Ribosome recycling factor, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosome recycling factor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ57_LEIDO

TriTrypDb:

LdBPK_300450.1 , LdCL_300009600 , LDHU3_30.0630

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJ57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ57

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043023	ribosomal large subunit binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.529
CLV_MEL_PAP_1	174	180	PF00089	0.341
CLV_NRD_NRD_1	205	207	PF00675	0.248
CLV_NRD_NRD_1	53	55	PF00675	0.479
CLV_NRD_NRD_1	57	59	PF00675	0.473
CLV_NRD_NRD_1	66	68	PF00675	0.404
CLV_NRD_NRD_1	76	78	PF00675	0.387
CLV_PCSK_KEX2_1	205	207	PF00082	0.258
CLV_PCSK_KEX2_1	66	68	PF00082	0.446
CLV_PCSK_KEX2_1	76	78	PF00082	0.511
CLV_PCSK_PC7_1	62	68	PF00082	0.458
CLV_PCSK_SKI1_1	230	234	PF00082	0.385
CLV_PCSK_SKI1_1	3	7	PF00082	0.516
CLV_PCSK_SKI1_1	66	70	PF00082	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DEG_SPOP_SBC_1	154	158	PF00917	0.514
DEG_SPOP_SBC_1	34	38	PF00917	0.620
DOC_CYCLIN_RxL_1	124	138	PF00134	0.332
DOC_MAPK_gen_1	177	187	PF00069	0.448
DOC_MAPK_gen_1	225	234	PF00069	0.541
DOC_MAPK_MEF2A_6	130	139	PF00069	0.457
DOC_MAPK_MEF2A_6	189	198	PF00069	0.448
DOC_PP1_RVXF_1	64	71	PF00149	0.430
DOC_USP7_MATH_1	112	116	PF00917	0.457
DOC_USP7_MATH_1	34	38	PF00917	0.513
DOC_USP7_UBL2_3	113	117	PF12436	0.513
DOC_USP7_UBL2_3	189	193	PF12436	0.448
DOC_USP7_UBL2_3	55	59	PF12436	0.594
DOC_WW_Pin1_4	161	166	PF00397	0.499
LIG_14-3-3_CanoR_1	3	11	PF00244	0.533
LIG_14-3-3_CanoR_1	66	71	PF00244	0.417
LIG_BRCT_BRCA1_1	166	170	PF00533	0.541
LIG_BRCT_BRCA1_1	99	103	PF00533	0.487
LIG_Clathr_ClatBox_1	134	138	PF01394	0.480
LIG_FHA_1	142	148	PF00498	0.494
LIG_FHA_1	156	162	PF00498	0.376
LIG_FHA_1	227	233	PF00498	0.489
LIG_FHA_1	247	253	PF00498	0.280
LIG_FHA_1	274	280	PF00498	0.452
LIG_FHA_1	48	54	PF00498	0.519
LIG_FHA_2	157	163	PF00498	0.504
LIG_FHA_2	207	213	PF00498	0.548
LIG_FHA_2	67	73	PF00498	0.425
LIG_Integrin_RGD_1	62	64	PF01839	0.504
LIG_SH3_3	193	199	PF00018	0.462
LIG_SUMO_SIM_anti_2	144	149	PF11976	0.559
LIG_SUMO_SIM_anti_2	266	273	PF11976	0.486
LIG_SUMO_SIM_par_1	133	138	PF11976	0.480
LIG_SUMO_SIM_par_1	156	164	PF11976	0.491
LIG_TRAF2_1	69	72	PF00917	0.420
LIG_WRC_WIRS_1	217	222	PF05994	0.528
MOD_CK1_1	157	163	PF00069	0.420
MOD_CK1_1	25	31	PF00069	0.656
MOD_CK1_1	35	41	PF00069	0.539
MOD_CK2_1	156	162	PF00069	0.475
MOD_CK2_1	206	212	PF00069	0.545
MOD_CK2_1	66	72	PF00069	0.413
MOD_GlcNHglycan	120	123	PF01048	0.410
MOD_GlcNHglycan	16	19	PF01048	0.571
MOD_GlcNHglycan	166	169	PF01048	0.313
MOD_GlcNHglycan	182	185	PF01048	0.316
MOD_GlcNHglycan	47	50	PF01048	0.426
MOD_GSK3_1	10	17	PF00069	0.532
MOD_GSK3_1	153	160	PF00069	0.467
MOD_GSK3_1	166	173	PF00069	0.433
MOD_GSK3_1	176	183	PF00069	0.453
MOD_GSK3_1	185	192	PF00069	0.442
MOD_GSK3_1	25	32	PF00069	0.592
MOD_GSK3_1	33	40	PF00069	0.607
MOD_N-GLC_1	118	123	PF02516	0.409
MOD_NEK2_1	170	175	PF00069	0.524
MOD_NEK2_1	216	221	PF00069	0.531
MOD_NEK2_1	251	256	PF00069	0.464
MOD_NEK2_1	45	50	PF00069	0.607
MOD_PIKK_1	22	28	PF00454	0.650
MOD_PKA_1	66	72	PF00069	0.413
MOD_PKA_2	176	182	PF00069	0.448
MOD_PKA_2	22	28	PF00069	0.508
MOD_PKA_2	66	72	PF00069	0.440
MOD_PKA_2	84	90	PF00069	0.622
MOD_Plk_1	118	124	PF00069	0.410
MOD_Plk_1	206	212	PF00069	0.513
MOD_Plk_1	246	252	PF00069	0.458
MOD_Plk_2-3	268	274	PF00069	0.540
MOD_Plk_4	10	16	PF00069	0.640
MOD_Plk_4	141	147	PF00069	0.535
MOD_Plk_4	170	176	PF00069	0.545
MOD_ProDKin_1	161	167	PF00069	0.499
TRG_DiLeu_BaEn_1	212	217	PF01217	0.506
TRG_DiLeu_BaEn_1	247	252	PF01217	0.481
TRG_ER_diArg_1	220	223	PF00400	0.528
TRG_ER_diArg_1	66	68	PF00400	0.433
TRG_ER_diArg_1	76	78	PF00400	0.466
TRG_NES_CRM1_1	268	283	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR8	Leptomonas seymouri	74%	100%
A0A0S4KKH0	Bodo saltans	43%	100%
A0A1X0P2I0	Trypanosomatidae	55%	100%
A0A422N514	Trypanosoma rangeli	58%	100%
A4HHZ5	Leishmania braziliensis	86%	100%
A4I572	Leishmania infantum	100%	100%
C9ZQJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	84%
E9B0G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7R4	Leishmania major	97%	100%