Dynein regulatory complex protein 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ71_LEIDO

TriTrypDb:

LdBPK_161490.1 , LdCL_160019900 , LDHU3_16.1770

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005856	cytoskeleton	5	10
GO:0005929	cilium	4	10
GO:0031514	motile cilium	5	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A0A3Q8IJ71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ71

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.524
CLV_NRD_NRD_1	366	368	PF00675	0.538
CLV_NRD_NRD_1	377	379	PF00675	0.537
CLV_NRD_NRD_1	386	388	PF00675	0.486
CLV_NRD_NRD_1	511	513	PF00675	0.612
CLV_NRD_NRD_1	57	59	PF00675	0.584
CLV_NRD_NRD_1	64	66	PF00675	0.575
CLV_PCSK_FUR_1	406	410	PF00082	0.539
CLV_PCSK_KEX2_1	366	368	PF00082	0.540
CLV_PCSK_KEX2_1	386	388	PF00082	0.381
CLV_PCSK_KEX2_1	408	410	PF00082	0.539
CLV_PCSK_KEX2_1	513	515	PF00082	0.622
CLV_PCSK_KEX2_1	57	59	PF00082	0.668
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.539
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.622
CLV_PCSK_SKI1_1	140	144	PF00082	0.520
CLV_PCSK_SKI1_1	177	181	PF00082	0.423
DEG_Nend_UBRbox_2	1	3	PF02207	0.544
DEG_SCF_FBW7_2	130	135	PF00400	0.523
DEG_SPOP_SBC_1	122	126	PF00917	0.609
DOC_MAPK_gen_1	265	273	PF00069	0.375
DOC_MAPK_MEF2A_6	265	273	PF00069	0.490
DOC_USP7_MATH_1	122	126	PF00917	0.604
DOC_USP7_MATH_1	238	242	PF00917	0.712
DOC_USP7_MATH_1	244	248	PF00917	0.654
DOC_USP7_MATH_1	354	358	PF00917	0.437
DOC_USP7_MATH_1	411	415	PF00917	0.437
DOC_USP7_MATH_1	90	94	PF00917	0.693
DOC_USP7_MATH_2	32	38	PF00917	0.569
DOC_USP7_UBL2_3	218	222	PF12436	0.554
DOC_USP7_UBL2_3	509	513	PF12436	0.618
DOC_USP7_UBL2_3	517	521	PF12436	0.636
DOC_WW_Pin1_4	128	133	PF00397	0.558
DOC_WW_Pin1_4	77	82	PF00397	0.600
LIG_14-3-3_CanoR_1	280	286	PF00244	0.458
LIG_14-3-3_CanoR_1	366	371	PF00244	0.481
LIG_14-3-3_CanoR_1	500	507	PF00244	0.645
LIG_14-3-3_CanoR_1	87	95	PF00244	0.539
LIG_14-3-3_CanoR_1	99	107	PF00244	0.551
LIG_CaM_IQ_9	487	502	PF13499	0.411
LIG_FHA_1	199	205	PF00498	0.516
LIG_FHA_1	304	310	PF00498	0.535
LIG_FHA_1	345	351	PF00498	0.385
LIG_FHA_1	440	446	PF00498	0.435
LIG_FHA_1	78	84	PF00498	0.727
LIG_FHA_2	156	162	PF00498	0.477
LIG_FHA_2	205	211	PF00498	0.407
LIG_FHA_2	282	288	PF00498	0.441
LIG_FHA_2	359	365	PF00498	0.460
LIG_FHA_2	405	411	PF00498	0.530
LIG_FHA_2	416	422	PF00498	0.439
LIG_FHA_2	46	52	PF00498	0.555
LIG_FHA_2	5	11	PF00498	0.591
LIG_FHA_2	501	507	PF00498	0.519
LIG_LIR_Gen_1	170	180	PF02991	0.396
LIG_LIR_Gen_1	353	362	PF02991	0.492
LIG_LIR_Gen_1	461	469	PF02991	0.463
LIG_LIR_Nem_3	152	157	PF02991	0.576
LIG_LIR_Nem_3	170	175	PF02991	0.345
LIG_LIR_Nem_3	210	216	PF02991	0.502
LIG_PTB_Apo_2	310	317	PF02174	0.523
LIG_PTB_Phospho_1	310	316	PF10480	0.526
LIG_SH2_CRK	292	296	PF00017	0.423
LIG_SH2_SRC	316	319	PF00017	0.380
LIG_SH2_SRC	59	62	PF00017	0.527
LIG_SH2_STAP1	225	229	PF00017	0.650
LIG_SH2_STAP1	59	63	PF00017	0.520
LIG_SH2_STAT3	420	423	PF00017	0.389
LIG_SH2_STAT5	225	228	PF00017	0.525
LIG_SH2_STAT5	316	319	PF00017	0.524
LIG_SH2_STAT5	343	346	PF00017	0.383
LIG_SH2_STAT5	55	58	PF00017	0.594
LIG_SUMO_SIM_par_1	439	450	PF11976	0.447
LIG_TRAF2_1	336	339	PF00917	0.452
LIG_TRAF2_1	357	360	PF00917	0.459
LIG_TRAF2_1	361	364	PF00917	0.420
LIG_TRAF2_1	447	450	PF00917	0.536
LIG_TRAF2_1	7	10	PF00917	0.512
MOD_CK1_1	124	130	PF00069	0.704
MOD_CK1_1	227	233	PF00069	0.630
MOD_CK1_1	404	410	PF00069	0.538
MOD_CK1_1	89	95	PF00069	0.699
MOD_CK1_1	97	103	PF00069	0.673
MOD_CK2_1	281	287	PF00069	0.468
MOD_CK2_1	354	360	PF00069	0.569
MOD_CK2_1	4	10	PF00069	0.606
MOD_CK2_1	404	410	PF00069	0.555
MOD_CK2_1	500	506	PF00069	0.570
MOD_GlcNHglycan	413	416	PF01048	0.394
MOD_GlcNHglycan	423	426	PF01048	0.386
MOD_GlcNHglycan	88	91	PF01048	0.658
MOD_GlcNHglycan	96	99	PF01048	0.560
MOD_GSK3_1	103	110	PF00069	0.645
MOD_GSK3_1	121	128	PF00069	0.591
MOD_GSK3_1	223	230	PF00069	0.527
MOD_GSK3_1	238	245	PF00069	0.757
MOD_GSK3_1	354	361	PF00069	0.547
MOD_GSK3_1	411	418	PF00069	0.455
MOD_GSK3_1	45	52	PF00069	0.542
MOD_GSK3_1	86	93	PF00069	0.703
MOD_GSK3_1	94	101	PF00069	0.669
MOD_N-GLC_1	280	285	PF02516	0.460
MOD_N-GLC_1	404	409	PF02516	0.473
MOD_NEK2_1	204	209	PF00069	0.484
MOD_NEK2_1	224	229	PF00069	0.359
MOD_NEK2_1	269	274	PF00069	0.514
MOD_NEK2_1	358	363	PF00069	0.537
MOD_NEK2_1	49	54	PF00069	0.545
MOD_NEK2_1	86	91	PF00069	0.713
MOD_PIKK_1	232	238	PF00454	0.675
MOD_PIKK_1	248	254	PF00454	0.618
MOD_PIKK_1	500	506	PF00454	0.498
MOD_PK_1	40	46	PF00069	0.551
MOD_PKA_1	366	372	PF00069	0.458
MOD_PKA_2	366	372	PF00069	0.482
MOD_PKA_2	49	55	PF00069	0.654
MOD_PKA_2	64	70	PF00069	0.398
MOD_PKA_2	86	92	PF00069	0.592
MOD_PKA_2	93	99	PF00069	0.525
MOD_PKB_1	278	286	PF00069	0.512
MOD_Plk_1	280	286	PF00069	0.458
MOD_Plk_1	33	39	PF00069	0.579
MOD_Plk_1	40	46	PF00069	0.627
MOD_Plk_4	34	40	PF00069	0.587
MOD_ProDKin_1	128	134	PF00069	0.549
MOD_ProDKin_1	77	83	PF00069	0.602
MOD_SUMO_for_1	12	15	PF00179	0.471
TRG_DiLeu_BaEn_4	23	29	PF01217	0.548
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.549
TRG_ENDOCYTIC_2	154	157	PF00928	0.480
TRG_ENDOCYTIC_2	172	175	PF00928	0.283
TRG_ENDOCYTIC_2	213	216	PF00928	0.433
TRG_ENDOCYTIC_2	292	295	PF00928	0.424
TRG_ENDOCYTIC_2	316	319	PF00928	0.423
TRG_ENDOCYTIC_2	494	497	PF00928	0.544
TRG_ER_diArg_1	277	280	PF00400	0.506
TRG_ER_diArg_1	386	388	PF00400	0.472
TRG_ER_diArg_1	56	58	PF00400	0.485
TRG_NLS_MonoCore_2	511	516	PF00514	0.570
TRG_NLS_MonoExtC_3	511	516	PF00514	0.608
TRG_NLS_MonoExtN_4	509	516	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I290	Leptomonas seymouri	56%	94%
A0A1X0NYT0	Trypanosomatidae	32%	100%
A0A3R7M3F0	Trypanosoma rangeli	38%	100%
A4HX37	Leishmania infantum	100%	100%
C9ZVV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QEM5	Leishmania major	94%	100%
V5DJ53	Trypanosoma cruzi	35%	100%