DREV_methyltransferase_putative/GeneDB:LmjF.30.11 00

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DREV methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJA6_LEIDO

TriTrypDb:

LdBPK_301160.1 , LdCL_300016800 , LDHU3_30.1500

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0106370	protein-L-histidine N-pros-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.307
CLV_NRD_NRD_1	154	156	PF00675	0.348
CLV_NRD_NRD_1	177	179	PF00675	0.307
CLV_NRD_NRD_1	297	299	PF00675	0.372
CLV_NRD_NRD_1	95	97	PF00675	0.412
CLV_PCSK_FUR_1	151	155	PF00082	0.412
CLV_PCSK_FUR_1	229	233	PF00082	0.321
CLV_PCSK_KEX2_1	153	155	PF00082	0.372
CLV_PCSK_KEX2_1	177	179	PF00082	0.307
CLV_PCSK_KEX2_1	231	233	PF00082	0.329
CLV_PCSK_KEX2_1	299	301	PF00082	0.515
CLV_PCSK_KEX2_1	95	97	PF00082	0.388
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.402
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.505
CLV_PCSK_PC7_1	149	155	PF00082	0.412
CLV_PCSK_PC7_1	173	179	PF00082	0.224
CLV_PCSK_SKI1_1	18	22	PF00082	0.510
CLV_PCSK_SKI1_1	61	65	PF00082	0.376
CLV_PCSK_SKI1_1	95	99	PF00082	0.341
CLV_Separin_Metazoa	268	272	PF03568	0.400
DEG_Nend_UBRbox_3	1	3	PF02207	0.612
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.248
DOC_MAPK_JIP1_4	207	213	PF00069	0.400
DOC_MAPK_MEF2A_6	207	216	PF00069	0.330
DOC_MAPK_MEF2A_6	256	265	PF00069	0.412
DOC_PP2B_LxvP_1	98	101	PF13499	0.411
DOC_USP7_MATH_1	25	29	PF00917	0.361
DOC_WW_Pin1_4	104	109	PF00397	0.382
LIG_14-3-3_CanoR_1	246	251	PF00244	0.348
LIG_14-3-3_CanoR_1	26	30	PF00244	0.407
LIG_14-3-3_CanoR_1	55	60	PF00244	0.433
LIG_14-3-3_CanoR_1	74	81	PF00244	0.131
LIG_AP2alpha_2	164	166	PF02296	0.344
LIG_APCC_ABBA_1	159	164	PF00400	0.344
LIG_DLG_GKlike_1	246	254	PF00625	0.348
LIG_FHA_1	127	133	PF00498	0.297
LIG_FHA_1	25	31	PF00498	0.339
LIG_FHA_1	46	52	PF00498	0.339
LIG_FHA_1	89	95	PF00498	0.388
LIG_GBD_Chelix_1	64	72	PF00786	0.361
LIG_Integrin_RGD_1	300	302	PF01839	0.584
LIG_IRF3_LxIS_1	8	13	PF10401	0.481
LIG_LIR_Gen_1	112	123	PF02991	0.376
LIG_LIR_Gen_1	286	295	PF02991	0.307
LIG_LIR_Gen_1	66	72	PF02991	0.398
LIG_LIR_Nem_3	112	118	PF02991	0.348
LIG_LIR_Nem_3	176	182	PF02991	0.328
LIG_LIR_Nem_3	286	290	PF02991	0.307
LIG_LIR_Nem_3	66	70	PF02991	0.382
LIG_PCNA_yPIPBox_3	53	63	PF02747	0.414
LIG_PDZ_Class_1	302	307	PF00595	0.466
LIG_Pex14_2	67	71	PF04695	0.400
LIG_RPA_C_Fungi	50	62	PF08784	0.398
LIG_SH2_CRK	287	291	PF00017	0.307
LIG_SH2_STAT5	11	14	PF00017	0.536
LIG_SH2_STAT5	140	143	PF00017	0.400
LIG_SH2_STAT5	179	182	PF00017	0.412
LIG_SH2_STAT5	277	280	PF00017	0.307
LIG_SH3_3	105	111	PF00018	0.365
LIG_SH3_3	213	219	PF00018	0.278
LIG_SH3_3	258	264	PF00018	0.291
LIG_SH3_3	98	104	PF00018	0.385
LIG_TYR_ITIM	285	290	PF00017	0.376
LIG_UBA3_1	198	207	PF00899	0.367
MOD_CK1_1	73	79	PF00069	0.306
MOD_CK2_1	25	31	PF00069	0.224
MOD_GlcNHglycan	12	15	PF01048	0.451
MOD_GlcNHglycan	143	147	PF01048	0.360
MOD_GSK3_1	246	253	PF00069	0.287
MOD_GSK3_1	51	58	PF00069	0.339
MOD_GSK3_1	66	73	PF00069	0.373
MOD_N-GLC_1	55	60	PF02516	0.347
MOD_NEK2_1	10	15	PF00069	0.491
MOD_NEK2_1	144	149	PF00069	0.428
MOD_NEK2_1	202	207	PF00069	0.299
MOD_NEK2_1	250	255	PF00069	0.326
MOD_NEK2_1	51	56	PF00069	0.391
MOD_NEK2_1	72	77	PF00069	0.332
MOD_PK_1	55	61	PF00069	0.263
MOD_PKA_1	231	237	PF00069	0.358
MOD_PKA_2	202	208	PF00069	0.307
MOD_PKA_2	231	237	PF00069	0.358
MOD_PKA_2	25	31	PF00069	0.420
MOD_PKA_2	270	276	PF00069	0.400
MOD_PKA_2	73	79	PF00069	0.326
MOD_PKB_1	53	61	PF00069	0.438
MOD_Plk_1	250	256	PF00069	0.291
MOD_Plk_1	45	51	PF00069	0.393
MOD_Plk_1	55	61	PF00069	0.266
MOD_Plk_4	114	120	PF00069	0.291
MOD_Plk_4	194	200	PF00069	0.351
MOD_Plk_4	25	31	PF00069	0.420
MOD_Plk_4	55	61	PF00069	0.324
MOD_Plk_4	66	72	PF00069	0.367
MOD_ProDKin_1	104	110	PF00069	0.382
TRG_DiLeu_BaEn_2	45	51	PF01217	0.412
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.224
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.376
TRG_ENDOCYTIC_2	157	160	PF00928	0.291
TRG_ENDOCYTIC_2	179	182	PF00928	0.293
TRG_ENDOCYTIC_2	287	290	PF00928	0.307
TRG_ER_diArg_1	150	153	PF00400	0.356
TRG_ER_diArg_1	16	19	PF00400	0.458
TRG_ER_diArg_1	177	179	PF00400	0.350
TRG_ER_diArg_1	297	300	PF00400	0.412
TRG_ER_diArg_1	52	55	PF00400	0.361
TRG_ER_diArg_1	94	96	PF00400	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ8	Leptomonas seymouri	73%	100%
A0A0S4J0V6	Bodo saltans	48%	100%
A0A1X0P223	Trypanosomatidae	53%	92%
A0A3S5ISQ6	Trypanosoma rangeli	52%	99%
A4HI64	Leishmania braziliensis	84%	100%
A4I5E1	Leishmania infantum	99%	100%
C9ZQS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9B0N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q0VCJ8	Bos taurus	39%	97%
Q4Q7J3	Leishmania major	96%	100%
Q5ZMH6	Gallus gallus	37%	96%
Q9EPL4	Mus musculus	41%	97%
Q9H1A3	Homo sapiens	40%	97%
V5DQR7	Trypanosoma cruzi	54%	98%