ER membrane protein complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Protein:

Gene product:

Protein of unknown function (DUF1077), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJD4_LEIDO

TriTrypDb:

LdBPK_301660.1 , LdCL_300021900 , LDHU3_30.2250

Length:

150


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0032991	protein-containing complex	1	1
GO:0072546	EMC complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

A0A3Q8IJD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJD4


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.258
CLV_PCSK_SKI1_1	13	17	PF00082	0.644
CLV_PCSK_SKI1_1	18	22	PF00082	0.503
DOC_MAPK_MEF2A_6	38	46	PF00069	0.274
DOC_PP1_RVXF_1	116	122	PF00149	0.269
DOC_USP7_MATH_1	126	130	PF00917	0.334
DOC_USP7_MATH_1	69	73	PF00917	0.440
DOC_WW_Pin1_4	133	138	PF00397	0.254
LIG_14-3-3_CanoR_1	28	36	PF00244	0.272
LIG_BIR_II_1	1	5	PF00653	0.407
LIG_BIR_III_3	1	5	PF00653	0.445
LIG_BRCT_BRCA1_1	144	148	PF00533	0.413
LIG_BRCT_BRCA1_1	57	61	PF00533	0.288
LIG_eIF4E_1	104	110	PF01652	0.301
LIG_FHA_1	32	38	PF00498	0.340
LIG_FHA_2	137	143	PF00498	0.404
LIG_FHA_2	14	20	PF00498	0.423
LIG_FHA_2	85	91	PF00498	0.372
LIG_LIR_Gen_1	139	148	PF02991	0.429
LIG_LIR_Gen_1	55	65	PF02991	0.288
LIG_LIR_Nem_3	139	143	PF02991	0.434
LIG_Pex14_2	57	61	PF04695	0.269
LIG_SH2_STAT5	104	107	PF00017	0.276
LIG_SH3_3	63	69	PF00018	0.269
LIG_TRAF2_1	139	142	PF00917	0.443
LIG_UBA3_1	109	118	PF00899	0.289
LIG_WW_1	137	140	PF00397	0.359
MOD_CK1_1	55	61	PF00069	0.288
MOD_CK1_1	72	78	PF00069	0.482
MOD_CK2_1	13	19	PF00069	0.394
MOD_CK2_1	136	142	PF00069	0.398
MOD_GlcNHglycan	10	13	PF01048	0.570
MOD_GlcNHglycan	144	147	PF01048	0.664
MOD_GlcNHglycan	2	5	PF01048	0.662
MOD_GlcNHglycan	74	77	PF01048	0.290
MOD_GlcNHglycan	94	97	PF01048	0.177
MOD_GSK3_1	27	34	PF00069	0.296
MOD_N-GLC_1	8	13	PF02516	0.621
MOD_PIKK_1	31	37	PF00454	0.305
MOD_PKA_2	27	33	PF00069	0.316
MOD_Plk_1	52	58	PF00069	0.293
MOD_Plk_4	40	46	PF00069	0.238
MOD_Plk_4	52	58	PF00069	0.246
MOD_Plk_4	69	75	PF00069	0.426
MOD_ProDKin_1	133	139	PF00069	0.254
MOD_SUMO_rev_2	82	89	PF00179	0.521
TRG_ENDOCYTIC_2	140	143	PF00928	0.433
TRG_ER_diArg_1	22	25	PF00400	0.247
TRG_NES_CRM1_1	39	53	PF08389	0.355


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL3	Leptomonas seymouri	80%	100%
A0A0S4J2Y6	Bodo saltans	51%	100%
A0A1X0P234	Trypanosomatidae	66%	100%
A0A3R7RTR5	Trypanosoma rangeli	56%	100%
A4HIA9	Leishmania braziliensis	89%	100%
A4I5J3	Leishmania infantum	99%	100%
B5XB24	Salmo salar	32%	80%
C9ZQS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B0T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O94520	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	78%
P53073	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	79%
Q3T0K8	Bos taurus	32%	82%
Q4Q7D8	Leishmania major	95%	100%
Q5J8M3	Homo sapiens	32%	82%
Q5RC35	Pongo abelii	32%	82%
Q6GR43	Xenopus laevis	32%	83%
Q6P011	Danio rerio	32%	79%
Q6PBF7	Xenopus tropicalis	32%	83%
Q9CZX9	Mus musculus	32%	82%