LeishMANIAdb
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Ribosomal L18p/L5e family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal L18p/L5e family protein
Gene product:
60S ribosomal protein L5, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IJC5_LEIDO
TriTrypDb:
LdBPK_351870.1 , LdCL_350023600 , LdCL_350023700 , LdCL_350023800 , LdCL_350023900 , LdCL_350024000 , LDHU3_35.2440 , LDHU3_35.2450 , LDHU3_35.2460 , LDHU3_35.2470 , LDHU3_35.2480
Length:
305

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L5

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 10
GO:0005737 cytoplasm 2 12
GO:0005840 ribosome 5 10
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 10
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0005730 nucleolus 5 2
GO:0015934 large ribosomal subunit 4 2
GO:0022625 cytosolic large ribosomal subunit 5 2
GO:0044391 ribosomal subunit 3 2

Expansion

Sequence features

A0A3Q8IJC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJC5

PDB structure(s): 6az3_O

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 12
GO:0006518 peptide metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009059 macromolecule biosynthetic process 4 12
GO:0009987 cellular process 1 12
GO:0019538 protein metabolic process 3 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 12
GO:0043043 peptide biosynthetic process 5 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043603 amide metabolic process 3 12
GO:0043604 amide biosynthetic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044260 obsolete cellular macromolecule metabolic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
GO:0000027 ribosomal large subunit assembly 7 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0022618 ribonucleoprotein complex assembly 6 2
GO:0043933 protein-containing complex organization 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0071826 ribonucleoprotein complex subunit organization 5 2
GO:0071840 cellular component organization or biogenesis 2 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003735 structural constituent of ribosome 2 12
GO:0005198 structural molecule activity 1 12
GO:0005488 binding 1 12
GO:0008097 5S rRNA binding 6 12
GO:0019843 rRNA binding 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 194 198 PF00656 0.627
CLV_NRD_NRD_1 107 109 PF00675 0.333
CLV_NRD_NRD_1 23 25 PF00675 0.367
CLV_NRD_NRD_1 33 35 PF00675 0.368
CLV_PCSK_FUR_1 21 25 PF00082 0.364
CLV_PCSK_KEX2_1 107 109 PF00082 0.333
CLV_PCSK_KEX2_1 14 16 PF00082 0.364
CLV_PCSK_KEX2_1 21 23 PF00082 0.364
CLV_PCSK_KEX2_1 288 290 PF00082 0.409
CLV_PCSK_KEX2_1 33 35 PF00082 0.365
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.364
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.409
CLV_PCSK_SKI1_1 149 153 PF00082 0.333
CLV_PCSK_SKI1_1 215 219 PF00082 0.581
CLV_PCSK_SKI1_1 266 270 PF00082 0.371
CLV_PCSK_SKI1_1 5 9 PF00082 0.520
DEG_APCC_DBOX_1 106 114 PF00400 0.533
DEG_SPOP_SBC_1 157 161 PF00917 0.533
DOC_MAPK_gen_1 107 115 PF00069 0.533
DOC_MAPK_gen_1 48 55 PF00069 0.554
DOC_MAPK_MEF2A_6 149 156 PF00069 0.533
DOC_MAPK_MEF2A_6 48 55 PF00069 0.533
DOC_PP1_RVXF_1 226 233 PF00149 0.661
DOC_PP4_FxxP_1 44 47 PF00568 0.546
DOC_SPAK_OSR1_1 15 19 PF12202 0.564
DOC_USP7_MATH_1 125 129 PF00917 0.588
DOC_USP7_MATH_1 258 262 PF00917 0.626
DOC_USP7_MATH_1 274 278 PF00917 0.604
DOC_USP7_UBL2_3 10 14 PF12436 0.508
DOC_USP7_UBL2_3 262 266 PF12436 0.546
DOC_WW_Pin1_4 43 48 PF00397 0.546
LIG_14-3-3_CanoR_1 107 111 PF00244 0.588
LIG_14-3-3_CanoR_1 158 166 PF00244 0.531
LIG_eIF4E_1 99 105 PF01652 0.533
LIG_FHA_1 278 284 PF00498 0.579
LIG_FHA_1 99 105 PF00498 0.536
LIG_FHA_2 132 138 PF00498 0.533
LIG_FHA_2 54 60 PF00498 0.554
LIG_LIR_Apic_2 42 47 PF02991 0.549
LIG_LIR_Nem_3 126 132 PF02991 0.538
LIG_LIR_Nem_3 46 52 PF02991 0.546
LIG_PTB_Apo_2 6 13 PF02174 0.507
LIG_PTB_Phospho_1 6 12 PF10480 0.507
LIG_SH2_CRK 129 133 PF00017 0.533
LIG_SH2_CRK 49 53 PF00017 0.546
LIG_SH2_NCK_1 95 99 PF00017 0.533
LIG_SH2_STAP1 79 83 PF00017 0.533
LIG_SH2_STAP1 95 99 PF00017 0.533
LIG_SH2_STAT3 213 216 PF00017 0.492
LIG_SH2_STAT5 12 15 PF00017 0.558
LIG_SH2_STAT5 213 216 PF00017 0.492
LIG_SH3_2 180 185 PF14604 0.641
LIG_SH3_3 177 183 PF00018 0.546
LIG_UBA3_1 60 68 PF00899 0.493
MOD_CDK_SPK_2 43 48 PF00069 0.395
MOD_CDK_SPxxK_3 43 50 PF00069 0.395
MOD_CK1_1 277 283 PF00069 0.479
MOD_CK2_1 281 287 PF00069 0.424
MOD_GlcNHglycan 129 132 PF01048 0.501
MOD_GlcNHglycan 283 286 PF01048 0.509
MOD_GSK3_1 127 134 PF00069 0.426
MOD_GSK3_1 277 284 PF00069 0.382
MOD_GSK3_1 39 46 PF00069 0.403
MOD_NEK2_1 156 161 PF00069 0.377
MOD_PKA_1 281 287 PF00069 0.501
MOD_PKA_2 106 112 PF00069 0.454
MOD_PKA_2 157 163 PF00069 0.375
MOD_PKA_2 53 59 PF00069 0.395
MOD_Plk_1 191 197 PF00069 0.657
MOD_Plk_2-3 192 198 PF00069 0.581
MOD_ProDKin_1 43 49 PF00069 0.395
MOD_SUMO_for_1 217 220 PF00179 0.586
MOD_SUMO_for_1 268 271 PF00179 0.406
MOD_SUMO_rev_2 192 200 PF00179 0.644
MOD_SUMO_rev_2 220 230 PF00179 0.569
TRG_ENDOCYTIC_2 129 132 PF00928 0.376
TRG_ENDOCYTIC_2 49 52 PF00928 0.395
TRG_ER_diArg_1 20 23 PF00400 0.420
TRG_NLS_Bipartite_1 250 270 PF00514 0.395
TRG_NLS_MonoExtC_3 265 270 PF00514 0.410
TRG_NLS_MonoExtN_4 265 270 PF00514 0.413
TRG_Pf-PMV_PEXEL_1 239 243 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P958 Leptomonas seymouri 91% 100%
A0A0S4JJ00 Bodo saltans 79% 100%
A0A1X0P669 Trypanosomatidae 84% 99%
A1RVN4 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 36% 100%
A2BMD8 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 36% 100%
A2WXX3 Oryza sativa subsp. indica 51% 100%
A3MSJ3 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 37% 100%
A4HMK9 Leishmania braziliensis 95% 100%
A4IB88 Leishmania infantum 100% 100%
A4WMD6 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 37% 100%
A8AC01 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 30% 100%
A8M9I3 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) 36% 100%
B1Y8V2 Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) 37% 100%
C9ZZL2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 81% 99%
E9AF09 Leishmania major 99% 100%
E9AF10 Leishmania major 99% 100%
E9B665 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O22608 Dunaliella salina 49% 100%
O44248 Anopheles gambiae 54% 94%
O59953 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 54% 100%
O65353 Helianthus annuus 51% 100%
O74306 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
O76190 Bombyx mori 52% 100%
P09895 Rattus norvegicus 56% 100%
P15125 Xenopus laevis 56% 100%
P15126 Xenopus laevis 55% 100%
P22451 Gallus gallus 56% 100%
P26321 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 51% 100%
P46777 Homo sapiens 56% 100%
P47962 Mus musculus 56% 100%
P49227 Arabidopsis thaliana 54% 100%
P49405 Caenorhabditis elegans 55% 100%
P52822 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
Q0JGY1 Oryza sativa subsp. japonica 51% 100%
Q18GG8 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 30% 100%
Q1HQU2 Aedes aegypti 54% 100%
Q231U7 Tetrahymena thermophila (strain SB210) 50% 100%
Q26481 Styela clava 52% 100%
Q4KTI3 Suberites domuncula 54% 100%
Q4N655 Theileria parva 53% 100%
Q4R5M0 Macaca fascicularis 56% 100%
Q4UDE7 Theileria annulata 52% 100%
Q54XX3 Dictyostelium discoideum 55% 100%
Q56FG6 Lysiphlebus testaceipes 51% 100%
Q58DW5 Bos taurus 56% 100%
Q5AGZ7 Candida albicans (strain SC5314 / ATCC MYA-2876) 52% 100%
Q5EY89 Eimeria tenella 53% 98%
Q5XUC7 Toxoptera citricida 50% 100%
Q627R7 Caenorhabditis briggsae 55% 100%
Q6JWW5 Oikopleura dioica 52% 100%
Q6UNT2 Cucumis sativus 52% 100%
Q8L4L4 Oryza sativa subsp. japonica 52% 100%
Q8LBI1 Arabidopsis thaliana 54% 100%
Q8ZVV7 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 39% 100%
Q9W5R8 Drosophila melanogaster 53% 100%
Q9YF94 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 33% 100%
V5BHY0 Trypanosoma cruzi 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS