Roadblock/LC7 domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-associated roadblock protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IJB4_LEIDO

TriTrypDb:

LdBPK_351740.1 , LdCL_350022300 , LDHU3_35.2280

Length:

119

Annotations

Annotations by Jardim et al.

Structural Proteins, Dynein-associated roadblock -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005815	microtubule organizing center	2	1
GO:0005868	cytoplasmic dynein complex	4	4
GO:0005874	microtubule	6	3
GO:0005875	microtubule associated complex	2	4
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0036064	ciliary basal body	3	1
GO:0099080	supramolecular complex	2	3

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Expansion

Sequence features

A0A3Q8IJB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJB4

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0045505	dynein intermediate chain binding	3	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.597
DEG_Nend_UBRbox_3	1	3	PF02207	0.515
DOC_CYCLIN_yClb1_LxF_4	86	92	PF00134	0.350
DOC_MAPK_gen_1	95	103	PF00069	0.350
DOC_MAPK_MEF2A_6	107	114	PF00069	0.350
DOC_USP7_MATH_1	11	15	PF00917	0.499
DOC_USP7_MATH_1	51	55	PF00917	0.373
DOC_WW_Pin1_4	47	52	PF00397	0.410
LIG_14-3-3_CanoR_1	20	30	PF00244	0.501
LIG_14-3-3_CanoR_1	32	39	PF00244	0.309

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V1	Leptomonas seymouri	41%	100%
A0A0N1HUN3	Leptomonas seymouri	95%	100%
A0A0S4KIT1	Bodo saltans	84%	100%
A0A1X0P773	Trypanosomatidae	48%	100%
A0A3Q8IJQ7	Leishmania donovani	37%	100%
A0A422P0L4	Trypanosoma rangeli	47%	100%
A4H9K8	Leishmania braziliensis	35%	100%
A4HMJ5	Leishmania braziliensis	96%	100%
A4HXX4	Leishmania infantum	37%	100%
A4IB75	Leishmania infantum	100%	100%

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