Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJG5_LEIDO

TriTrypDb:

LdBPK_170920.1 , LdCL_170015200 , LDHU3_17.1340

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.566
CLV_C14_Caspase3-7	398	402	PF00656	0.603
CLV_NRD_NRD_1	182	184	PF00675	0.669
CLV_NRD_NRD_1	486	488	PF00675	0.653
CLV_PCSK_KEX2_1	182	184	PF00082	0.666
CLV_PCSK_KEX2_1	486	488	PF00082	0.654
CLV_PCSK_SKI1_1	30	34	PF00082	0.598
CLV_PCSK_SKI1_1	50	54	PF00082	0.662
CLV_PCSK_SKI1_1	504	508	PF00082	0.643
DEG_Nend_UBRbox_2	1	3	PF02207	0.565
DEG_SPOP_SBC_1	154	158	PF00917	0.626
DEG_SPOP_SBC_1	493	497	PF00917	0.658
DEG_SPOP_SBC_1	557	561	PF00917	0.628
DOC_MAPK_MEF2A_6	170	177	PF00069	0.630
DOC_USP7_MATH_1	108	112	PF00917	0.637
DOC_USP7_MATH_1	227	231	PF00917	0.644
DOC_USP7_MATH_1	259	263	PF00917	0.631
DOC_USP7_MATH_1	296	300	PF00917	0.830
DOC_USP7_MATH_1	356	360	PF00917	0.616
DOC_USP7_MATH_1	46	50	PF00917	0.669
DOC_USP7_MATH_1	476	480	PF00917	0.693
DOC_USP7_MATH_1	488	492	PF00917	0.579
DOC_USP7_MATH_1	508	512	PF00917	0.507
DOC_USP7_MATH_1	63	67	PF00917	0.655
DOC_WW_Pin1_4	120	125	PF00397	0.711
DOC_WW_Pin1_4	128	133	PF00397	0.654
DOC_WW_Pin1_4	15	20	PF00397	0.608
DOC_WW_Pin1_4	169	174	PF00397	0.603
DOC_WW_Pin1_4	233	238	PF00397	0.664
DOC_WW_Pin1_4	243	248	PF00397	0.716
DOC_WW_Pin1_4	310	315	PF00397	0.668
DOC_WW_Pin1_4	319	324	PF00397	0.675
DOC_WW_Pin1_4	361	366	PF00397	0.644
DOC_WW_Pin1_4	51	56	PF00397	0.626
LIG_14-3-3_CanoR_1	10	16	PF00244	0.616
LIG_14-3-3_CanoR_1	242	247	PF00244	0.688
LIG_14-3-3_CanoR_1	405	412	PF00244	0.525
LIG_14-3-3_CanoR_1	494	503	PF00244	0.649
LIG_14-3-3_CanoR_1	50	55	PF00244	0.616
LIG_14-3-3_CanoR_1	548	552	PF00244	0.623
LIG_BRCT_BRCA1_1	173	177	PF00533	0.626
LIG_BRCT_BRCA1_1	571	575	PF00533	0.626
LIG_FHA_1	134	140	PF00498	0.634
LIG_FHA_1	229	235	PF00498	0.663
LIG_FHA_1	275	281	PF00498	0.524
LIG_FHA_2	73	79	PF00498	0.680
LIG_Integrin_isoDGR_2	590	592	PF01839	0.731
LIG_LIR_Gen_1	572	580	PF02991	0.624
LIG_LIR_Gen_1	98	108	PF02991	0.588
LIG_LIR_LC3C_4	150	155	PF02991	0.686
LIG_LIR_Nem_3	414	419	PF02991	0.681
LIG_LIR_Nem_3	572	578	PF02991	0.625
LIG_LIR_Nem_3	98	103	PF02991	0.584
LIG_Pex14_1	291	295	PF04695	0.688
LIG_SH2_PTP2	311	314	PF00017	0.632
LIG_SH2_STAP1	28	32	PF00017	0.598
LIG_SH2_STAT5	311	314	PF00017	0.632
LIG_SH2_STAT5	378	381	PF00017	0.644
LIG_SH3_3	13	19	PF00018	0.628
LIG_SH3_3	231	237	PF00018	0.654
LIG_SH3_3	424	430	PF00018	0.616
LIG_SH3_3	463	469	PF00018	0.566
LIG_SH3_3	497	503	PF00018	0.644
LIG_SH3_3	52	58	PF00018	0.681
LIG_SH3_3	68	74	PF00018	0.608
LIG_SUMO_SIM_anti_2	270	277	PF11976	0.533
LIG_TRAF2_1	70	73	PF00917	0.708
LIG_TRAF2_1	91	94	PF00917	0.588
MOD_CDK_SPK_2	319	324	PF00069	0.639
MOD_CDK_SPK_2	51	56	PF00069	0.589
MOD_CK1_1	112	118	PF00069	0.660
MOD_CK1_1	133	139	PF00069	0.641
MOD_CK1_1	147	153	PF00069	0.617
MOD_CK1_1	194	200	PF00069	0.548
MOD_CK1_1	230	236	PF00069	0.709
MOD_CK1_1	253	259	PF00069	0.662
MOD_CK1_1	274	280	PF00069	0.605
MOD_CK1_1	304	310	PF00069	0.797
MOD_CK1_1	322	328	PF00069	0.599
MOD_CK1_1	332	338	PF00069	0.664
MOD_CK1_1	361	367	PF00069	0.666
MOD_CK1_1	42	48	PF00069	0.571
MOD_CK1_1	438	444	PF00069	0.698
MOD_CK1_1	531	537	PF00069	0.650
MOD_CK1_1	546	552	PF00069	0.692
MOD_CK1_1	569	575	PF00069	0.623
MOD_CK2_1	15	21	PF00069	0.577
MOD_CK2_1	537	543	PF00069	0.619
MOD_GlcNHglycan	11	14	PF01048	0.671
MOD_GlcNHglycan	111	114	PF01048	0.725
MOD_GlcNHglycan	132	135	PF01048	0.656
MOD_GlcNHglycan	150	153	PF01048	0.723
MOD_GlcNHglycan	161	164	PF01048	0.692
MOD_GlcNHglycan	193	196	PF01048	0.664
MOD_GlcNHglycan	211	214	PF01048	0.581
MOD_GlcNHglycan	223	226	PF01048	0.599
MOD_GlcNHglycan	255	258	PF01048	0.637
MOD_GlcNHglycan	261	264	PF01048	0.569
MOD_GlcNHglycan	324	327	PF01048	0.657
MOD_GlcNHglycan	351	354	PF01048	0.631
MOD_GlcNHglycan	437	440	PF01048	0.651
MOD_GlcNHglycan	44	47	PF01048	0.695
MOD_GlcNHglycan	488	491	PF01048	0.685
MOD_GlcNHglycan	496	499	PF01048	0.661
MOD_GlcNHglycan	533	536	PF01048	0.625
MOD_GlcNHglycan	538	542	PF01048	0.623
MOD_GlcNHglycan	560	563	PF01048	0.651
MOD_GSK3_1	108	115	PF00069	0.623
MOD_GSK3_1	120	127	PF00069	0.677
MOD_GSK3_1	144	151	PF00069	0.780
MOD_GSK3_1	155	162	PF00069	0.591
MOD_GSK3_1	223	230	PF00069	0.627
MOD_GSK3_1	30	37	PF00069	0.574
MOD_GSK3_1	340	347	PF00069	0.633
MOD_GSK3_1	373	380	PF00069	0.740
MOD_GSK3_1	38	45	PF00069	0.562
MOD_GSK3_1	390	397	PF00069	0.578
MOD_GSK3_1	46	53	PF00069	0.559
MOD_GSK3_1	478	485	PF00069	0.609
MOD_GSK3_1	488	495	PF00069	0.654
MOD_GSK3_1	537	544	PF00069	0.643
MOD_GSK3_1	558	565	PF00069	0.642
MOD_GSK3_1	566	573	PF00069	0.635
MOD_N-GLC_1	120	125	PF02516	0.742
MOD_N-GLC_1	38	43	PF02516	0.578
MOD_N-GLC_1	46	51	PF02516	0.575
MOD_N-GLC_1	531	536	PF02516	0.626
MOD_N-GLC_1	562	567	PF02516	0.623
MOD_NEK2_1	153	158	PF00069	0.712
MOD_NEK2_1	349	354	PF00069	0.670
MOD_NEK2_1	462	467	PF00069	0.598
MOD_NEK2_1	558	563	PF00069	0.630
MOD_NEK2_1	570	575	PF00069	0.625
MOD_NEK2_1	8	13	PF00069	0.621
MOD_PIKK_1	112	118	PF00454	0.582
MOD_PIKK_1	194	200	PF00454	0.566
MOD_PIKK_1	446	452	PF00454	0.664
MOD_PK_1	183	189	PF00069	0.635
MOD_PKA_1	486	492	PF00069	0.728
MOD_PKA_2	241	247	PF00069	0.687
MOD_PKA_2	391	397	PF00069	0.616
MOD_PKA_2	404	410	PF00069	0.596
MOD_PKA_2	486	492	PF00069	0.685
MOD_PKA_2	493	499	PF00069	0.622
MOD_PKA_2	547	553	PF00069	0.634
MOD_PKA_2	9	15	PF00069	0.618
MOD_PKB_1	120	128	PF00069	0.733
MOD_Plk_1	271	277	PF00069	0.530
MOD_Plk_1	46	52	PF00069	0.628
MOD_Plk_1	531	537	PF00069	0.625
MOD_Plk_1	566	572	PF00069	0.623
MOD_Plk_2-3	72	78	PF00069	0.646
MOD_Plk_4	171	177	PF00069	0.597
MOD_Plk_4	23	29	PF00069	0.598
MOD_Plk_4	271	277	PF00069	0.530
MOD_Plk_4	344	350	PF00069	0.714
MOD_Plk_4	570	576	PF00069	0.626
MOD_ProDKin_1	120	126	PF00069	0.711
MOD_ProDKin_1	128	134	PF00069	0.651
MOD_ProDKin_1	15	21	PF00069	0.610
MOD_ProDKin_1	169	175	PF00069	0.601
MOD_ProDKin_1	233	239	PF00069	0.664
MOD_ProDKin_1	243	249	PF00069	0.716
MOD_ProDKin_1	310	316	PF00069	0.669
MOD_ProDKin_1	319	325	PF00069	0.676
MOD_ProDKin_1	361	367	PF00069	0.644
MOD_ProDKin_1	51	57	PF00069	0.624
MOD_SUMO_for_1	506	509	PF00179	0.726
TRG_DiLeu_BaEn_1	271	276	PF01217	0.532
TRG_DiLeu_BaEn_4	271	277	PF01217	0.536
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.525
TRG_ER_diArg_1	119	122	PF00400	0.754
TRG_ER_diArg_1	182	184	PF00400	0.660
TRG_ER_diArg_1	486	488	PF00400	0.732
TRG_ER_diArg_1	520	523	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I516	Leptomonas seymouri	54%	100%
A4H946	Leishmania braziliensis	85%	100%
A4HXG0	Leishmania infantum	100%	100%
E9AR55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QEA8	Leishmania major	96%	100%