Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJB7_LEIDO

TriTrypDb:

LdBPK_362330.1 , LdCL_360029000 , LDHU3_36.3110

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.475
CLV_C14_Caspase3-7	321	325	PF00656	0.725
CLV_C14_Caspase3-7	417	421	PF00656	0.617
CLV_C14_Caspase3-7	561	565	PF00656	0.657
CLV_NRD_NRD_1	100	102	PF00675	0.642
CLV_NRD_NRD_1	117	119	PF00675	0.507
CLV_NRD_NRD_1	141	143	PF00675	0.688
CLV_NRD_NRD_1	340	342	PF00675	0.771
CLV_NRD_NRD_1	402	404	PF00675	0.724
CLV_NRD_NRD_1	460	462	PF00675	0.691
CLV_NRD_NRD_1	521	523	PF00675	0.696
CLV_NRD_NRD_1	528	530	PF00675	0.585
CLV_NRD_NRD_1	589	591	PF00675	0.745
CLV_NRD_NRD_1	616	618	PF00675	0.790
CLV_PCSK_FUR_1	340	344	PF00082	0.728
CLV_PCSK_FUR_1	535	539	PF00082	0.705
CLV_PCSK_KEX2_1	100	102	PF00082	0.578
CLV_PCSK_KEX2_1	117	119	PF00082	0.507
CLV_PCSK_KEX2_1	340	342	PF00082	0.806
CLV_PCSK_KEX2_1	402	404	PF00082	0.597
CLV_PCSK_KEX2_1	459	461	PF00082	0.693
CLV_PCSK_KEX2_1	530	532	PF00082	0.695
CLV_PCSK_KEX2_1	534	536	PF00082	0.657
CLV_PCSK_KEX2_1	537	539	PF00082	0.735
CLV_PCSK_KEX2_1	550	552	PF00082	0.591
CLV_PCSK_KEX2_1	554	556	PF00082	0.528
CLV_PCSK_KEX2_1	588	590	PF00082	0.732
CLV_PCSK_KEX2_1	616	618	PF00082	0.844
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.726
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.712
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.657
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.628
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.591
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.528
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.732
CLV_PCSK_PC7_1	336	342	PF00082	0.522
CLV_PCSK_PC7_1	456	462	PF00082	0.669
CLV_PCSK_SKI1_1	154	158	PF00082	0.591
CLV_PCSK_SKI1_1	21	25	PF00082	0.583
CLV_PCSK_SKI1_1	279	283	PF00082	0.709
CLV_PCSK_SKI1_1	288	292	PF00082	0.619
CLV_PCSK_SKI1_1	368	372	PF00082	0.714
CLV_PCSK_SKI1_1	389	393	PF00082	0.602
CLV_PCSK_SKI1_1	551	555	PF00082	0.747
CLV_PCSK_SKI1_1	607	611	PF00082	0.794
DEG_APCC_DBOX_1	232	240	PF00400	0.628
DEG_APCC_DBOX_1	367	375	PF00400	0.713
DEG_Nend_UBRbox_2	1	3	PF02207	0.579
DEG_SPOP_SBC_1	9	13	PF00917	0.564
DOC_CYCLIN_RxL_1	285	296	PF00134	0.650
DOC_CYCLIN_RxL_1	365	373	PF00134	0.726
DOC_CYCLIN_RxL_1	518	528	PF00134	0.735
DOC_CYCLIN_yCln2_LP_2	609	612	PF00134	0.740
DOC_MAPK_gen_1	209	218	PF00069	0.503
DOC_MAPK_gen_1	425	432	PF00069	0.526
DOC_MAPK_gen_1	534	542	PF00069	0.758
DOC_MAPK_MEF2A_6	154	163	PF00069	0.520
DOC_MAPK_MEF2A_6	209	218	PF00069	0.538
DOC_MAPK_MEF2A_6	384	392	PF00069	0.486
DOC_PP1_RVXF_1	105	111	PF00149	0.554
DOC_PP2B_LxvP_1	218	221	PF13499	0.584
DOC_PP2B_LxvP_1	239	242	PF13499	0.600
DOC_PP2B_LxvP_1	290	293	PF13499	0.720
DOC_PP2B_LxvP_1	609	612	PF13499	0.740
DOC_PP4_FxxP_1	163	166	PF00568	0.601
DOC_USP7_MATH_1	186	190	PF00917	0.708
DOC_USP7_MATH_1	194	198	PF00917	0.669
DOC_USP7_MATH_1	242	246	PF00917	0.541
DOC_USP7_MATH_1	255	259	PF00917	0.628
DOC_USP7_MATH_1	268	272	PF00917	0.662
DOC_USP7_MATH_1	32	36	PF00917	0.674
DOC_USP7_MATH_1	47	51	PF00917	0.391
DOC_USP7_MATH_1	476	480	PF00917	0.714
DOC_USP7_MATH_1	558	562	PF00917	0.660
DOC_USP7_MATH_1	59	63	PF00917	0.702
DOC_USP7_MATH_1	601	605	PF00917	0.742
DOC_USP7_MATH_1	9	13	PF00917	0.642
DOC_USP7_MATH_1	96	100	PF00917	0.756
DOC_USP7_UBL2_3	530	534	PF12436	0.766
DOC_USP7_UBL2_3	550	554	PF12436	0.747
DOC_USP7_UBL2_3	584	588	PF12436	0.761
DOC_WW_Pin1_4	203	208	PF00397	0.573
DOC_WW_Pin1_4	484	489	PF00397	0.804
DOC_WW_Pin1_4	579	584	PF00397	0.762
DOC_WW_Pin1_4	621	626	PF00397	0.704
DOC_WW_Pin1_4	89	94	PF00397	0.747
LIG_14-3-3_CanoR_1	150	154	PF00244	0.617
LIG_14-3-3_CanoR_1	272	278	PF00244	0.635
LIG_14-3-3_CanoR_1	343	349	PF00244	0.798
LIG_14-3-3_CanoR_1	389	395	PF00244	0.623
LIG_14-3-3_CanoR_1	425	430	PF00244	0.635
LIG_14-3-3_CanoR_1	600	610	PF00244	0.746
LIG_14-3-3_CanoR_1	616	623	PF00244	0.567
LIG_AP2alpha_1	153	157	PF02296	0.462
LIG_APCC_ABBA_1	445	450	PF00400	0.670
LIG_FHA_1	200	206	PF00498	0.632
LIG_FHA_1	383	389	PF00498	0.704
LIG_FHA_1	424	430	PF00498	0.585
LIG_FHA_1	442	448	PF00498	0.619
LIG_FHA_1	604	610	PF00498	0.830
LIG_FHA_2	166	172	PF00498	0.644
LIG_FHA_2	415	421	PF00498	0.635
LIG_FHA_2	493	499	PF00498	0.817
LIG_LIR_Apic_2	393	397	PF02991	0.653
LIG_LIR_Gen_1	304	312	PF02991	0.608
LIG_LIR_Gen_1	363	371	PF02991	0.670
LIG_LIR_Gen_1	385	394	PF02991	0.627
LIG_LIR_LC3C_4	170	174	PF02991	0.548
LIG_LIR_Nem_3	304	308	PF02991	0.598
LIG_LIR_Nem_3	363	367	PF02991	0.528
LIG_LIR_Nem_3	385	390	PF02991	0.623
LIG_MAD2	389	397	PF02301	0.591
LIG_NRBOX	235	241	PF00104	0.614
LIG_Pex14_2	153	157	PF04695	0.501
LIG_RPA_C_Fungi	331	343	PF08784	0.522
LIG_SH2_CRK	305	309	PF00017	0.598
LIG_SH2_CRK	364	368	PF00017	0.608
LIG_SH2_CRK	394	398	PF00017	0.704
LIG_SH2_NCK_1	448	452	PF00017	0.591
LIG_SH2_SRC	6	9	PF00017	0.551
LIG_SH2_STAP1	305	309	PF00017	0.590
LIG_SH2_STAP1	448	452	PF00017	0.591
LIG_SH2_STAP1	6	10	PF00017	0.661
LIG_SH3_2	95	100	PF14604	0.560
LIG_SH3_3	41	47	PF00018	0.496
LIG_SH3_3	90	96	PF00018	0.740
LIG_SUMO_SIM_par_1	212	217	PF11976	0.635
LIG_SUMO_SIM_par_1	245	251	PF11976	0.688
LIG_TYR_ITIM	303	308	PF00017	0.598
MOD_CDC14_SPxK_1	206	209	PF00782	0.503
MOD_CDK_SPK_2	579	584	PF00069	0.762
MOD_CDK_SPxK_1	203	209	PF00069	0.549
MOD_CK1_1	12	18	PF00069	0.569
MOD_CK1_1	199	205	PF00069	0.737
MOD_CK1_1	271	277	PF00069	0.709
MOD_CK1_1	304	310	PF00069	0.703
MOD_CK1_1	486	492	PF00069	0.714
MOD_CK1_1	582	588	PF00069	0.677
MOD_CK1_1	62	68	PF00069	0.739
MOD_CK1_1	89	95	PF00069	0.789
MOD_CK1_1	99	105	PF00069	0.518
MOD_CK2_1	223	229	PF00069	0.567
MOD_CK2_1	407	413	PF00069	0.621
MOD_CK2_1	492	498	PF00069	0.817
MOD_CK2_1	67	73	PF00069	0.813
MOD_CMANNOS	110	113	PF00535	0.625
MOD_Cter_Amidation	532	535	PF01082	0.752
MOD_GlcNHglycan	136	141	PF01048	0.693
MOD_GlcNHglycan	187	191	PF01048	0.653
MOD_GlcNHglycan	194	197	PF01048	0.658
MOD_GlcNHglycan	257	260	PF01048	0.623
MOD_GlcNHglycan	318	321	PF01048	0.604
MOD_GlcNHglycan	336	339	PF01048	0.761
MOD_GlcNHglycan	34	37	PF01048	0.681
MOD_GlcNHglycan	351	355	PF01048	0.558
MOD_GlcNHglycan	398	401	PF01048	0.597
MOD_GlcNHglycan	462	465	PF01048	0.683
MOD_GlcNHglycan	478	481	PF01048	0.775
MOD_GlcNHglycan	559	563	PF01048	0.818
MOD_GlcNHglycan	59	62	PF01048	0.761
MOD_GlcNHglycan	601	604	PF01048	0.753
MOD_GlcNHglycan	88	91	PF01048	0.689
MOD_GSK3_1	192	199	PF00069	0.659
MOD_GSK3_1	219	226	PF00069	0.701
MOD_GSK3_1	253	260	PF00069	0.660
MOD_GSK3_1	26	33	PF00069	0.589
MOD_GSK3_1	304	311	PF00069	0.608
MOD_GSK3_1	370	377	PF00069	0.719
MOD_GSK3_1	405	412	PF00069	0.669
MOD_GSK3_1	460	467	PF00069	0.596
MOD_GSK3_1	482	489	PF00069	0.667
MOD_GSK3_1	55	62	PF00069	0.657
MOD_GSK3_1	558	565	PF00069	0.658
MOD_GSK3_1	599	606	PF00069	0.790
MOD_GSK3_1	615	622	PF00069	0.686
MOD_GSK3_1	63	70	PF00069	0.660
MOD_GSK3_1	8	15	PF00069	0.583
MOD_N-GLC_1	374	379	PF02516	0.733
MOD_N-GLC_2	506	508	PF02516	0.710
MOD_NEK2_1	138	143	PF00069	0.723
MOD_NEK2_1	223	228	PF00069	0.599
MOD_NEK2_1	308	313	PF00069	0.569
MOD_NEK2_1	360	365	PF00069	0.613
MOD_NEK2_1	370	375	PF00069	0.611
MOD_NEK2_1	405	410	PF00069	0.633
MOD_NEK2_1	423	428	PF00069	0.587
MOD_NEK2_1	454	459	PF00069	0.619
MOD_PIKK_1	374	380	PF00454	0.641
MOD_PIKK_1	382	388	PF00454	0.543
MOD_PIKK_1	465	471	PF00454	0.613
MOD_PKA_1	460	466	PF00069	0.787
MOD_PKA_2	149	155	PF00069	0.543
MOD_PKA_2	199	205	PF00069	0.616
MOD_PKA_2	229	235	PF00069	0.646
MOD_PKA_2	271	277	PF00069	0.580
MOD_PKA_2	344	350	PF00069	0.692
MOD_PKA_2	441	447	PF00069	0.675
MOD_PKA_2	460	466	PF00069	0.655
MOD_PKA_2	544	550	PF00069	0.843
MOD_PKA_2	574	580	PF00069	0.786
MOD_PKA_2	599	605	PF00069	0.745
MOD_PKA_2	615	621	PF00069	0.644
MOD_PKA_2	62	68	PF00069	0.720
MOD_PKA_2	633	639	PF00069	0.492
MOD_PKA_2	99	105	PF00069	0.586
MOD_Plk_1	248	254	PF00069	0.598
MOD_Plk_2-3	326	332	PF00069	0.695
MOD_Plk_4	219	225	PF00069	0.628
MOD_Plk_4	235	241	PF00069	0.491
MOD_Plk_4	242	248	PF00069	0.561
MOD_Plk_4	273	279	PF00069	0.652
MOD_Plk_4	304	310	PF00069	0.604
MOD_Plk_4	47	53	PF00069	0.413
MOD_ProDKin_1	203	209	PF00069	0.571
MOD_ProDKin_1	484	490	PF00069	0.808
MOD_ProDKin_1	579	585	PF00069	0.761
MOD_ProDKin_1	621	627	PF00069	0.703
MOD_ProDKin_1	89	95	PF00069	0.744
TRG_DiLeu_BaEn_2	449	455	PF01217	0.713
TRG_ENDOCYTIC_2	305	308	PF00928	0.592
TRG_ENDOCYTIC_2	364	367	PF00928	0.538
TRG_ER_diArg_1	100	103	PF00400	0.633
TRG_ER_diArg_1	117	120	PF00400	0.514
TRG_ER_diArg_1	340	343	PF00400	0.769
TRG_ER_diArg_1	401	403	PF00400	0.686
TRG_ER_diArg_1	424	427	PF00400	0.596
TRG_ER_diArg_1	459	461	PF00400	0.689
TRG_ER_diArg_1	529	532	PF00400	0.681
TRG_ER_diArg_1	542	545	PF00400	0.745
TRG_NLS_Bipartite_1	522	538	PF00514	0.651
TRG_NLS_MonoExtC_3	340	345	PF00514	0.688
TRG_NLS_MonoExtC_3	533	538	PF00514	0.689
TRG_NLS_MonoExtN_4	340	346	PF00514	0.725
TRG_NLS_MonoExtN_4	531	538	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ5	Leptomonas seymouri	43%	100%
A4HP89	Leishmania braziliensis	74%	98%
A4IDJ4	Leishmania infantum	100%	100%
E9ASZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	96%
Q4Q1K1	Leishmania major	91%	100%