Paraflagellar rod component, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ99_LEIDO

TriTrypDb:

LdBPK_366130.1 , LdCL_360068700 , LDHU3_36.8090

Length:

795

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

A0A3Q8IJ99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.649
CLV_C14_Caspase3-7	475	479	PF00656	0.668
CLV_MEL_PAP_1	485	491	PF00089	0.531
CLV_NRD_NRD_1	284	286	PF00675	0.675
CLV_NRD_NRD_1	438	440	PF00675	0.486
CLV_NRD_NRD_1	503	505	PF00675	0.475
CLV_NRD_NRD_1	579	581	PF00675	0.414
CLV_NRD_NRD_1	724	726	PF00675	0.728
CLV_PCSK_FUR_1	436	440	PF00082	0.485
CLV_PCSK_FUR_1	501	505	PF00082	0.526
CLV_PCSK_KEX2_1	327	329	PF00082	0.507
CLV_PCSK_KEX2_1	438	440	PF00082	0.486
CLV_PCSK_KEX2_1	503	505	PF00082	0.477
CLV_PCSK_KEX2_1	723	725	PF00082	0.540
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.466
CLV_PCSK_SKI1_1	161	165	PF00082	0.380
CLV_PCSK_SKI1_1	183	187	PF00082	0.388
CLV_PCSK_SKI1_1	388	392	PF00082	0.338
CLV_PCSK_SKI1_1	439	443	PF00082	0.358
CLV_PCSK_SKI1_1	503	507	PF00082	0.457
CLV_PCSK_SKI1_1	560	564	PF00082	0.498
CLV_PCSK_SKI1_1	589	593	PF00082	0.609
CLV_PCSK_SKI1_1	68	72	PF00082	0.479
CLV_PCSK_SKI1_1	748	752	PF00082	0.524
DEG_APCC_DBOX_1	182	190	PF00400	0.430
DEG_APCC_DBOX_1	438	446	PF00400	0.353
DEG_APCC_DBOX_1	502	510	PF00400	0.455
DEG_APCC_DBOX_1	53	61	PF00400	0.498
DEG_APCC_DBOX_1	588	596	PF00400	0.500
DEG_APCC_DBOX_1	724	732	PF00400	0.520
DEG_APCC_DBOX_1	747	755	PF00400	0.493
DEG_Nend_UBRbox_2	1	3	PF02207	0.533
DEG_SPOP_SBC_1	227	231	PF00917	0.770
DOC_CKS1_1	333	338	PF01111	0.397
DOC_CKS1_1	353	358	PF01111	0.346
DOC_CYCLIN_RxL_1	382	394	PF00134	0.489
DOC_MAPK_DCC_7	748	756	PF00069	0.504
DOC_MAPK_gen_1	324	331	PF00069	0.447
DOC_MAPK_gen_1	340	349	PF00069	0.421
DOC_MAPK_gen_1	501	508	PF00069	0.469
DOC_MAPK_gen_1	580	586	PF00069	0.433
DOC_MAPK_gen_1	721	730	PF00069	0.534
DOC_MAPK_gen_1	745	753	PF00069	0.490
DOC_MAPK_MEF2A_6	371	379	PF00069	0.523
DOC_MAPK_MEF2A_6	721	730	PF00069	0.689
DOC_MAPK_MEF2A_6	748	756	PF00069	0.574
DOC_MAPK_NFAT4_5	723	731	PF00069	0.461
DOC_PIKK_1	475	482	PF02985	0.442
DOC_PP1_RVXF_1	159	165	PF00149	0.414
DOC_PP2B_LxvP_1	390	393	PF13499	0.490
DOC_PP2B_LxvP_1	465	468	PF13499	0.386
DOC_PP4_FxxP_1	49	52	PF00568	0.470
DOC_PP4_FxxP_1	53	56	PF00568	0.509
DOC_PP4_FxxP_1	749	752	PF00568	0.554
DOC_USP7_MATH_1	118	122	PF00917	0.645
DOC_USP7_MATH_1	150	154	PF00917	0.481
DOC_USP7_MATH_1	369	373	PF00917	0.621
DOC_USP7_MATH_1	585	589	PF00917	0.528
DOC_USP7_MATH_1	624	628	PF00917	0.685
DOC_USP7_MATH_1	633	637	PF00917	0.732
DOC_USP7_MATH_1	658	662	PF00917	0.651
DOC_USP7_MATH_1	703	707	PF00917	0.565
DOC_USP7_MATH_1	733	737	PF00917	0.563
DOC_USP7_MATH_2	598	604	PF00917	0.491
DOC_WW_Pin1_4	21	26	PF00397	0.509
DOC_WW_Pin1_4	252	257	PF00397	0.503
DOC_WW_Pin1_4	269	274	PF00397	0.597
DOC_WW_Pin1_4	332	337	PF00397	0.422
DOC_WW_Pin1_4	352	357	PF00397	0.316
DOC_WW_Pin1_4	69	74	PF00397	0.552
DOC_WW_Pin1_4	716	721	PF00397	0.548
DOC_WW_Pin1_4	757	762	PF00397	0.611
DOC_WW_Pin1_4	9	14	PF00397	0.515
DOC_WW_Pin1_4	94	99	PF00397	0.445
LIG_14-3-3_CanoR_1	165	173	PF00244	0.452
LIG_14-3-3_CanoR_1	59	65	PF00244	0.432
LIG_14-3-3_CanoR_1	637	643	PF00244	0.550
LIG_14-3-3_CanoR_1	660	664	PF00244	0.609
LIG_14-3-3_CanoR_1	764	770	PF00244	0.702
LIG_Actin_WH2_2	53	70	PF00022	0.533
LIG_AP2alpha_2	312	314	PF02296	0.589
LIG_BRCT_BRCA1_1	398	402	PF00533	0.464
LIG_CSL_BTD_1	15	18	PF09270	0.456
LIG_eIF4E_1	61	67	PF01652	0.474
LIG_FHA_1	133	139	PF00498	0.480
LIG_FHA_1	333	339	PF00498	0.504
LIG_FHA_1	371	377	PF00498	0.538
LIG_FHA_1	406	412	PF00498	0.404
LIG_FHA_1	453	459	PF00498	0.327
LIG_FHA_1	514	520	PF00498	0.509
LIG_FHA_1	529	535	PF00498	0.345
LIG_FHA_1	61	67	PF00498	0.404
LIG_FHA_1	660	666	PF00498	0.662
LIG_FHA_1	699	705	PF00498	0.423
LIG_FHA_2	274	280	PF00498	0.563
LIG_LIR_Apic_2	47	52	PF02991	0.445
LIG_LIR_Gen_1	110	119	PF02991	0.490
LIG_LIR_Gen_1	12	22	PF02991	0.689
LIG_LIR_Gen_1	133	142	PF02991	0.370
LIG_LIR_Gen_1	194	204	PF02991	0.334
LIG_LIR_Gen_1	24	35	PF02991	0.634
LIG_LIR_Gen_1	39	50	PF02991	0.282
LIG_LIR_Gen_1	455	465	PF02991	0.333
LIG_LIR_Gen_1	779	790	PF02991	0.419
LIG_LIR_Nem_3	110	114	PF02991	0.489
LIG_LIR_Nem_3	12	17	PF02991	0.689
LIG_LIR_Nem_3	133	139	PF02991	0.370
LIG_LIR_Nem_3	157	163	PF02991	0.395
LIG_LIR_Nem_3	194	200	PF02991	0.415
LIG_LIR_Nem_3	24	30	PF02991	0.666
LIG_LIR_Nem_3	312	317	PF02991	0.693
LIG_LIR_Nem_3	39	45	PF02991	0.286
LIG_LIR_Nem_3	455	460	PF02991	0.316
LIG_LIR_Nem_3	779	785	PF02991	0.483
LIG_Pex14_1	314	318	PF04695	0.635
LIG_Pex14_2	160	164	PF04695	0.362
LIG_Pex14_2	49	53	PF04695	0.525
LIG_Pex14_2	749	753	PF04695	0.412
LIG_PTB_Apo_2	562	569	PF02174	0.426
LIG_Rb_LxCxE_1	569	588	PF01857	0.328
LIG_SH2_CRK	111	115	PF00017	0.479
LIG_SH2_CRK	134	138	PF00017	0.361
LIG_SH2_CRK	139	143	PF00017	0.387
LIG_SH2_CRK	184	188	PF00017	0.513
LIG_SH2_CRK	27	31	PF00017	0.528
LIG_SH2_CRK	81	85	PF00017	0.419
LIG_SH2_GRB2like	27	30	PF00017	0.536
LIG_SH2_GRB2like	429	432	PF00017	0.546
LIG_SH2_NCK_1	27	31	PF00017	0.467
LIG_SH2_PTP2	429	432	PF00017	0.448
LIG_SH2_SRC	27	30	PF00017	0.536
LIG_SH2_SRC	429	432	PF00017	0.550
LIG_SH2_SRC	474	477	PF00017	0.411
LIG_SH2_STAP1	134	138	PF00017	0.485
LIG_SH2_STAP1	27	31	PF00017	0.528
LIG_SH2_STAT5	134	137	PF00017	0.363
LIG_SH2_STAT5	318	321	PF00017	0.496
LIG_SH2_STAT5	429	432	PF00017	0.448
LIG_SH2_STAT5	495	498	PF00017	0.381
LIG_SH2_STAT5	668	671	PF00017	0.490
LIG_SH3_3	637	643	PF00018	0.711
LIG_SH3_3	660	666	PF00018	0.655
LIG_SH3_3	7	13	PF00018	0.514
LIG_SUMO_SIM_anti_2	461	467	PF11976	0.431
LIG_SUMO_SIM_anti_2	574	580	PF11976	0.508
LIG_SUMO_SIM_anti_2	705	712	PF11976	0.349
LIG_SUMO_SIM_anti_2	86	95	PF11976	0.413
LIG_SUMO_SIM_par_1	126	133	PF11976	0.585
LIG_SUMO_SIM_par_1	375	381	PF11976	0.510
LIG_SUMO_SIM_par_1	388	394	PF11976	0.301
LIG_SUMO_SIM_par_1	530	536	PF11976	0.392
LIG_TRAF2_1	169	172	PF00917	0.521
LIG_TRAF2_1	18	21	PF00917	0.656
LIG_TRAF2_1	272	275	PF00917	0.706
LIG_TYR_ITIM	132	137	PF00017	0.315
LIG_TYR_ITIM	79	84	PF00017	0.482
LIG_UBA3_1	376	382	PF00899	0.455
LIG_UBA3_1	575	581	PF00899	0.450
LIG_UBA3_1	789	794	PF00899	0.556
LIG_WRC_WIRS_1	407	412	PF05994	0.512
MOD_CDK_SPK_2	69	74	PF00069	0.552
MOD_CDK_SPK_2	716	721	PF00069	0.528
MOD_CDK_SPxK_1	352	358	PF00069	0.419
MOD_CDK_SPxxK_3	716	723	PF00069	0.532
MOD_CDK_SPxxK_3	757	764	PF00069	0.531
MOD_CK1_1	12	18	PF00069	0.578
MOD_CK1_1	121	127	PF00069	0.603
MOD_CK1_1	225	231	PF00069	0.694
MOD_CK1_1	232	238	PF00069	0.573
MOD_CK1_1	255	261	PF00069	0.493
MOD_CK1_1	378	384	PF00069	0.626
MOD_CK1_1	719	725	PF00069	0.606
MOD_CK1_1	768	774	PF00069	0.521
MOD_CK2_1	120	126	PF00069	0.490
MOD_CK2_1	166	172	PF00069	0.497
MOD_CK2_1	269	275	PF00069	0.607
MOD_CK2_1	391	397	PF00069	0.560
MOD_CK2_1	474	480	PF00069	0.619
MOD_GlcNHglycan	102	105	PF01048	0.498
MOD_GlcNHglycan	363	366	PF01048	0.694
MOD_GlcNHglycan	482	485	PF01048	0.620
MOD_GlcNHglycan	523	526	PF01048	0.421
MOD_GlcNHglycan	589	592	PF01048	0.536
MOD_GlcNHglycan	602	605	PF01048	0.707
MOD_GlcNHglycan	626	629	PF01048	0.707
MOD_GlcNHglycan	654	657	PF01048	0.711
MOD_GSK3_1	120	127	PF00069	0.635
MOD_GSK3_1	222	229	PF00069	0.693
MOD_GSK3_1	251	258	PF00069	0.423
MOD_GSK3_1	269	276	PF00069	0.530
MOD_GSK3_1	587	594	PF00069	0.628
MOD_GSK3_1	698	705	PF00069	0.500
MOD_GSK3_1	764	771	PF00069	0.621
MOD_N-GLC_1	480	485	PF02516	0.528
MOD_N-GLC_1	741	746	PF02516	0.580
MOD_NEK2_1	119	124	PF00069	0.533
MOD_NEK2_1	132	137	PF00069	0.306
MOD_NEK2_1	214	219	PF00069	0.496
MOD_NEK2_1	260	265	PF00069	0.452
MOD_NEK2_2	452	457	PF00069	0.288
MOD_OFUCOSY	732	737	PF10250	0.561
MOD_PIKK_1	166	172	PF00454	0.509
MOD_PIKK_1	255	261	PF00454	0.512
MOD_PIKK_1	495	501	PF00454	0.447
MOD_PKA_2	150	156	PF00069	0.428
MOD_PKA_2	521	527	PF00069	0.527
MOD_PKA_2	659	665	PF00069	0.634
MOD_Plk_1	132	138	PF00069	0.480
MOD_Plk_1	396	402	PF00069	0.482
MOD_Plk_1	405	411	PF00069	0.332
MOD_Plk_1	741	747	PF00069	0.456
MOD_Plk_4	132	138	PF00069	0.495
MOD_Plk_4	397	403	PF00069	0.587
MOD_Plk_4	406	412	PF00069	0.491
MOD_Plk_4	452	458	PF00069	0.442
MOD_Plk_4	703	709	PF00069	0.517
MOD_ProDKin_1	21	27	PF00069	0.512
MOD_ProDKin_1	252	258	PF00069	0.496
MOD_ProDKin_1	269	275	PF00069	0.607
MOD_ProDKin_1	332	338	PF00069	0.419
MOD_ProDKin_1	352	358	PF00069	0.323
MOD_ProDKin_1	69	75	PF00069	0.551
MOD_ProDKin_1	716	722	PF00069	0.551
MOD_ProDKin_1	757	763	PF00069	0.619
MOD_ProDKin_1	9	15	PF00069	0.517
MOD_ProDKin_1	94	100	PF00069	0.453
MOD_SUMO_for_1	412	415	PF00179	0.521
TRG_DiLeu_BaEn_2	405	411	PF01217	0.363
TRG_DiLeu_BaEn_3	88	94	PF01217	0.456
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.635
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.396
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.479
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.675
TRG_DiLeu_LyEn_5	126	131	PF01217	0.483
TRG_ENDOCYTIC_2	111	114	PF00928	0.468
TRG_ENDOCYTIC_2	134	137	PF00928	0.363
TRG_ENDOCYTIC_2	184	187	PF00928	0.458
TRG_ENDOCYTIC_2	197	200	PF00928	0.346
TRG_ENDOCYTIC_2	27	30	PF00928	0.536
TRG_ENDOCYTIC_2	782	785	PF00928	0.440
TRG_ENDOCYTIC_2	81	84	PF00928	0.434
TRG_ER_diArg_1	436	439	PF00400	0.349
TRG_ER_diArg_1	502	504	PF00400	0.486
TRG_ER_diArg_1	723	725	PF00400	0.649
TRG_ER_diArg_1	743	746	PF00400	0.493
TRG_NES_CRM1_1	34	48	PF08389	0.407
TRG_NES_CRM1_1	480	492	PF08389	0.551
TRG_NES_CRM1_1	75	89	PF08389	0.538
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.468
TRG_PTS1	792	795	PF00515	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS3	Leptomonas seymouri	44%	97%
A0A0S4JAE8	Bodo saltans	28%	100%
A0A1X0NLN9	Trypanosomatidae	28%	100%
A0A3R7K3C1	Trypanosoma rangeli	28%	100%
A4HQA5	Leishmania braziliensis	67%	99%
A4IE00	Leishmania infantum	100%	100%
D0A406	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AU22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0H3	Leishmania major	89%	100%
V5BJ29	Trypanosoma cruzi	28%	100%