Ribosomal L22e family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L22, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJA8_LEIDO

TriTrypDb:

LdBPK_363430.1 , LdCL_360041100 , LDHU3_36.4690

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 32

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IJA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJA8

PDB structure(s): 6az3_U

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:0002181	cytoplasmic translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.494
CLV_NRD_NRD_1	59	61	PF00675	0.409
CLV_NRD_NRD_1	85	87	PF00675	0.398
CLV_PCSK_SKI1_1	23	27	PF00082	0.438
CLV_PCSK_SKI1_1	88	92	PF00082	0.409
CLV_PCSK_SKI1_1	95	99	PF00082	0.409
DOC_MAPK_gen_1	60	70	PF00069	0.409
DOC_MAPK_gen_1	99	109	PF00069	0.409
DOC_MAPK_HePTP_8	57	72	PF00069	0.409
DOC_MAPK_MEF2A_6	63	72	PF00069	0.409
DOC_USP7_UBL2_3	17	21	PF12436	0.545
DOC_USP7_UBL2_3	23	27	PF12436	0.379
DOC_USP7_UBL2_3	63	67	PF12436	0.409
DOC_USP7_UBL2_3	87	91	PF12436	0.409
DOC_USP7_UBL2_3	95	99	PF12436	0.409
LIG_14-3-3_CanoR_1	69	73	PF00244	0.494
LIG_FHA_1	114	120	PF00498	0.425
LIG_Integrin_isoDGR_2	58	60	PF01839	0.425
LIG_LIR_Gen_1	105	111	PF02991	0.396
LIG_LIR_Nem_3	105	109	PF02991	0.396
LIG_Pex14_2	47	51	PF04695	0.409
LIG_SH2_GRB2like	121	124	PF00017	0.409
LIG_SH2_STAT3	13	16	PF00017	0.646
LIG_SH2_STAT5	121	124	PF00017	0.404
LIG_SH2_STAT5	13	16	PF00017	0.598
LIG_SH2_STAT5	89	92	PF00017	0.409
LIG_SUMO_SIM_par_1	74	82	PF11976	0.409
LIG_TYR_ITIM	119	124	PF00017	0.409
MOD_Cter_Amidation	21	24	PF01082	0.528
MOD_Cter_Amidation	58	61	PF01082	0.409
MOD_GSK3_1	109	116	PF00069	0.530
MOD_GSK3_1	75	82	PF00069	0.398
MOD_NEK2_1	77	82	PF00069	0.409
MOD_PKA_2	68	74	PF00069	0.494
MOD_Plk_1	28	34	PF00069	0.421
TRG_ENDOCYTIC_2	121	124	PF00928	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE6	Leptomonas seymouri	95%	100%
A0A0S4IZF7	Bodo saltans	80%	98%
A0A1X0P1I5	Trypanosomatidae	84%	99%
A0A381MX11	Leishmania infantum	100%	100%
A0A3Q8ILD5	Leishmania donovani	99%	100%
A0A3R7MXP1	Trypanosoma rangeli	84%	99%
A4FUH0	Bos taurus	44%	100%
A4HPJ4	Leishmania braziliensis	97%	100%
A4HPV9	Leishmania braziliensis	98%	100%
A4IDM1	Leishmania infantum	100%	100%
D0A4A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	99%
D0A8M1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	99%
E9ATA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P05749	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P35268	Homo sapiens	38%	100%
P47198	Rattus norvegicus	41%	100%
P50886	Xenopus laevis	43%	100%
P52819	Caenorhabditis elegans	36%	99%
P52865	Gadus morhua	39%	100%
P56628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P67984	Mus musculus	41%	100%
P67985	Sus scrofa	41%	100%
Q09668	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q23BV5	Tetrahymena thermophila (strain SB210)	41%	100%
Q28IL6	Xenopus tropicalis	43%	100%
Q4Q0X2	Leishmania major	100%	100%
Q4R5I3	Macaca fascicularis	41%	100%
Q54GK6	Dictyostelium discoideum	42%	100%
Q54JE3	Dictyostelium discoideum	43%	100%
Q5I0R6	Xenopus tropicalis	43%	100%
Q6P5R6	Homo sapiens	46%	100%
Q8SS49	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q90YU6	Ictalurus punctatus	38%	100%
Q98TF8	Gallus gallus	38%	100%
Q9D7S7	Mus musculus	44%	100%
Q9FE58	Arabidopsis thaliana	39%	100%
Q9M9W1	Arabidopsis thaliana	41%	100%
Q9SRX7	Arabidopsis thaliana	38%	100%