Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJB8_LEIDO

TriTrypDb:

LdBPK_363540.1 , LdCL_360042400 , LDHU3_36.4820

Length:

135

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IJB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.605
CLV_NRD_NRD_1	3	5	PF00675	0.611
CLV_PCSK_KEX2_1	10	12	PF00082	0.595
CLV_PCSK_KEX2_1	3	5	PF00082	0.594
CLV_PCSK_SKI1_1	54	58	PF00082	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.447
LIG_14-3-3_CanoR_1	10	20	PF00244	0.386
LIG_14-3-3_CanoR_1	3	9	PF00244	0.421
LIG_BRCT_BRCA1_1	44	48	PF00533	0.354
LIG_BRCT_BRCA1_1	52	56	PF00533	0.330
LIG_FHA_1	65	71	PF00498	0.427
LIG_FHA_2	23	29	PF00498	0.398
LIG_LIR_Gen_1	45	56	PF02991	0.328
LIG_LIR_Nem_3	45	51	PF02991	0.329
LIG_PCNA_yPIPBox_3	34	44	PF02747	0.423
LIG_SH2_STAT5	69	72	PF00017	0.355
LIG_SH3_3	107	113	PF00018	0.597
LIG_SH3_3	86	92	PF00018	0.360
LIG_TRAF2_1	129	132	PF00917	0.596
LIG_TRAF2_1	25	28	PF00917	0.464
MOD_CK1_1	42	48	PF00069	0.378
MOD_CK2_1	22	28	PF00069	0.361
MOD_GlcNHglycan	13	16	PF01048	0.658
MOD_GlcNHglycan	79	82	PF01048	0.573
MOD_GSK3_1	22	29	PF00069	0.355
MOD_GSK3_1	39	46	PF00069	0.386
MOD_NEK2_1	2	7	PF00069	0.421
MOD_NEK2_1	26	31	PF00069	0.366
MOD_NEK2_1	50	55	PF00069	0.365
MOD_PK_1	4	10	PF00069	0.501
MOD_PKA_1	3	9	PF00069	0.482
MOD_PKA_2	102	108	PF00069	0.592
MOD_PKA_2	2	8	PF00069	0.424
MOD_Plk_1	64	70	PF00069	0.420
MOD_Plk_4	39	45	PF00069	0.435
MOD_Plk_4	4	10	PF00069	0.447
MOD_SUMO_for_1	115	118	PF00179	0.676
TRG_ER_diArg_1	2	4	PF00400	0.407
TRG_ER_diArg_1	9	11	PF00400	0.398
TRG_NES_CRM1_1	39	52	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE1	Leptomonas seymouri	66%	100%
A0A0S4JIS2	Bodo saltans	32%	100%
A0A1X0P4N6	Trypanosomatidae	51%	100%
A0A3S5IS04	Trypanosoma rangeli	46%	96%
A4HPK5	Leishmania braziliensis	86%	100%
A4ID59	Leishmania infantum	100%	100%
D0A8K8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ATB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q180	Leishmania major	96%	100%