Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prolyl endopeptidase

Species:

Leishmania donovani

UniProt:

A0A3Q8IJI4_LEIDO

TriTrypDb:

LdBPK_367060.1 , LdCL_360083200 , LDHU3_36.9430

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A0A3Q8IJI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJI4

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0070012	oligopeptidase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.543
CLV_NRD_NRD_1	309	311	PF00675	0.333
CLV_NRD_NRD_1	358	360	PF00675	0.409
CLV_NRD_NRD_1	9	11	PF00675	0.326
CLV_PCSK_KEX2_1	274	276	PF00082	0.274
CLV_PCSK_KEX2_1	9	11	PF00082	0.326
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.274
CLV_PCSK_SKI1_1	10	14	PF00082	0.369
CLV_PCSK_SKI1_1	336	340	PF00082	0.402
CLV_PCSK_SKI1_1	482	486	PF00082	0.328

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	25%	95%
A0A0N0P803	Leptomonas seymouri	78%	100%
A0A0N1PDP3	Leptomonas seymouri	21%	80%
A0A0S4IIS9	Bodo saltans	59%	100%
A0A1X0NKN5	Trypanosomatidae	24%	76%
A0A1X0NLB6	Trypanosomatidae	63%	100%
A0A3S5H5P5	Leishmania donovani	21%	77%
A0A422N761	Trypanosoma rangeli	24%	98%
A4H4J9	Leishmania braziliensis	21%	100%
A4H5Q8	Leishmania braziliensis	24%	100%

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