Zn-finger_in_Ran_binding_protein_and_others/OTU-l ike_cysteine_protease_putative/Pfam:PF00641/Pfam:PF02338

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/OTU-like cysteine protease, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ90_LEIDO

TriTrypDb:

LdBPK_351400.1 , LdCL_350018900 , LDHU3_35.1830

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJ90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ90

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:0016579	protein deubiquitination	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	3
GO:0016787	hydrolase activity	2	3
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0140096	catalytic activity, acting on a protein	2	3
GO:0004843	cysteine-type deubiquitinase activity	5	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0019783	ubiquitin-like protein peptidase activity	4	1
GO:0101005	deubiquitinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.507
CLV_NRD_NRD_1	100	102	PF00675	0.489
CLV_NRD_NRD_1	155	157	PF00675	0.699
CLV_NRD_NRD_1	168	170	PF00675	0.695
CLV_NRD_NRD_1	333	335	PF00675	0.707
CLV_NRD_NRD_1	9	11	PF00675	0.469
CLV_PCSK_FUR_1	153	157	PF00082	0.664
CLV_PCSK_FUR_1	566	570	PF00082	0.700
CLV_PCSK_KEX2_1	100	102	PF00082	0.489
CLV_PCSK_KEX2_1	155	157	PF00082	0.660
CLV_PCSK_KEX2_1	168	170	PF00082	0.667
CLV_PCSK_KEX2_1	333	335	PF00082	0.870
CLV_PCSK_KEX2_1	388	390	PF00082	0.563
CLV_PCSK_KEX2_1	565	567	PF00082	0.615
CLV_PCSK_KEX2_1	568	570	PF00082	0.630
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.546
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.673
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.713
CLV_PCSK_SKI1_1	106	110	PF00082	0.602
CLV_PCSK_SKI1_1	180	184	PF00082	0.630
CLV_PCSK_SKI1_1	388	392	PF00082	0.570
CLV_PCSK_SKI1_1	456	460	PF00082	0.459
CLV_PCSK_SKI1_1	49	53	PF00082	0.663
CLV_PCSK_SKI1_1	565	569	PF00082	0.656
CLV_PCSK_SKI1_1	609	613	PF00082	0.796
DEG_APCC_DBOX_1	220	228	PF00400	0.593
DEG_Nend_UBRbox_2	1	3	PF02207	0.657
DEG_SCF_FBW7_2	226	233	PF00400	0.578
DEG_SCF_TRCP1_1	578	584	PF00400	0.707
DEG_SPOP_SBC_1	146	150	PF00917	0.717
DEG_SPOP_SBC_1	24	28	PF00917	0.739
DEG_SPOP_SBC_1	33	37	PF00917	0.863
DOC_CKS1_1	227	232	PF01111	0.603
DOC_CKS1_1	301	306	PF01111	0.505
DOC_CKS1_1	95	100	PF01111	0.476
DOC_CYCLIN_RxL_1	605	614	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.648
DOC_MAPK_gen_1	478	486	PF00069	0.638
DOC_MAPK_gen_1	49	58	PF00069	0.598
DOC_MAPK_gen_1	69	78	PF00069	0.497
DOC_MAPK_HePTP_8	68	80	PF00069	0.600
DOC_MAPK_MEF2A_6	478	486	PF00069	0.544
DOC_MAPK_MEF2A_6	71	80	PF00069	0.576
DOC_MAPK_MEF2A_6	84	92	PF00069	0.436
DOC_MIT_MIM_1	387	397	PF04212	0.613
DOC_PIKK_1	369	377	PF02985	0.595
DOC_PP1_RVXF_1	55	61	PF00149	0.620
DOC_PP2B_LxvP_1	90	93	PF13499	0.547
DOC_PP4_FxxP_1	207	210	PF00568	0.644
DOC_PP4_FxxP_1	420	423	PF00568	0.575
DOC_PP4_FxxP_1	448	451	PF00568	0.503
DOC_USP7_MATH_1	175	179	PF00917	0.772
DOC_USP7_MATH_1	22	26	PF00917	0.773
DOC_USP7_MATH_1	220	224	PF00917	0.609
DOC_USP7_MATH_1	326	330	PF00917	0.826
DOC_USP7_MATH_1	33	37	PF00917	0.758
DOC_USP7_MATH_1	435	439	PF00917	0.601
DOC_USP7_MATH_1	576	580	PF00917	0.781
DOC_USP7_MATH_1	585	589	PF00917	0.741
DOC_USP7_MATH_1	598	602	PF00917	0.879
DOC_USP7_MATH_1	634	638	PF00917	0.792
DOC_USP7_UBL2_3	335	339	PF12436	0.709
DOC_WW_Pin1_4	121	126	PF00397	0.677
DOC_WW_Pin1_4	226	231	PF00397	0.836
DOC_WW_Pin1_4	300	305	PF00397	0.540
DOC_WW_Pin1_4	535	540	PF00397	0.584
DOC_WW_Pin1_4	543	548	PF00397	0.482
DOC_WW_Pin1_4	572	577	PF00397	0.801
DOC_WW_Pin1_4	63	68	PF00397	0.576
DOC_WW_Pin1_4	630	635	PF00397	0.763
DOC_WW_Pin1_4	667	672	PF00397	0.797
DOC_WW_Pin1_4	94	99	PF00397	0.463
LIG_14-3-3_CanoR_1	100	108	PF00244	0.531
LIG_14-3-3_CanoR_1	162	170	PF00244	0.633
LIG_14-3-3_CanoR_1	221	225	PF00244	0.569
LIG_14-3-3_CanoR_1	264	273	PF00244	0.654
LIG_14-3-3_CanoR_1	49	58	PF00244	0.701
LIG_14-3-3_CanoR_1	505	510	PF00244	0.674
LIG_14-3-3_CanoR_1	569	576	PF00244	0.780
LIG_14-3-3_CanoR_1	619	627	PF00244	0.771
LIG_14-3-3_CanoR_1	648	657	PF00244	0.784
LIG_14-3-3_CanoR_1	84	88	PF00244	0.577
LIG_deltaCOP1_diTrp_1	492	498	PF00928	0.587
LIG_eIF4E_1	527	533	PF01652	0.477
LIG_FHA_1	124	130	PF00498	0.748
LIG_FHA_1	212	218	PF00498	0.592
LIG_FHA_1	504	510	PF00498	0.878
LIG_FHA_1	581	587	PF00498	0.784
LIG_FHA_1	63	69	PF00498	0.646
LIG_FHA_2	301	307	PF00498	0.510
LIG_FHA_2	371	377	PF00498	0.592
LIG_FHA_2	464	470	PF00498	0.637
LIG_FHA_2	523	529	PF00498	0.569
LIG_GSK3_LRP6_1	667	673	PF00069	0.740
LIG_IRF3_LxIS_1	394	400	PF10401	0.596
LIG_LIR_Apic_2	184	189	PF02991	0.546
LIG_LIR_Gen_1	104	114	PF02991	0.547
LIG_LIR_Gen_1	441	452	PF02991	0.560
LIG_LIR_Gen_1	492	498	PF02991	0.542
LIG_LIR_Gen_1	601	611	PF02991	0.712
LIG_LIR_Gen_1	86	95	PF02991	0.562
LIG_LIR_Nem_3	104	110	PF02991	0.552
LIG_LIR_Nem_3	132	137	PF02991	0.703
LIG_LIR_Nem_3	441	447	PF02991	0.547
LIG_LIR_Nem_3	453	457	PF02991	0.538
LIG_LIR_Nem_3	492	497	PF02991	0.542
LIG_LIR_Nem_3	525	530	PF02991	0.658
LIG_LIR_Nem_3	531	536	PF02991	0.519
LIG_LIR_Nem_3	601	606	PF02991	0.712
LIG_LIR_Nem_3	86	90	PF02991	0.503
LIG_NRBOX	3	9	PF00104	0.563
LIG_NRBOX	554	560	PF00104	0.640
LIG_PCNA_yPIPBox_3	180	194	PF02747	0.588
LIG_PDZ_Class_2	675	680	PF00595	0.710
LIG_Pex14_1	494	498	PF04695	0.544
LIG_PTB_Apo_2	414	421	PF02174	0.575
LIG_SH2_CRK	444	448	PF00017	0.559
LIG_SH2_NCK_1	301	305	PF00017	0.616
LIG_SH2_NCK_1	542	546	PF00017	0.471
LIG_SH2_SRC	542	545	PF00017	0.437
LIG_SH2_STAP1	444	448	PF00017	0.557
LIG_SH2_STAT5	294	297	PF00017	0.634
LIG_SH2_STAT5	3	6	PF00017	0.547
LIG_SH2_STAT5	427	430	PF00017	0.601
LIG_SH2_STAT5	457	460	PF00017	0.557
LIG_SH2_STAT5	536	539	PF00017	0.525
LIG_SH2_STAT5	87	90	PF00017	0.499
LIG_SH3_1	665	671	PF00018	0.838
LIG_SH3_3	119	125	PF00018	0.612
LIG_SH3_3	134	140	PF00018	0.535
LIG_SH3_3	210	216	PF00018	0.597
LIG_SH3_3	604	610	PF00018	0.748
LIG_SH3_3	612	618	PF00018	0.709
LIG_SH3_3	639	645	PF00018	0.796
LIG_SH3_3	660	666	PF00018	0.790
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.544
LIG_TRAF2_1	373	376	PF00917	0.659
LIG_TRAF2_1	489	492	PF00917	0.647
LIG_TYR_ITIM	540	545	PF00017	0.455
LIG_TYR_ITSM	523	530	PF00017	0.554
LIG_WRC_WIRS_1	182	187	PF05994	0.573
LIG_WRC_WIRS_1	190	195	PF05994	0.617
MOD_CDC14_SPxK_1	66	69	PF00782	0.582
MOD_CDK_SPxK_1	63	69	PF00069	0.575
MOD_CDK_SPxK_1	94	100	PF00069	0.456
MOD_CDK_SPxxK_3	94	101	PF00069	0.456
MOD_CK1_1	121	127	PF00069	0.693
MOD_CK1_1	178	184	PF00069	0.704
MOD_CK1_1	25	31	PF00069	0.690
MOD_CK1_1	277	283	PF00069	0.498
MOD_CK1_1	431	437	PF00069	0.583
MOD_CK1_1	438	444	PF00069	0.387
MOD_CK1_1	579	585	PF00069	0.834
MOD_CK1_1	601	607	PF00069	0.758
MOD_CK1_1	637	643	PF00069	0.721
MOD_CK1_1	670	676	PF00069	0.841
MOD_CK1_1	86	92	PF00069	0.544
MOD_CK2_1	370	376	PF00069	0.550
MOD_CK2_1	486	492	PF00069	0.526
MOD_CK2_1	522	528	PF00069	0.594
MOD_CK2_1	626	632	PF00069	0.808
MOD_GlcNHglycan	164	167	PF01048	0.784
MOD_GlcNHglycan	171	174	PF01048	0.780
MOD_GlcNHglycan	177	180	PF01048	0.706
MOD_GlcNHglycan	27	30	PF01048	0.780
MOD_GlcNHglycan	328	331	PF01048	0.731
MOD_GlcNHglycan	335	338	PF01048	0.674
MOD_GlcNHglycan	52	55	PF01048	0.733
MOD_GlcNHglycan	559	562	PF01048	0.590
MOD_GlcNHglycan	578	581	PF01048	0.745
MOD_GlcNHglycan	583	586	PF01048	0.808
MOD_GlcNHglycan	587	590	PF01048	0.781
MOD_GlcNHglycan	592	595	PF01048	0.617
MOD_GSK3_1	141	148	PF00069	0.716
MOD_GSK3_1	174	181	PF00069	0.692
MOD_GSK3_1	235	242	PF00069	0.758
MOD_GSK3_1	24	31	PF00069	0.751
MOD_GSK3_1	322	329	PF00069	0.695
MOD_GSK3_1	431	438	PF00069	0.584
MOD_GSK3_1	570	577	PF00069	0.784
MOD_GSK3_1	581	588	PF00069	0.770
MOD_GSK3_1	601	608	PF00069	0.875
MOD_GSK3_1	626	633	PF00069	0.714
MOD_GSK3_1	644	651	PF00069	0.827
MOD_GSK3_1	653	660	PF00069	0.817
MOD_GSK3_1	666	673	PF00069	0.725
MOD_LATS_1	343	349	PF00433	0.658
MOD_N-GLC_1	569	574	PF02516	0.743
MOD_N-GLC_1	601	606	PF02516	0.712
MOD_N-GLC_1	62	67	PF02516	0.556
MOD_N-GLC_1	637	642	PF02516	0.837
MOD_NEK2_1	129	134	PF00069	0.812
MOD_NEK2_1	145	150	PF00069	0.746
MOD_NEK2_1	164	169	PF00069	0.706
MOD_NEK2_1	397	402	PF00069	0.596
MOD_NEK2_1	428	433	PF00069	0.506
MOD_NEK2_1	503	508	PF00069	0.653
MOD_NEK2_1	520	525	PF00069	0.589
MOD_NEK2_1	626	631	PF00069	0.713
MOD_NEK2_1	78	83	PF00069	0.463
MOD_PIKK_1	274	280	PF00454	0.583
MOD_PK_1	118	124	PF00069	0.590
MOD_PKA_1	100	106	PF00069	0.502
MOD_PKA_1	333	339	PF00069	0.616
MOD_PKA_2	100	106	PF00069	0.502
MOD_PKA_2	220	226	PF00069	0.593
MOD_PKA_2	263	269	PF00069	0.636
MOD_PKA_2	333	339	PF00069	0.870
MOD_PKA_2	620	626	PF00069	0.901
MOD_PKA_2	83	89	PF00069	0.562
MOD_PKB_1	646	654	PF00069	0.826
MOD_Plk_1	601	607	PF00069	0.750
MOD_Plk_2-3	370	376	PF00069	0.559
MOD_Plk_2-3	463	469	PF00069	0.520
MOD_Plk_4	129	135	PF00069	0.697
MOD_Plk_4	141	147	PF00069	0.650
MOD_Plk_4	181	187	PF00069	0.642
MOD_Plk_4	189	195	PF00069	0.582
MOD_Plk_4	528	534	PF00069	0.564
MOD_Plk_4	83	89	PF00069	0.583
MOD_ProDKin_1	121	127	PF00069	0.675
MOD_ProDKin_1	226	232	PF00069	0.837
MOD_ProDKin_1	300	306	PF00069	0.541
MOD_ProDKin_1	535	541	PF00069	0.582
MOD_ProDKin_1	543	549	PF00069	0.495
MOD_ProDKin_1	572	578	PF00069	0.809
MOD_ProDKin_1	63	69	PF00069	0.575
MOD_ProDKin_1	630	636	PF00069	0.763
MOD_ProDKin_1	667	673	PF00069	0.795
MOD_ProDKin_1	94	100	PF00069	0.456
TRG_DiLeu_BaEn_1	159	164	PF01217	0.664
TRG_DiLeu_BaEn_2	202	208	PF01217	0.674
TRG_DiLeu_BaEn_4	159	165	PF01217	0.753
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.621
TRG_DiLeu_BaLyEn_6	607	612	PF01217	0.628
TRG_DiLeu_LyEn_5	159	164	PF01217	0.664
TRG_ENDOCYTIC_2	134	137	PF00928	0.675
TRG_ENDOCYTIC_2	320	323	PF00928	0.625
TRG_ENDOCYTIC_2	444	447	PF00928	0.388
TRG_ENDOCYTIC_2	527	530	PF00928	0.540
TRG_ENDOCYTIC_2	542	545	PF00928	0.368
TRG_ENDOCYTIC_2	87	90	PF00928	0.545
TRG_ER_diArg_1	152	155	PF00400	0.634
TRG_ER_diArg_1	168	171	PF00400	0.737
TRG_ER_diArg_1	618	621	PF00400	0.693
TRG_ER_diArg_1	645	648	PF00400	0.789
TRG_NLS_MonoExtC_3	564	569	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	609	614	PF00026	0.872

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V7	Leptomonas seymouri	56%	100%
A0A1X0NIV4	Trypanosomatidae	32%	87%
A0A3R7MGK1	Trypanosoma rangeli	38%	98%
A4HMG1	Leishmania braziliensis	69%	100%
A4IB32	Leishmania infantum	100%	100%
C9ZNN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	74%
E9AEW2	Leishmania major	94%	100%
E9B618	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BC93	Trypanosoma cruzi	37%	100%