXL_yS_3	620	623	PF13949	0.349
LIG_PAM2_1	76	88	PF00658	0.609
LIG_PCNA_yPIPBox_3	571	582	PF02747	0.362
LIG_Pex14_1	589	593	PF04695	0.349
LIG_REV1ctd_RIR_1	182	189	PF16727	0.514
LIG_SH2_CRK	358	362	PF00017	0.560
LIG_SH2_CRK	608	612	PF00017	0.328
LIG_SH2_PTP2	152	155	PF00017	0.609
LIG_SH2_PTP2	290	293	PF00017	0.474
LIG_SH2_PTP2	430	433	PF00017	0.425
LIG_SH2_SRC	290	293	PF00017	0.474
LIG_SH2_SRC	530	533	PF00017	0.462
LIG_SH2_STAP1	684	688	PF00017	0.367
LIG_SH2_STAT3	85	88	PF00017	0.529
LIG_SH2_STAT5	152	155	PF00017	0.573
LIG_SH2_STAT5	209	212	PF00017	0.614
LIG_SH2_STAT5	246	249	PF00017	0.545
LIG_SH2_STAT5	28	31	PF00017	0.569
LIG_SH2_STAT5	290	293	PF00017	0.545
LIG_SH2_STAT5	348	351	PF00017	0.520
LIG_SH2_STAT5	403	406	PF00017	0.570
LIG_SH2_STAT5	430	433	PF00017	0.442
LIG_SH2_STAT5	530	533	PF00017	0.449
LIG_SH2_STAT5	642	645	PF00017	0.397
LIG_SH3_3	226	232	PF00018	0.525
LIG_SH3_3	455	461	PF00018	0.460
LIG_SH3_3	615	621	PF00018	0.427
LIG_SH3_4	671	678	PF00018	0.349
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.545
LIG_SUMO_SIM_anti_2	342	348	PF11976	0.554
LIG_SUMO_SIM_par_1	622	627	PF11976	0.349
LIG_TRAF2_1	269	272	PF00917	0.529
LIG_TRAF2_1	320	323	PF00917	0.573
LIG_TRAF2_1	328	331	PF00917	0.490
LIG_TRAF2_1	596	599	PF00917	0.370
LIG_TYR_ITIM	618	623	PF00017	0.367
LIG_UBA3_1	260	265	PF00899	0.570
LIG_UBA3_1	299	306	PF00899	0.549
LIG_WRC_WIRS_1	283	288	PF05994	0.620
LIG_WRC_WIRS_1	388	393	PF05994	0.533
MOD_CDC14_SPxK_1	479	482	PF00782	0.404
MOD_CDK_SPxK_1	476	482	PF00069	0.404
MOD_CK1_1	174	180	PF00069	0.607
MOD_CK1_1	379	385	PF00069	0.525
MOD_CK1_1	457	463	PF00069	0.545
MOD_CK1_1	538	544	PF00069	0.397
MOD_CK1_1	76	82	PF00069	0.570
MOD_CK2_1	130	136	PF00069	0.520
MOD_CK2_1	18	24	PF00069	0.545
MOD_CK2_1	265	271	PF00069	0.598
MOD_CK2_1	317	323	PF00069	0.533
MOD_CK2_1	51	57	PF00069	0.560
MOD_CK2_1	646	652	PF00069	0.493
MOD_GlcNHglycan	119	122	PF01048	0.395
MOD_GlcNHglycan	173	176	PF01048	0.353
MOD_GlcNHglycan	203	206	PF01048	0.395
MOD_GlcNHglycan	438	441	PF01048	0.499
MOD_GlcNHglycan	525	528	PF01048	0.473
MOD_GSK3_1	117	124	PF00069	0.580
MOD_GSK3_1	141	148	PF00069	0.573
MOD_GSK3_1	302	309	PF00069	0.579
MOD_GSK3_1	375	382	PF00069	0.542
MOD_GSK3_1	387	394	PF00069	0.515
MOD_GSK3_1	436	443	PF00069	0.459
MOD_GSK3_1	470	477	PF00069	0.397
MOD_GSK3_1	519	526	PF00069	0.473
MOD_GSK3_1	535	542	PF00069	0.390
MOD_GSK3_1	642	649	PF00069	0.337
MOD_GSK3_1	687	694	PF00069	0.317
MOD_GSK3_1	72	79	PF00069	0.570
MOD_N-GLC_1	94	99	PF02516	0.339
MOD_N-GLC_2	253	255	PF02516	0.338
MOD_NEK2_1	100	105	PF00069	0.548
MOD_NEK2_1	139	144	PF00069	0.577
MOD_NEK2_1	300	305	PF00069	0.603
MOD_NEK2_1	391	396	PF00069	0.545
MOD_NEK2_1	470	475	PF00069	0.389
MOD_NEK2_1	545	550	PF00069	0.373
MOD_NEK2_1	646	651	PF00069	0.337
MOD_NEK2_1	687	692	PF00069	0.337
MOD_NEK2_2	412	417	PF00069	0.652
MOD_NEK2_2	636	641	PF00069	0.367
MOD_PK_1	312	318	PF00069	0.543
MOD_PKA_1	452	458	PF00069	0.514
MOD_PKA_2	512	518	PF00069	0.486
MOD_PKA_2	64	70	PF00069	0.556
MOD_PKA_2	73	79	PF00069	0.508
MOD_Plk_1	563	569	PF00069	0.449
MOD_Plk_1	94	100	PF00069	0.539
MOD_Plk_4	108	114	PF00069	0.481
MOD_Plk_4	282	288	PF00069	0.582
MOD_Plk_4	329	335	PF00069	0.567
MOD_Plk_4	340	346	PF00069	0.514
MOD_Plk_4	376	382	PF00069	0.572
MOD_Plk_4	392	398	PF00069	0.507
MOD_Plk_4	412	418	PF00069	0.675
MOD_Plk_4	94	100	PF00069	0.534
MOD_ProDKin_1	454	460	PF00069	0.429
MOD_ProDKin_1	472	478	PF00069	0.416
MOD_ProDKin_1	535	541	PF00069	0.367
MOD_ProDKin_1	606	612	PF00069	0.349
MOD_SUMO_rev_2	271	276	PF00179	0.663
MOD_SUMO_rev_2	30	40	PF00179	0.545
MOD_SUMO_rev_2	319	326	PF00179	0.604
MOD_SUMO_rev_2	350	355	PF00179	0.514
TRG_DiLeu_BaEn_2	35	41	PF01217	0.545
TRG_ENDOCYTIC_2	152	155	PF00928	0.609
TRG_ENDOCYTIC_2	189	192	PF00928	0.518
TRG_ENDOCYTIC_2	209	212	PF00928	0.428
TRG_ENDOCYTIC_2	246	249	PF00928	0.545
TRG_ENDOCYTIC_2	26	29	PF00928	0.527
TRG_ENDOCYTIC_2	270	273	PF00928	0.637
TRG_ENDOCYTIC_2	290	293	PF00928	0.521
TRG_ENDOCYTIC_2	358	361	PF00928	0.545
TRG_ENDOCYTIC_2	430	433	PF00928	0.453
TRG_ENDOCYTIC_2	467	470	PF00928	0.391
TRG_ENDOCYTIC_2	5	8	PF00928	0.404
TRG_ENDOCYTIC_2	504	507	PF00928	0.338
TRG_ENDOCYTIC_2	608	611	PF00928	0.337
TRG_ENDOCYTIC_2	620	623	PF00928	0.374
TRG_ENDOCYTIC_2	684	687	PF00928	0.349
TRG_ER_diArg_1	8	10	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	25%	95%
A0A0N0P803	Leptomonas seymouri	78%	100%
A0A0N1PDP3	Leptomonas seymouri	21%	80%
A0A0S4IIS9	Bodo saltans	59%	100%
A0A1X0NKN5	Trypanosomatidae	24%	76%
A0A1X0NLB6	Trypanosomatidae	63%	100%
A0A3S5H5P5	Leishmania donovani	21%	77%
A0A422N761	Trypanosoma rangeli	24%	98%
A4H4J9	Leishmania braziliensis	21%	100%
A4H5Q8	Leishmania braziliensis	24%	100%
A4HQJ7	Leishmania braziliensis	82%	100%
A4HSS5	Leishmania infantum	21%	100%
A4ICB5	Leishmania infantum	100%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	77%
D0A3P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E2JFG1	Amanita bisporigera	39%	92%
E2JFG2	Amanita bisporigera	37%	95%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9AUB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
H2E7Q7	Galerina marginata (strain CBS 339.88)	37%	94%
H2E7Q8	Galerina marginata (strain CBS 339.88)	36%	95%
O07834	Pseudoxanthomonas mexicana	28%	96%
O70196	Rattus norvegicus	43%	98%
P23687	Sus scrofa	44%	98%
P24555	Escherichia coli (strain K12)	26%	100%
P27028	Elizabethkingia meningoseptica	38%	99%
P27195	Elizabethkingia miricola	37%	99%
P48147	Homo sapiens	44%	98%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	22%	92%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	22%	99%
Q06903	Aeromonas hydrophila	38%	100%
Q4Q080	Leishmania major	96%	100%
Q4QJ45	Leishmania major	21%	100%
Q59536	Moraxella lacunata	25%	100%
Q86AS5	Dictyostelium discoideum	36%	92%
Q9QUR6	Mus musculus	44%	98%
Q9XTA2	Bos taurus	43%	98%
V5B5S3	Trypanosoma cruzi	24%	81%
V5B860	Trypanosoma cruzi	25%	97%
V5BM62	Trypanosoma cruzi	65%	100%