Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ79_LEIDO

TriTrypDb:

LdBPK_353150.1 , LdCL_350036400 , LDHU3_35.4120

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2

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Expansion

Sequence features

A0A3Q8IJ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ79

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	2
GO:0003724	RNA helicase activity	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	893	897	PF00656	0.790
CLV_NRD_NRD_1	170	172	PF00675	0.776
CLV_NRD_NRD_1	214	216	PF00675	0.784
CLV_NRD_NRD_1	229	231	PF00675	0.728
CLV_NRD_NRD_1	256	258	PF00675	0.810
CLV_NRD_NRD_1	269	271	PF00675	0.666
CLV_NRD_NRD_1	304	306	PF00675	0.777
CLV_NRD_NRD_1	311	313	PF00675	0.769
CLV_NRD_NRD_1	333	335	PF00675	0.864
CLV_NRD_NRD_1	413	415	PF00675	0.793

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDN6	Bodo saltans	52%	100%
A0A3Q8IF94	Leishmania donovani	51%	100%
A4HMX7	Leishmania braziliensis	80%	95%
A4I7K4	Leishmania infantum	51%	100%
A4IBK1	Leishmania infantum	99%	100%
E9AFD4	Leishmania major	94%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B6I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5P5	Leishmania major	49%	100%

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