Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJH6_LEIDO

TriTrypDb:

LdBPK_171100.1 , LdCL_170017000 , LDHU3_17.1540

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.631
CLV_C14_Caspase3-7	578	582	PF00656	0.506
CLV_NRD_NRD_1	404	406	PF00675	0.541
CLV_PCSK_KEX2_1	248	250	PF00082	0.540
CLV_PCSK_KEX2_1	404	406	PF00082	0.541
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.571
CLV_PCSK_SKI1_1	248	252	PF00082	0.516
CLV_PCSK_SKI1_1	404	408	PF00082	0.551
CLV_PCSK_SKI1_1	636	640	PF00082	0.431
DEG_COP1_1	203	213	PF00400	0.468
DEG_SPOP_SBC_1	258	262	PF00917	0.617
DEG_SPOP_SBC_1	303	307	PF00917	0.641
DOC_CKS1_1	108	113	PF01111	0.432
DOC_CKS1_1	618	623	PF01111	0.344
DOC_CKS1_1	655	660	PF01111	0.408
DOC_CYCLIN_RxL_1	399	408	PF00134	0.533
DOC_CYCLIN_yClb3_PxF_3	397	405	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	538	544	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.334
DOC_MAPK_DCC_7	462	470	PF00069	0.383
DOC_MAPK_gen_1	633	641	PF00069	0.366
DOC_MAPK_MEF2A_6	462	470	PF00069	0.383
DOC_MAPK_MEF2A_6	561	568	PF00069	0.555
DOC_MAPK_MEF2A_6	633	641	PF00069	0.369
DOC_PP2B_LxvP_1	208	211	PF13499	0.446
DOC_PP2B_LxvP_1	496	499	PF13499	0.508
DOC_PP2B_LxvP_1	538	541	PF13499	0.620
DOC_PP2B_LxvP_1	637	640	PF13499	0.390
DOC_PP4_FxxP_1	394	397	PF00568	0.554
DOC_PP4_FxxP_1	618	621	PF00568	0.340
DOC_USP7_MATH_1	209	213	PF00917	0.407
DOC_USP7_MATH_1	270	274	PF00917	0.602
DOC_USP7_MATH_1	275	279	PF00917	0.590
DOC_USP7_MATH_1	318	322	PF00917	0.565
DOC_USP7_MATH_1	4	8	PF00917	0.516
DOC_USP7_MATH_1	59	63	PF00917	0.599
DOC_USP7_MATH_1	626	630	PF00917	0.425
DOC_USP7_MATH_1	685	689	PF00917	0.566
DOC_USP7_MATH_1	717	721	PF00917	0.586
DOC_USP7_MATH_1	722	726	PF00917	0.548
DOC_USP7_UBL2_3	338	342	PF12436	0.612
DOC_WW_Pin1_4	107	112	PF00397	0.422
DOC_WW_Pin1_4	139	144	PF00397	0.382
DOC_WW_Pin1_4	262	267	PF00397	0.662
DOC_WW_Pin1_4	358	363	PF00397	0.646
DOC_WW_Pin1_4	530	535	PF00397	0.748
DOC_WW_Pin1_4	568	573	PF00397	0.531
DOC_WW_Pin1_4	617	622	PF00397	0.341
DOC_WW_Pin1_4	654	659	PF00397	0.420
DOC_WW_Pin1_4	683	688	PF00397	0.504
DOC_WW_Pin1_4	695	700	PF00397	0.679
LIG_14-3-3_CanoR_1	14	21	PF00244	0.388
LIG_14-3-3_CanoR_1	446	453	PF00244	0.421
LIG_14-3-3_CanoR_1	606	613	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BIR_III_4	555	559	PF00653	0.541
LIG_BRCT_BRCA1_1	195	199	PF00533	0.488
LIG_BRCT_BRCA1_1	439	443	PF00533	0.456
LIG_FHA_1	212	218	PF00498	0.361
LIG_FHA_1	231	237	PF00498	0.487
LIG_FHA_1	289	295	PF00498	0.644
LIG_FHA_1	446	452	PF00498	0.421
LIG_FHA_1	618	624	PF00498	0.345
LIG_FHA_2	199	205	PF00498	0.503
LIG_FHA_2	279	285	PF00498	0.772
LIG_FHA_2	569	575	PF00498	0.453
LIG_FHA_2	626	632	PF00498	0.475
LIG_LIR_Apic_2	393	397	PF02991	0.552
LIG_LIR_Apic_2	412	416	PF02991	0.460
LIG_LIR_Apic_2	616	621	PF02991	0.349
LIG_LIR_Gen_1	125	134	PF02991	0.435
LIG_LIR_Gen_1	609	619	PF02991	0.394
LIG_LIR_Gen_1	673	682	PF02991	0.428
LIG_LIR_Nem_3	120	124	PF02991	0.449
LIG_LIR_Nem_3	125	129	PF02991	0.467
LIG_LIR_Nem_3	196	202	PF02991	0.464
LIG_LIR_Nem_3	378	384	PF02991	0.527
LIG_LIR_Nem_3	609	615	PF02991	0.416
LIG_LIR_Nem_3	673	679	PF02991	0.422
LIG_Pex14_1	428	432	PF04695	0.360
LIG_Pex14_2	202	206	PF04695	0.462
LIG_PTAP_UEV_1	266	271	PF05743	0.618
LIG_SH2_GRB2like	352	355	PF00017	0.612
LIG_SH2_NCK_1	289	293	PF00017	0.598
LIG_SH2_NCK_1	352	356	PF00017	0.590
LIG_SH2_SRC	169	172	PF00017	0.331
LIG_SH2_STAP1	232	236	PF00017	0.421
LIG_SH2_STAP1	437	441	PF00017	0.402
LIG_SH2_STAT3	227	230	PF00017	0.364
LIG_SH2_STAT5	103	106	PF00017	0.452
LIG_SH2_STAT5	227	230	PF00017	0.364
LIG_SH2_STAT5	232	235	PF00017	0.437
LIG_SH2_STAT5	365	368	PF00017	0.594
LIG_SH2_STAT5	432	435	PF00017	0.436
LIG_SH2_STAT5	437	440	PF00017	0.434
LIG_SH2_STAT5	627	630	PF00017	0.480
LIG_SH3_3	148	154	PF00018	0.387
LIG_SH3_3	264	270	PF00018	0.622
LIG_SH3_3	296	302	PF00018	0.595
LIG_SH3_3	312	318	PF00018	0.522
LIG_SH3_3	340	346	PF00018	0.663
LIG_SH3_3	394	400	PF00018	0.577
LIG_SH3_3	419	425	PF00018	0.362
LIG_SH3_3	528	534	PF00018	0.681
LIG_SH3_3	538	544	PF00018	0.753
LIG_SH3_3	652	658	PF00018	0.444
LIG_SH3_3	697	703	PF00018	0.592
LIG_SH3_4	193	200	PF00018	0.389
LIG_SUMO_SIM_anti_2	479	485	PF11976	0.405
LIG_SUMO_SIM_par_1	547	552	PF11976	0.579
LIG_TRAF2_1	473	476	PF00917	0.357
LIG_TRAF2_1	607	610	PF00917	0.401
LIG_WRC_WIRS_1	199	204	PF05994	0.472
LIG_WRC_WIRS_1	77	82	PF05994	0.341
LIG_WW_2	299	302	PF00397	0.590
MOD_CDC14_SPxK_1	533	536	PF00782	0.668
MOD_CDK_SPxK_1	530	536	PF00069	0.673
MOD_CK1_1	13	19	PF00069	0.362
MOD_CK1_1	2	8	PF00069	0.548
MOD_CK1_1	252	258	PF00069	0.681
MOD_CK1_1	262	268	PF00069	0.588
MOD_CK1_1	273	279	PF00069	0.604
MOD_CK1_1	290	296	PF00069	0.543
MOD_CK1_1	333	339	PF00069	0.587
MOD_CK1_1	452	458	PF00069	0.499
MOD_CK2_1	198	204	PF00069	0.465
MOD_CK2_1	278	284	PF00069	0.672
MOD_CK2_1	436	442	PF00069	0.402
MOD_CK2_1	470	476	PF00069	0.355
MOD_CK2_1	482	488	PF00069	0.343
MOD_CK2_1	604	610	PF00069	0.492
MOD_GlcNHglycan	15	18	PF01048	0.296
MOD_GlcNHglycan	2	5	PF01048	0.619
MOD_GlcNHglycan	217	220	PF01048	0.338
MOD_GlcNHglycan	245	248	PF01048	0.553
MOD_GlcNHglycan	261	264	PF01048	0.630
MOD_GlcNHglycan	267	270	PF01048	0.719
MOD_GlcNHglycan	272	275	PF01048	0.604
MOD_GlcNHglycan	277	280	PF01048	0.574
MOD_GlcNHglycan	335	338	PF01048	0.592
MOD_GlcNHglycan	370	373	PF01048	0.516
MOD_GlcNHglycan	439	442	PF01048	0.416
MOD_GlcNHglycan	45	48	PF01048	0.488
MOD_GlcNHglycan	454	457	PF01048	0.632
MOD_GlcNHglycan	511	514	PF01048	0.695
MOD_GlcNHglycan	517	521	PF01048	0.646
MOD_GlcNHglycan	52	55	PF01048	0.630
MOD_GlcNHglycan	551	554	PF01048	0.686
MOD_GlcNHglycan	568	571	PF01048	0.452
MOD_GlcNHglycan	6	9	PF01048	0.618
MOD_GlcNHglycan	628	631	PF01048	0.430
MOD_GlcNHglycan	633	636	PF01048	0.448
MOD_GlcNHglycan	724	727	PF01048	0.571
MOD_GlcNHglycan	86	89	PF01048	0.380
MOD_GSK3_1	103	110	PF00069	0.391
MOD_GSK3_1	156	163	PF00069	0.340
MOD_GSK3_1	211	218	PF00069	0.398
MOD_GSK3_1	249	256	PF00069	0.601
MOD_GSK3_1	257	264	PF00069	0.588
MOD_GSK3_1	283	290	PF00069	0.632
MOD_GSK3_1	329	336	PF00069	0.586
MOD_GSK3_1	405	412	PF00069	0.533
MOD_GSK3_1	43	50	PF00069	0.484
MOD_GSK3_1	431	438	PF00069	0.424
MOD_GSK3_1	445	452	PF00069	0.349
MOD_GSK3_1	575	582	PF00069	0.513
MOD_GSK3_1	722	729	PF00069	0.662
MOD_N-GLC_1	363	368	PF02516	0.591
MOD_N-GLC_1	527	532	PF02516	0.690
MOD_NEK2_1	10	15	PF00069	0.430
MOD_NEK2_1	102	107	PF00069	0.400
MOD_NEK2_1	242	247	PF00069	0.555
MOD_NEK2_1	304	309	PF00069	0.656
MOD_NEK2_1	330	335	PF00069	0.611
MOD_NEK2_1	529	534	PF00069	0.557
MOD_NEK2_1	579	584	PF00069	0.491
MOD_NEK2_2	363	368	PF00069	0.571
MOD_OFUCOSY	167	173	PF10250	0.332
MOD_PIKK_1	193	199	PF00454	0.468
MOD_PIKK_1	717	723	PF00454	0.596
MOD_PK_1	156	162	PF00069	0.424
MOD_PKA_2	13	19	PF00069	0.398
MOD_PKA_2	445	451	PF00069	0.413
MOD_PKA_2	47	53	PF00069	0.638
MOD_PKA_2	605	611	PF00069	0.393
MOD_Plk_1	363	369	PF00069	0.590
MOD_Plk_1	470	476	PF00069	0.376
MOD_Plk_1	527	533	PF00069	0.682
MOD_Plk_1	59	65	PF00069	0.607
MOD_Plk_4	177	183	PF00069	0.377
MOD_Plk_4	330	336	PF00069	0.557
MOD_Plk_4	479	485	PF00069	0.363
MOD_Plk_4	685	691	PF00069	0.531
MOD_Plk_4	76	82	PF00069	0.411
MOD_ProDKin_1	107	113	PF00069	0.425
MOD_ProDKin_1	139	145	PF00069	0.381
MOD_ProDKin_1	262	268	PF00069	0.662
MOD_ProDKin_1	358	364	PF00069	0.644
MOD_ProDKin_1	530	536	PF00069	0.748
MOD_ProDKin_1	568	574	PF00069	0.527
MOD_ProDKin_1	617	623	PF00069	0.343
MOD_ProDKin_1	654	660	PF00069	0.412
MOD_ProDKin_1	683	689	PF00069	0.510
MOD_ProDKin_1	695	701	PF00069	0.681
MOD_SUMO_for_1	416	419	PF00179	0.479
MOD_SUMO_rev_2	507	512	PF00179	0.680
TRG_AP2beta_CARGO_1	673	683	PF09066	0.382
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.447
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.344
TRG_ER_diArg_1	367	370	PF00400	0.611
TRG_ER_diArg_1	403	405	PF00400	0.551
TRG_ER_diArg_1	598	601	PF00400	0.405
TRG_NES_CRM1_1	464	476	PF08389	0.379
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y2	Leptomonas seymouri	59%	100%
A4H955	Leishmania braziliensis	74%	99%
A4HXH7	Leishmania infantum	100%	100%
E9AR72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QE91	Leishmania major	90%	100%