Kinetoplastid_membrane_protein-11/GeneDB:LmjF.35. 2210/GeneDB:LmjF.35.2220

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid membrane protein-11

Species:

Leishmania donovani

UniProt:

A0A3Q8IJE8_LEIDO

TriTrypDb:

LdBPK_352260.1 , LdCL_350027500 , LdCL_350027600 , LDHU3_35.2890 , LDHU3_35.2900

Length:

Annotations

Annotations by Jardim et al.

Membrane associated proteins, Kinetoplastid membrane -11 KMP11-1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 15

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005874	microtubule	6	13
GO:0099080	supramolecular complex	2	13
GO:0099081	supramolecular polymer	3	13
GO:0099512	supramolecular fiber	4	13
GO:0099513	polymeric cytoskeletal fiber	5	13
GO:0110165	cellular anatomical entity	1	13
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Expansion

Sequence features

A0A3Q8IJE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJE8

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	13
GO:0006952	defense response	3	13
GO:0008284	positive regulation of cell population proliferation	5	13
GO:0042127	regulation of cell population proliferation	4	13
GO:0048518	positive regulation of biological process	3	13
GO:0048522	positive regulation of cellular process	4	13
GO:0050789	regulation of biological process	2	13
GO:0050794	regulation of cellular process	3	13
GO:0050896	response to stimulus	1	13
GO:0065007	biological regulation	1	13
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0031023	microtubule organizing center organization	3	1
GO:0032053	ciliary basal body organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.404
CLV_PCSK_SKI1_1	53	57	PF00082	0.438
DOC_USP7_MATH_1	35	39	PF00917	0.600
DOC_USP7_UBL2_3	61	65	PF12436	0.594
DOC_WW_Pin1_4	38	43	PF00397	0.575
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	69	73	PF00533	0.575
LIG_FHA_2	1	7	PF00498	0.602
LIG_LIR_Gen_1	3	12	PF02991	0.641
LIG_LIR_Gen_1	46	55	PF02991	0.575
LIG_LIR_Nem_3	3	8	PF02991	0.641
LIG_LIR_Nem_3	46	51	PF02991	0.575
LIG_Pex14_2	73	77	PF04695	0.575
LIG_REV1ctd_RIR_1	28	34	PF16727	0.575
LIG_TRAF2_1	4	7	PF00917	0.600
MOD_CDK_SPxxK_3	38	45	PF00069	0.575
MOD_CK1_1	38	44	PF00069	0.600
MOD_CK2_1	1	7	PF00069	0.600
MOD_GlcNHglycan	6	11	PF01048	0.404
MOD_Plk_1	35	41	PF00069	0.587
MOD_ProDKin_1	38	44	PF00069	0.575
TRG_ENDOCYTIC_2	48	51	PF00928	0.587
TRG_ENDOCYTIC_2	5	8	PF00928	0.641
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAE0	Bodo saltans	84%	100%
A0A3S7X9H1	Leishmania donovani	97%	100%
A4HMP3	Leishmania braziliensis	96%	100%
A4IBB2	Leishmania infantum	97%	100%
A4IBB3	Leishmania infantum	100%	100%
C9ZZD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9AF45	Leishmania major	100%	100%
E9B6A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B6A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B6A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O21436	Leishmania tropica	100%	100%
P69300	Trypanosoma brucei brucei	83%	100%
P69301	Trypanosoma brucei rhodesiense	83%	100%
Q25297	Leishmania infantum	99%	100%
Q25298	Leishmania infantum	99%	100%
Q36736	Leishmania donovani	98%	100%
Q9U6Z1	Trypanosoma cruzi	86%	100%
V5B3U8	Trypanosoma cruzi	87%	100%