Pumilio/PUF_RNA_binding_protein_7_putative/GeneDB:LmjF.32.1750

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 7, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJA2_LEIDO

TriTrypDb:

LdBPK_321830.1 , LdCL_320023800 , LDHU3_32.2320

Length:

778

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJA2

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.407
CLV_C14_Caspase3-7	591	595	PF00656	0.733
CLV_NRD_NRD_1	128	130	PF00675	0.454
CLV_NRD_NRD_1	357	359	PF00675	0.510
CLV_NRD_NRD_1	614	616	PF00675	0.576
CLV_NRD_NRD_1	662	664	PF00675	0.422
CLV_NRD_NRD_1	724	726	PF00675	0.661
CLV_NRD_NRD_1	83	85	PF00675	0.428
CLV_PCSK_KEX2_1	128	130	PF00082	0.467
CLV_PCSK_KEX2_1	273	275	PF00082	0.743
CLV_PCSK_KEX2_1	611	613	PF00082	0.535
CLV_PCSK_KEX2_1	723	725	PF00082	0.672
CLV_PCSK_KEX2_1	738	740	PF00082	0.452
CLV_PCSK_KEX2_1	83	85	PF00082	0.428
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.692
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.682
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.715
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.665
CLV_PCSK_PC7_1	734	740	PF00082	0.557
CLV_PCSK_SKI1_1	216	220	PF00082	0.466
CLV_PCSK_SKI1_1	359	363	PF00082	0.522
CLV_PCSK_SKI1_1	404	408	PF00082	0.649
CLV_PCSK_SKI1_1	434	438	PF00082	0.378
CLV_PCSK_SKI1_1	608	612	PF00082	0.565
CLV_PCSK_SKI1_1	663	667	PF00082	0.472
CLV_PCSK_SKI1_1	685	689	PF00082	0.408
CLV_PCSK_SKI1_1	734	738	PF00082	0.616
CLV_PCSK_SKI1_1	770	774	PF00082	0.634
CLV_PCSK_SKI1_1	84	88	PF00082	0.518
DEG_APCC_DBOX_1	684	692	PF00400	0.390
DEG_APCC_DBOX_1	82	90	PF00400	0.447
DEG_SPOP_SBC_1	380	384	PF00917	0.682
DOC_CKS1_1	238	243	PF01111	0.546
DOC_CKS1_1	367	372	PF01111	0.595
DOC_CYCLIN_RxL_1	15	28	PF00134	0.547
DOC_CYCLIN_RxL_1	356	363	PF00134	0.543
DOC_CYCLIN_RxL_1	657	669	PF00134	0.536
DOC_CYCLIN_RxL_1	767	775	PF00134	0.708
DOC_CYCLIN_RxL_1	81	88	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.603
DOC_MAPK_gen_1	236	244	PF00069	0.556
DOC_MAPK_gen_1	83	89	PF00069	0.434
DOC_MAPK_MEF2A_6	341	348	PF00069	0.381
DOC_MAPK_MEF2A_6	57	66	PF00069	0.424
DOC_PP1_RVXF_1	3	9	PF00149	0.502
DOC_PP1_RVXF_1	702	709	PF00149	0.477
DOC_USP7_MATH_1	225	229	PF00917	0.504
DOC_USP7_MATH_1	250	254	PF00917	0.505
DOC_USP7_MATH_1	380	384	PF00917	0.786
DOC_USP7_MATH_1	406	410	PF00917	0.747
DOC_USP7_MATH_1	412	416	PF00917	0.803
DOC_USP7_MATH_1	421	425	PF00917	0.509
DOC_USP7_MATH_1	432	436	PF00917	0.200
DOC_USP7_MATH_1	465	469	PF00917	0.558
DOC_USP7_MATH_1	507	511	PF00917	0.413
DOC_USP7_MATH_1	531	535	PF00917	0.482
DOC_USP7_MATH_1	547	551	PF00917	0.298
DOC_USP7_MATH_1	633	637	PF00917	0.325
DOC_USP7_UBL2_3	398	402	PF12436	0.791
DOC_USP7_UBL2_3	404	408	PF12436	0.761
DOC_USP7_UBL2_3	41	45	PF12436	0.407
DOC_USP7_UBL2_3	607	611	PF12436	0.730
DOC_WW_Pin1_4	237	242	PF00397	0.500
DOC_WW_Pin1_4	366	371	PF00397	0.608
DOC_WW_Pin1_4	468	473	PF00397	0.418
DOC_WW_Pin1_4	677	682	PF00397	0.422
DOC_WW_Pin1_4	89	94	PF00397	0.344
LIG_Actin_WH2_2	40	58	PF00022	0.489
LIG_BRCT_BRCA1_1	496	500	PF00533	0.568
LIG_CaM_IQ_9	644	660	PF13499	0.321
LIG_EH1_1	644	652	PF00400	0.344
LIG_eIF4E_1	645	651	PF01652	0.385
LIG_FHA_1	230	236	PF00498	0.465
LIG_FHA_1	286	292	PF00498	0.654
LIG_FHA_1	428	434	PF00498	0.424
LIG_FHA_1	452	458	PF00498	0.571
LIG_FHA_1	499	505	PF00498	0.427
LIG_FHA_1	57	63	PF00498	0.444
LIG_FHA_1	654	660	PF00498	0.443
LIG_FHA_2	238	244	PF00498	0.496
LIG_FHA_2	405	411	PF00498	0.814
LIG_FHA_2	575	581	PF00498	0.586
LIG_FHA_2	63	69	PF00498	0.447
LIG_Integrin_isoDGR_2	376	378	PF01839	0.581
LIG_LIR_Apic_2	258	262	PF02991	0.475
LIG_LIR_Apic_2	278	284	PF02991	0.595
LIG_LIR_Gen_1	322	331	PF02991	0.419
LIG_LIR_Gen_1	497	508	PF02991	0.468
LIG_LIR_Nem_3	124	130	PF02991	0.435
LIG_LIR_Nem_3	190	196	PF02991	0.420
LIG_LIR_Nem_3	322	327	PF02991	0.417
LIG_LIR_Nem_3	497	503	PF02991	0.550
LIG_NRBOX	230	236	PF00104	0.418
LIG_NRBOX	490	496	PF00104	0.498
LIG_NRBOX	62	68	PF00104	0.438
LIG_PCNA_yPIPBox_3	96	109	PF02747	0.336
LIG_PTB_Apo_2	702	709	PF02174	0.436
LIG_SH2_CRK	308	312	PF00017	0.529
LIG_SH2_CRK	33	37	PF00017	0.498
LIG_SH2_NCK_1	196	200	PF00017	0.553
LIG_SH2_STAP1	536	540	PF00017	0.465
LIG_SH2_STAT3	645	648	PF00017	0.340
LIG_SH2_STAT5	177	180	PF00017	0.474
LIG_SH2_STAT5	259	262	PF00017	0.425
LIG_SH2_STAT5	308	311	PF00017	0.345
LIG_SH2_STAT5	645	648	PF00017	0.385
LIG_SH3_3	149	155	PF00018	0.469
LIG_SH3_3	466	472	PF00018	0.424
LIG_SH3_3	501	507	PF00018	0.475
LIG_SH3_3	521	527	PF00018	0.145
LIG_SUMO_SIM_anti_2	488	495	PF11976	0.469
LIG_SUMO_SIM_par_1	240	246	PF11976	0.484
LIG_SUMO_SIM_par_1	423	431	PF11976	0.524
LIG_SUMO_SIM_par_1	62	68	PF11976	0.466
LIG_SxIP_EBH_1	294	307	PF03271	0.490
LIG_TRAF2_1	224	227	PF00917	0.517
LIG_TRAF2_1	520	523	PF00917	0.410
LIG_TRAF2_1	577	580	PF00917	0.491
LIG_UBA3_1	333	341	PF00899	0.415
LIG_UBA3_1	666	671	PF00899	0.426
LIG_UBA3_1	772	778	PF00899	0.698
MOD_CK1_1	292	298	PF00069	0.724
MOD_CK1_1	325	331	PF00069	0.477
MOD_CK1_1	468	474	PF00069	0.503
MOD_CK1_1	502	508	PF00069	0.413
MOD_CK1_1	574	580	PF00069	0.546
MOD_CK1_1	693	699	PF00069	0.553
MOD_CK1_1	716	722	PF00069	0.642
MOD_CK1_1	750	756	PF00069	0.683
MOD_CK2_1	221	227	PF00069	0.467
MOD_CK2_1	237	243	PF00069	0.539
MOD_CK2_1	574	580	PF00069	0.522
MOD_CK2_1	611	617	PF00069	0.626
MOD_CK2_1	754	760	PF00069	0.764
MOD_GlcNHglycan	223	226	PF01048	0.444
MOD_GlcNHglycan	263	266	PF01048	0.530
MOD_GlcNHglycan	291	294	PF01048	0.684
MOD_GlcNHglycan	324	327	PF01048	0.541
MOD_GlcNHglycan	329	332	PF01048	0.445
MOD_GlcNHglycan	695	698	PF01048	0.468
MOD_GlcNHglycan	757	760	PF01048	0.789
MOD_GSK3_1	221	228	PF00069	0.490
MOD_GSK3_1	285	292	PF00069	0.704
MOD_GSK3_1	387	394	PF00069	0.687
MOD_GSK3_1	494	501	PF00069	0.567
MOD_GSK3_1	51	58	PF00069	0.431
MOD_GSK3_1	561	568	PF00069	0.432
MOD_GSK3_1	750	757	PF00069	0.692
MOD_N-GLC_1	495	500	PF02516	0.489
MOD_N-GLC_1	55	60	PF02516	0.493
MOD_NEK2_1	18	23	PF00069	0.520
MOD_NEK2_1	214	219	PF00069	0.429
MOD_NEK2_1	229	234	PF00069	0.320
MOD_NEK2_1	365	370	PF00069	0.513
MOD_NEK2_1	512	517	PF00069	0.425
MOD_NEK2_1	540	545	PF00069	0.506
MOD_NEK2_1	55	60	PF00069	0.413
MOD_NEK2_1	772	777	PF00069	0.632
MOD_NEK2_1	9	14	PF00069	0.545
MOD_OFUCOSY	587	592	PF10250	0.579
MOD_PIKK_1	451	457	PF00454	0.511
MOD_PKA_1	273	279	PF00069	0.677
MOD_PKA_1	404	410	PF00069	0.803
MOD_PKA_1	611	617	PF00069	0.682
MOD_PKA_2	273	279	PF00069	0.552
MOD_PKA_2	421	427	PF00069	0.533
MOD_PKA_2	445	451	PF00069	0.538
MOD_PKA_2	611	617	PF00069	0.587
MOD_Plk_1	214	220	PF00069	0.446
MOD_Plk_1	225	231	PF00069	0.372
MOD_Plk_1	498	504	PF00069	0.541
MOD_Plk_1	561	567	PF00069	0.395
MOD_Plk_4	214	220	PF00069	0.469
MOD_Plk_4	225	231	PF00069	0.406
MOD_Plk_4	421	427	PF00069	0.551
MOD_Plk_4	499	505	PF00069	0.381
MOD_Plk_4	507	513	PF00069	0.297
MOD_Plk_4	531	537	PF00069	0.491
MOD_Plk_4	561	567	PF00069	0.359
MOD_Plk_4	62	68	PF00069	0.381
MOD_Plk_4	687	693	PF00069	0.466
MOD_Plk_4	94	100	PF00069	0.449
MOD_ProDKin_1	237	243	PF00069	0.503
MOD_ProDKin_1	366	372	PF00069	0.624
MOD_ProDKin_1	468	474	PF00069	0.416
MOD_ProDKin_1	677	683	PF00069	0.418
MOD_ProDKin_1	89	95	PF00069	0.344
MOD_SUMO_rev_2	394	401	PF00179	0.728
MOD_SUMO_rev_2	579	588	PF00179	0.557
MOD_SUMO_rev_2	603	613	PF00179	0.697
MOD_SUMO_rev_2	660	666	PF00179	0.523
MOD_SUMO_rev_2	743	753	PF00179	0.673
MOD_SUMO_rev_2	754	764	PF00179	0.752
TRG_DiLeu_BaEn_1	499	504	PF01217	0.452
TRG_DiLeu_BaEn_1	662	667	PF01217	0.532
TRG_DiLeu_BaEn_4	226	232	PF01217	0.507
TRG_ENDOCYTIC_2	308	311	PF00928	0.393
TRG_ENDOCYTIC_2	627	630	PF00928	0.600
TRG_ER_diArg_1	127	129	PF00400	0.429
TRG_ER_diArg_1	654	657	PF00400	0.409
TRG_ER_diArg_1	82	84	PF00400	0.410
TRG_NLS_MonoCore_2	401	406	PF00514	0.741
TRG_NLS_MonoCore_2	767	772	PF00514	0.740
TRG_NLS_MonoExtC_3	271	277	PF00514	0.686
TRG_NLS_MonoExtN_4	399	406	PF00514	0.809
TRG_NLS_MonoExtN_4	722	727	PF00514	0.699
TRG_NLS_MonoExtN_4	765	772	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICI6	Leptomonas seymouri	68%	100%
A0A0S4JFA8	Bodo saltans	41%	100%
A0A1X0NUE8	Trypanosomatidae	41%	100%
A0A422NH58	Trypanosoma rangeli	46%	100%
A4HKG2	Leishmania braziliensis	80%	99%
A4I7Z0	Leishmania infantum	100%	100%
D0AA57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2V1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5A5	Leishmania major	93%	100%
V5DFW5	Trypanosoma cruzi	45%	100%