Mitochondrial inner membrane protease ATP23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase M76 family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ83_LEIDO

TriTrypDb:

LdBPK_361770.1 , LdCL_360023200 , LDHU3_36.2330

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0019898	extrinsic component of membrane	2	1
GO:0031312	extrinsic component of organelle membrane	3	1
GO:0031314	extrinsic component of mitochondrial inner membrane	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJ83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ83

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016485	protein processing	5	1
GO:0022607	cellular component assembly	4	1
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	1
GO:0034982	mitochondrial protein processing	6	1
GO:0043461	proton-transporting ATP synthase complex assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0051604	protein maturation	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004222	metalloendopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.305
CLV_C14_Caspase3-7	297	301	PF00656	0.485
CLV_NRD_NRD_1	237	239	PF00675	0.315
CLV_NRD_NRD_1	254	256	PF00675	0.186
CLV_PCSK_KEX2_1	253	255	PF00082	0.325
CLV_PCSK_KEX2_1	31	33	PF00082	0.669
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.411
CLV_PCSK_SKI1_1	70	74	PF00082	0.439
DEG_SPOP_SBC_1	152	156	PF00917	0.384
DOC_MAPK_gen_1	250	260	PF00069	0.289
DOC_PP4_FxxP_1	288	291	PF00568	0.359
DOC_USP7_MATH_1	153	157	PF00917	0.400
DOC_USP7_MATH_1	161	165	PF00917	0.360
DOC_USP7_MATH_1	170	174	PF00917	0.269
DOC_USP7_MATH_1	208	212	PF00917	0.479
DOC_USP7_MATH_1	294	298	PF00917	0.472
DOC_WW_Pin1_4	148	153	PF00397	0.389
DOC_WW_Pin1_4	94	99	PF00397	0.391
LIG_14-3-3_CanoR_1	267	274	PF00244	0.293
LIG_14-3-3_CanoR_1	52	58	PF00244	0.393
LIG_BIR_III_4	204	208	PF00653	0.281
LIG_FHA_2	152	158	PF00498	0.391
LIG_LIR_Apic_2	286	291	PF02991	0.266
LIG_LIR_Nem_3	283	288	PF02991	0.266
LIG_MYND_3	184	188	PF01753	0.331
LIG_NRBOX	174	180	PF00104	0.414
LIG_PDZ_Class_2	305	310	PF00595	0.501
LIG_SH2_STAT3	59	62	PF00017	0.331
LIG_SH2_STAT5	49	52	PF00017	0.312
LIG_SH3_1	78	84	PF00018	0.411
LIG_SH3_3	78	84	PF00018	0.362
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.281
LIG_SUMO_SIM_par_1	118	124	PF11976	0.281
LIG_TRAF2_1	63	66	PF00917	0.281
MOD_CDK_SPxK_1	94	100	PF00069	0.411
MOD_CK1_1	13	19	PF00069	0.550
MOD_CK1_1	151	157	PF00069	0.432
MOD_CK1_1	164	170	PF00069	0.444
MOD_CK1_1	5	11	PF00069	0.599
MOD_CK1_1	89	95	PF00069	0.396
MOD_CK2_1	280	286	PF00069	0.266
MOD_CK2_1	60	66	PF00069	0.281
MOD_DYRK1A_RPxSP_1	148	152	PF00069	0.265
MOD_GlcNHglycan	108	111	PF01048	0.354
MOD_GlcNHglycan	12	15	PF01048	0.554
MOD_GlcNHglycan	227	230	PF01048	0.266
MOD_GlcNHglycan	91	94	PF01048	0.310
MOD_GSK3_1	148	155	PF00069	0.377
MOD_GSK3_1	161	168	PF00069	0.324
MOD_GSK3_1	2	9	PF00069	0.595
MOD_GSK3_1	294	301	PF00069	0.590
MOD_N-GLC_1	304	309	PF02516	0.600
MOD_NEK2_1	106	111	PF00069	0.287
MOD_NEK2_1	129	134	PF00069	0.331
MOD_NEK2_1	179	184	PF00069	0.482
MOD_NEK2_1	3	8	PF00069	0.596
MOD_NEK2_2	273	278	PF00069	0.331
MOD_NEK2_2	304	309	PF00069	0.600
MOD_NMyristoyl	1	7	PF02799	0.567
MOD_PIKK_1	168	174	PF00454	0.374
MOD_PIKK_1	179	185	PF00454	0.421
MOD_PIKK_1	298	304	PF00454	0.584
MOD_PKA_2	225	231	PF00069	0.266
MOD_Plk_4	273	279	PF00069	0.411
MOD_Plk_4	32	38	PF00069	0.538
MOD_ProDKin_1	148	154	PF00069	0.389
MOD_ProDKin_1	94	100	PF00069	0.391
MOD_SUMO_rev_2	26	33	PF00179	0.531
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.331
TRG_ENDOCYTIC_2	285	288	PF00928	0.266
TRG_ER_diArg_1	252	255	PF00400	0.320

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ07	Leptomonas seymouri	72%	100%
A0A0S4IYE0	Bodo saltans	39%	100%
A0A1X0P8Q9	Trypanosomatidae	50%	100%
A0A422MWT3	Trypanosoma rangeli	51%	100%
A4HP33	Leishmania braziliensis	83%	100%
A4IDE0	Leishmania infantum	100%	100%
D0A316	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ASU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q1Q5	Leishmania major	94%	100%
V5B4E2	Trypanosoma cruzi	52%	100%