Putative RanGDP binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted RanGDP binding protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ60_LEIDO

TriTrypDb:

LdBPK_361470.1 , LdCL_360020200 , LDHU3_36.1880

Length:

872

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ60

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.717
CLV_C14_Caspase3-7	516	520	PF00656	0.592
CLV_NRD_NRD_1	195	197	PF00675	0.546
CLV_NRD_NRD_1	227	229	PF00675	0.514
CLV_NRD_NRD_1	29	31	PF00675	0.702
CLV_NRD_NRD_1	355	357	PF00675	0.598
CLV_NRD_NRD_1	505	507	PF00675	0.532
CLV_NRD_NRD_1	577	579	PF00675	0.616
CLV_NRD_NRD_1	592	594	PF00675	0.446
CLV_NRD_NRD_1	622	624	PF00675	0.601
CLV_NRD_NRD_1	796	798	PF00675	0.471
CLV_PCSK_FUR_1	196	200	PF00082	0.585
CLV_PCSK_FUR_1	353	357	PF00082	0.464
CLV_PCSK_FUR_1	394	398	PF00082	0.566
CLV_PCSK_KEX2_1	195	197	PF00082	0.546
CLV_PCSK_KEX2_1	198	200	PF00082	0.578
CLV_PCSK_KEX2_1	29	31	PF00082	0.702
CLV_PCSK_KEX2_1	355	357	PF00082	0.634
CLV_PCSK_KEX2_1	396	398	PF00082	0.684
CLV_PCSK_KEX2_1	505	507	PF00082	0.532
CLV_PCSK_KEX2_1	592	594	PF00082	0.627
CLV_PCSK_KEX2_1	622	624	PF00082	0.544
CLV_PCSK_KEX2_1	795	797	PF00082	0.447
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.597
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.684
CLV_PCSK_SKI1_1	239	243	PF00082	0.660
CLV_PCSK_SKI1_1	314	318	PF00082	0.636
CLV_PCSK_SKI1_1	506	510	PF00082	0.616
CLV_PCSK_SKI1_1	578	582	PF00082	0.614
CLV_PCSK_SKI1_1	714	718	PF00082	0.537
DEG_APCC_DBOX_1	29	37	PF00400	0.763
DEG_APCC_DBOX_1	693	701	PF00400	0.631
DEG_APCC_DBOX_1	794	802	PF00400	0.548
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DEG_SCF_FBW7_1	405	411	PF00400	0.782
DEG_SCF_FBW7_1	650	657	PF00400	0.599
DEG_SCF_FBW7_1	739	746	PF00400	0.587
DEG_SPOP_SBC_1	669	673	PF00917	0.626
DEG_SPOP_SBC_1	76	80	PF00917	0.731
DOC_CKS1_1	405	410	PF01111	0.785
DOC_CKS1_1	651	656	PF01111	0.599
DOC_CYCLIN_RxL_1	575	584	PF00134	0.596
DOC_MAPK_gen_1	29	38	PF00069	0.712
DOC_MAPK_gen_1	482	490	PF00069	0.526
DOC_MAPK_gen_1	522	531	PF00069	0.468
DOC_MAPK_gen_1	809	818	PF00069	0.557
DOC_MAPK_MEF2A_6	482	490	PF00069	0.505
DOC_MAPK_MEF2A_6	556	563	PF00069	0.493
DOC_PP1_RVXF_1	203	210	PF00149	0.641
DOC_PP1_RVXF_1	324	331	PF00149	0.567
DOC_PP1_RVXF_1	504	511	PF00149	0.567
DOC_PP1_RVXF_1	696	703	PF00149	0.614
DOC_PP2B_LxvP_1	18	21	PF13499	0.593
DOC_PP2B_LxvP_1	36	39	PF13499	0.762
DOC_USP7_MATH_1	174	178	PF00917	0.664
DOC_USP7_MATH_1	234	238	PF00917	0.587
DOC_USP7_MATH_1	386	390	PF00917	0.676
DOC_USP7_MATH_1	424	428	PF00917	0.558
DOC_USP7_MATH_1	446	450	PF00917	0.761
DOC_USP7_MATH_1	534	538	PF00917	0.693
DOC_USP7_MATH_1	547	551	PF00917	0.729
DOC_USP7_MATH_1	677	681	PF00917	0.601
DOC_USP7_MATH_1	77	81	PF00917	0.687
DOC_USP7_MATH_1	862	866	PF00917	0.675
DOC_WW_Pin1_4	112	117	PF00397	0.765
DOC_WW_Pin1_4	164	169	PF00397	0.773
DOC_WW_Pin1_4	404	409	PF00397	0.725
DOC_WW_Pin1_4	466	471	PF00397	0.753
DOC_WW_Pin1_4	472	477	PF00397	0.757
DOC_WW_Pin1_4	535	540	PF00397	0.720
DOC_WW_Pin1_4	55	60	PF00397	0.730
DOC_WW_Pin1_4	650	655	PF00397	0.620
DOC_WW_Pin1_4	739	744	PF00397	0.601
DOC_WW_Pin1_4	811	816	PF00397	0.592
DOC_WW_Pin1_4	843	848	PF00397	0.655
LIG_14-3-3_CanoR_1	15	19	PF00244	0.717
LIG_14-3-3_CanoR_1	314	323	PF00244	0.638
LIG_14-3-3_CanoR_1	32	37	PF00244	0.628
LIG_14-3-3_CanoR_1	358	364	PF00244	0.593
LIG_14-3-3_CanoR_1	365	372	PF00244	0.655
LIG_14-3-3_CanoR_1	505	511	PF00244	0.608
LIG_14-3-3_CanoR_1	660	665	PF00244	0.700
LIG_BIR_III_4	705	709	PF00653	0.487
LIG_BRCT_BRCA1_1	470	474	PF00533	0.596
LIG_deltaCOP1_diTrp_1	492	498	PF00928	0.550
LIG_eIF4E_1	8	14	PF01652	0.765
LIG_EVH1_1	405	409	PF00568	0.682
LIG_FHA_1	251	257	PF00498	0.555
LIG_FHA_1	33	39	PF00498	0.709
LIG_FHA_1	385	391	PF00498	0.667
LIG_FHA_1	405	411	PF00498	0.714
LIG_FHA_1	416	422	PF00498	0.688
LIG_FHA_1	438	444	PF00498	0.685
LIG_FHA_1	497	503	PF00498	0.561
LIG_FHA_1	739	745	PF00498	0.602
LIG_FHA_1	77	83	PF00498	0.710
LIG_FHA_1	844	850	PF00498	0.649
LIG_FHA_2	507	513	PF00498	0.642
LIG_FHA_2	628	634	PF00498	0.578
LIG_FHA_2	651	657	PF00498	0.639
LIG_FHA_2	661	667	PF00498	0.616
LIG_FHA_2	812	818	PF00498	0.464
LIG_Integrin_RGD_1	199	201	PF01839	0.532
LIG_LIR_Apic_2	302	306	PF02991	0.568
LIG_LIR_Apic_2	569	575	PF02991	0.507
LIG_LIR_Gen_1	216	225	PF02991	0.548
LIG_LIR_Gen_1	509	515	PF02991	0.621
LIG_LIR_Nem_3	189	194	PF02991	0.578
LIG_LIR_Nem_3	216	220	PF02991	0.455
LIG_LIR_Nem_3	240	245	PF02991	0.720
LIG_LIR_Nem_3	471	477	PF02991	0.594
LIG_LIR_Nem_3	492	498	PF02991	0.623
LIG_LIR_Nem_3	509	513	PF02991	0.485
LIG_PDZ_Class_2	867	872	PF00595	0.805
LIG_Pex14_1	42	46	PF04695	0.712
LIG_Pex14_1	572	576	PF04695	0.509
LIG_PTB_Apo_2	338	345	PF02174	0.615
LIG_Rb_LxCxE_1	612	635	PF01857	0.631
LIG_SH2_CRK	217	221	PF00017	0.487
LIG_SH2_GRB2like	359	362	PF00017	0.658
LIG_SH2_SRC	8	11	PF00017	0.721
LIG_SH2_STAP1	359	363	PF00017	0.655
LIG_SH2_STAT5	202	205	PF00017	0.618
LIG_SH2_STAT5	576	579	PF00017	0.531
LIG_SH2_STAT5	824	827	PF00017	0.582
LIG_SH3_1	19	25	PF00018	0.704
LIG_SH3_3	136	142	PF00018	0.764
LIG_SH3_3	19	25	PF00018	0.704
LIG_SH3_3	403	409	PF00018	0.726
LIG_SH3_3	467	473	PF00018	0.792
LIG_SH3_3	485	491	PF00018	0.519
LIG_SH3_3	648	654	PF00018	0.557
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.498
LIG_SUMO_SIM_anti_2	557	563	PF11976	0.650
LIG_SUMO_SIM_anti_2	837	846	PF11976	0.642
LIG_SUMO_SIM_par_1	813	820	PF11976	0.567
LIG_TRAF2_1	59	62	PF00917	0.696
LIG_TRAF2_1	630	633	PF00917	0.586
MOD_CDC14_SPxK_1	167	170	PF00782	0.688
MOD_CDK_SPxK_1	164	170	PF00069	0.786
MOD_CK1_1	149	155	PF00069	0.809
MOD_CK1_1	219	225	PF00069	0.603
MOD_CK1_1	237	243	PF00069	0.470
MOD_CK1_1	466	472	PF00069	0.705
MOD_CK1_1	48	54	PF00069	0.761
MOD_CK1_1	535	541	PF00069	0.700
MOD_CK1_1	546	552	PF00069	0.520
MOD_CK1_1	665	671	PF00069	0.645
MOD_CK1_1	78	84	PF00069	0.707
MOD_CK1_1	784	790	PF00069	0.509
MOD_CK1_1	800	806	PF00069	0.405
MOD_CK1_1	838	844	PF00069	0.639
MOD_CK1_1	96	102	PF00069	0.571
MOD_CK2_1	627	633	PF00069	0.588
MOD_CK2_1	650	656	PF00069	0.445
MOD_CK2_1	743	749	PF00069	0.565
MOD_CK2_1	831	837	PF00069	0.566
MOD_Cter_Amidation	196	199	PF01082	0.450
MOD_GlcNHglycan	10	13	PF01048	0.564
MOD_GlcNHglycan	148	151	PF01048	0.810
MOD_GlcNHglycan	163	167	PF01048	0.641
MOD_GlcNHglycan	223	226	PF01048	0.579
MOD_GlcNHglycan	239	242	PF01048	0.596
MOD_GlcNHglycan	269	272	PF01048	0.708
MOD_GlcNHglycan	412	415	PF01048	0.748
MOD_GlcNHglycan	426	429	PF01048	0.752
MOD_GlcNHglycan	448	451	PF01048	0.726
MOD_GlcNHglycan	52	56	PF01048	0.711
MOD_GlcNHglycan	534	537	PF01048	0.722
MOD_GlcNHglycan	545	548	PF01048	0.757
MOD_GlcNHglycan	666	670	PF01048	0.660
MOD_GlcNHglycan	679	682	PF01048	0.637
MOD_GlcNHglycan	745	748	PF01048	0.431
MOD_GlcNHglycan	825	828	PF01048	0.557
MOD_GSK3_1	104	111	PF00069	0.785
MOD_GSK3_1	126	133	PF00069	0.683
MOD_GSK3_1	174	181	PF00069	0.662
MOD_GSK3_1	216	223	PF00069	0.492
MOD_GSK3_1	233	240	PF00069	0.481
MOD_GSK3_1	260	267	PF00069	0.568
MOD_GSK3_1	314	321	PF00069	0.591
MOD_GSK3_1	404	411	PF00069	0.701
MOD_GSK3_1	459	466	PF00069	0.691
MOD_GSK3_1	468	475	PF00069	0.714
MOD_GSK3_1	51	58	PF00069	0.735
MOD_GSK3_1	534	541	PF00069	0.700
MOD_GSK3_1	542	549	PF00069	0.504
MOD_GSK3_1	650	657	PF00069	0.624
MOD_GSK3_1	665	672	PF00069	0.621
MOD_GSK3_1	739	746	PF00069	0.507
MOD_GSK3_1	765	772	PF00069	0.530
MOD_GSK3_1	78	85	PF00069	0.666
MOD_GSK3_1	797	804	PF00069	0.516
MOD_GSK3_1	831	838	PF00069	0.495
MOD_GSK3_1	93	100	PF00069	0.623
MOD_LATS_1	504	510	PF00433	0.603
MOD_N-GLC_1	258	263	PF02516	0.579
MOD_N-GLC_1	506	511	PF02516	0.604
MOD_N-GLC_1	781	786	PF02516	0.536
MOD_N-GLC_1	838	843	PF02516	0.710
MOD_NEK2_1	14	19	PF00069	0.684
MOD_NEK2_1	220	225	PF00069	0.600
MOD_NEK2_1	328	333	PF00069	0.556
MOD_NEK2_1	410	415	PF00069	0.786
MOD_NEK2_1	430	435	PF00069	0.730
MOD_NEK2_1	581	586	PF00069	0.579
MOD_NEK2_1	670	675	PF00069	0.653
MOD_NEK2_1	685	690	PF00069	0.552
MOD_NEK2_1	781	786	PF00069	0.480
MOD_NEK2_1	801	806	PF00069	0.255
MOD_NEK2_2	190	195	PF00069	0.692
MOD_PIKK_1	108	114	PF00454	0.808
MOD_PIKK_1	314	320	PF00454	0.598
MOD_PIKK_1	459	465	PF00454	0.673
MOD_PIKK_1	581	587	PF00454	0.521
MOD_PK_1	622	628	PF00069	0.579
MOD_PKA_1	622	628	PF00069	0.579
MOD_PKA_2	108	114	PF00069	0.793
MOD_PKA_2	14	20	PF00069	0.734
MOD_PKA_2	264	270	PF00069	0.573
MOD_PKA_2	357	363	PF00069	0.615
MOD_PKA_2	364	370	PF00069	0.700
MOD_PKA_2	446	452	PF00069	0.713
MOD_PKA_2	48	54	PF00069	0.774
MOD_PKA_2	581	587	PF00069	0.480
MOD_PKA_2	622	628	PF00069	0.594
MOD_PKA_2	659	665	PF00069	0.706
MOD_PKA_2	784	790	PF00069	0.488
MOD_PKB_1	30	38	PF00069	0.710
MOD_PKB_1	795	803	PF00069	0.551
MOD_Plk_1	401	407	PF00069	0.777
MOD_Plk_1	506	512	PF00069	0.612
MOD_Plk_1	611	617	PF00069	0.622
MOD_Plk_1	665	671	PF00069	0.548
MOD_Plk_1	781	787	PF00069	0.554
MOD_Plk_1	838	844	PF00069	0.666
MOD_Plk_4	3	9	PF00069	0.736
MOD_Plk_4	339	345	PF00069	0.483
MOD_Plk_4	359	365	PF00069	0.576
MOD_Plk_4	386	392	PF00069	0.663
MOD_ProDKin_1	112	118	PF00069	0.765
MOD_ProDKin_1	164	170	PF00069	0.775
MOD_ProDKin_1	404	410	PF00069	0.726
MOD_ProDKin_1	466	472	PF00069	0.752
MOD_ProDKin_1	535	541	PF00069	0.722
MOD_ProDKin_1	55	61	PF00069	0.725
MOD_ProDKin_1	650	656	PF00069	0.633
MOD_ProDKin_1	739	745	PF00069	0.596
MOD_ProDKin_1	811	817	PF00069	0.590
MOD_ProDKin_1	843	849	PF00069	0.656
MOD_SUMO_rev_2	475	484	PF00179	0.756
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.707
TRG_ENDOCYTIC_2	217	220	PF00928	0.446
TRG_ER_diArg_1	194	196	PF00400	0.578
TRG_ER_diArg_1	28	30	PF00400	0.702
TRG_ER_diArg_1	355	358	PF00400	0.541
TRG_ER_diArg_1	521	524	PF00400	0.533
TRG_ER_diArg_1	691	694	PF00400	0.534
TRG_ER_diArg_1	783	786	PF00400	0.501
TRG_ER_diArg_1	795	797	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS2	Leptomonas seymouri	46%	100%
A0A0S4JGK3	Bodo saltans	28%	100%
A0A1X0P808	Trypanosomatidae	31%	82%
A4HP01	Leishmania braziliensis	70%	100%
A4ICJ5	Leishmania infantum	99%	100%
D0A2X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
E9ASR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q1T5	Leishmania major	88%	100%
V5B4G3	Trypanosoma cruzi	32%	86%