Putative zinc finger protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ86_LEIDO

TriTrypDb:

LdBPK_363080.1 , LdCL_360037200 , LDHU3_36.4250

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IJ86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.473
CLV_C14_Caspase3-7	411	415	PF00656	0.730
CLV_NRD_NRD_1	427	429	PF00675	0.586
CLV_NRD_NRD_1	442	444	PF00675	0.436
CLV_NRD_NRD_1	509	511	PF00675	0.567
CLV_NRD_NRD_1	545	547	PF00675	0.563
CLV_PCSK_FUR_1	509	513	PF00082	0.555
CLV_PCSK_KEX2_1	427	429	PF00082	0.586
CLV_PCSK_KEX2_1	441	443	PF00082	0.420
CLV_PCSK_KEX2_1	509	511	PF00082	0.559
CLV_PCSK_KEX2_1	544	546	PF00082	0.526
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.530
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.570
CLV_PCSK_PC7_1	437	443	PF00082	0.542
CLV_PCSK_SKI1_1	114	118	PF00082	0.438
CLV_PCSK_SKI1_1	208	212	PF00082	0.498
CLV_PCSK_SKI1_1	287	291	PF00082	0.458
CLV_PCSK_SKI1_1	33	37	PF00082	0.344
DEG_APCC_DBOX_1	113	121	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.501
DEG_SPOP_SBC_1	401	405	PF00917	0.654
DOC_CDC14_PxL_1	2	10	PF14671	0.476
DOC_MAPK_gen_1	363	372	PF00069	0.724
DOC_MAPK_gen_1	441	447	PF00069	0.755
DOC_MAPK_MEF2A_6	363	372	PF00069	0.724
DOC_PP1_RVXF_1	270	276	PF00149	0.623
DOC_PP4_FxxP_1	71	74	PF00568	0.541
DOC_USP7_MATH_1	348	352	PF00917	0.682
DOC_USP7_MATH_1	368	372	PF00917	0.804
DOC_USP7_MATH_1	401	405	PF00917	0.779
DOC_USP7_MATH_1	494	498	PF00917	0.792
DOC_USP7_MATH_1	74	78	PF00917	0.463
DOC_WW_Pin1_4	258	263	PF00397	0.658
DOC_WW_Pin1_4	416	421	PF00397	0.799
DOC_WW_Pin1_4	460	465	PF00397	0.714
DOC_WW_Pin1_4	487	492	PF00397	0.761
DOC_WW_Pin1_4	495	500	PF00397	0.779
DOC_WW_Pin1_4	517	522	PF00397	0.681
DOC_WW_Pin1_4	70	75	PF00397	0.546
LIG_14-3-3_CanoR_1	192	198	PF00244	0.430
LIG_14-3-3_CanoR_1	208	214	PF00244	0.677
LIG_14-3-3_CanoR_1	33	42	PF00244	0.489
LIG_14-3-3_CanoR_1	369	373	PF00244	0.761
LIG_14-3-3_CanoR_1	402	408	PF00244	0.808
LIG_14-3-3_CanoR_1	442	446	PF00244	0.708
LIG_14-3-3_CanoR_1	528	535	PF00244	0.791
LIG_14-3-3_CanoR_1	60	65	PF00244	0.514
LIG_14-3-3_CanoR_1	67	72	PF00244	0.457
LIG_Actin_WH2_2	179	194	PF00022	0.492
LIG_APCC_ABBA_1	230	235	PF00400	0.654
LIG_APCC_ABBA_1	500	505	PF00400	0.612
LIG_BRCT_BRCA1_1	76	80	PF00533	0.476
LIG_CSL_BTD_1	71	74	PF09270	0.485
LIG_CtBP_PxDLS_1	423	427	PF00389	0.791
LIG_EH_1	230	234	PF12763	0.691
LIG_EH1_1	58	66	PF00400	0.443
LIG_eIF4E_1	24	30	PF01652	0.438
LIG_FHA_1	106	112	PF00498	0.492
LIG_FHA_1	171	177	PF00498	0.410
LIG_FHA_1	179	185	PF00498	0.259
LIG_FHA_1	2	8	PF00498	0.468
LIG_FHA_1	25	31	PF00498	0.448
LIG_FHA_1	301	307	PF00498	0.542
LIG_FHA_1	34	40	PF00498	0.352
LIG_FHA_1	382	388	PF00498	0.717
LIG_FHA_1	488	494	PF00498	0.818
LIG_FHA_1	536	542	PF00498	0.825
LIG_FHA_2	120	126	PF00498	0.616
LIG_HP1_1	368	372	PF01393	0.776
LIG_LIR_Apic_2	70	74	PF02991	0.540
LIG_LIR_Gen_1	48	55	PF02991	0.373
LIG_LIR_Nem_3	238	243	PF02991	0.627
LIG_LIR_Nem_3	291	296	PF02991	0.619
LIG_LIR_Nem_3	48	54	PF02991	0.433
LIG_LIR_Nem_3	85	90	PF02991	0.481
LIG_NRBOX	143	149	PF00104	0.415
LIG_Pex14_1	264	268	PF04695	0.643
LIG_Pex14_2	51	55	PF04695	0.492
LIG_Pex14_2	68	72	PF04695	0.340
LIG_SH2_CRK	160	164	PF00017	0.463
LIG_SH2_CRK	180	184	PF00017	0.417
LIG_SH2_CRK	2	6	PF00017	0.483
LIG_SH2_CRK	207	211	PF00017	0.631
LIG_SH2_CRK	286	290	PF00017	0.631
LIG_SH2_GRB2like	24	27	PF00017	0.357
LIG_SH2_NCK_1	2	6	PF00017	0.505
LIG_SH2_NCK_1	88	92	PF00017	0.495
LIG_SH2_SRC	243	246	PF00017	0.624
LIG_SH2_STAP1	13	17	PF00017	0.438
LIG_SH2_STAP1	180	184	PF00017	0.376
LIG_SH2_STAT5	160	163	PF00017	0.388
LIG_SH2_STAT5	180	183	PF00017	0.354
LIG_SH2_STAT5	185	188	PF00017	0.363
LIG_SH2_STAT5	243	246	PF00017	0.599
LIG_SH2_STAT5	256	259	PF00017	0.527
LIG_SH2_STAT5	274	277	PF00017	0.640
LIG_SH3_3	386	392	PF00018	0.759
LIG_SH3_3	417	423	PF00018	0.767
LIG_SH3_3	488	494	PF00018	0.757
LIG_SH3_3	496	502	PF00018	0.704
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.422
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.556
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.438
LIG_TRAF2_1	164	167	PF00917	0.461
LIG_TRAF2_1	463	466	PF00917	0.767
LIG_TRFH_1	160	164	PF08558	0.425
LIG_UBA3_1	42	46	PF00899	0.492
LIG_WRC_WIRS_1	68	73	PF05994	0.538
MOD_CDK_SPxxK_3	460	467	PF00069	0.714
MOD_CK1_1	193	199	PF00069	0.415
MOD_CK1_1	212	218	PF00069	0.475
MOD_CK1_1	258	264	PF00069	0.657
MOD_CK1_1	455	461	PF00069	0.736
MOD_CK1_1	523	529	PF00069	0.772
MOD_CK2_1	119	125	PF00069	0.558
MOD_CK2_1	132	138	PF00069	0.607
MOD_CK2_1	460	466	PF00069	0.779
MOD_Cter_Amidation	507	510	PF01082	0.623
MOD_GlcNHglycan	117	120	PF01048	0.390
MOD_GlcNHglycan	134	137	PF01048	0.462
MOD_GlcNHglycan	192	195	PF01048	0.492
MOD_GlcNHglycan	226	230	PF01048	0.474
MOD_GlcNHglycan	279	282	PF01048	0.433
MOD_GlcNHglycan	410	413	PF01048	0.511
MOD_GlcNHglycan	478	481	PF01048	0.542
MOD_GlcNHglycan	505	509	PF01048	0.603
MOD_GlcNHglycan	522	525	PF01048	0.456
MOD_GlcNHglycan	532	535	PF01048	0.605
MOD_GSK3_1	115	122	PF00069	0.505
MOD_GSK3_1	158	165	PF00069	0.374
MOD_GSK3_1	166	173	PF00069	0.428
MOD_GSK3_1	193	200	PF00069	0.415
MOD_GSK3_1	25	32	PF00069	0.372
MOD_GSK3_1	254	261	PF00069	0.601
MOD_GSK3_1	402	409	PF00069	0.725
MOD_GSK3_1	414	421	PF00069	0.674
MOD_GSK3_1	516	523	PF00069	0.795
MOD_GSK3_1	70	77	PF00069	0.491
MOD_GSK3_1	82	89	PF00069	0.476
MOD_N-GLC_1	25	30	PF02516	0.438
MOD_N-GLC_1	74	79	PF02516	0.708
MOD_NEK2_1	1	6	PF00069	0.466
MOD_NEK2_1	148	153	PF00069	0.422
MOD_NEK2_1	178	183	PF00069	0.393
MOD_NEK2_1	197	202	PF00069	0.562
MOD_NEK2_1	225	230	PF00069	0.644
MOD_NEK2_1	29	34	PF00069	0.526
MOD_NEK2_1	38	43	PF00069	0.334
MOD_NEK2_1	383	388	PF00069	0.728
MOD_NEK2_1	400	405	PF00069	0.808
MOD_NEK2_1	408	413	PF00069	0.747
MOD_NEK2_1	53	58	PF00069	0.346
MOD_NEK2_1	80	85	PF00069	0.510
MOD_NEK2_2	322	327	PF00069	0.544
MOD_PIKK_1	130	136	PF00454	0.643
MOD_PIKK_1	166	172	PF00454	0.483
MOD_PIKK_1	212	218	PF00454	0.646
MOD_PIKK_1	414	420	PF00454	0.740
MOD_PIKK_1	80	86	PF00454	0.470
MOD_PK_1	292	298	PF00069	0.619
MOD_PKA_1	441	447	PF00069	0.745
MOD_PKA_2	362	368	PF00069	0.738
MOD_PKA_2	401	407	PF00069	0.801
MOD_PKA_2	441	447	PF00069	0.707
MOD_PKA_2	476	482	PF00069	0.631
MOD_PKA_2	527	533	PF00069	0.684
MOD_Plk_1	124	130	PF00069	0.673
MOD_Plk_1	25	31	PF00069	0.379
MOD_Plk_1	469	475	PF00069	0.651
MOD_Plk_4	143	149	PF00069	0.427
MOD_Plk_4	158	164	PF00069	0.386
MOD_Plk_4	172	178	PF00069	0.238
MOD_Plk_4	179	185	PF00069	0.342
MOD_Plk_4	197	203	PF00069	0.516
MOD_Plk_4	25	31	PF00069	0.401
MOD_Plk_4	38	44	PF00069	0.303
MOD_Plk_4	60	66	PF00069	0.524
MOD_ProDKin_1	258	264	PF00069	0.658
MOD_ProDKin_1	416	422	PF00069	0.799
MOD_ProDKin_1	460	466	PF00069	0.714
MOD_ProDKin_1	487	493	PF00069	0.761
MOD_ProDKin_1	495	501	PF00069	0.778
MOD_ProDKin_1	517	523	PF00069	0.683
MOD_ProDKin_1	70	76	PF00069	0.540
TRG_DiLeu_BaEn_2	137	143	PF01217	0.473
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.781
TRG_ENDOCYTIC_2	159	162	PF00928	0.429
TRG_ENDOCYTIC_2	180	183	PF00928	0.420
TRG_ENDOCYTIC_2	2	5	PF00928	0.486
TRG_ENDOCYTIC_2	207	210	PF00928	0.629
TRG_ENDOCYTIC_2	286	289	PF00928	0.647
TRG_ENDOCYTIC_2	432	435	PF00928	0.749
TRG_ER_diArg_1	426	428	PF00400	0.791
TRG_ER_diArg_1	509	512	PF00400	0.754
TRG_ER_diArg_1	544	546	PF00400	0.761
TRG_NLS_Bipartite_1	427	445	PF00514	0.753
TRG_NLS_MonoExtC_3	509	514	PF00514	0.777
TRG_NLS_MonoExtN_4	509	515	PF00514	0.781
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B9	Leptomonas seymouri	54%	100%
A0A3R7NH33	Trypanosoma rangeli	24%	100%
A4HPF9	Leishmania braziliensis	78%	100%
A4ID81	Leishmania infantum	100%	100%
E9AT71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	97%
Q4Q1C6	Leishmania major	94%	100%
V5BKC4	Trypanosoma cruzi	23%	99%