ZZ-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJH5_LEIDO

TriTrypDb:

LdBPK_366910.1 , LdCL_360081600 , LDHU3_36.9220

Length:

751

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.485
CLV_C14_Caspase3-7	506	510	PF00656	0.681
CLV_NRD_NRD_1	155	157	PF00675	0.541
CLV_PCSK_SKI1_1	336	340	PF00082	0.499
CLV_PCSK_SKI1_1	451	455	PF00082	0.475
CLV_PCSK_SKI1_1	619	623	PF00082	0.394
DEG_APCC_DBOX_1	330	338	PF00400	0.547
DEG_APCC_DBOX_1	356	364	PF00400	0.507
DEG_SCF_FBW7_1	693	700	PF00400	0.735
DEG_SCF_SKP2-CKS1_1	692	699	PF00560	0.668
DOC_CDC14_PxL_1	196	204	PF14671	0.468
DOC_CDC14_PxL_1	638	646	PF14671	0.560
DOC_CKS1_1	685	690	PF01111	0.639
DOC_CYCLIN_RxL_1	296	307	PF00134	0.505
DOC_CYCLIN_RxL_1	596	606	PF00134	0.468
DOC_MAPK_DCC_7	213	221	PF00069	0.518
DOC_MAPK_gen_1	331	339	PF00069	0.518
DOC_MAPK_gen_1	354	362	PF00069	0.472
DOC_MAPK_gen_1	396	404	PF00069	0.421
DOC_MAPK_MEF2A_6	333	341	PF00069	0.510
DOC_MAPK_MEF2A_6	354	362	PF00069	0.489
DOC_PP2B_LxvP_1	315	318	PF13499	0.497
DOC_PP2B_LxvP_1	608	611	PF13499	0.527
DOC_PP2B_LxvP_1	622	625	PF13499	0.360
DOC_PP4_FxxP_1	477	480	PF00568	0.542
DOC_USP7_MATH_1	141	145	PF00917	0.618
DOC_USP7_MATH_1	535	539	PF00917	0.528
DOC_USP7_MATH_1	697	701	PF00917	0.732
DOC_USP7_MATH_1	745	749	PF00917	0.760
DOC_WW_Pin1_4	139	144	PF00397	0.613
DOC_WW_Pin1_4	42	47	PF00397	0.516
DOC_WW_Pin1_4	458	463	PF00397	0.507
DOC_WW_Pin1_4	489	494	PF00397	0.747
DOC_WW_Pin1_4	514	519	PF00397	0.580
DOC_WW_Pin1_4	684	689	PF00397	0.577
DOC_WW_Pin1_4	693	698	PF00397	0.481
DOC_WW_Pin1_4	708	713	PF00397	0.609
DOC_WW_Pin1_4	93	98	PF00397	0.532
LIG_14-3-3_CanoR_1	23	28	PF00244	0.532
LIG_14-3-3_CanoR_1	281	287	PF00244	0.493
LIG_14-3-3_CanoR_1	336	342	PF00244	0.472
LIG_14-3-3_CanoR_1	396	402	PF00244	0.501
LIG_14-3-3_CanoR_1	669	679	PF00244	0.504
LIG_APCC_ABBAyCdc20_2	399	405	PF00400	0.519
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BRCT_BRCA1_1	378	382	PF00533	0.471
LIG_FAT_LD_1	449	457	PF03623	0.534
LIG_FHA_1	202	208	PF00498	0.477
LIG_FHA_1	232	238	PF00498	0.499
LIG_FHA_1	275	281	PF00498	0.550
LIG_FHA_1	585	591	PF00498	0.443
LIG_FHA_2	107	113	PF00498	0.555
LIG_FHA_2	180	186	PF00498	0.484
LIG_FHA_2	212	218	PF00498	0.558
LIG_FHA_2	338	344	PF00498	0.541
LIG_FHA_2	354	360	PF00498	0.408
LIG_FHA_2	386	392	PF00498	0.478
LIG_FHA_2	504	510	PF00498	0.672
LIG_LIR_Apic_2	474	480	PF02991	0.421
LIG_LIR_Gen_1	223	232	PF02991	0.478
LIG_LIR_Gen_1	284	294	PF02991	0.474
LIG_LIR_Gen_1	400	409	PF02991	0.502
LIG_LIR_Gen_1	516	527	PF02991	0.446
LIG_LIR_Gen_1	605	614	PF02991	0.509
LIG_LIR_Gen_1	646	656	PF02991	0.524
LIG_LIR_Nem_3	117	123	PF02991	0.409
LIG_LIR_Nem_3	187	192	PF02991	0.374
LIG_LIR_Nem_3	223	227	PF02991	0.397
LIG_LIR_Nem_3	284	289	PF02991	0.468
LIG_LIR_Nem_3	400	404	PF02991	0.506
LIG_LIR_Nem_3	516	522	PF02991	0.529
LIG_LIR_Nem_3	605	610	PF02991	0.517
LIG_LIR_Nem_3	646	652	PF02991	0.509
LIG_LYPXL_S_1	198	202	PF13949	0.467
LIG_LYPXL_SIV_4	188	196	PF13949	0.398
LIG_LYPXL_yS_3	199	202	PF13949	0.428
LIG_LYPXL_yS_3	641	644	PF13949	0.558
LIG_NRBOX	171	177	PF00104	0.463
LIG_NRBOX	448	454	PF00104	0.532
LIG_NRBOX	616	622	PF00104	0.524
LIG_PCNA_yPIPBox_3	669	679	PF02747	0.523
LIG_Pex14_2	227	231	PF04695	0.479
LIG_Rb_pABgroove_1	167	175	PF01858	0.537
LIG_SH2_CRK	173	177	PF00017	0.500
LIG_SH2_CRK	189	193	PF00017	0.260
LIG_SH2_CRK	519	523	PF00017	0.502
LIG_SH2_CRK	525	529	PF00017	0.537
LIG_SH2_CRK	649	653	PF00017	0.473
LIG_SH2_GRB2like	713	716	PF00017	0.765
LIG_SH2_NCK_1	473	477	PF00017	0.481
LIG_SH2_SRC	465	468	PF00017	0.505
LIG_SH2_SRC	678	681	PF00017	0.571
LIG_SH2_SRC	77	80	PF00017	0.642
LIG_SH2_STAP1	473	477	PF00017	0.481
LIG_SH2_STAP1	649	653	PF00017	0.398
LIG_SH2_STAT5	224	227	PF00017	0.372
LIG_SH2_STAT5	288	291	PF00017	0.502
LIG_SH2_STAT5	401	404	PF00017	0.540
LIG_SH2_STAT5	432	435	PF00017	0.515
LIG_SH2_STAT5	465	468	PF00017	0.473
LIG_SH2_STAT5	539	542	PF00017	0.492
LIG_SH2_STAT5	559	562	PF00017	0.200
LIG_SH2_STAT5	607	610	PF00017	0.538
LIG_SH2_STAT5	678	681	PF00017	0.428
LIG_SH2_STAT5	692	695	PF00017	0.742
LIG_SH2_STAT5	713	716	PF00017	0.765
LIG_SH3_3	194	200	PF00018	0.450
LIG_SH3_3	277	283	PF00018	0.507
LIG_SH3_3	359	365	PF00018	0.502
LIG_SH3_3	40	46	PF00018	0.525
LIG_SH3_3	529	535	PF00018	0.526
LIG_SH3_3	549	555	PF00018	0.276
LIG_SH3_3	576	582	PF00018	0.617
LIG_SH3_3	682	688	PF00018	0.559
LIG_SH3_5	73	77	PF00018	0.584
LIG_SUMO_SIM_anti_2	359	364	PF11976	0.495
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.477
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.287
LIG_SUMO_SIM_anti_2	587	595	PF11976	0.537
LIG_SUMO_SIM_par_1	599	606	PF11976	0.505
LIG_TRAF2_1	57	60	PF00917	0.555
LIG_TRAF2_1	748	751	PF00917	0.714
LIG_TRFH_1	93	97	PF08558	0.605
LIG_TYR_ITIM	171	176	PF00017	0.524
LIG_TYR_ITIM	197	202	PF00017	0.430
LIG_TYR_ITIM	647	652	PF00017	0.396
LIG_UBA3_1	448	454	PF00899	0.472
LIG_WW_2	579	582	PF00397	0.625
MOD_CDK_SPxK_1	684	690	PF00069	0.620
MOD_CDK_SPxK_1	693	699	PF00069	0.493
MOD_CK1_1	114	120	PF00069	0.567
MOD_CK1_1	32	38	PF00069	0.565
MOD_CK1_1	538	544	PF00069	0.554
MOD_CK1_1	643	649	PF00069	0.551
MOD_CK1_1	711	717	PF00069	0.756
MOD_CK2_1	179	185	PF00069	0.517
MOD_CK2_1	200	206	PF00069	0.436
MOD_CK2_1	385	391	PF00069	0.430
MOD_CK2_1	42	48	PF00069	0.452
MOD_CK2_1	54	60	PF00069	0.424
MOD_CK2_1	544	550	PF00069	0.377
MOD_CK2_1	588	594	PF00069	0.341
MOD_CK2_1	745	751	PF00069	0.719
MOD_GlcNHglycan	124	127	PF01048	0.535
MOD_GlcNHglycan	14	19	PF01048	0.523
MOD_GlcNHglycan	163	166	PF01048	0.567
MOD_GlcNHglycan	193	196	PF01048	0.478
MOD_GlcNHglycan	444	447	PF01048	0.540
MOD_GlcNHglycan	529	532	PF01048	0.601
MOD_GlcNHglycan	540	543	PF01048	0.527
MOD_GlcNHglycan	546	549	PF01048	0.493
MOD_GlcNHglycan	573	576	PF01048	0.737
MOD_GlcNHglycan	708	711	PF01048	0.712
MOD_GlcNHglycan	719	722	PF01048	0.617
MOD_GSK3_1	339	346	PF00069	0.436
MOD_GSK3_1	454	461	PF00069	0.461
MOD_GSK3_1	584	591	PF00069	0.535
MOD_GSK3_1	693	700	PF00069	0.726
MOD_GSK3_1	713	720	PF00069	0.648
MOD_GSK3_1	89	96	PF00069	0.514
MOD_N-GLC_1	129	134	PF02516	0.482
MOD_N-GLC_1	714	719	PF02516	0.763
MOD_N-GLC_2	416	418	PF02516	0.577
MOD_NEK2_1	231	236	PF00069	0.469
MOD_NEK2_1	274	279	PF00069	0.439
MOD_NEK2_1	337	342	PF00069	0.472
MOD_NEK2_1	419	424	PF00069	0.498
MOD_NEK2_1	456	461	PF00069	0.493
MOD_NEK2_1	602	607	PF00069	0.546
MOD_NEK2_1	706	711	PF00069	0.710
MOD_PIKK_1	419	425	PF00454	0.382
MOD_PIKK_1	456	462	PF00454	0.485
MOD_PK_1	23	29	PF00069	0.537
MOD_PK_1	54	60	PF00069	0.472
MOD_PKA_1	513	519	PF00069	0.553
MOD_PKA_2	353	359	PF00069	0.551
MOD_PKB_1	87	95	PF00069	0.510
MOD_Plk_1	129	135	PF00069	0.489
MOD_Plk_1	673	679	PF00069	0.519
MOD_Plk_1	714	720	PF00069	0.735
MOD_Plk_1	89	95	PF00069	0.558
MOD_Plk_4	318	324	PF00069	0.586
MOD_Plk_4	588	594	PF00069	0.545
MOD_Plk_4	603	609	PF00069	0.436
MOD_Plk_4	719	725	PF00069	0.686
MOD_ProDKin_1	139	145	PF00069	0.603
MOD_ProDKin_1	42	48	PF00069	0.519
MOD_ProDKin_1	458	464	PF00069	0.498
MOD_ProDKin_1	489	495	PF00069	0.736
MOD_ProDKin_1	514	520	PF00069	0.571
MOD_ProDKin_1	684	690	PF00069	0.591
MOD_ProDKin_1	693	699	PF00069	0.481
MOD_ProDKin_1	708	714	PF00069	0.609
MOD_ProDKin_1	93	99	PF00069	0.526
TRG_DiLeu_BaEn_2	222	228	PF01217	0.476
TRG_DiLeu_BaEn_2	242	248	PF01217	0.269
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.356
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.477
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.334
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.523
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.551
TRG_ENDOCYTIC_2	120	123	PF00928	0.384
TRG_ENDOCYTIC_2	173	176	PF00928	0.490
TRG_ENDOCYTIC_2	189	192	PF00928	0.262
TRG_ENDOCYTIC_2	199	202	PF00928	0.355
TRG_ENDOCYTIC_2	224	227	PF00928	0.471
TRG_ENDOCYTIC_2	401	404	PF00928	0.540
TRG_ENDOCYTIC_2	519	522	PF00928	0.414
TRG_ENDOCYTIC_2	557	560	PF00928	0.484
TRG_ENDOCYTIC_2	607	610	PF00928	0.538
TRG_ENDOCYTIC_2	641	644	PF00928	0.436
TRG_ENDOCYTIC_2	649	652	PF00928	0.414
TRG_ER_diArg_1	331	334	PF00400	0.559
TRG_ER_diArg_1	480	483	PF00400	0.637
TRG_NES_CRM1_1	384	398	PF08389	0.486
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	633	637	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z3	Leptomonas seymouri	68%	100%
A0A1X0NLV7	Trypanosomatidae	30%	100%
A0A422NKF8	Trypanosoma rangeli	29%	100%
A4HQI3	Leishmania braziliensis	89%	100%
D0A3N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AHZ2	Leishmania infantum	100%	100%
E9AU96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q095	Leishmania major	96%	100%
V5AXM1	Trypanosoma cruzi	31%	100%