WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ91_LEIDO

TriTrypDb:

LdBPK_353350.1 , LdCL_350038500 , LDHU3_35.4400

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	579	583	PF00656	0.598
CLV_NRD_NRD_1	178	180	PF00675	0.765
CLV_NRD_NRD_1	302	304	PF00675	0.618
CLV_NRD_NRD_1	345	347	PF00675	0.565
CLV_NRD_NRD_1	387	389	PF00675	0.459
CLV_NRD_NRD_1	464	466	PF00675	0.572
CLV_NRD_NRD_1	487	489	PF00675	0.636
CLV_NRD_NRD_1	531	533	PF00675	0.568
CLV_PCSK_FUR_1	176	180	PF00082	0.769
CLV_PCSK_KEX2_1	178	180	PF00082	0.769
CLV_PCSK_KEX2_1	301	303	PF00082	0.619
CLV_PCSK_KEX2_1	386	388	PF00082	0.486
CLV_PCSK_KEX2_1	464	466	PF00082	0.572
CLV_PCSK_KEX2_1	487	489	PF00082	0.674
CLV_PCSK_KEX2_1	533	535	PF00082	0.587
CLV_PCSK_KEX2_1	586	588	PF00082	0.840
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.558
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.514
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.840
CLV_PCSK_PC7_1	383	389	PF00082	0.559
CLV_PCSK_SKI1_1	114	118	PF00082	0.441
CLV_PCSK_SKI1_1	292	296	PF00082	0.723
CLV_PCSK_SKI1_1	356	360	PF00082	0.718
CLV_PCSK_SKI1_1	387	391	PF00082	0.511
CLV_PCSK_SKI1_1	434	438	PF00082	0.506
CLV_PCSK_SKI1_1	465	469	PF00082	0.591
CLV_PCSK_SKI1_1	489	493	PF00082	0.769
CLV_PCSK_SKI1_1	534	538	PF00082	0.571
DEG_SPOP_SBC_1	490	494	PF00917	0.616
DEG_SPOP_SBC_1	576	580	PF00917	0.824
DOC_CKS1_1	235	240	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.507
DOC_MAPK_MEF2A_6	423	432	PF00069	0.577
DOC_MAPK_NFAT4_5	423	431	PF00069	0.677
DOC_PP1_RVXF_1	432	439	PF00149	0.532
DOC_PP2B_LxvP_1	82	85	PF13499	0.763
DOC_USP7_MATH_1	163	167	PF00917	0.763
DOC_USP7_MATH_1	231	235	PF00917	0.532
DOC_USP7_MATH_1	334	338	PF00917	0.707
DOC_USP7_MATH_1	36	40	PF00917	0.571
DOC_USP7_MATH_1	398	402	PF00917	0.729
DOC_USP7_MATH_1	490	494	PF00917	0.732
DOC_USP7_MATH_1	576	580	PF00917	0.824
DOC_USP7_MATH_1	592	596	PF00917	0.600
DOC_USP7_MATH_1	7	11	PF00917	0.651
DOC_USP7_MATH_1	75	79	PF00917	0.675
DOC_USP7_UBL2_3	468	472	PF12436	0.755
DOC_USP7_UBL2_3	629	633	PF12436	0.665
DOC_WW_Pin1_4	153	158	PF00397	0.597
DOC_WW_Pin1_4	234	239	PF00397	0.521
DOC_WW_Pin1_4	322	327	PF00397	0.671
DOC_WW_Pin1_4	392	397	PF00397	0.595
DOC_WW_Pin1_4	491	496	PF00397	0.748
DOC_WW_Pin1_4	502	507	PF00397	0.699
DOC_WW_Pin1_4	510	515	PF00397	0.603
DOC_WW_Pin1_4	555	560	PF00397	0.724
LIG_14-3-3_CanoR_1	143	153	PF00244	0.445
LIG_14-3-3_CanoR_1	203	211	PF00244	0.597
LIG_14-3-3_CanoR_1	292	298	PF00244	0.624
LIG_14-3-3_CanoR_1	387	396	PF00244	0.576
LIG_14-3-3_CanoR_1	593	601	PF00244	0.611
LIG_Actin_WH2_2	419	435	PF00022	0.655
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BRCT_BRCA1_1	457	461	PF00533	0.576
LIG_FHA_1	235	241	PF00498	0.529
LIG_FHA_1	411	417	PF00498	0.486
LIG_FHA_1	48	54	PF00498	0.528
LIG_FHA_1	507	513	PF00498	0.646
LIG_FHA_1	620	626	PF00498	0.649
LIG_FHA_2	116	122	PF00498	0.458
LIG_Integrin_isoDGR_2	571	573	PF01839	0.751
LIG_LIR_Apic_2	227	231	PF02991	0.598
LIG_LIR_Gen_1	6	15	PF02991	0.521
LIG_LIR_LC3C_4	106	109	PF02991	0.663
LIG_LIR_LC3C_4	237	242	PF02991	0.591
LIG_LIR_Nem_3	325	331	PF02991	0.708
LIG_LIR_Nem_3	6	11	PF02991	0.538
LIG_SH2_CRK	15	19	PF00017	0.483
LIG_SH2_PTP2	228	231	PF00017	0.602
LIG_SH2_PTP2	328	331	PF00017	0.671
LIG_SH2_SRC	406	409	PF00017	0.627
LIG_SH2_STAT3	133	136	PF00017	0.495
LIG_SH2_STAT3	215	218	PF00017	0.395
LIG_SH2_STAT5	200	203	PF00017	0.488
LIG_SH2_STAT5	228	231	PF00017	0.602
LIG_SH2_STAT5	328	331	PF00017	0.748
LIG_SH2_STAT5	406	409	PF00017	0.579
LIG_SH2_STAT5	528	531	PF00017	0.598
LIG_SH2_STAT5	606	609	PF00017	0.603
LIG_SH3_3	124	130	PF00018	0.435
LIG_SH3_3	280	286	PF00018	0.800
LIG_SH3_3	320	326	PF00018	0.577
LIG_SUMO_SIM_anti_2	208	215	PF11976	0.566
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.602
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.604
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.639
LIG_SUMO_SIM_anti_2	622	631	PF11976	0.701
LIG_TRAF2_1	312	315	PF00917	0.735
LIG_UBA3_1	428	434	PF00899	0.544
LIG_UBA3_1	473	481	PF00899	0.666
LIG_WRC_WIRS_1	294	299	PF05994	0.583
LIG_WRC_WIRS_1	566	571	PF05994	0.739
LIG_WRC_WIRS_1	8	13	PF05994	0.661
MOD_CDK_SPxK_1	491	497	PF00069	0.718
MOD_CK1_1	234	240	PF00069	0.616
MOD_CK1_1	493	499	PF00069	0.597
MOD_CK1_1	553	559	PF00069	0.621
MOD_CK1_1	585	591	PF00069	0.684
MOD_CK1_1	599	605	PF00069	0.616
MOD_CK1_1	74	80	PF00069	0.645
MOD_CK2_1	115	121	PF00069	0.496
MOD_CK2_1	163	169	PF00069	0.656
MOD_CK2_1	279	285	PF00069	0.700
MOD_CK2_1	472	478	PF00069	0.578
MOD_CK2_1	502	508	PF00069	0.749
MOD_CK2_1	510	516	PF00069	0.606
MOD_GlcNHglycan	28	32	PF01048	0.543
MOD_GlcNHglycan	336	339	PF01048	0.557
MOD_GlcNHglycan	353	356	PF01048	0.605
MOD_GlcNHglycan	39	42	PF01048	0.461
MOD_GlcNHglycan	408	411	PF01048	0.540
MOD_GlcNHglycan	455	458	PF01048	0.637
MOD_GlcNHglycan	5	8	PF01048	0.579
MOD_GlcNHglycan	552	555	PF01048	0.634
MOD_GlcNHglycan	587	590	PF01048	0.716
MOD_GlcNHglycan	596	599	PF01048	0.671
MOD_GlcNHglycan	601	604	PF01048	0.566
MOD_GlcNHglycan	630	633	PF01048	0.769
MOD_GlcNHglycan	73	76	PF01048	0.730
MOD_GlcNHglycan	77	80	PF01048	0.695
MOD_GSK3_1	202	209	PF00069	0.524
MOD_GSK3_1	229	236	PF00069	0.614
MOD_GSK3_1	3	10	PF00069	0.600
MOD_GSK3_1	392	399	PF00069	0.598
MOD_GSK3_1	402	409	PF00069	0.601
MOD_GSK3_1	449	456	PF00069	0.626
MOD_GSK3_1	489	496	PF00069	0.683
MOD_GSK3_1	502	509	PF00069	0.590
MOD_GSK3_1	578	585	PF00069	0.703
MOD_GSK3_1	592	599	PF00069	0.774
MOD_GSK3_1	71	78	PF00069	0.717
MOD_N-GLC_1	163	168	PF02516	0.662
MOD_N-GLC_1	18	23	PF02516	0.548
MOD_N-GLC_2	446	448	PF02516	0.520
MOD_NEK2_1	202	207	PF00069	0.450
MOD_NEK2_1	233	238	PF00069	0.640
MOD_NEK2_1	418	423	PF00069	0.650
MOD_NEK2_1	453	458	PF00069	0.608
MOD_NEK2_1	507	512	PF00069	0.696
MOD_NEK2_1	627	632	PF00069	0.678
MOD_NEK2_1	71	76	PF00069	0.593
MOD_NEK2_2	192	197	PF00069	0.464
MOD_NEK2_2	449	454	PF00069	0.572
MOD_NEK2_2	7	12	PF00069	0.675
MOD_PIKK_1	455	461	PF00454	0.756
MOD_PIKK_1	47	53	PF00454	0.568
MOD_PK_1	134	140	PF00069	0.519
MOD_PKA_1	178	184	PF00069	0.670
MOD_PKA_1	387	393	PF00069	0.516
MOD_PKA_2	178	184	PF00069	0.701
MOD_PKA_2	202	208	PF00069	0.501
MOD_PKA_2	387	393	PF00069	0.597
MOD_PKA_2	592	598	PF00069	0.730
MOD_PKB_1	176	184	PF00069	0.713
MOD_Plk_1	18	24	PF00069	0.544
MOD_Plk_1	370	376	PF00069	0.587
MOD_Plk_1	507	513	PF00069	0.632
MOD_Plk_2-3	279	285	PF00069	0.802
MOD_Plk_4	224	230	PF00069	0.517
MOD_Plk_4	293	299	PF00069	0.710
MOD_Plk_4	402	408	PF00069	0.570
MOD_ProDKin_1	153	159	PF00069	0.604
MOD_ProDKin_1	234	240	PF00069	0.514
MOD_ProDKin_1	322	328	PF00069	0.674
MOD_ProDKin_1	392	398	PF00069	0.605
MOD_ProDKin_1	491	497	PF00069	0.750
MOD_ProDKin_1	502	508	PF00069	0.694
MOD_ProDKin_1	510	516	PF00069	0.591
MOD_ProDKin_1	555	561	PF00069	0.727
TRG_DiLeu_BaEn_1	425	430	PF01217	0.670
TRG_DiLeu_BaEn_1	623	628	PF01217	0.683
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.513
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.553
TRG_ENDOCYTIC_2	15	18	PF00928	0.567
TRG_ENDOCYTIC_2	328	331	PF00928	0.710
TRG_ENDOCYTIC_2	606	609	PF00928	0.501
TRG_ER_diArg_1	177	179	PF00400	0.764
TRG_ER_diArg_1	301	303	PF00400	0.598
TRG_ER_diArg_1	387	389	PF00400	0.472
TRG_ER_diArg_1	53	56	PF00400	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD2	Leptomonas seymouri	45%	100%
A4HMZ7	Leishmania braziliensis	71%	99%
A4IBM0	Leishmania infantum	99%	100%
E9AFF4	Leishmania major	90%	100%
E9B6K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%