Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJI3_LEIDO

TriTrypDb:

LdBPK_352800.1 , LdCL_350032900 , LDHU3_35.3560

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.596
CLV_C14_Caspase3-7	487	491	PF00656	0.488
CLV_NRD_NRD_1	161	163	PF00675	0.521
CLV_NRD_NRD_1	283	285	PF00675	0.621
CLV_NRD_NRD_1	286	288	PF00675	0.615
CLV_NRD_NRD_1	340	342	PF00675	0.546
CLV_NRD_NRD_1	480	482	PF00675	0.609
CLV_NRD_NRD_1	569	571	PF00675	0.533
CLV_PCSK_FUR_1	284	288	PF00082	0.527
CLV_PCSK_KEX2_1	161	163	PF00082	0.535
CLV_PCSK_KEX2_1	285	287	PF00082	0.542
CLV_PCSK_KEX2_1	366	368	PF00082	0.645
CLV_PCSK_KEX2_1	399	401	PF00082	0.566
CLV_PCSK_KEX2_1	480	482	PF00082	0.609
CLV_PCSK_KEX2_1	569	571	PF00082	0.571
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.520
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.587
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.566
CLV_PCSK_PC7_1	157	163	PF00082	0.446
CLV_PCSK_SKI1_1	157	161	PF00082	0.485
CLV_PCSK_SKI1_1	294	298	PF00082	0.605
CLV_PCSK_SKI1_1	381	385	PF00082	0.567
CLV_PCSK_SKI1_1	5	9	PF00082	0.506
CLV_PCSK_SKI1_1	569	573	PF00082	0.539
CLV_PCSK_SKI1_1	65	69	PF00082	0.479
CLV_Separin_Metazoa	553	557	PF03568	0.659
DEG_APCC_DBOX_1	156	164	PF00400	0.520
DEG_APCC_DBOX_1	293	301	PF00400	0.619
DEG_APCC_DBOX_1	482	490	PF00400	0.661
DEG_MDM2_SWIB_1	67	74	PF02201	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.516
DEG_SPOP_SBC_1	41	45	PF00917	0.481
DOC_CKS1_1	320	325	PF01111	0.659
DOC_CYCLIN_RxL_1	291	298	PF00134	0.608
DOC_MAPK_FxFP_2	514	517	PF00069	0.633
DOC_MAPK_gen_1	480	488	PF00069	0.624
DOC_MAPK_gen_1	569	575	PF00069	0.572
DOC_MAPK_MEF2A_6	92	99	PF00069	0.535
DOC_PP2B_LxvP_1	208	211	PF13499	0.700
DOC_PP4_FxxP_1	514	517	PF00568	0.633
DOC_USP7_MATH_1	131	135	PF00917	0.595
DOC_USP7_MATH_1	175	179	PF00917	0.742
DOC_USP7_MATH_1	262	266	PF00917	0.692
DOC_USP7_MATH_1	41	45	PF00917	0.556
DOC_USP7_MATH_1	438	442	PF00917	0.522
DOC_USP7_MATH_1	501	505	PF00917	0.691
DOC_USP7_MATH_1	506	510	PF00917	0.735
DOC_USP7_MATH_1	58	62	PF00917	0.440
DOC_USP7_MATH_1	587	591	PF00917	0.663
DOC_WW_Pin1_4	171	176	PF00397	0.799
DOC_WW_Pin1_4	179	184	PF00397	0.710
DOC_WW_Pin1_4	188	193	PF00397	0.616
DOC_WW_Pin1_4	319	324	PF00397	0.685
DOC_WW_Pin1_4	79	84	PF00397	0.452
DOC_WW_Pin1_4	91	96	PF00397	0.468
LIG_14-3-3_CanoR_1	121	126	PF00244	0.611
LIG_14-3-3_CanoR_1	57	63	PF00244	0.497
LIG_14-3-3_CanoR_1	70	75	PF00244	0.378
LIG_BIR_III_4	268	272	PF00653	0.618
LIG_BIR_III_4	496	500	PF00653	0.622
LIG_BRCT_BRCA1_1	42	46	PF00533	0.453
LIG_Clathr_ClatBox_1	96	100	PF01394	0.583
LIG_eIF4E_1	534	540	PF01652	0.660
LIG_FHA_1	144	150	PF00498	0.548
LIG_FHA_1	153	159	PF00498	0.422
LIG_FHA_1	218	224	PF00498	0.808
LIG_FHA_1	407	413	PF00498	0.441
LIG_FHA_1	80	86	PF00498	0.495
LIG_FHA_2	389	395	PF00498	0.425
LIG_LIR_Gen_1	73	83	PF02991	0.490
LIG_LIR_Nem_3	50	55	PF02991	0.521
LIG_LIR_Nem_3	515	521	PF02991	0.562
LIG_LIR_Nem_3	73	78	PF02991	0.485
LIG_LIR_Nem_3	81	87	PF02991	0.415
LIG_NRBOX	296	302	PF00104	0.622
LIG_NRBOX	353	359	PF00104	0.433
LIG_PCNA_yPIPBox_3	241	252	PF02747	0.563
LIG_Pex14_1	71	75	PF04695	0.448
LIG_Pex14_2	67	71	PF04695	0.456
LIG_PTB_Apo_2	61	68	PF02174	0.457
LIG_SH2_CRK	518	522	PF00017	0.495
LIG_SH2_CRK	52	56	PF00017	0.423
LIG_SH2_NCK_1	75	79	PF00017	0.472
LIG_SH2_STAP1	408	412	PF00017	0.522
LIG_SH2_STAP1	75	79	PF00017	0.472
LIG_SH2_STAT3	534	537	PF00017	0.662
LIG_SH2_STAT5	17	20	PF00017	0.421
LIG_SH2_STAT5	37	40	PF00017	0.220
LIG_SH2_STAT5	408	411	PF00017	0.444
LIG_SH2_STAT5	84	87	PF00017	0.572
LIG_SH3_3	208	214	PF00018	0.826
LIG_SH3_3	22	28	PF00018	0.470
LIG_SH3_3	226	232	PF00018	0.512
LIG_SH3_3	301	307	PF00018	0.670
LIG_SUMO_SIM_par_1	144	151	PF11976	0.533
LIG_SUMO_SIM_par_1	250	256	PF11976	0.565
LIG_TRAF2_1	244	247	PF00917	0.710
LIG_TRAF2_1	328	331	PF00917	0.693
LIG_TRAF2_1	411	414	PF00917	0.516
LIG_TRAF2_1	441	444	PF00917	0.542
LIG_TYR_ITIM	15	20	PF00017	0.415
LIG_UBA3_1	560	565	PF00899	0.636
LIG_WRC_WIRS_1	99	104	PF05994	0.638
MOD_CK1_1	133	139	PF00069	0.677
MOD_CK1_1	239	245	PF00069	0.723
MOD_CK1_1	44	50	PF00069	0.479
MOD_CK2_1	318	324	PF00069	0.682
MOD_CK2_1	356	362	PF00069	0.620
MOD_CK2_1	388	394	PF00069	0.478
MOD_CK2_1	438	444	PF00069	0.488
MOD_CK2_1	44	50	PF00069	0.470
MOD_CK2_1	70	76	PF00069	0.428
MOD_GlcNHglycan	133	136	PF01048	0.653
MOD_GlcNHglycan	143	146	PF01048	0.493
MOD_GlcNHglycan	177	180	PF01048	0.750
MOD_GlcNHglycan	264	267	PF01048	0.624
MOD_GlcNHglycan	374	378	PF01048	0.617
MOD_GlcNHglycan	503	506	PF01048	0.762
MOD_GSK3_1	130	137	PF00069	0.673
MOD_GSK3_1	148	155	PF00069	0.313
MOD_GSK3_1	171	178	PF00069	0.800
MOD_GSK3_1	302	309	PF00069	0.778
MOD_GSK3_1	341	348	PF00069	0.538
MOD_GSK3_1	37	44	PF00069	0.467
MOD_GSK3_1	583	590	PF00069	0.708
MOD_N-GLC_1	175	180	PF02516	0.698
MOD_N-GLC_1	239	244	PF02516	0.702
MOD_N-GLC_1	464	469	PF02516	0.618
MOD_N-GLC_1	546	551	PF02516	0.581
MOD_N-GLC_1	63	68	PF02516	0.457
MOD_NEK2_1	533	538	PF00069	0.658
MOD_PIKK_1	356	362	PF00454	0.457
MOD_PIKK_1	406	412	PF00454	0.575
MOD_PIKK_1	420	426	PF00454	0.501
MOD_PIKK_1	528	534	PF00454	0.673
MOD_PK_1	121	127	PF00069	0.581
MOD_PKA_1	341	347	PF00069	0.540
MOD_PKA_2	348	354	PF00069	0.473
MOD_Plk_1	464	470	PF00069	0.621
MOD_Plk_1	63	69	PF00069	0.457
MOD_Plk_2-3	490	496	PF00069	0.701
MOD_Plk_4	70	76	PF00069	0.457
MOD_ProDKin_1	171	177	PF00069	0.802
MOD_ProDKin_1	179	185	PF00069	0.708
MOD_ProDKin_1	188	194	PF00069	0.618
MOD_ProDKin_1	319	325	PF00069	0.678
MOD_ProDKin_1	79	85	PF00069	0.457
MOD_ProDKin_1	91	97	PF00069	0.472
MOD_SUMO_rev_2	265	272	PF00179	0.659
MOD_SUMO_rev_2	542	551	PF00179	0.474
TRG_DiLeu_BaEn_1	2	7	PF01217	0.497
TRG_DiLeu_BaEn_1	247	252	PF01217	0.686
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.617
TRG_ENDOCYTIC_2	16	19	PF00928	0.424
TRG_ENDOCYTIC_2	36	39	PF00928	0.226
TRG_ENDOCYTIC_2	518	521	PF00928	0.505
TRG_ENDOCYTIC_2	52	55	PF00928	0.394
TRG_ENDOCYTIC_2	75	78	PF00928	0.496
TRG_ENDOCYTIC_2	84	87	PF00928	0.403
TRG_ER_diArg_1	160	162	PF00400	0.457
TRG_ER_diArg_1	284	287	PF00400	0.644
TRG_ER_diArg_1	479	481	PF00400	0.519
TRG_ER_diArg_1	482	485	PF00400	0.521
TRG_ER_diArg_1	568	570	PF00400	0.570
TRG_NES_CRM1_1	562	574	PF08389	0.565
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q8	Leptomonas seymouri	42%	100%
E9AF99	Leishmania major	88%	100%
E9AIW7	Leishmania braziliensis	66%	100%
E9B6F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%