Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ88_LEIDO

TriTrypDb:

LdBPK_321680.1 , LdCL_320022300 , LDHU3_32.2130

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.607
CLV_C14_Caspase3-7	378	382	PF00656	0.685
CLV_NRD_NRD_1	100	102	PF00675	0.809
CLV_NRD_NRD_1	215	217	PF00675	0.694
CLV_NRD_NRD_1	34	36	PF00675	0.719
CLV_NRD_NRD_1	486	488	PF00675	0.798
CLV_NRD_NRD_1	520	522	PF00675	0.775
CLV_NRD_NRD_1	550	552	PF00675	0.730
CLV_PCSK_KEX2_1	215	217	PF00082	0.694
CLV_PCSK_KEX2_1	34	36	PF00082	0.719
CLV_PCSK_KEX2_1	486	488	PF00082	0.744
CLV_PCSK_KEX2_1	520	522	PF00082	0.775
CLV_PCSK_SKI1_1	320	324	PF00082	0.766
CLV_PCSK_SKI1_1	34	38	PF00082	0.509
CLV_PCSK_SKI1_1	404	408	PF00082	0.785
CLV_PCSK_SKI1_1	448	452	PF00082	0.803
CLV_PCSK_SKI1_1	618	622	PF00082	0.638
CLV_PCSK_SKI1_1	74	78	PF00082	0.678
DEG_APCC_DBOX_1	12	20	PF00400	0.529
DEG_APCC_DBOX_1	623	631	PF00400	0.687
DEG_SCF_FBW7_2	238	245	PF00400	0.662
DEG_SPOP_SBC_1	369	373	PF00917	0.724
DEG_SPOP_SBC_1	527	531	PF00917	0.742
DEG_SPOP_SBC_1	61	65	PF00917	0.746
DOC_CKS1_1	239	244	PF01111	0.724
DOC_MAPK_DCC_7	556	566	PF00069	0.716
DOC_MAPK_gen_1	276	284	PF00069	0.587
DOC_MAPK_gen_1	560	568	PF00069	0.679
DOC_MAPK_JIP1_4	562	568	PF00069	0.675
DOC_MAPK_MEF2A_6	560	568	PF00069	0.679
DOC_PP4_FxxP_1	211	214	PF00568	0.671
DOC_PP4_FxxP_1	451	454	PF00568	0.658
DOC_PP4_FxxP_1	656	659	PF00568	0.701
DOC_USP7_MATH_1	142	146	PF00917	0.703
DOC_USP7_MATH_1	217	221	PF00917	0.692
DOC_USP7_MATH_1	304	308	PF00917	0.660
DOC_USP7_MATH_1	331	335	PF00917	0.625
DOC_USP7_MATH_1	370	374	PF00917	0.843
DOC_USP7_MATH_1	47	51	PF00917	0.646
DOC_USP7_MATH_1	519	523	PF00917	0.799
DOC_USP7_MATH_1	547	551	PF00917	0.736
DOC_USP7_MATH_1	59	63	PF00917	0.699
DOC_USP7_MATH_1	75	79	PF00917	0.555
DOC_USP7_MATH_2	355	361	PF00917	0.666
DOC_USP7_UBL2_3	552	556	PF12436	0.710
DOC_WW_Pin1_4	111	116	PF00397	0.690
DOC_WW_Pin1_4	161	166	PF00397	0.717
DOC_WW_Pin1_4	171	176	PF00397	0.739
DOC_WW_Pin1_4	187	192	PF00397	0.661
DOC_WW_Pin1_4	210	215	PF00397	0.704
DOC_WW_Pin1_4	226	231	PF00397	0.724
DOC_WW_Pin1_4	234	239	PF00397	0.716
DOC_WW_Pin1_4	285	290	PF00397	0.686
DOC_WW_Pin1_4	332	337	PF00397	0.738
DOC_WW_Pin1_4	347	352	PF00397	0.745
DOC_WW_Pin1_4	485	490	PF00397	0.748
DOC_WW_Pin1_4	62	67	PF00397	0.768
LIG_14-3-3_CanoR_1	216	222	PF00244	0.747
LIG_14-3-3_CanoR_1	247	255	PF00244	0.792
LIG_14-3-3_CanoR_1	320	328	PF00244	0.742
LIG_14-3-3_CanoR_1	404	411	PF00244	0.726
LIG_14-3-3_CanoR_1	463	473	PF00244	0.759
LIG_14-3-3_CanoR_1	479	485	PF00244	0.617
LIG_14-3-3_CanoR_1	506	515	PF00244	0.840
LIG_14-3-3_CanoR_1	549	555	PF00244	0.835
LIG_14-3-3_CanoR_1	624	628	PF00244	0.679
LIG_14-3-3_CanoR_1	644	648	PF00244	0.437
LIG_14-3-3_CanoR_1	74	83	PF00244	0.831
LIG_14-3-3_CanoR_1	8	16	PF00244	0.498
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	1	5	PF00533	0.635
LIG_BRCT_BRCA1_1	203	207	PF00533	0.797
LIG_deltaCOP1_diTrp_1	428	431	PF00928	0.744
LIG_FHA_1	150	156	PF00498	0.805
LIG_FHA_1	216	222	PF00498	0.725
LIG_FHA_1	223	229	PF00498	0.739
LIG_FHA_1	363	369	PF00498	0.748
LIG_FHA_1	420	426	PF00498	0.741
LIG_FHA_1	55	61	PF00498	0.749
LIG_FHA_1	83	89	PF00498	0.755
LIG_FHA_2	20	26	PF00498	0.566
LIG_FHA_2	239	245	PF00498	0.756
LIG_FHA_2	247	253	PF00498	0.676
LIG_FHA_2	263	269	PF00498	0.477
LIG_FHA_2	342	348	PF00498	0.849
LIG_FHA_2	472	478	PF00498	0.712
LIG_FHA_2	575	581	PF00498	0.500
LIG_FHA_2	611	617	PF00498	0.525
LIG_HCF-1_HBM_1	38	41	PF13415	0.661
LIG_LIR_Apic_2	209	214	PF02991	0.675
LIG_LIR_Apic_2	597	603	PF02991	0.622
LIG_LIR_Apic_2	655	659	PF02991	0.711
LIG_LIR_Gen_1	265	273	PF02991	0.616
LIG_LIR_Gen_1	580	590	PF02991	0.528
LIG_LIR_Gen_1	641	649	PF02991	0.767
LIG_LIR_Nem_3	265	270	PF02991	0.631
LIG_LIR_Nem_3	580	585	PF02991	0.501
LIG_LIR_Nem_3	641	645	PF02991	0.770
LIG_NRBOX	580	586	PF00104	0.507
LIG_Pex14_2	106	110	PF04695	0.741
LIG_Pex14_2	207	211	PF04695	0.674
LIG_Pex14_2	406	410	PF04695	0.671
LIG_RPA_C_Fungi	35	47	PF08784	0.443
LIG_SH2_CRK	600	604	PF00017	0.620
LIG_SH2_CRK	642	646	PF00017	0.642
LIG_SH2_STAT5	41	44	PF00017	0.632
LIG_SH2_STAT5	611	614	PF00017	0.531
LIG_SH3_3	164	170	PF00018	0.791
LIG_SH3_3	190	196	PF00018	0.702
LIG_SH3_3	211	217	PF00018	0.692
LIG_SH3_3	335	341	PF00018	0.667
LIG_SH3_3	364	370	PF00018	0.731
LIG_SH3_3	655	661	PF00018	0.643
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.829
LIG_TRAF2_1	22	25	PF00917	0.592
LIG_TRAF2_1	242	245	PF00917	0.795
LIG_TRAF2_1	313	316	PF00917	0.722
LIG_TRAF2_1	613	616	PF00917	0.618
LIG_TRFH_1	600	604	PF08558	0.620
MOD_CDC14_SPxK_1	213	216	PF00782	0.689
MOD_CDK_SPK_2	210	215	PF00069	0.704
MOD_CDK_SPK_2	226	231	PF00069	0.724
MOD_CDK_SPK_2	238	243	PF00069	0.760
MOD_CDK_SPK_2	334	339	PF00069	0.834
MOD_CDK_SPxK_1	210	216	PF00069	0.684
MOD_CDK_SPxK_1	347	353	PF00069	0.747
MOD_CDK_SPxxK_3	161	168	PF00069	0.618
MOD_CDK_SPxxK_3	332	339	PF00069	0.736
MOD_CK1_1	246	252	PF00069	0.694
MOD_CK1_1	288	294	PF00069	0.807
MOD_CK1_1	334	340	PF00069	0.831
MOD_CK1_1	362	368	PF00069	0.719
MOD_CK1_1	504	510	PF00069	0.793
MOD_CK1_1	529	535	PF00069	0.752
MOD_CK1_1	543	549	PF00069	0.630
MOD_CK1_1	550	556	PF00069	0.694
MOD_CK1_1	62	68	PF00069	0.758
MOD_CK1_1	626	632	PF00069	0.705
MOD_CK1_1	648	654	PF00069	0.688
MOD_CK2_1	142	148	PF00069	0.749
MOD_CK2_1	19	25	PF00069	0.591
MOD_CK2_1	238	244	PF00069	0.723
MOD_CK2_1	341	347	PF00069	0.843
MOD_CK2_1	351	357	PF00069	0.678
MOD_CK2_1	471	477	PF00069	0.735
MOD_CK2_1	478	484	PF00069	0.650
MOD_CK2_1	574	580	PF00069	0.496
MOD_CK2_1	610	616	PF00069	0.528
MOD_GlcNHglycan	128	131	PF01048	0.701
MOD_GlcNHglycan	142	145	PF01048	0.617
MOD_GlcNHglycan	49	52	PF01048	0.703
MOD_GlcNHglycan	503	506	PF01048	0.722
MOD_GlcNHglycan	516	519	PF01048	0.730
MOD_GlcNHglycan	521	524	PF01048	0.672
MOD_GlcNHglycan	531	534	PF01048	0.500
MOD_GlcNHglycan	552	555	PF01048	0.741
MOD_GlcNHglycan	647	650	PF01048	0.767
MOD_GlcNHglycan	68	71	PF01048	0.594
MOD_GlcNHglycan	9	12	PF01048	0.563
MOD_GlcNHglycan	97	100	PF01048	0.706
MOD_GSK3_1	140	147	PF00069	0.755
MOD_GSK3_1	15	22	PF00069	0.570
MOD_GSK3_1	222	229	PF00069	0.648
MOD_GSK3_1	234	241	PF00069	0.803
MOD_GSK3_1	251	258	PF00069	0.734
MOD_GSK3_1	284	291	PF00069	0.679
MOD_GSK3_1	304	311	PF00069	0.747
MOD_GSK3_1	322	329	PF00069	0.725
MOD_GSK3_1	341	348	PF00069	0.768
MOD_GSK3_1	394	401	PF00069	0.767
MOD_GSK3_1	419	426	PF00069	0.730
MOD_GSK3_1	436	443	PF00069	0.777
MOD_GSK3_1	459	466	PF00069	0.739
MOD_GSK3_1	501	508	PF00069	0.831
MOD_GSK3_1	536	543	PF00069	0.792
MOD_GSK3_1	590	597	PF00069	0.715
MOD_GSK3_1	61	68	PF00069	0.840
MOD_GSK3_1	70	77	PF00069	0.789
MOD_GSK3_1	82	89	PF00069	0.597
MOD_N-GLC_1	226	231	PF02516	0.654
MOD_N-GLC_1	398	403	PF02516	0.789
MOD_NEK2_1	110	115	PF00069	0.699
MOD_NEK2_1	282	287	PF00069	0.701
MOD_NEK2_1	322	327	PF00069	0.772
MOD_NEK2_1	411	416	PF00069	0.732
MOD_NEK2_1	459	464	PF00069	0.625
MOD_NEK2_1	623	628	PF00069	0.571
MOD_PIKK_1	508	514	PF00454	0.651
MOD_PIKK_1	77	83	PF00454	0.828
MOD_PKA_1	215	221	PF00069	0.746
MOD_PKA_2	14	20	PF00069	0.578
MOD_PKA_2	215	221	PF00069	0.704
MOD_PKA_2	246	252	PF00069	0.801
MOD_PKA_2	459	465	PF00069	0.730
MOD_PKA_2	478	484	PF00069	0.577
MOD_PKA_2	505	511	PF00069	0.763
MOD_PKA_2	513	519	PF00069	0.692
MOD_PKA_2	550	556	PF00069	0.658
MOD_PKA_2	623	629	PF00069	0.576
MOD_PKA_2	643	649	PF00069	0.436
MOD_PKA_2	7	13	PF00069	0.551
MOD_PKB_1	13	21	PF00069	0.602
MOD_Plk_1	243	249	PF00069	0.740
MOD_Plk_1	251	257	PF00069	0.643
MOD_Plk_1	262	268	PF00069	0.726
MOD_Plk_1	357	363	PF00069	0.628
MOD_Plk_1	380	386	PF00069	0.726
MOD_Plk_1	420	426	PF00069	0.702
MOD_Plk_1	568	574	PF00069	0.558
MOD_Plk_2-3	263	269	PF00069	0.640
MOD_Plk_2-3	594	600	PF00069	0.635
MOD_Plk_4	251	257	PF00069	0.729
MOD_Plk_4	288	294	PF00069	0.736
MOD_Plk_4	568	574	PF00069	0.558
MOD_Plk_4	626	632	PF00069	0.628
MOD_ProDKin_1	111	117	PF00069	0.691
MOD_ProDKin_1	161	167	PF00069	0.712
MOD_ProDKin_1	171	177	PF00069	0.739
MOD_ProDKin_1	187	193	PF00069	0.654
MOD_ProDKin_1	210	216	PF00069	0.706
MOD_ProDKin_1	226	232	PF00069	0.726
MOD_ProDKin_1	234	240	PF00069	0.716
MOD_ProDKin_1	285	291	PF00069	0.691
MOD_ProDKin_1	332	338	PF00069	0.737
MOD_ProDKin_1	347	353	PF00069	0.747
MOD_ProDKin_1	485	491	PF00069	0.747
MOD_ProDKin_1	62	68	PF00069	0.770
TRG_DiLeu_BaEn_1	580	585	PF01217	0.501
TRG_DiLeu_BaEn_2	37	43	PF01217	0.658
TRG_DiLeu_BaEn_4	615	621	PF01217	0.627
TRG_ENDOCYTIC_2	642	645	PF00928	0.776
TRG_ER_diArg_1	12	15	PF00400	0.516
TRG_ER_diArg_1	156	159	PF00400	0.532
TRG_ER_diArg_1	214	216	PF00400	0.691
TRG_ER_diArg_1	34	36	PF00400	0.573
TRG_ER_diArg_1	485	487	PF00400	0.805
TRG_ER_diArg_1	519	521	PF00400	0.753
TRG_ER_diArg_1	585	588	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICJ5	Leptomonas seymouri	36%	100%
A4HKE7	Leishmania braziliensis	59%	100%
A4I7X5	Leishmania infantum	98%	100%
E9B2T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q5C1	Leishmania major	85%	100%