UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine--dolichyl-phosphaten-ac et ylglucosaminephosphotransferase

Species:

Leishmania donovani

UniProt:

A0A3Q8IJH0_LEIDO

TriTrypDb:

LdBPK_364390.1 , LdCL_360051000 , LDHU3_36.5950

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IJH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJH0

Function

Biological processes
Term	Name	Level	Count
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	12
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	12
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.414
CLV_MEL_PAP_1	181	187	PF00089	0.523
CLV_NRD_NRD_1	73	75	PF00675	0.366
CLV_PCSK_KEX2_1	72	74	PF00082	0.379
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.379
CLV_PCSK_SKI1_1	155	159	PF00082	0.245
CLV_PCSK_SKI1_1	195	199	PF00082	0.459
CLV_PCSK_SKI1_1	297	301	PF00082	0.561
CLV_PCSK_SKI1_1	311	315	PF00082	0.481
CLV_PCSK_SKI1_1	320	324	PF00082	0.393
CLV_PCSK_SKI1_1	370	374	PF00082	0.499
CLV_PCSK_SKI1_1	454	458	PF00082	0.329
CLV_PCSK_SKI1_1	46	50	PF00082	0.340
CLV_PCSK_SKI1_1	51	55	PF00082	0.336
DEG_APCC_DBOX_1	183	191	PF00400	0.350
DEG_APCC_DBOX_1	296	304	PF00400	0.198
DOC_CDC14_PxL_1	384	392	PF14671	0.343
DOC_CYCLIN_RxL_1	43	50	PF00134	0.551
DOC_MAPK_gen_1	151	158	PF00069	0.445
DOC_MAPK_gen_1	194	200	PF00069	0.198
DOC_MAPK_gen_1	337	347	PF00069	0.505
DOC_PP1_RVXF_1	432	438	PF00149	0.561
DOC_PP2B_PxIxI_1	326	332	PF00149	0.334
DOC_PP4_FxxP_1	185	188	PF00568	0.323
DOC_PP4_FxxP_1	375	378	PF00568	0.314
DOC_USP7_MATH_1	124	128	PF00917	0.326
DOC_USP7_MATH_1	279	283	PF00917	0.383
DOC_USP7_MATH_1	299	303	PF00917	0.114
DOC_USP7_MATH_1	360	364	PF00917	0.445
DOC_USP7_UBL2_3	151	155	PF12436	0.531
DOC_USP7_UBL2_3	68	72	PF12436	0.598
DOC_USP7_UBL2_3	81	85	PF12436	0.618
LIG_14-3-3_CanoR_1	212	216	PF00244	0.350
LIG_14-3-3_CanoR_1	454	462	PF00244	0.565
LIG_14-3-3_CanoR_1	74	83	PF00244	0.630
LIG_Actin_WH2_2	285	303	PF00022	0.352
LIG_APCC_ABBA_1	424	429	PF00400	0.579
LIG_BRCT_BRCA1_1	216	220	PF00533	0.343
LIG_CtBP_PxDLS_1	89	93	PF00389	0.474
LIG_eIF4E_1	368	374	PF01652	0.336
LIG_FHA_1	106	112	PF00498	0.413
LIG_FHA_1	132	138	PF00498	0.301
LIG_FHA_1	187	193	PF00498	0.307
LIG_FHA_1	208	214	PF00498	0.356
LIG_FHA_1	235	241	PF00498	0.251
LIG_FHA_1	256	262	PF00498	0.313
LIG_FHA_1	369	375	PF00498	0.245
LIG_FHA_1	406	412	PF00498	0.592
LIG_FHA_1	434	440	PF00498	0.457
LIG_FHA_2	45	51	PF00498	0.561
LIG_GBD_Chelix_1	103	111	PF00786	0.445
LIG_GBD_Chelix_1	422	430	PF00786	0.307
LIG_HP1_1	124	128	PF01393	0.142
LIG_IBAR_NPY_1	123	125	PF08397	0.364
LIG_LIR_Gen_1	122	133	PF02991	0.333
LIG_LIR_Gen_1	217	224	PF02991	0.359
LIG_LIR_Gen_1	228	234	PF02991	0.266
LIG_LIR_Gen_1	282	292	PF02991	0.365
LIG_LIR_Gen_1	349	359	PF02991	0.294
LIG_LIR_Gen_1	414	425	PF02991	0.484
LIG_LIR_Gen_1	436	445	PF02991	0.400
LIG_LIR_Nem_3	122	128	PF02991	0.401
LIG_LIR_Nem_3	217	223	PF02991	0.361
LIG_LIR_Nem_3	228	232	PF02991	0.251
LIG_LIR_Nem_3	282	288	PF02991	0.365
LIG_LIR_Nem_3	349	354	PF02991	0.294
LIG_LIR_Nem_3	414	420	PF02991	0.484
LIG_LIR_Nem_3	436	440	PF02991	0.400
LIG_LIR_Nem_3	459	465	PF02991	0.359
LIG_NRBOX	136	142	PF00104	0.328
LIG_NRBOX	318	324	PF00104	0.445
LIG_SH2_CRK	417	421	PF00017	0.472
LIG_SH2_PTP2	125	128	PF00017	0.142
LIG_SH2_PTP2	229	232	PF00017	0.337
LIG_SH2_SRC	462	465	PF00017	0.407
LIG_SH2_STAP1	351	355	PF00017	0.298
LIG_SH2_STAP1	368	372	PF00017	0.271
LIG_SH2_STAT5	100	103	PF00017	0.298
LIG_SH2_STAT5	125	128	PF00017	0.224
LIG_SH2_STAT5	222	225	PF00017	0.308
LIG_SH2_STAT5	229	232	PF00017	0.258
LIG_SH2_STAT5	241	244	PF00017	0.184
LIG_SH2_STAT5	246	249	PF00017	0.199
LIG_SH2_STAT5	34	37	PF00017	0.329
LIG_SH2_STAT5	351	354	PF00017	0.298
LIG_SH2_STAT5	40	43	PF00017	0.499
LIG_SH2_STAT5	417	420	PF00017	0.470
LIG_SH2_STAT5	425	428	PF00017	0.494
LIG_SH2_STAT5	455	458	PF00017	0.300
LIG_SH3_3	123	129	PF00018	0.266
LIG_SH3_3	173	179	PF00018	0.302
LIG_SH3_3	210	216	PF00018	0.323
LIG_SH3_3	391	397	PF00018	0.405
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.349
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.301
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.383
LIG_SUMO_SIM_par_1	102	108	PF11976	0.365
LIG_SUMO_SIM_par_1	24	30	PF11976	0.412
LIG_SUMO_SIM_par_1	275	282	PF11976	0.356
LIG_SUMO_SIM_par_1	357	363	PF11976	0.383
LIG_UBA3_1	426	434	PF00899	0.536
LIG_UBA3_1	53	60	PF00899	0.591
LIG_WRC_WIRS_1	457	462	PF05994	0.521
MOD_CK1_1	362	368	PF00069	0.383
MOD_CK2_1	44	50	PF00069	0.541
MOD_GlcNHglycan	234	237	PF01048	0.534
MOD_GSK3_1	156	163	PF00069	0.314
MOD_GSK3_1	166	173	PF00069	0.314
MOD_GSK3_1	186	193	PF00069	0.114
MOD_GSK3_1	207	214	PF00069	0.339
MOD_GSK3_1	230	237	PF00069	0.291
MOD_GSK3_1	362	369	PF00069	0.333
MOD_GSK3_1	405	412	PF00069	0.524
MOD_N-GLC_1	190	195	PF02516	0.528
MOD_N-GLC_1	415	420	PF02516	0.273
MOD_NEK2_1	105	110	PF00069	0.395
MOD_NEK2_1	133	138	PF00069	0.388
MOD_NEK2_1	190	195	PF00069	0.322
MOD_NEK2_1	211	216	PF00069	0.350
MOD_NEK2_1	27	32	PF00069	0.403
MOD_NEK2_1	354	359	PF00069	0.291
MOD_NEK2_1	383	388	PF00069	0.297
MOD_NEK2_1	411	416	PF00069	0.476
MOD_NEK2_1	5	10	PF00069	0.401
MOD_NEK2_2	207	212	PF00069	0.295
MOD_NEK2_2	34	39	PF00069	0.346
MOD_PKA_2	211	217	PF00069	0.350
MOD_PKB_1	398	406	PF00069	0.564
MOD_Plk_1	415	421	PF00069	0.481
MOD_Plk_4	172	178	PF00069	0.411
MOD_Plk_4	215	221	PF00069	0.362
MOD_Plk_4	248	254	PF00069	0.377
MOD_Plk_4	27	33	PF00069	0.345
MOD_Plk_4	272	278	PF00069	0.314
MOD_Plk_4	279	285	PF00069	0.314
MOD_Plk_4	349	355	PF00069	0.312
MOD_Plk_4	368	374	PF00069	0.275
MOD_Plk_4	415	421	PF00069	0.470
MOD_Plk_4	456	462	PF00069	0.424
MOD_Plk_4	99	105	PF00069	0.418
MOD_SUMO_rev_2	429	436	PF00179	0.565
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.364
TRG_ENDOCYTIC_2	100	103	PF00928	0.333
TRG_ENDOCYTIC_2	125	128	PF00928	0.331
TRG_ENDOCYTIC_2	229	232	PF00928	0.322
TRG_ENDOCYTIC_2	249	252	PF00928	0.114
TRG_ENDOCYTIC_2	285	288	PF00928	0.310
TRG_ENDOCYTIC_2	351	354	PF00928	0.294
TRG_ENDOCYTIC_2	417	420	PF00928	0.475
TRG_ENDOCYTIC_2	462	465	PF00928	0.378
TRG_ER_diArg_1	397	400	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUV1	Leptomonas seymouri	71%	100%
A0A0S4IKK6	Bodo saltans	49%	100%
A0A1X0P351	Trypanosomatidae	46%	100%
A0A3R7MVB5	Trypanosoma rangeli	48%	100%
A4HPT7	Leishmania braziliensis	85%	100%
A4IE55	Leishmania infantum	100%	100%
D0A8Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P07286	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P0CD61	Dictyostelium discoideum	36%	100%
P23338	Cricetulus longicaudatus	34%	100%
P24140	Cricetulus griseus	34%	100%
P42864	Leishmania amazonensis	93%	100%
P42867	Mus musculus	34%	100%
P42881	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4Q0Z6	Leishmania major	96%	100%
Q5EA65	Bos taurus	34%	100%
Q9H3H5	Homo sapiens	35%	100%
V5B6U2	Trypanosoma cruzi	49%	100%