Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJH1_LEIDO

TriTrypDb:

LdBPK_302170.1 , LdCL_300027200 , LDHU3_30.2930

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.617
CLV_C14_Caspase3-7	539	543	PF00656	0.672
CLV_C14_Caspase3-7	547	551	PF00656	0.700
CLV_C14_Caspase3-7	591	595	PF00656	0.592
CLV_NRD_NRD_1	170	172	PF00675	0.543
CLV_NRD_NRD_1	326	328	PF00675	0.585
CLV_NRD_NRD_1	377	379	PF00675	0.573
CLV_NRD_NRD_1	397	399	PF00675	0.697
CLV_NRD_NRD_1	410	412	PF00675	0.572
CLV_NRD_NRD_1	458	460	PF00675	0.611
CLV_NRD_NRD_1	470	472	PF00675	0.548
CLV_PCSK_KEX2_1	326	328	PF00082	0.585
CLV_PCSK_KEX2_1	377	379	PF00082	0.573
CLV_PCSK_KEX2_1	414	416	PF00082	0.711
CLV_PCSK_KEX2_1	458	460	PF00082	0.611
CLV_PCSK_KEX2_1	470	472	PF00082	0.548
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.711
CLV_PCSK_SKI1_1	252	256	PF00082	0.581
CLV_PCSK_SKI1_1	304	308	PF00082	0.508
CLV_PCSK_SKI1_1	411	415	PF00082	0.557
CLV_PCSK_SKI1_1	470	474	PF00082	0.546
CLV_PCSK_SKI1_1	51	55	PF00082	0.565
DEG_APCC_DBOX_1	21	29	PF00400	0.530
DEG_APCC_DBOX_1	295	303	PF00400	0.552
DEG_APCC_DBOX_1	340	348	PF00400	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.712
DEG_SCF_FBW7_1	557	563	PF00400	0.536
DEG_SPOP_SBC_1	230	234	PF00917	0.607
DOC_ANK_TNKS_1	170	177	PF00023	0.571
DOC_CKS1_1	557	562	PF01111	0.669
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.565
DOC_MAPK_HePTP_8	178	190	PF00069	0.502
DOC_MAPK_MEF2A_6	115	123	PF00069	0.550
DOC_MAPK_MEF2A_6	181	190	PF00069	0.496
DOC_MAPK_MEF2A_6	55	63	PF00069	0.565
DOC_PP1_RVXF_1	362	368	PF00149	0.494
DOC_PP2B_LxvP_1	240	243	PF13499	0.640
DOC_PP2B_LxvP_1	472	475	PF13499	0.573
DOC_PP4_FxxP_1	250	253	PF00568	0.653
DOC_PP4_FxxP_1	516	519	PF00568	0.571
DOC_USP7_MATH_1	229	233	PF00917	0.678
DOC_USP7_MATH_1	253	257	PF00917	0.556
DOC_USP7_MATH_1	345	349	PF00917	0.576
DOC_USP7_MATH_1	447	451	PF00917	0.691
DOC_USP7_MATH_1	475	479	PF00917	0.664
DOC_USP7_MATH_1	502	506	PF00917	0.510
DOC_USP7_MATH_1	588	592	PF00917	0.588
DOC_USP7_MATH_2	560	566	PF00917	0.526
DOC_WW_Pin1_4	23	28	PF00397	0.595
DOC_WW_Pin1_4	243	248	PF00397	0.717
DOC_WW_Pin1_4	29	34	PF00397	0.580
DOC_WW_Pin1_4	556	561	PF00397	0.653
LIG_14-3-3_CanoR_1	29	33	PF00244	0.541
LIG_14-3-3_CanoR_1	481	488	PF00244	0.555
LIG_14-3-3_CanoR_1	525	532	PF00244	0.632
LIG_14-3-3_CanoR_1	584	588	PF00244	0.579
LIG_14-3-3_CanoR_1	596	604	PF00244	0.608
LIG_Actin_WH2_2	183	201	PF00022	0.614
LIG_Actin_WH2_2	362	379	PF00022	0.531
LIG_APCC_ABBA_1	279	284	PF00400	0.453
LIG_Clathr_ClatBox_1	219	223	PF01394	0.624
LIG_eIF4E_1	305	311	PF01652	0.520
LIG_FHA_1	112	118	PF00498	0.621
LIG_FHA_1	152	158	PF00498	0.618
LIG_FHA_1	236	242	PF00498	0.629
LIG_FHA_1	246	252	PF00498	0.597
LIG_FHA_1	273	279	PF00498	0.544
LIG_FHA_1	306	312	PF00498	0.523
LIG_FHA_1	364	370	PF00498	0.518
LIG_FHA_1	371	377	PF00498	0.541
LIG_FHA_1	483	489	PF00498	0.529
LIG_FHA_1	527	533	PF00498	0.612
LIG_FHA_1	56	62	PF00498	0.521
LIG_FHA_1	561	567	PF00498	0.599
LIG_FHA_1	584	590	PF00498	0.612
LIG_FHA_1	595	601	PF00498	0.564
LIG_FHA_1	615	621	PF00498	0.593
LIG_FHA_2	146	152	PF00498	0.549
LIG_FHA_2	35	41	PF00498	0.698
LIG_FHA_2	353	359	PF00498	0.551
LIG_FHA_2	430	436	PF00498	0.616
LIG_FHA_2	52	58	PF00498	0.507
LIG_FHA_2	542	548	PF00498	0.672
LIG_FHA_2	557	563	PF00498	0.536
LIG_FHA_2	569	575	PF00498	0.517
LIG_FHA_2	619	625	PF00498	0.654
LIG_FHA_2	627	633	PF00498	0.587
LIG_LIR_Apic_2	248	253	PF02991	0.599
LIG_LIR_Apic_2	514	519	PF02991	0.684
LIG_LIR_Gen_1	118	128	PF02991	0.692
LIG_LIR_Gen_1	284	289	PF02991	0.510
LIG_LIR_Gen_1	292	302	PF02991	0.564
LIG_LIR_Nem_3	118	123	PF02991	0.687
LIG_LIR_Nem_3	280	285	PF02991	0.518
LIG_LIR_Nem_3	292	297	PF02991	0.538
LIG_NRBOX	58	64	PF00104	0.594
LIG_Pex14_2	77	81	PF04695	0.553
LIG_SH2_CRK	285	289	PF00017	0.509
LIG_SH2_PTP2	294	297	PF00017	0.642
LIG_SH2_STAP1	285	289	PF00017	0.509
LIG_SH2_STAT5	169	172	PF00017	0.647
LIG_SH2_STAT5	294	297	PF00017	0.706
LIG_SH2_STAT5	305	308	PF00017	0.466
LIG_SH3_3	130	136	PF00018	0.580
LIG_SH3_3	185	191	PF00018	0.528
LIG_SH3_3	212	218	PF00018	0.517
LIG_SH3_3	292	298	PF00018	0.556
LIG_SH3_3	348	354	PF00018	0.531
LIG_SH3_3	518	524	PF00018	0.571
LIG_SH3_3	552	558	PF00018	0.729
LIG_SH3_4	45	52	PF00018	0.490
LIG_SUMO_SIM_anti_2	56	66	PF11976	0.628
LIG_SUMO_SIM_anti_2	571	577	PF11976	0.646
LIG_SUMO_SIM_par_1	121	126	PF11976	0.621
LIG_SUMO_SIM_par_1	56	66	PF11976	0.567
LIG_TRAF2_1	148	151	PF00917	0.583
LIG_TRAF2_1	354	357	PF00917	0.565
LIG_TRAF2_1	54	57	PF00917	0.669
LIG_TRAF2_1	559	562	PF00917	0.623
LIG_UBA3_1	360	364	PF00899	0.453
LIG_WW_2	351	354	PF00397	0.526
MOD_CDC14_SPxK_1	26	29	PF00782	0.527
MOD_CDK_SPxK_1	23	29	PF00069	0.581
MOD_CK1_1	145	151	PF00069	0.575
MOD_CK1_1	256	262	PF00069	0.516
MOD_CK1_1	329	335	PF00069	0.600
MOD_CK1_1	441	447	PF00069	0.706
MOD_CK1_1	450	456	PF00069	0.580
MOD_CK1_1	535	541	PF00069	0.648
MOD_CK1_1	583	589	PF00069	0.591
MOD_CK1_1	595	601	PF00069	0.660
MOD_CK1_1	618	624	PF00069	0.608
MOD_CK2_1	123	129	PF00069	0.607
MOD_CK2_1	145	151	PF00069	0.552
MOD_CK2_1	34	40	PF00069	0.678
MOD_CK2_1	352	358	PF00069	0.631
MOD_CK2_1	429	435	PF00069	0.710
MOD_CK2_1	480	486	PF00069	0.642
MOD_CK2_1	51	57	PF00069	0.587
MOD_CK2_1	556	562	PF00069	0.646
MOD_CK2_1	568	574	PF00069	0.501
MOD_CK2_1	626	632	PF00069	0.572
MOD_CK2_1	640	646	PF00069	0.577
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.528
MOD_GlcNHglycan	100	103	PF01048	0.598
MOD_GlcNHglycan	255	258	PF01048	0.627
MOD_GlcNHglycan	259	262	PF01048	0.476
MOD_GlcNHglycan	289	292	PF01048	0.623
MOD_GlcNHglycan	317	320	PF01048	0.600
MOD_GlcNHglycan	379	382	PF01048	0.524
MOD_GlcNHglycan	443	446	PF01048	0.767
MOD_GlcNHglycan	449	452	PF01048	0.593
MOD_GlcNHglycan	590	593	PF01048	0.598
MOD_GSK3_1	103	110	PF00069	0.553
MOD_GSK3_1	138	145	PF00069	0.621
MOD_GSK3_1	231	238	PF00069	0.643
MOD_GSK3_1	253	260	PF00069	0.529
MOD_GSK3_1	311	318	PF00069	0.641
MOD_GSK3_1	40	47	PF00069	0.671
MOD_GSK3_1	476	483	PF00069	0.648
MOD_GSK3_1	497	504	PF00069	0.566
MOD_GSK3_1	51	58	PF00069	0.583
MOD_GSK3_1	532	539	PF00069	0.668
MOD_GSK3_1	542	549	PF00069	0.762
MOD_GSK3_1	556	563	PF00069	0.555
MOD_GSK3_1	588	595	PF00069	0.685
MOD_GSK3_1	614	621	PF00069	0.678
MOD_GSK3_1	94	101	PF00069	0.586
MOD_N-GLC_1	533	538	PF02516	0.677
MOD_N-GLC_2	130	132	PF02516	0.677
MOD_NEK2_1	123	128	PF00069	0.629
MOD_NEK2_1	162	167	PF00069	0.537
MOD_NEK2_1	532	537	PF00069	0.730
MOD_NEK2_1	614	619	PF00069	0.798
MOD_PIKK_1	143	149	PF00454	0.623
MOD_PIKK_1	305	311	PF00454	0.605
MOD_PIKK_1	70	76	PF00454	0.522
MOD_PKA_1	326	332	PF00069	0.565
MOD_PKA_1	377	383	PF00069	0.524
MOD_PKA_2	142	148	PF00069	0.656
MOD_PKA_2	235	241	PF00069	0.765
MOD_PKA_2	28	34	PF00069	0.534
MOD_PKA_2	326	332	PF00069	0.565
MOD_PKA_2	370	376	PF00069	0.509
MOD_PKA_2	377	383	PF00069	0.556
MOD_PKA_2	480	486	PF00069	0.642
MOD_PKA_2	583	589	PF00069	0.579
MOD_PKA_2	595	601	PF00069	0.602
MOD_Plk_1	123	129	PF00069	0.640
MOD_Plk_1	273	279	PF00069	0.538
MOD_Plk_1	393	399	PF00069	0.656
MOD_Plk_1	55	61	PF00069	0.512
MOD_Plk_1	614	620	PF00069	0.627
MOD_Plk_2-3	419	425	PF00069	0.668
MOD_Plk_2-3	542	548	PF00069	0.685
MOD_Plk_2-3	606	612	PF00069	0.627
MOD_Plk_4	103	109	PF00069	0.564
MOD_Plk_4	201	207	PF00069	0.510
MOD_Plk_4	55	61	PF00069	0.560
MOD_Plk_4	562	568	PF00069	0.608
MOD_Plk_4	615	621	PF00069	0.578
MOD_ProDKin_1	23	29	PF00069	0.598
MOD_ProDKin_1	243	249	PF00069	0.711
MOD_ProDKin_1	34	40	PF00069	0.618
MOD_ProDKin_1	556	562	PF00069	0.649
MOD_SUMO_for_1	413	416	PF00179	0.629
TRG_AP2beta_CARGO_1	118	127	PF09066	0.627
TRG_DiLeu_BaEn_1	274	279	PF01217	0.529
TRG_DiLeu_BaEn_1	284	289	PF01217	0.464
TRG_DiLeu_BaEn_1	56	61	PF01217	0.566
TRG_DiLeu_BaEn_1	562	567	PF01217	0.662
TRG_DiLeu_BaEn_4	356	362	PF01217	0.597
TRG_ENDOCYTIC_2	212	215	PF00928	0.582
TRG_ENDOCYTIC_2	285	288	PF00928	0.505
TRG_ENDOCYTIC_2	294	297	PF00928	0.574
TRG_ER_diArg_1	325	327	PF00400	0.570
TRG_ER_diArg_1	376	378	PF00400	0.525
TRG_ER_diArg_1	457	459	PF00400	0.690
TRG_ER_diArg_1	470	472	PF00400	0.508
TRG_NES_CRM1_1	564	578	PF08389	0.652
TRG_NLS_Bipartite_1	398	415	PF00514	0.600
TRG_NLS_MonoExtC_3	410	415	PF00514	0.648
TRG_NLS_MonoExtN_4	409	415	PF00514	0.554
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E3	Leptomonas seymouri	36%	97%
A4HIE8	Leishmania braziliensis	68%	100%
A4I5P5	Leishmania infantum	100%	100%
E9B0Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q777	Leishmania major	89%	100%