Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IJD1_LEIDO

TriTrypDb:

LdBPK_363790.1 , LdCL_360044900 , LDHU3_36.5120

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IJD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.519
CLV_C14_Caspase3-7	252	256	PF00656	0.713
CLV_NRD_NRD_1	108	110	PF00675	0.403
CLV_NRD_NRD_1	113	115	PF00675	0.402
CLV_NRD_NRD_1	133	135	PF00675	0.484
CLV_NRD_NRD_1	166	168	PF00675	0.337
CLV_NRD_NRD_1	197	199	PF00675	0.547
CLV_NRD_NRD_1	246	248	PF00675	0.568
CLV_NRD_NRD_1	277	279	PF00675	0.520
CLV_PCSK_FUR_1	109	113	PF00082	0.384
CLV_PCSK_KEX2_1	111	113	PF00082	0.423
CLV_PCSK_KEX2_1	133	135	PF00082	0.426
CLV_PCSK_KEX2_1	166	168	PF00082	0.419
CLV_PCSK_KEX2_1	197	199	PF00082	0.547
CLV_PCSK_KEX2_1	246	248	PF00082	0.637
CLV_PCSK_KEX2_1	277	279	PF00082	0.520
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.390
CLV_PCSK_PC7_1	109	115	PF00082	0.346
CLV_PCSK_SKI1_1	113	117	PF00082	0.399
CLV_PCSK_SKI1_1	3	7	PF00082	0.683
DEG_SPOP_SBC_1	14	18	PF00917	0.504
DEG_SPOP_SBC_1	74	78	PF00917	0.494
DOC_MAPK_gen_1	133	140	PF00069	0.598
DOC_MAPK_HePTP_8	80	92	PF00069	0.346
DOC_MAPK_MEF2A_6	83	92	PF00069	0.346
DOC_PP4_FxxP_1	291	294	PF00568	0.678
DOC_USP7_MATH_1	182	186	PF00917	0.675
DOC_USP7_MATH_1	69	73	PF00917	0.608
DOC_USP7_MATH_1	81	85	PF00917	0.370
DOC_USP7_UBL2_3	116	120	PF12436	0.614
DOC_WW_Pin1_4	279	284	PF00397	0.820
DOC_WW_Pin1_4	63	68	PF00397	0.563
LIG_deltaCOP1_diTrp_1	230	238	PF00928	0.662
LIG_deltaCOP1_diTrp_1	40	47	PF00928	0.409
LIG_FHA_1	43	49	PF00498	0.440
LIG_FHA_1	75	81	PF00498	0.492
LIG_FHA_1	83	89	PF00498	0.296
LIG_FHA_2	15	21	PF00498	0.521
LIG_FHA_2	269	275	PF00498	0.754
LIG_LIR_Nem_3	254	260	PF02991	0.711
LIG_LYPXL_yS_3	260	263	PF13949	0.646
LIG_PCNA_yPIPBox_3	166	176	PF02747	0.636
LIG_SH2_CRK	286	290	PF00017	0.711
LIG_SH2_STAP1	213	217	PF00017	0.713
LIG_SH2_STAP1	286	290	PF00017	0.694
LIG_SH2_STAT5	106	109	PF00017	0.422
LIG_SH2_STAT5	268	271	PF00017	0.709
LIG_SH2_STAT5	57	60	PF00017	0.434
LIG_SH3_3	236	242	PF00018	0.738
LIG_SH3_3	277	283	PF00018	0.701
LIG_Sin3_3	91	98	PF02671	0.332
LIG_SUMO_SIM_anti_2	84	91	PF11976	0.346
LIG_TRAF2_1	115	118	PF00917	0.606
LIG_TRAF2_1	128	131	PF00917	0.672
LIG_WW_1	283	286	PF00397	0.713
MOD_CK1_1	177	183	PF00069	0.667
MOD_CK1_1	18	24	PF00069	0.525
MOD_CK1_1	187	193	PF00069	0.686
MOD_CK1_1	266	272	PF00069	0.732
MOD_CK1_1	62	68	PF00069	0.494
MOD_CK1_1	70	76	PF00069	0.477
MOD_CK2_1	221	227	PF00069	0.803
MOD_CK2_1	268	274	PF00069	0.754
MOD_GlcNHglycan	189	192	PF01048	0.499
MOD_GlcNHglycan	251	254	PF01048	0.540
MOD_GlcNHglycan	72	75	PF01048	0.725
MOD_GSK3_1	12	19	PF00069	0.573
MOD_GSK3_1	221	228	PF00069	0.726
MOD_GSK3_1	266	273	PF00069	0.709
MOD_GSK3_1	59	66	PF00069	0.520
MOD_GSK3_1	69	76	PF00069	0.509
MOD_N-GLC_1	70	75	PF02516	0.737
MOD_NEK2_1	13	18	PF00069	0.490
MOD_NEK2_1	189	194	PF00069	0.720
MOD_PIKK_1	184	190	PF00454	0.813
MOD_PIKK_1	231	237	PF00454	0.737
MOD_PIKK_1	59	65	PF00454	0.433
MOD_PKA_2	7	13	PF00069	0.503
MOD_Plk_1	81	87	PF00069	0.405
MOD_Plk_4	263	269	PF00069	0.743
MOD_Plk_4	75	81	PF00069	0.507
MOD_Plk_4	82	88	PF00069	0.287
MOD_ProDKin_1	279	285	PF00069	0.818
MOD_ProDKin_1	63	69	PF00069	0.566
MOD_SUMO_for_1	115	118	PF00179	0.606
MOD_SUMO_rev_2	117	122	PF00179	0.615
TRG_ENDOCYTIC_2	260	263	PF00928	0.706
TRG_ENDOCYTIC_2	286	289	PF00928	0.711
TRG_ER_diArg_1	112	114	PF00400	0.621
TRG_ER_diArg_1	245	247	PF00400	0.751
TRG_ER_diArg_1	276	278	PF00400	0.739
TRG_ER_FFAT_2	262	273	PF00635	0.652
TRG_NLS_MonoCore_2	108	113	PF00514	0.543
TRG_NLS_MonoExtC_3	108	113	PF00514	0.619
TRG_NLS_MonoExtN_4	109	115	PF00514	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HPN0	Leishmania braziliensis	61%	97%
A4ID36	Leishmania infantum	100%	100%
E9ATE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q155	Leishmania major	89%	98%