Branchpoint-bridging protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

branch point binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ64_LEIDO

TriTrypDb:

LdBPK_365660.1 , LdCL_360064000 , LDHU3_36.7530

Length:

289

Annotations

Annotations by Jardim et al.

Ribosomal Protein, branch point binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	12
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Phosphorylation

Promastigote: 273

Expansion

Sequence features

A0A3Q8IJ64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ64

Function

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Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0036002	pre-mRNA binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0045131	pre-mRNA branch point binding	6	12
GO:0046872	metal ion binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.547
CLV_NRD_NRD_1	218	220	PF00675	0.519
CLV_NRD_NRD_1	238	240	PF00675	0.637
CLV_NRD_NRD_1	265	267	PF00675	0.874
CLV_PCSK_KEX2_1	118	120	PF00082	0.527
CLV_PCSK_KEX2_1	217	219	PF00082	0.518
CLV_PCSK_KEX2_1	238	240	PF00082	0.637
CLV_PCSK_KEX2_1	267	269	PF00082	0.751
CLV_PCSK_KEX2_1	87	89	PF00082	0.511
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.637

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAH9	Leptomonas seymouri	82%	100%
A0A0S4JQ68	Bodo saltans	44%	99%
A0A1X0P0K4	Trypanosomatidae	54%	100%
A0A3R7MP14	Trypanosoma rangeli	53%	100%
A4HQ57	Leishmania braziliensis	93%	98%
A4IDV6	Leishmania infantum	100%	100%
D0A460	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ATX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q0L9	Leishmania major	99%	100%
V5B558	Trypanosoma cruzi	54%	95%

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