LeishMANIAdb
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Nitrate reductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nitrate reductase, putative
Gene product:
nitrate reductase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IJ69_LEIDO
TriTrypDb:
LdBPK_300630.1 , LdCL_300011400 , LDHU3_30.0810
Length:
537

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ69
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ69

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 10
GO:0008940 nitrate reductase activity 4 8
GO:0009703 nitrate reductase (NADH) activity 6 8
GO:0016491 oxidoreductase activity 2 11
GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3 8
GO:0020037 heme binding 4 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor 4 8
GO:0046872 metal ion binding 4 10
GO:0046906 tetrapyrrole binding 3 10
GO:0050463 nitrate reductase [NAD(P)H] activity 5 8
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H 5 1
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 1
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.402
CLV_C14_Caspase3-7 514 518 PF00656 0.389
CLV_NRD_NRD_1 127 129 PF00675 0.383
CLV_NRD_NRD_1 147 149 PF00675 0.169
CLV_NRD_NRD_1 260 262 PF00675 0.514
CLV_NRD_NRD_1 443 445 PF00675 0.347
CLV_PCSK_KEX2_1 127 129 PF00082 0.383
CLV_PCSK_KEX2_1 259 261 PF00082 0.598
CLV_PCSK_KEX2_1 443 445 PF00082 0.440
CLV_PCSK_SKI1_1 123 127 PF00082 0.482
CLV_PCSK_SKI1_1 132 136 PF00082 0.397
CLV_PCSK_SKI1_1 196 200 PF00082 0.346
CLV_PCSK_SKI1_1 244 248 PF00082 0.334
CLV_PCSK_SKI1_1 302 306 PF00082 0.408
CLV_PCSK_SKI1_1 461 465 PF00082 0.393
CLV_PCSK_SKI1_1 82 86 PF00082 0.562
DEG_SCF_FBW7_1 50 56 PF00400 0.699
DEG_SPOP_SBC_1 6 10 PF00917 0.578
DOC_CKS1_1 333 338 PF01111 0.442
DOC_CKS1_1 430 435 PF01111 0.441
DOC_CKS1_1 50 55 PF01111 0.699
DOC_MAPK_gen_1 212 221 PF00069 0.464
DOC_MAPK_MEF2A_6 457 466 PF00069 0.449
DOC_PP2B_LxvP_1 72 75 PF13499 0.767
DOC_PP4_FxxP_1 306 309 PF00568 0.389
DOC_PP4_FxxP_1 333 336 PF00568 0.445
DOC_PP4_FxxP_1 371 374 PF00568 0.474
DOC_USP7_UBL2_3 243 247 PF12436 0.346
DOC_WW_Pin1_4 161 166 PF00397 0.692
DOC_WW_Pin1_4 168 173 PF00397 0.745
DOC_WW_Pin1_4 206 211 PF00397 0.383
DOC_WW_Pin1_4 259 264 PF00397 0.581
DOC_WW_Pin1_4 332 337 PF00397 0.326
DOC_WW_Pin1_4 429 434 PF00397 0.441
DOC_WW_Pin1_4 46 51 PF00397 0.817
DOC_WW_Pin1_4 467 472 PF00397 0.454
LIG_14-3-3_CanoR_1 294 304 PF00244 0.409
LIG_14-3-3_CanoR_1 448 455 PF00244 0.369
LIG_14-3-3_CanoR_1 490 496 PF00244 0.463
LIG_14-3-3_CanoR_1 7 13 PF00244 0.779
LIG_14-3-3_CanoR_1 82 88 PF00244 0.582
LIG_APCC_ABBA_1 199 204 PF00400 0.424
LIG_BRCT_BRCA1_1 356 360 PF00533 0.383
LIG_BRCT_BRCA1_1 422 426 PF00533 0.266
LIG_FHA_1 111 117 PF00498 0.344
LIG_FHA_1 171 177 PF00498 0.738
LIG_FHA_1 185 191 PF00498 0.323
LIG_FHA_1 285 291 PF00498 0.490
LIG_FHA_1 296 302 PF00498 0.382
LIG_FHA_1 402 408 PF00498 0.404
LIG_FHA_1 457 463 PF00498 0.406
LIG_FHA_1 99 105 PF00498 0.447
LIG_FHA_2 430 436 PF00498 0.480
LIG_FHA_2 512 518 PF00498 0.402
LIG_FHA_2 53 59 PF00498 0.723
LIG_FHA_2 84 90 PF00498 0.400
LIG_Integrin_isoDGR_2 226 228 PF01839 0.480
LIG_Integrin_isoDGR_2 353 355 PF01839 0.402
LIG_LIR_Apic_2 305 309 PF02991 0.393
LIG_LIR_Apic_2 330 336 PF02991 0.414
LIG_LIR_Apic_2 368 374 PF02991 0.355
LIG_LIR_Gen_1 232 242 PF02991 0.378
LIG_LIR_Nem_3 232 237 PF02991 0.335
LIG_LIR_Nem_3 300 306 PF02991 0.493
LIG_LIR_Nem_3 331 337 PF02991 0.383
LIG_LIR_Nem_3 357 363 PF02991 0.391
LIG_MLH1_MIPbox_1 356 360 PF16413 0.383
LIG_OCRL_FandH_1 233 245 PF00620 0.363
LIG_Pex14_2 333 337 PF04695 0.480
LIG_REV1ctd_RIR_1 358 368 PF16727 0.383
LIG_SH2_CRK 323 327 PF00017 0.431
LIG_SH2_GRB2like 323 326 PF00017 0.480
LIG_SH2_STAP1 449 453 PF00017 0.480
LIG_SH2_STAT5 250 253 PF00017 0.361
LIG_SH2_STAT5 303 306 PF00017 0.487
LIG_SH2_STAT5 334 337 PF00017 0.365
LIG_SH2_STAT5 359 362 PF00017 0.408
LIG_SH3_1 260 266 PF00018 0.439
LIG_SH3_3 251 257 PF00018 0.422
LIG_SH3_3 260 266 PF00018 0.589
LIG_SH3_3 276 282 PF00018 0.562
LIG_SH3_3 371 377 PF00018 0.335
LIG_SH3_3 427 433 PF00018 0.441
LIG_SH3_3 47 53 PF00018 0.781
LIG_SH3_3 506 512 PF00018 0.448
LIG_SUMO_SIM_anti_2 101 107 PF11976 0.381
LIG_SUMO_SIM_par_1 101 107 PF11976 0.480
LIG_SUMO_SIM_par_1 197 204 PF11976 0.363
LIG_SUMO_SIM_par_1 461 467 PF11976 0.468
LIG_TRAF2_1 14 17 PF00917 0.816
LIG_TRAF2_1 167 170 PF00917 0.759
LIG_TRAF2_1 391 394 PF00917 0.514
LIG_TRAF2_1 65 68 PF00917 0.786
LIG_TRFH_1 249 253 PF08558 0.480
LIG_WRC_WIRS_1 112 117 PF05994 0.408
LIG_WRC_WIRS_1 303 308 PF05994 0.480
MOD_CDC14_SPxK_1 262 265 PF00782 0.562
MOD_CDK_SPxK_1 206 212 PF00069 0.429
MOD_CDK_SPxK_1 259 265 PF00069 0.598
MOD_CDK_SPxK_1 332 338 PF00069 0.421
MOD_CK1_1 140 146 PF00069 0.487
MOD_CK1_1 160 166 PF00069 0.429
MOD_CK1_1 297 303 PF00069 0.493
MOD_CK1_1 411 417 PF00069 0.479
MOD_CK1_1 422 428 PF00069 0.458
MOD_CK1_1 429 435 PF00069 0.400
MOD_CK1_1 467 473 PF00069 0.493
MOD_CK1_1 480 486 PF00069 0.249
MOD_CK1_1 8 14 PF00069 0.599
MOD_CK2_1 52 58 PF00069 0.787
MOD_CK2_1 62 68 PF00069 0.772
MOD_CK2_1 83 89 PF00069 0.533
MOD_GlcNHglycan 10 13 PF01048 0.755
MOD_GlcNHglycan 123 126 PF01048 0.459
MOD_GlcNHglycan 142 145 PF01048 0.480
MOD_GlcNHglycan 273 276 PF01048 0.680
MOD_GlcNHglycan 356 359 PF01048 0.490
MOD_GlcNHglycan 64 67 PF01048 0.746
MOD_GSK3_1 111 118 PF00069 0.375
MOD_GSK3_1 157 164 PF00069 0.518
MOD_GSK3_1 184 191 PF00069 0.564
MOD_GSK3_1 22 29 PF00069 0.725
MOD_GSK3_1 328 335 PF00069 0.385
MOD_GSK3_1 336 343 PF00069 0.318
MOD_GSK3_1 416 423 PF00069 0.419
MOD_GSK3_1 44 51 PF00069 0.785
MOD_GSK3_1 472 479 PF00069 0.449
MOD_GSK3_1 492 499 PF00069 0.430
MOD_LATS_1 319 325 PF00433 0.434
MOD_LATS_1 5 11 PF00433 0.679
MOD_N-GLC_1 295 300 PF02516 0.519
MOD_NEK2_1 115 120 PF00069 0.342
MOD_NEK2_1 304 309 PF00069 0.434
MOD_NEK2_1 33 38 PF00069 0.646
MOD_NEK2_1 426 431 PF00069 0.335
MOD_NEK2_1 44 49 PF00069 0.667
MOD_NEK2_1 464 469 PF00069 0.411
MOD_NEK2_2 137 142 PF00069 0.480
MOD_PIKK_1 281 287 PF00454 0.493
MOD_PIKK_1 416 422 PF00454 0.480
MOD_PIKK_1 529 535 PF00454 0.504
MOD_PKA_2 354 360 PF00069 0.430
MOD_PKA_2 447 453 PF00069 0.448
MOD_PKA_2 489 495 PF00069 0.463
MOD_PKA_2 6 12 PF00069 0.778
MOD_Plk_1 110 116 PF00069 0.337
MOD_Plk_1 328 334 PF00069 0.396
MOD_Plk_1 472 478 PF00069 0.480
MOD_Plk_4 111 117 PF00069 0.471
MOD_Plk_4 217 223 PF00069 0.481
MOD_Plk_4 230 236 PF00069 0.402
MOD_Plk_4 422 428 PF00069 0.335
MOD_ProDKin_1 161 167 PF00069 0.696
MOD_ProDKin_1 168 174 PF00069 0.744
MOD_ProDKin_1 206 212 PF00069 0.383
MOD_ProDKin_1 259 265 PF00069 0.575
MOD_ProDKin_1 332 338 PF00069 0.326
MOD_ProDKin_1 429 435 PF00069 0.441
MOD_ProDKin_1 46 52 PF00069 0.815
MOD_ProDKin_1 467 473 PF00069 0.454
TRG_DiLeu_BaEn_1 89 94 PF01217 0.480
TRG_DiLeu_BaEn_4 67 73 PF01217 0.668
TRG_ENDOCYTIC_2 303 306 PF00928 0.487
TRG_ENDOCYTIC_2 323 326 PF00928 0.150
TRG_ENDOCYTIC_2 334 337 PF00928 0.227
TRG_ER_diArg_1 126 128 PF00400 0.383
TRG_ER_diArg_1 179 182 PF00400 0.574
TRG_ER_diArg_1 259 261 PF00400 0.637
TRG_ER_diArg_1 442 444 PF00400 0.391
TRG_Pf-PMV_PEXEL_1 148 152 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.518
TRG_Pf-PMV_PEXEL_1 288 293 PF00026 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZN6 Leptomonas seymouri 44% 85%
A0A1X0P389 Trypanosomatidae 34% 100%
A0A422NIH2 Trypanosoma rangeli 33% 100%
A4HI12 Leishmania braziliensis 71% 100%
A4I589 Leishmania infantum 99% 100%
C9ZQM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9B0I6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q7P5 Leishmania major 89% 100%
V5B7R2 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS