Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ98_LEIDO

TriTrypDb:

LdBPK_363240.1 , LdCL_360039000 , LDHU3_36.4450

Length:

824

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.797
CLV_C14_Caspase3-7	644	648	PF00656	0.592
CLV_NRD_NRD_1	53	55	PF00675	0.634
CLV_PCSK_KEX2_1	112	114	PF00082	0.553
CLV_PCSK_KEX2_1	245	247	PF00082	0.687
CLV_PCSK_KEX2_1	53	55	PF00082	0.634
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.553
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.687
CLV_PCSK_SKI1_1	107	111	PF00082	0.622
CLV_PCSK_SKI1_1	118	122	PF00082	0.434
CLV_PCSK_SKI1_1	351	355	PF00082	0.778
CLV_PCSK_SKI1_1	53	57	PF00082	0.531
CLV_PCSK_SKI1_1	532	536	PF00082	0.646
DEG_APCC_DBOX_1	129	137	PF00400	0.633
DEG_Kelch_Keap1_1	287	292	PF01344	0.758
DEG_MDM2_SWIB_1	529	536	PF02201	0.701
DEG_Nend_UBRbox_3	1	3	PF02207	0.829
DEG_SCF_FBW7_1	424	429	PF00400	0.777
DEG_SCF_FBW7_1	701	706	PF00400	0.538
DEG_SCF_FBW7_2	815	821	PF00400	0.618
DEG_SPOP_SBC_1	211	215	PF00917	0.633
DEG_SPOP_SBC_1	555	559	PF00917	0.633
DEG_SPOP_SBC_1	574	578	PF00917	0.379
DOC_CKS1_1	136	141	PF01111	0.643
DOC_CKS1_1	815	820	PF01111	0.616
DOC_CYCLIN_RxL_1	50	58	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.869
DOC_MAPK_gen_1	233	241	PF00069	0.421
DOC_USP7_MATH_1	14	18	PF00917	0.422
DOC_USP7_MATH_1	217	221	PF00917	0.498
DOC_USP7_MATH_1	266	270	PF00917	0.864
DOC_USP7_MATH_1	278	282	PF00917	0.658
DOC_USP7_MATH_1	331	335	PF00917	0.788
DOC_USP7_MATH_1	426	430	PF00917	0.853
DOC_USP7_MATH_1	610	614	PF00917	0.560
DOC_USP7_UBL2_3	7	11	PF12436	0.700
DOC_WW_Pin1_4	135	140	PF00397	0.650
DOC_WW_Pin1_4	420	425	PF00397	0.863
DOC_WW_Pin1_4	566	571	PF00397	0.662
DOC_WW_Pin1_4	699	704	PF00397	0.525
DOC_WW_Pin1_4	814	819	PF00397	0.692
LIG_14-3-3_CanoR_1	246	256	PF00244	0.672
LIG_14-3-3_CanoR_1	279	283	PF00244	0.742
LIG_14-3-3_CanoR_1	478	484	PF00244	0.698
LIG_14-3-3_CanoR_1	53	63	PF00244	0.529
LIG_14-3-3_CanoR_1	532	537	PF00244	0.644
LIG_14-3-3_CanoR_1	66	71	PF00244	0.349
LIG_Actin_WH2_2	691	707	PF00022	0.580
LIG_APCC_ABBA_1	634	639	PF00400	0.551
LIG_BIR_III_2	476	480	PF00653	0.791
LIG_BRCT_BRCA1_1	116	120	PF00533	0.654
LIG_BRCT_BRCA1_1	48	52	PF00533	0.623
LIG_eIF4E_1	616	622	PF01652	0.553
LIG_FHA_1	136	142	PF00498	0.637
LIG_FHA_1	206	212	PF00498	0.656
LIG_FHA_1	378	384	PF00498	0.864
LIG_FHA_1	455	461	PF00498	0.748
LIG_FHA_1	566	572	PF00498	0.558
LIG_FHA_1	576	582	PF00498	0.606
LIG_FHA_1	734	740	PF00498	0.630
LIG_FHA_2	152	158	PF00498	0.608
LIG_FHA_2	265	271	PF00498	0.752
LIG_FHA_2	350	356	PF00498	0.793
LIG_FHA_2	451	457	PF00498	0.832
LIG_FHA_2	514	520	PF00498	0.786
LIG_FHA_2	533	539	PF00498	0.440
LIG_FHA_2	575	581	PF00498	0.665
LIG_FHA_2	727	733	PF00498	0.663
LIG_IRF3_LxIS_1	619	625	PF10401	0.382
LIG_LIR_Gen_1	406	417	PF02991	0.868
LIG_LIR_Gen_1	530	541	PF02991	0.686
LIG_LIR_Gen_1	740	749	PF02991	0.576
LIG_LIR_Gen_1	766	777	PF02991	0.593
LIG_LIR_Nem_3	117	123	PF02991	0.620
LIG_LIR_Nem_3	406	412	PF02991	0.874
LIG_LIR_Nem_3	49	55	PF02991	0.616
LIG_LIR_Nem_3	530	536	PF02991	0.698
LIG_LIR_Nem_3	613	619	PF02991	0.567
LIG_LIR_Nem_3	740	746	PF02991	0.417
LIG_LIR_Nem_3	766	772	PF02991	0.595
LIG_NRBOX	618	624	PF00104	0.478
LIG_PCNA_yPIPBox_3	146	159	PF02747	0.589
LIG_PDZ_Class_3	819	824	PF00595	0.831
LIG_Pex14_1	168	172	PF04695	0.633
LIG_Pex14_2	52	56	PF04695	0.626
LIG_Pex14_2	529	533	PF04695	0.728
LIG_PTB_Apo_2	523	530	PF02174	0.720
LIG_SH2_CRK	616	620	PF00017	0.552
LIG_SH2_CRK	743	747	PF00017	0.578
LIG_SH2_NCK_1	595	599	PF00017	0.512
LIG_SH2_STAT5	158	161	PF00017	0.635
LIG_SH2_STAT5	587	590	PF00017	0.620
LIG_SH2_STAT5	677	680	PF00017	0.556
LIG_SH2_STAT5	776	779	PF00017	0.609
LIG_SH3_3	253	259	PF00018	0.813
LIG_SH3_3	359	365	PF00018	0.856
LIG_SH3_3	385	391	PF00018	0.757
LIG_SH3_3	425	431	PF00018	0.780
LIG_SH3_3	665	671	PF00018	0.530
LIG_SH3_3	812	818	PF00018	0.631
LIG_SH3_3	84	90	PF00018	0.774
LIG_SUMO_SIM_anti_2	620	625	PF11976	0.557
LIG_SUMO_SIM_par_1	620	625	PF11976	0.480
LIG_SUMO_SIM_par_1	723	732	PF11976	0.639
LIG_TRAF2_1	260	263	PF00917	0.774
LIG_TRAF2_1	293	296	PF00917	0.670
LIG_TRAF2_1	317	320	PF00917	0.670
LIG_TRAF2_1	357	360	PF00917	0.874
LIG_TRAF2_1	408	411	PF00917	0.812
LIG_TRAF2_1	431	434	PF00917	0.784
LIG_TRAF2_1	537	540	PF00917	0.675
LIG_TRAF2_1	686	689	PF00917	0.518
LIG_TYR_ITIM	593	598	PF00017	0.595
LIG_TYR_ITIM	614	619	PF00017	0.564
LIG_UBA3_1	600	608	PF00899	0.590
LIG_UBA3_1	697	705	PF00899	0.563
LIG_UBA3_1	715	723	PF00899	0.281
LIG_WRC_WIRS_1	102	107	PF05994	0.542
LIG_WRC_WIRS_1	224	229	PF05994	0.635
MOD_CDK_SPK_2	135	140	PF00069	0.650
MOD_CDK_SPxK_1	699	705	PF00069	0.530
MOD_CK1_1	170	176	PF00069	0.652
MOD_CK1_1	215	221	PF00069	0.681
MOD_CK1_1	287	293	PF00069	0.812
MOD_CK1_1	646	652	PF00069	0.600
MOD_CK1_1	98	104	PF00069	0.622
MOD_CK2_1	14	20	PF00069	0.629
MOD_CK2_1	151	157	PF00069	0.613
MOD_CK2_1	170	176	PF00069	0.652
MOD_CK2_1	192	198	PF00069	0.687
MOD_CK2_1	264	270	PF00069	0.762
MOD_CK2_1	283	289	PF00069	0.670
MOD_CK2_1	404	410	PF00069	0.832
MOD_CK2_1	532	538	PF00069	0.685
MOD_CK2_1	580	586	PF00069	0.618
MOD_CK2_1	726	732	PF00069	0.651
MOD_GlcNHglycan	194	197	PF01048	0.553
MOD_GlcNHglycan	214	217	PF01048	0.416
MOD_GlcNHglycan	219	222	PF01048	0.552
MOD_GlcNHglycan	230	233	PF01048	0.408
MOD_GlcNHglycan	286	289	PF01048	0.800
MOD_GlcNHglycan	406	409	PF01048	0.801
MOD_GlcNHglycan	437	440	PF01048	0.768
MOD_GlcNHglycan	442	446	PF01048	0.768
MOD_GlcNHglycan	481	484	PF01048	0.800
MOD_GlcNHglycan	506	509	PF01048	0.772
MOD_GlcNHglycan	664	667	PF01048	0.583
MOD_GlcNHglycan	773	776	PF01048	0.578
MOD_GlcNHglycan	793	799	PF01048	0.565
MOD_GlcNHglycan	811	814	PF01048	0.845
MOD_GSK3_1	153	160	PF00069	0.571
MOD_GSK3_1	211	218	PF00069	0.653
MOD_GSK3_1	283	290	PF00069	0.736
MOD_GSK3_1	420	427	PF00069	0.844
MOD_GSK3_1	450	457	PF00069	0.810
MOD_GSK3_1	510	517	PF00069	0.868
MOD_GSK3_1	562	569	PF00069	0.667
MOD_GSK3_1	608	615	PF00069	0.618
MOD_GSK3_1	699	706	PF00069	0.536
MOD_GSK3_1	733	740	PF00069	0.595
MOD_LATS_1	44	50	PF00433	0.656
MOD_LATS_1	64	70	PF00433	0.246
MOD_N-GLC_1	114	119	PF02516	0.671
MOD_N-GLC_1	514	519	PF02516	0.863
MOD_N-GLC_1	565	570	PF02516	0.678
MOD_N-GLC_2	763	765	PF02516	0.570
MOD_NEK2_1	167	172	PF00069	0.560
MOD_NEK2_1	192	197	PF00069	0.560
MOD_NEK2_1	48	53	PF00069	0.544
MOD_NEK2_1	657	662	PF00069	0.550
MOD_NEK2_1	664	669	PF00069	0.473
MOD_NEK2_1	704	709	PF00069	0.533
MOD_NEK2_1	737	742	PF00069	0.582
MOD_NEK2_2	331	336	PF00069	0.751
MOD_PIKK_1	14	20	PF00454	0.629
MOD_PIKK_1	454	460	PF00454	0.827
MOD_PIKK_1	737	743	PF00454	0.458
MOD_PK_1	66	72	PF00069	0.490
MOD_PKA_2	278	284	PF00069	0.763
MOD_Plk_1	520	526	PF00069	0.785
MOD_Plk_1	733	739	PF00069	0.651
MOD_Plk_2-3	450	456	PF00069	0.789
MOD_Plk_2-3	580	586	PF00069	0.618
MOD_Plk_4	223	229	PF00069	0.635
MOD_Plk_4	520	526	PF00069	0.785
MOD_Plk_4	556	562	PF00069	0.665
MOD_Plk_4	617	623	PF00069	0.555
MOD_Plk_4	637	643	PF00069	0.290
MOD_Plk_4	646	652	PF00069	0.451
MOD_Plk_4	733	739	PF00069	0.651
MOD_Plk_4	98	104	PF00069	0.610
MOD_ProDKin_1	135	141	PF00069	0.641
MOD_ProDKin_1	420	426	PF00069	0.859
MOD_ProDKin_1	566	572	PF00069	0.665
MOD_ProDKin_1	699	705	PF00069	0.530
MOD_ProDKin_1	814	820	PF00069	0.683
MOD_SUMO_rev_2	268	274	PF00179	0.796
MOD_SUMO_rev_2	625	634	PF00179	0.615
MOD_SUMO_rev_2	78	87	PF00179	0.717
MOD_SUMO_rev_2	788	798	PF00179	0.797
MOD_SUMO_rev_2	804	813	PF00179	0.582
TRG_DiLeu_BaEn_1	630	635	PF01217	0.625
TRG_DiLeu_BaEn_2	767	773	PF01217	0.600
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.445
TRG_ENDOCYTIC_2	409	412	PF00928	0.873
TRG_ENDOCYTIC_2	595	598	PF00928	0.594
TRG_ENDOCYTIC_2	616	619	PF00928	0.552
TRG_ENDOCYTIC_2	743	746	PF00928	0.410
TRG_ER_diArg_1	52	54	PF00400	0.633
TRG_ER_diArg_1	745	748	PF00400	0.460
TRG_NES_CRM1_1	61	71	PF08389	0.603
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	779	783	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HPH5	Leishmania braziliensis	76%	98%
A4ID97	Leishmania infantum	100%	100%
E9AT87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1B0	Leishmania major	93%	100%