Endochitinase_putative/GeneDB:LmjF.36.1890

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endochitinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ94_LEIDO

TriTrypDb:

LdBPK_361970.1 , LdCL_360025200 , LDHU3_36.2570

Length:

179

Annotations

LeishMANIAdb annotations

Probably part of some larger protein. The previous identification as endochitinase is highly tenuous.

Annotations by Jardim et al.

Membrane associated proteins, endochitinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 2
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IJ94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	125	127	PF00082	0.619
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.619
CLV_PCSK_SKI1_1	13	17	PF00082	0.575
DOC_MAPK_MEF2A_6	8	16	PF00069	0.592
DOC_USP7_MATH_1	168	172	PF00917	0.675
DOC_USP7_MATH_1	31	35	PF00917	0.595
DOC_WW_Pin1_4	35	40	PF00397	0.501
DOC_WW_Pin1_4	50	55	PF00397	0.482
LIG_Actin_WH2_2	9	27	PF00022	0.475
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_FHA_1	100	106	PF00498	0.511
LIG_FHA_1	125	131	PF00498	0.432
LIG_FHA_1	84	90	PF00498	0.422
LIG_FHA_2	28	34	PF00498	0.652
LIG_GBD_Chelix_1	16	24	PF00786	0.573
LIG_LIR_Gen_1	148	157	PF02991	0.389
LIG_LIR_Nem_3	148	152	PF02991	0.336
LIG_LIR_Nem_3	153	158	PF02991	0.326
LIG_LIR_Nem_3	174	179	PF02991	0.633
LIG_SH2_CRK	144	148	PF00017	0.285
LIG_SH2_GRB2like	176	179	PF00017	0.622
LIG_SH2_NCK_1	144	148	PF00017	0.285
LIG_SH2_SRC	165	168	PF00017	0.682
LIG_SH2_STAP1	135	139	PF00017	0.490
LIG_SH2_STAT5	165	168	PF00017	0.643
LIG_SH2_STAT5	176	179	PF00017	0.597
LIG_SH2_STAT5	76	79	PF00017	0.393
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.513
LIG_SUMO_SIM_par_1	101	107	PF11976	0.444
LIG_SUMO_SIM_par_1	109	115	PF11976	0.383
LIG_TRAF2_1	30	33	PF00917	0.500
LIG_TYR_ITIM	142	147	PF00017	0.441
LIG_UBA3_1	154	163	PF00899	0.423
LIG_UBA3_1	89	97	PF00899	0.502
LIG_WRC_WIRS_1	146	151	PF05994	0.343
MOD_CK1_1	145	151	PF00069	0.332
MOD_CK1_1	34	40	PF00069	0.470
MOD_CK1_1	53	59	PF00069	0.429
MOD_CK2_1	168	174	PF00069	0.688
MOD_CK2_1	27	33	PF00069	0.653
MOD_CK2_1	61	67	PF00069	0.503
MOD_GSK3_1	120	127	PF00069	0.471
MOD_GSK3_1	27	34	PF00069	0.572
MOD_GSK3_1	56	63	PF00069	0.439
MOD_N-GLC_1	56	61	PF02516	0.585
MOD_N-GLC_1	99	104	PF02516	0.628
MOD_N-GLC_2	66	68	PF02516	0.597
MOD_NEK2_1	99	104	PF00069	0.513
MOD_OFUCOSY	119	124	PF10250	0.706
MOD_PIKK_1	76	82	PF00454	0.457
MOD_PKA_1	125	131	PF00069	0.418
MOD_PKA_2	125	131	PF00069	0.397
MOD_Plk_1	31	37	PF00069	0.576
MOD_Plk_1	56	62	PF00069	0.385
MOD_Plk_1	99	105	PF00069	0.496
MOD_Plk_4	142	148	PF00069	0.245
MOD_Plk_4	150	156	PF00069	0.279
MOD_Plk_4	99	105	PF00069	0.526
MOD_ProDKin_1	35	41	PF00069	0.503
MOD_ProDKin_1	50	56	PF00069	0.479
MOD_SUMO_for_1	130	133	PF00179	0.419
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.438
TRG_ENDOCYTIC_2	144	147	PF00928	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH5	Leptomonas seymouri	80%	100%
A0A0S4IW86	Bodo saltans	47%	100%
A0A0S4JL05	Bodo saltans	28%	75%
A0A0S4JS45	Bodo saltans	29%	67%
A0A1X0P825	Trypanosomatidae	65%	100%
A0A422MXC2	Trypanosoma rangeli	61%	100%
A4HP53	Leishmania braziliensis	83%	100%
A4IDG0	Leishmania infantum	100%	100%
E9ASW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1N5	Leishmania major	96%	100%
V5DL10	Trypanosoma cruzi	57%	96%