Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ79_LEIDO

TriTrypDb:

LdBPK_353150.1 , LdCL_350036400 , LDHU3_35.4120

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0034399	nuclear periphery	2	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097165	nuclear stress granule	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IJ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ79

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003724	RNA helicase activity	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	893	897	PF00656	0.790
CLV_NRD_NRD_1	170	172	PF00675	0.776
CLV_NRD_NRD_1	214	216	PF00675	0.784
CLV_NRD_NRD_1	229	231	PF00675	0.728
CLV_NRD_NRD_1	256	258	PF00675	0.810
CLV_NRD_NRD_1	269	271	PF00675	0.666
CLV_NRD_NRD_1	304	306	PF00675	0.777
CLV_NRD_NRD_1	311	313	PF00675	0.769
CLV_NRD_NRD_1	333	335	PF00675	0.864
CLV_NRD_NRD_1	413	415	PF00675	0.793
CLV_NRD_NRD_1	42	44	PF00675	0.777
CLV_NRD_NRD_1	422	424	PF00675	0.594
CLV_NRD_NRD_1	537	539	PF00675	0.415
CLV_NRD_NRD_1	561	563	PF00675	0.453
CLV_NRD_NRD_1	670	672	PF00675	0.561
CLV_NRD_NRD_1	732	734	PF00675	0.490
CLV_NRD_NRD_1	748	750	PF00675	0.333
CLV_NRD_NRD_1	823	825	PF00675	0.569
CLV_NRD_NRD_1	867	869	PF00675	0.785
CLV_NRD_NRD_1	907	909	PF00675	0.832
CLV_PCSK_FUR_1	309	313	PF00082	0.734
CLV_PCSK_FUR_1	40	44	PF00082	0.799
CLV_PCSK_KEX2_1	170	172	PF00082	0.776
CLV_PCSK_KEX2_1	214	216	PF00082	0.784
CLV_PCSK_KEX2_1	228	230	PF00082	0.743
CLV_PCSK_KEX2_1	256	258	PF00082	0.810
CLV_PCSK_KEX2_1	269	271	PF00082	0.666
CLV_PCSK_KEX2_1	304	306	PF00082	0.777
CLV_PCSK_KEX2_1	311	313	PF00082	0.769
CLV_PCSK_KEX2_1	333	335	PF00082	0.864
CLV_PCSK_KEX2_1	413	415	PF00082	0.793
CLV_PCSK_KEX2_1	42	44	PF00082	0.777
CLV_PCSK_KEX2_1	422	424	PF00082	0.594
CLV_PCSK_KEX2_1	666	668	PF00082	0.489
CLV_PCSK_KEX2_1	670	672	PF00082	0.486
CLV_PCSK_KEX2_1	732	734	PF00082	0.469
CLV_PCSK_KEX2_1	748	750	PF00082	0.361
CLV_PCSK_KEX2_1	823	825	PF00082	0.623
CLV_PCSK_KEX2_1	866	868	PF00082	0.772
CLV_PCSK_KEX2_1	907	909	PF00082	0.832
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.548
CLV_PCSK_SKI1_1	413	417	PF00082	0.712
CLV_PCSK_SKI1_1	459	463	PF00082	0.598
CLV_PCSK_SKI1_1	562	566	PF00082	0.475
CLV_PCSK_SKI1_1	598	602	PF00082	0.384
CLV_PCSK_SKI1_1	686	690	PF00082	0.600
CLV_PCSK_SKI1_1	824	828	PF00082	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.774
DEG_SPOP_SBC_1	681	685	PF00917	0.675
DOC_ANK_TNKS_1	879	886	PF00023	0.739
DOC_CYCLIN_RxL_1	609	620	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.554
DOC_MAPK_DCC_7	761	769	PF00069	0.642
DOC_MAPK_gen_1	438	446	PF00069	0.641
DOC_MAPK_gen_1	536	545	PF00069	0.615
DOC_MAPK_gen_1	670	678	PF00069	0.529
DOC_MAPK_gen_1	761	769	PF00069	0.637
DOC_MAPK_gen_1	820	829	PF00069	0.625
DOC_MAPK_MEF2A_6	493	500	PF00069	0.615
DOC_MAPK_MEF2A_6	538	547	PF00069	0.615
DOC_MAPK_MEF2A_6	820	829	PF00069	0.572
DOC_PP1_RVXF_1	560	567	PF00149	0.615
DOC_PP2B_LxvP_1	778	781	PF13499	0.653
DOC_PP4_FxxP_1	163	166	PF00568	0.771
DOC_PP4_FxxP_1	519	522	PF00568	0.615
DOC_PP4_FxxP_1	789	792	PF00568	0.615
DOC_USP7_MATH_1	107	111	PF00917	0.764
DOC_USP7_MATH_1	116	120	PF00917	0.716
DOC_USP7_MATH_1	356	360	PF00917	0.797
DOC_USP7_MATH_1	370	374	PF00917	0.672
DOC_USP7_MATH_1	385	389	PF00917	0.617
DOC_USP7_MATH_1	46	50	PF00917	0.791
DOC_WW_Pin1_4	102	107	PF00397	0.764
DOC_WW_Pin1_4	137	142	PF00397	0.721
DOC_WW_Pin1_4	357	362	PF00397	0.777
DOC_WW_Pin1_4	399	404	PF00397	0.779
DOC_WW_Pin1_4	486	491	PF00397	0.606
DOC_WW_Pin1_4	530	535	PF00397	0.617
DOC_WW_Pin1_4	762	767	PF00397	0.615
LIG_14-3-3_CanoR_1	536	542	PF00244	0.621
LIG_14-3-3_CanoR_1	562	567	PF00244	0.725
LIG_14-3-3_CanoR_1	638	645	PF00244	0.612
LIG_14-3-3_CanoR_1	648	652	PF00244	0.609
LIG_14-3-3_CanoR_1	680	688	PF00244	0.674
LIG_APCC_ABBA_1	555	560	PF00400	0.653
LIG_APCC_ABBA_1	717	722	PF00400	0.653
LIG_BRCT_BRCA1_1	653	657	PF00533	0.653
LIG_Clathr_ClatBox_1	718	722	PF01394	0.653
LIG_CtBP_PxDLS_1	453	457	PF00389	0.614
LIG_EH1_1	710	718	PF00400	0.615
LIG_FHA_1	548	554	PF00498	0.653
LIG_FHA_1	683	689	PF00498	0.631
LIG_FHA_1	763	769	PF00498	0.606
LIG_FHA_1	797	803	PF00498	0.615
LIG_FHA_2	25	31	PF00498	0.784
LIG_FHA_2	286	292	PF00498	0.748
LIG_FHA_2	642	648	PF00498	0.621
LIG_FHA_2	92	98	PF00498	0.795
LIG_LIR_Apic_2	160	166	PF02991	0.782
LIG_LIR_Apic_2	318	324	PF02991	0.869
LIG_LIR_Apic_2	516	522	PF02991	0.653
LIG_LIR_Gen_1	447	457	PF02991	0.682
LIG_LIR_Gen_1	465	475	PF02991	0.721
LIG_LIR_Gen_1	569	576	PF02991	0.618
LIG_LIR_Gen_1	603	613	PF02991	0.708
LIG_LIR_Gen_1	637	645	PF02991	0.615
LIG_LIR_Nem_3	297	303	PF02991	0.730
LIG_LIR_Nem_3	335	339	PF02991	0.782
LIG_LIR_Nem_3	447	452	PF02991	0.723
LIG_LIR_Nem_3	465	470	PF02991	0.568
LIG_LIR_Nem_3	568	574	PF02991	0.628
LIG_LIR_Nem_3	603	608	PF02991	0.710
LIG_Pex14_2	653	657	PF04695	0.615
LIG_PTAP_UEV_1	898	903	PF05743	0.782
LIG_PTB_Apo_2	599	606	PF02174	0.615
LIG_PTB_Phospho_1	599	605	PF10480	0.615
LIG_SH2_CRK	321	325	PF00017	0.877
LIG_SH2_CRK	449	453	PF00017	0.640
LIG_SH2_CRK	485	489	PF00017	0.669
LIG_SH2_CRK	494	498	PF00017	0.617
LIG_SH2_CRK	526	530	PF00017	0.615
LIG_SH2_CRK	572	576	PF00017	0.615
LIG_SH2_GRB2like	3	6	PF00017	0.728
LIG_SH2_NCK_1	449	453	PF00017	0.640
LIG_SH2_NCK_1	572	576	PF00017	0.615
LIG_SH2_SRC	232	235	PF00017	0.717
LIG_SH2_SRC	295	298	PF00017	0.743
LIG_SH2_STAP1	242	246	PF00017	0.750
LIG_SH2_STAP1	572	576	PF00017	0.615
LIG_SH2_STAP1	798	802	PF00017	0.615
LIG_SH2_STAT5	3	6	PF00017	0.769
LIG_SH2_STAT5	605	608	PF00017	0.653
LIG_SH2_STAT5	639	642	PF00017	0.637
LIG_SH2_STAT5	668	671	PF00017	0.526
LIG_SH2_STAT5	674	677	PF00017	0.520
LIG_SH2_STAT5	798	801	PF00017	0.653
LIG_SH2_STAT5	832	835	PF00017	0.581
LIG_SH3_3	143	149	PF00018	0.735
LIG_SH3_3	171	177	PF00018	0.687
LIG_SH3_3	387	393	PF00018	0.682
LIG_SH3_3	397	403	PF00018	0.843
LIG_SH3_3	543	549	PF00018	0.675
LIG_SH3_3	588	594	PF00018	0.653
LIG_SH3_3	896	902	PF00018	0.785
LIG_Sin3_3	468	475	PF02671	0.567
LIG_SUMO_SIM_par_1	496	501	PF11976	0.585
LIG_SUMO_SIM_par_1	765	772	PF11976	0.577
LIG_TRAF2_1	219	222	PF00917	0.771
LIG_TRAF2_1	369	372	PF00917	0.760
LIG_TYR_ITIM	524	529	PF00017	0.615
LIG_TYR_ITIM	570	575	PF00017	0.615
LIG_UBA3_1	661	666	PF00899	0.517
LIG_WRC_WIRS_1	25	30	PF05994	0.782
LIG_WRC_WIRS_1	336	341	PF05994	0.781
LIG_WRC_WIRS_1	605	610	PF05994	0.615
MOD_CDC14_SPxK_1	533	536	PF00782	0.620
MOD_CDK_SPxK_1	530	536	PF00069	0.620
MOD_CDK_SPxxK_3	486	493	PF00069	0.518
MOD_CK1_1	119	125	PF00069	0.737
MOD_CK1_1	513	519	PF00069	0.653
MOD_CK1_1	54	60	PF00069	0.758
MOD_CK1_1	637	643	PF00069	0.615
MOD_CK1_1	740	746	PF00069	0.615
MOD_CK1_1	897	903	PF00069	0.782
MOD_CK2_1	144	150	PF00069	0.735
MOD_CK2_1	285	291	PF00069	0.752
MOD_CK2_1	641	647	PF00069	0.575
MOD_CK2_1	7	13	PF00069	0.822
MOD_CK2_1	91	97	PF00069	0.796
MOD_Cter_Amidation	212	215	PF01082	0.770
MOD_Cter_Amidation	267	270	PF01082	0.764
MOD_Cter_Amidation	331	334	PF01082	0.784
MOD_Cter_Amidation	40	43	PF01082	0.799
MOD_Cter_Amidation	864	867	PF01082	0.757
MOD_Cter_Amidation	905	908	PF01082	0.806
MOD_GlcNHglycan	109	112	PF01048	0.638
MOD_GlcNHglycan	128	131	PF01048	0.725
MOD_GlcNHglycan	142	145	PF01048	0.635
MOD_GlcNHglycan	146	149	PF01048	0.737
MOD_GlcNHglycan	195	198	PF01048	0.755
MOD_GlcNHglycan	247	250	PF01048	0.758
MOD_GlcNHglycan	347	351	PF01048	0.786
MOD_GlcNHglycan	372	375	PF01048	0.767
MOD_GlcNHglycan	387	390	PF01048	0.699
MOD_GlcNHglycan	409	412	PF01048	0.772
MOD_GlcNHglycan	500	503	PF01048	0.426
MOD_GlcNHglycan	512	515	PF01048	0.400
MOD_GlcNHglycan	55	59	PF01048	0.802
MOD_GlcNHglycan	608	611	PF01048	0.507
MOD_GlcNHglycan	653	656	PF01048	0.427
MOD_GlcNHglycan	880	883	PF01048	0.798
MOD_GlcNHglycan	899	902	PF01048	0.883
MOD_GSK3_1	116	123	PF00069	0.727
MOD_GSK3_1	140	147	PF00069	0.739
MOD_GSK3_1	172	179	PF00069	0.667
MOD_GSK3_1	357	364	PF00069	0.769
MOD_GSK3_1	637	644	PF00069	0.675
MOD_GSK3_1	647	654	PF00069	0.635
MOD_GSK3_1	682	689	PF00069	0.667
MOD_GSK3_1	768	775	PF00069	0.653
MOD_GSK3_1	890	897	PF00069	0.792
MOD_GSK3_1	91	98	PF00069	0.783
MOD_N-GLC_1	102	107	PF02516	0.746
MOD_N-GLC_1	119	124	PF02516	0.627
MOD_N-GLC_1	686	691	PF02516	0.653
MOD_NEK2_1	346	351	PF00069	0.763
MOD_NEK2_1	606	611	PF00069	0.615
MOD_NEK2_1	634	639	PF00069	0.620
MOD_NEK2_1	651	656	PF00069	0.716
MOD_NEK2_1	720	725	PF00069	0.586
MOD_PIKK_1	405	411	PF00454	0.738
MOD_PIKK_1	686	692	PF00454	0.647
MOD_PKA_1	413	419	PF00069	0.710
MOD_PKA_1	562	568	PF00069	0.725
MOD_PKA_1	7	13	PF00069	0.778
MOD_PKA_2	413	419	PF00069	0.710
MOD_PKA_2	439	445	PF00069	0.699
MOD_PKA_2	537	543	PF00069	0.615
MOD_PKA_2	637	643	PF00069	0.675
MOD_PKA_2	647	653	PF00069	0.635
MOD_PKA_2	86	92	PF00069	0.783
MOD_PKA_2	897	903	PF00069	0.782
MOD_PKA_2	95	101	PF00069	0.703
MOD_Plk_2-3	24	30	PF00069	0.784
MOD_Plk_2-3	641	647	PF00069	0.615
MOD_Plk_4	647	653	PF00069	0.653
MOD_ProDKin_1	102	108	PF00069	0.765
MOD_ProDKin_1	137	143	PF00069	0.720
MOD_ProDKin_1	357	363	PF00069	0.771
MOD_ProDKin_1	399	405	PF00069	0.779
MOD_ProDKin_1	486	492	PF00069	0.514
MOD_ProDKin_1	530	536	PF00069	0.617
MOD_ProDKin_1	762	768	PF00069	0.615
MOD_SUMO_rev_2	2	10	PF00179	0.773
MOD_SUMO_rev_2	427	432	PF00179	0.622
MOD_SUMO_rev_2	455	464	PF00179	0.585
TRG_DiLeu_BaEn_1	586	591	PF01217	0.615
TRG_DiLeu_BaEn_1	852	857	PF01217	0.629
TRG_DiLeu_BaEn_2	646	652	PF01217	0.548
TRG_DiLeu_BaLyEn_6	700	705	PF01217	0.615
TRG_ENDOCYTIC_2	449	452	PF00928	0.696
TRG_ENDOCYTIC_2	526	529	PF00928	0.615
TRG_ENDOCYTIC_2	572	575	PF00928	0.615
TRG_ENDOCYTIC_2	605	608	PF00928	0.649
TRG_ENDOCYTIC_2	639	642	PF00928	0.662
TRG_ENDOCYTIC_2	673	676	PF00928	0.506
TRG_ER_diArg_1	214	216	PF00400	0.765
TRG_ER_diArg_1	227	230	PF00400	0.674
TRG_ER_diArg_1	255	257	PF00400	0.772
TRG_ER_diArg_1	269	271	PF00400	0.618
TRG_ER_diArg_1	303	305	PF00400	0.800
TRG_ER_diArg_1	310	312	PF00400	0.730
TRG_ER_diArg_1	324	327	PF00400	0.820
TRG_ER_diArg_1	40	43	PF00400	0.799
TRG_ER_diArg_1	412	414	PF00400	0.798
TRG_ER_diArg_1	421	423	PF00400	0.630
TRG_ER_diArg_1	669	671	PF00400	0.529
TRG_ER_diArg_1	732	734	PF00400	0.615
TRG_ER_diArg_1	823	825	PF00400	0.569
TRG_ER_diArg_1	866	868	PF00400	0.808
TRG_Pf-PMV_PEXEL_1	551	556	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	732	737	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	823	828	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JDN6	Bodo saltans	52%	100%
A0A3Q8IF94	Leishmania donovani	51%	100%
A4HMX7	Leishmania braziliensis	80%	95%
A4I7K4	Leishmania infantum	51%	100%
A4IBK1	Leishmania infantum	99%	100%
E9AFD4	Leishmania major	94%	100%
E9B2G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B6I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5P5	Leishmania major	49%	100%