Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJC4_LEIDO

TriTrypDb:

LdBPK_353790.1 , LdCL_350042900 , LDHU3_35.4950

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	260	262	PF00675	0.586
CLV_NRD_NRD_1	288	290	PF00675	0.605
CLV_NRD_NRD_1	77	79	PF00675	0.487
CLV_NRD_NRD_1	88	90	PF00675	0.498
CLV_NRD_NRD_1	92	94	PF00675	0.529
CLV_NRD_NRD_1	95	97	PF00675	0.472
CLV_PCSK_FUR_1	89	93	PF00082	0.547
CLV_PCSK_KEX2_1	260	262	PF00082	0.586
CLV_PCSK_KEX2_1	288	290	PF00082	0.502
CLV_PCSK_KEX2_1	76	78	PF00082	0.496
CLV_PCSK_KEX2_1	88	90	PF00082	0.465
CLV_PCSK_KEX2_1	91	93	PF00082	0.483
CLV_PCSK_KEX2_1	95	97	PF00082	0.421
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.539
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.390
CLV_PCSK_PC7_1	284	290	PF00082	0.616
CLV_PCSK_PC7_1	88	94	PF00082	0.555
CLV_PCSK_SKI1_1	78	82	PF00082	0.499
CLV_PCSK_SKI1_1	96	100	PF00082	0.454
DEG_APCC_DBOX_1	260	268	PF00400	0.536
DEG_SCF_FBW7_1	56	63	PF00400	0.644
DEG_SCF_FBW7_2	337	342	PF00400	0.575
DEG_SPOP_SBC_1	22	26	PF00917	0.475
DOC_CDC14_PxL_1	192	200	PF14671	0.469
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.525
DOC_PP1_RVXF_1	186	193	PF00149	0.390
DOC_PP2B_LxvP_1	245	248	PF13499	0.538
DOC_PP2B_LxvP_1	358	361	PF13499	0.477
DOC_PP4_FxxP_1	172	175	PF00568	0.423
DOC_PP4_FxxP_1	376	379	PF00568	0.420
DOC_USP7_MATH_1	221	225	PF00917	0.663
DOC_USP7_MATH_1	306	310	PF00917	0.675
DOC_USP7_MATH_1	35	39	PF00917	0.530
DOC_USP7_UBL2_3	57	61	PF12436	0.610
DOC_WW_Pin1_4	238	243	PF00397	0.433
DOC_WW_Pin1_4	335	340	PF00397	0.526
DOC_WW_Pin1_4	375	380	PF00397	0.447
DOC_WW_Pin1_4	56	61	PF00397	0.643
LIG_14-3-3_CanoR_1	132	142	PF00244	0.601
LIG_14-3-3_CanoR_1	253	259	PF00244	0.517
LIG_14-3-3_CanoR_1	365	371	PF00244	0.498
LIG_14-3-3_CanoR_1	42	47	PF00244	0.577
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.384
LIG_BRCT_BRCA1_1	42	46	PF00533	0.469
LIG_deltaCOP1_diTrp_1	270	276	PF00928	0.606
LIG_DLG_GKlike_1	42	49	PF00625	0.635
LIG_FHA_1	124	130	PF00498	0.534
LIG_FHA_1	133	139	PF00498	0.529
LIG_FHA_1	319	325	PF00498	0.448
LIG_FHA_1	61	67	PF00498	0.643
LIG_FHA_2	367	373	PF00498	0.534
LIG_HCF-1_HBM_1	13	16	PF13415	0.475
LIG_Integrin_isoDGR_2	103	105	PF01839	0.525
LIG_LIR_Apic_2	170	175	PF02991	0.446
LIG_LIR_Apic_2	200	205	PF02991	0.454
LIG_LIR_Apic_2	373	379	PF02991	0.423
LIG_LIR_Gen_1	13	23	PF02991	0.435
LIG_LIR_Gen_1	43	52	PF02991	0.588
LIG_LIR_Nem_3	13	19	PF02991	0.409
LIG_LIR_Nem_3	270	276	PF02991	0.568
LIG_LIR_Nem_3	43	49	PF02991	0.580
LIG_PCNA_PIPBox_1	67	76	PF02747	0.549
LIG_PCNA_yPIPBox_3	152	166	PF02747	0.474
LIG_SH2_CRK	16	20	PF00017	0.400
LIG_SH2_CRK	202	206	PF00017	0.444
LIG_SH2_CRK	208	212	PF00017	0.419
LIG_SH2_NCK_1	16	20	PF00017	0.505
LIG_SH2_SRC	16	19	PF00017	0.520
LIG_SH2_SRC	263	266	PF00017	0.590
LIG_SH2_STAT5	240	243	PF00017	0.445
LIG_SH2_STAT5	263	266	PF00017	0.476
LIG_SH2_STAT5	79	82	PF00017	0.493
LIG_SH3_3	183	189	PF00018	0.412
LIG_SH3_3	272	278	PF00018	0.525
LIG_SH3_3	294	300	PF00018	0.438
LIG_SH3_3	309	315	PF00018	0.494
LIG_SH3_3	321	327	PF00018	0.414
LIG_SH3_3	377	383	PF00018	0.378
LIG_SH3_4	174	181	PF00018	0.515
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.417
LIG_SUMO_SIM_par_1	320	326	PF11976	0.410
LIG_TYR_ITIM	206	211	PF00017	0.553
LIG_UBA3_1	70	76	PF00899	0.641
LIG_WRPW_2	273	276	PF00400	0.642
LIG_WW_1	383	386	PF00397	0.441
MOD_CDK_SPK_2	56	61	PF00069	0.643
MOD_CK1_1	123	129	PF00069	0.559
MOD_CK2_1	23	29	PF00069	0.474
MOD_CK2_1	366	372	PF00069	0.455
MOD_GlcNHglycan	122	125	PF01048	0.494
MOD_GlcNHglycan	309	312	PF01048	0.665
MOD_GlcNHglycan	32	35	PF01048	0.496
MOD_GSK3_1	116	123	PF00069	0.497
MOD_GSK3_1	128	135	PF00069	0.576
MOD_GSK3_1	236	243	PF00069	0.480
MOD_GSK3_1	36	43	PF00069	0.453
MOD_GSK3_1	51	58	PF00069	0.581
MOD_N-GLC_1	335	340	PF02516	0.440
MOD_NEK2_1	23	28	PF00069	0.506
MOD_NEK2_1	252	257	PF00069	0.463
MOD_NEK2_1	292	297	PF00069	0.452
MOD_NEK2_1	36	41	PF00069	0.448
MOD_NEK2_1	55	60	PF00069	0.645
MOD_NEK2_2	134	139	PF00069	0.531
MOD_NEK2_2	263	268	PF00069	0.589
MOD_PIKK_1	123	129	PF00454	0.431
MOD_PIKK_1	174	180	PF00454	0.511
MOD_PIKK_1	252	258	PF00454	0.453
MOD_PKA_2	221	227	PF00069	0.645
MOD_PKA_2	252	258	PF00069	0.497
MOD_Plk_1	228	234	PF00069	0.579
MOD_Plk_1	292	298	PF00069	0.453
MOD_Plk_4	23	29	PF00069	0.448
MOD_Plk_4	231	237	PF00069	0.366
MOD_Plk_4	292	298	PF00069	0.449
MOD_Plk_4	318	324	PF00069	0.380
MOD_Plk_4	359	365	PF00069	0.397
MOD_Plk_4	51	57	PF00069	0.550
MOD_ProDKin_1	238	244	PF00069	0.440
MOD_ProDKin_1	335	341	PF00069	0.526
MOD_ProDKin_1	375	381	PF00069	0.440
MOD_ProDKin_1	56	62	PF00069	0.646
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.496
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.486
TRG_ENDOCYTIC_2	16	19	PF00928	0.374
TRG_ENDOCYTIC_2	208	211	PF00928	0.552
TRG_ENDOCYTIC_2	84	87	PF00928	0.596
TRG_ER_diArg_1	259	261	PF00400	0.552
TRG_ER_diArg_1	287	289	PF00400	0.637
TRG_ER_diArg_1	77	79	PF00400	0.537
TRG_ER_diArg_1	87	89	PF00400	0.500
TRG_ER_diArg_1	92	95	PF00400	0.492
TRG_NLS_Bipartite_1	76	95	PF00514	0.536
TRG_NLS_MonoExtC_3	90	95	PF00514	0.588
TRG_NLS_MonoExtN_4	88	95	PF00514	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF2	Leptomonas seymouri	71%	100%
A0A0S4J0E9	Bodo saltans	32%	96%
A0A1X0P564	Trypanosomatidae	46%	100%
A0A3R7R9I8	Trypanosoma rangeli	47%	100%
A4HN45	Leishmania braziliensis	87%	100%
A4IBR3	Leishmania infantum	100%	100%
C9ZYW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AFJ8	Leishmania major	97%	100%
E9B6Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCU7	Trypanosoma cruzi	47%	100%