Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJG0_LEIDO

TriTrypDb:

LdBPK_363010.1 , LdCL_360035900 , LDHU3_36.4100

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.607
CLV_NRD_NRD_1	306	308	PF00675	0.465
CLV_NRD_NRD_1	394	396	PF00675	0.667
CLV_NRD_NRD_1	561	563	PF00675	0.751
CLV_PCSK_KEX2_1	254	256	PF00082	0.427
CLV_PCSK_KEX2_1	306	308	PF00082	0.465
CLV_PCSK_KEX2_1	394	396	PF00082	0.667
CLV_PCSK_KEX2_1	561	563	PF00082	0.751
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.427
CLV_PCSK_SKI1_1	221	225	PF00082	0.407
CLV_PCSK_SKI1_1	255	259	PF00082	0.408
CLV_PCSK_SKI1_1	284	288	PF00082	0.445
CLV_PCSK_SKI1_1	310	314	PF00082	0.405
CLV_PCSK_SKI1_1	363	367	PF00082	0.650
CLV_PCSK_SKI1_1	595	599	PF00082	0.721
CLV_Separin_Metazoa	218	222	PF03568	0.478
CLV_Separin_Metazoa	327	331	PF03568	0.680
DEG_APCC_DBOX_1	254	262	PF00400	0.406
DEG_APCC_DBOX_1	283	291	PF00400	0.443
DEG_SCF_FBW7_1	74	79	PF00400	0.589
DEG_SPOP_SBC_1	246	250	PF00917	0.646
DEG_SPOP_SBC_1	347	351	PF00917	0.660
DOC_CYCLIN_RxL_1	218	228	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.508
DOC_MAPK_DCC_7	194	203	PF00069	0.433
DOC_MAPK_gen_1	194	203	PF00069	0.433
DOC_MAPK_gen_1	254	260	PF00069	0.426
DOC_MAPK_gen_1	281	290	PF00069	0.437
DOC_MAPK_gen_1	306	314	PF00069	0.570
DOC_MAPK_gen_1	487	495	PF00069	0.583
DOC_MAPK_MEF2A_6	159	166	PF00069	0.419
DOC_MAPK_MEF2A_6	194	203	PF00069	0.428
DOC_MAPK_MEF2A_6	281	290	PF00069	0.437
DOC_PP1_RVXF_1	200	207	PF00149	0.386
DOC_PP1_RVXF_1	66	73	PF00149	0.620
DOC_PP2B_LxvP_1	321	324	PF13499	0.428
DOC_PP4_FxxP_1	9	12	PF00568	0.453
DOC_USP7_MATH_1	111	115	PF00917	0.799
DOC_USP7_MATH_1	124	128	PF00917	0.730
DOC_USP7_MATH_1	170	174	PF00917	0.419
DOC_USP7_MATH_1	175	179	PF00917	0.410
DOC_USP7_MATH_1	18	22	PF00917	0.614
DOC_USP7_MATH_1	205	209	PF00917	0.400
DOC_USP7_MATH_1	234	238	PF00917	0.656
DOC_USP7_MATH_1	246	250	PF00917	0.471
DOC_USP7_MATH_1	33	37	PF00917	0.379
DOC_USP7_MATH_1	347	351	PF00917	0.556
DOC_USP7_MATH_1	469	473	PF00917	0.735
DOC_USP7_MATH_1	578	582	PF00917	0.649
DOC_WW_Pin1_4	120	125	PF00397	0.663
DOC_WW_Pin1_4	146	151	PF00397	0.729
DOC_WW_Pin1_4	296	301	PF00397	0.521
DOC_WW_Pin1_4	363	368	PF00397	0.757
DOC_WW_Pin1_4	370	375	PF00397	0.656
DOC_WW_Pin1_4	427	432	PF00397	0.555
DOC_WW_Pin1_4	617	622	PF00397	0.581
DOC_WW_Pin1_4	72	77	PF00397	0.608
LIG_14-3-3_CanoR_1	153	157	PF00244	0.656
LIG_14-3-3_CanoR_1	221	227	PF00244	0.399
LIG_14-3-3_CanoR_1	337	341	PF00244	0.643
LIG_14-3-3_CanoR_1	346	353	PF00244	0.550
LIG_14-3-3_CanoR_1	384	390	PF00244	0.718
LIG_14-3-3_CanoR_1	561	568	PF00244	0.754
LIG_14-3-3_CanoR_1	595	601	PF00244	0.750
LIG_14-3-3_CanoR_1	633	637	PF00244	0.513
LIG_BRCT_BRCA1_1	349	353	PF00533	0.666
LIG_Clathr_ClatBox_1	183	187	PF01394	0.564
LIG_deltaCOP1_diTrp_1	602	606	PF00928	0.700
LIG_eIF4E_1	282	288	PF01652	0.434
LIG_FHA_1	198	204	PF00498	0.393
LIG_FHA_1	270	276	PF00498	0.445
LIG_FHA_1	278	284	PF00498	0.437
LIG_FHA_1	42	48	PF00498	0.400
LIG_FHA_1	519	525	PF00498	0.615
LIG_FHA_1	55	61	PF00498	0.577
LIG_FHA_1	618	624	PF00498	0.574
LIG_FHA_2	111	117	PF00498	0.781
LIG_FHA_2	260	266	PF00498	0.591
LIG_FHA_2	349	355	PF00498	0.679
LIG_FHA_2	76	82	PF00498	0.450
LIG_LIR_Gen_1	209	220	PF02991	0.509
LIG_LIR_Gen_1	423	431	PF02991	0.474
LIG_LIR_Gen_1	586	597	PF02991	0.748
LIG_LIR_Nem_3	209	215	PF02991	0.543
LIG_LIR_Nem_3	423	427	PF02991	0.485
LIG_LIR_Nem_3	536	540	PF02991	0.684
LIG_LIR_Nem_3	586	592	PF02991	0.751
LIG_LIR_Nem_3	609	615	PF02991	0.545
LIG_NRBOX	179	185	PF00104	0.544
LIG_NRBOX	282	288	PF00104	0.434
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.558
LIG_Pex14_2	9	13	PF04695	0.466
LIG_PTB_Apo_2	250	257	PF02174	0.432
LIG_PTB_Apo_2	531	538	PF02174	0.568
LIG_PTB_Apo_2	591	598	PF02174	0.666
LIG_PTB_Phospho_1	531	537	PF10480	0.569
LIG_SH2_CRK	212	216	PF00017	0.573
LIG_SH2_CRK	32	36	PF00017	0.382
LIG_SH2_GRB2like	537	540	PF00017	0.695
LIG_SH2_NCK_1	32	36	PF00017	0.382
LIG_SH2_NCK_1	344	348	PF00017	0.684
LIG_SH2_STAP1	212	216	PF00017	0.573
LIG_SH2_STAP1	540	544	PF00017	0.613
LIG_SH2_STAT5	229	232	PF00017	0.455
LIG_SH2_STAT5	282	285	PF00017	0.433
LIG_SH2_STAT5	588	591	PF00017	0.668
LIG_SH2_STAT5	69	72	PF00017	0.445
LIG_SH3_3	193	199	PF00018	0.463
LIG_SH3_3	425	431	PF00018	0.477
LIG_SH3_3	61	67	PF00018	0.515
LIG_SUMO_SIM_anti_2	44	52	PF11976	0.427
LIG_SUMO_SIM_par_1	256	262	PF11976	0.525
LIG_SUMO_SIM_par_1	271	276	PF11976	0.384
LIG_SUMO_SIM_par_1	44	52	PF11976	0.427
LIG_SUMO_SIM_par_1	613	620	PF11976	0.721
LIG_TRAF2_1	113	116	PF00917	0.715
LIG_TRAF2_1	324	327	PF00917	0.629
LIG_TRAF2_1	454	457	PF00917	0.644
LIG_TYR_ITIM	623	628	PF00017	0.535
LIG_UBA3_1	59	68	PF00899	0.514
LIG_WRC_WIRS_1	421	426	PF05994	0.499
MOD_CDK_SPK_2	72	77	PF00069	0.608
MOD_CDK_SPxxK_3	146	153	PF00069	0.627
MOD_CDK_SPxxK_3	363	370	PF00069	0.752
MOD_CK1_1	102	108	PF00069	0.621
MOD_CK1_1	120	126	PF00069	0.777
MOD_CK1_1	149	155	PF00069	0.789
MOD_CK1_1	345	351	PF00069	0.642
MOD_CK1_1	373	379	PF00069	0.693
MOD_CK1_1	388	394	PF00069	0.793
MOD_CK1_1	408	414	PF00069	0.558
MOD_CK1_1	460	466	PF00069	0.763
MOD_CK1_1	530	536	PF00069	0.629
MOD_CK1_1	546	552	PF00069	0.516
MOD_CK1_1	563	569	PF00069	0.656
MOD_CK2_1	109	115	PF00069	0.774
MOD_CK2_1	120	126	PF00069	0.576
MOD_CK2_1	265	271	PF00069	0.447
MOD_CK2_1	348	354	PF00069	0.668
MOD_CK2_1	471	477	PF00069	0.665
MOD_CK2_1	596	602	PF00069	0.642
MOD_CK2_1	75	81	PF00069	0.603
MOD_DYRK1A_RPxSP_1	370	374	PF00069	0.685
MOD_GlcNHglycan	101	104	PF01048	0.747
MOD_GlcNHglycan	115	120	PF01048	0.563
MOD_GlcNHglycan	139	142	PF01048	0.701
MOD_GlcNHglycan	171	175	PF01048	0.603
MOD_GlcNHglycan	177	180	PF01048	0.408
MOD_GlcNHglycan	236	239	PF01048	0.508
MOD_GlcNHglycan	275	278	PF01048	0.435
MOD_GlcNHglycan	412	415	PF01048	0.819
MOD_GlcNHglycan	417	420	PF01048	0.645
MOD_GlcNHglycan	459	462	PF01048	0.733
MOD_GlcNHglycan	471	474	PF01048	0.590
MOD_GlcNHglycan	51	54	PF01048	0.691
MOD_GlcNHglycan	639	642	PF01048	0.565
MOD_GSK3_1	111	118	PF00069	0.753
MOD_GSK3_1	120	127	PF00069	0.731
MOD_GSK3_1	132	139	PF00069	0.594
MOD_GSK3_1	18	25	PF00069	0.612
MOD_GSK3_1	224	231	PF00069	0.411
MOD_GSK3_1	240	247	PF00069	0.527
MOD_GSK3_1	261	268	PF00069	0.454
MOD_GSK3_1	269	276	PF00069	0.421
MOD_GSK3_1	336	343	PF00069	0.679
MOD_GSK3_1	345	352	PF00069	0.586
MOD_GSK3_1	366	373	PF00069	0.714
MOD_GSK3_1	397	404	PF00069	0.748
MOD_GSK3_1	457	464	PF00069	0.756
MOD_GSK3_1	526	533	PF00069	0.639
MOD_GSK3_1	539	546	PF00069	0.542
MOD_GSK3_1	54	61	PF00069	0.604
MOD_GSK3_1	72	79	PF00069	0.339
MOD_N-GLC_1	533	538	PF02516	0.723
MOD_NEK2_1	151	156	PF00069	0.658
MOD_NEK2_1	206	211	PF00069	0.568
MOD_NEK2_1	224	229	PF00069	0.317
MOD_NEK2_1	269	274	PF00069	0.440
MOD_NEK2_1	275	280	PF00069	0.444
MOD_NEK2_1	328	333	PF00069	0.689
MOD_NEK2_1	340	345	PF00069	0.506
MOD_NEK2_1	353	358	PF00069	0.710
MOD_NEK2_1	459	464	PF00069	0.712
MOD_NEK2_1	49	54	PF00069	0.573
MOD_NEK2_1	527	532	PF00069	0.650
MOD_NEK2_1	560	565	PF00069	0.759
MOD_NEK2_1	577	582	PF00069	0.725
MOD_NEK2_1	59	64	PF00069	0.462
MOD_NEK2_1	632	637	PF00069	0.656
MOD_NEK2_1	92	97	PF00069	0.626
MOD_NEK2_1	99	104	PF00069	0.660
MOD_NEK2_2	124	129	PF00069	0.764
MOD_NEK2_2	506	511	PF00069	0.676
MOD_NEK2_2	540	545	PF00069	0.668
MOD_PIKK_1	139	145	PF00454	0.788
MOD_PIKK_1	373	379	PF00454	0.741
MOD_PKA_2	1	7	PF00069	0.503
MOD_PKA_2	152	158	PF00069	0.679
MOD_PKA_2	290	296	PF00069	0.482
MOD_PKA_2	336	342	PF00069	0.670
MOD_PKA_2	345	351	PF00069	0.608
MOD_PKA_2	560	566	PF00069	0.732
MOD_PKA_2	632	638	PF00069	0.513
MOD_Plk_1	353	359	PF00069	0.712
MOD_Plk_1	527	533	PF00069	0.765
MOD_Plk_2-3	265	271	PF00069	0.447
MOD_Plk_4	1	7	PF00069	0.503
MOD_Plk_4	225	231	PF00069	0.415
MOD_Plk_4	247	253	PF00069	0.617
MOD_Plk_4	265	271	PF00069	0.360
MOD_Plk_4	310	316	PF00069	0.402
MOD_Plk_4	336	342	PF00069	0.628
MOD_Plk_4	461	467	PF00069	0.648
MOD_Plk_4	471	477	PF00069	0.558
MOD_Plk_4	527	533	PF00069	0.628
MOD_Plk_4	632	638	PF00069	0.513
MOD_ProDKin_1	120	126	PF00069	0.663
MOD_ProDKin_1	146	152	PF00069	0.725
MOD_ProDKin_1	296	302	PF00069	0.524
MOD_ProDKin_1	363	369	PF00069	0.759
MOD_ProDKin_1	370	376	PF00069	0.657
MOD_ProDKin_1	427	433	PF00069	0.552
MOD_ProDKin_1	617	623	PF00069	0.577
MOD_ProDKin_1	72	78	PF00069	0.598
MOD_SUMO_rev_2	417	424	PF00179	0.604
TRG_ENDOCYTIC_2	212	215	PF00928	0.582
TRG_ENDOCYTIC_2	32	35	PF00928	0.382
TRG_ENDOCYTIC_2	479	482	PF00928	0.580
TRG_ENDOCYTIC_2	625	628	PF00928	0.525
TRG_ENDOCYTIC_2	69	72	PF00928	0.603
TRG_ER_diArg_1	305	307	PF00400	0.490
TRG_ER_diArg_1	329	332	PF00400	0.550
TRG_ER_diArg_1	560	562	PF00400	0.755
TRG_NES_CRM1_1	420	433	PF08389	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B6	Leptomonas seymouri	55%	98%
A4HPE7	Leishmania braziliensis	77%	100%
A4ICI8	Leishmania infantum	100%	100%
E9AT58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1D9	Leishmania major	94%	100%