Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ49_LEIDO

TriTrypDb:

LdBPK_362580.1 , LdCL_360031800 , LDHU3_36.3530

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IJ49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.684
CLV_C14_Caspase3-7	200	204	PF00656	0.766
CLV_C14_Caspase3-7	326	330	PF00656	0.635
CLV_C14_Caspase3-7	62	66	PF00656	0.667
CLV_MEL_PAP_1	26	32	PF00089	0.540
CLV_NRD_NRD_1	345	347	PF00675	0.364
CLV_NRD_NRD_1	35	37	PF00675	0.454
CLV_NRD_NRD_1	394	396	PF00675	0.362
CLV_PCSK_KEX2_1	34	36	PF00082	0.454
CLV_PCSK_KEX2_1	345	347	PF00082	0.377
CLV_PCSK_KEX2_1	394	396	PF00082	0.362
CLV_PCSK_KEX2_1	40	42	PF00082	0.490
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.500
CLV_PCSK_PC7_1	36	42	PF00082	0.517
CLV_PCSK_SKI1_1	174	178	PF00082	0.387
CLV_PCSK_SKI1_1	444	448	PF00082	0.329
DEG_APCC_DBOX_1	324	332	PF00400	0.542
DEG_COP1_1	200	209	PF00400	0.604
DEG_Nend_UBRbox_3	1	3	PF02207	0.387
DOC_CKS1_1	19	24	PF01111	0.306
DOC_CYCLIN_RxL_1	169	179	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.355
DOC_MAPK_gen_1	228	236	PF00069	0.712
DOC_MAPK_gen_1	342	351	PF00069	0.619
DOC_MAPK_MEF2A_6	228	236	PF00069	0.630
DOC_MAPK_MEF2A_6	345	353	PF00069	0.569
DOC_PP1_RVXF_1	338	344	PF00149	0.573
DOC_PP2B_LxvP_1	272	275	PF13499	0.778
DOC_PP2B_LxvP_1	349	352	PF13499	0.590
DOC_PP4_FxxP_1	278	281	PF00568	0.783
DOC_PP4_FxxP_1	418	421	PF00568	0.522
DOC_USP7_MATH_1	186	190	PF00917	0.557
DOC_USP7_MATH_1	248	252	PF00917	0.746
DOC_USP7_MATH_1	321	325	PF00917	0.606
DOC_USP7_MATH_1	352	356	PF00917	0.617
DOC_USP7_MATH_1	50	54	PF00917	0.716
DOC_USP7_UBL2_3	101	105	PF12436	0.539
DOC_USP7_UBL2_3	440	444	PF12436	0.630
DOC_WW_Pin1_4	18	23	PF00397	0.306
DOC_WW_Pin1_4	220	225	PF00397	0.710
DOC_WW_Pin1_4	270	275	PF00397	0.706
DOC_WW_Pin1_4	277	282	PF00397	0.692
DOC_WW_Pin1_4	304	309	PF00397	0.556
LIG_14-3-3_CanoR_1	167	177	PF00244	0.546
LIG_14-3-3_CanoR_1	196	202	PF00244	0.712
LIG_14-3-3_CanoR_1	345	350	PF00244	0.528
LIG_14-3-3_CanoR_1	405	414	PF00244	0.628
LIG_14-3-3_CanoR_1	41	49	PF00244	0.761
LIG_14-3-3_CanoR_1	428	434	PF00244	0.587
LIG_APCC_ABBAyCdc20_2	430	436	PF00400	0.586
LIG_BIR_III_4	285	289	PF00653	0.595
LIG_BIR_III_4	65	69	PF00653	0.562
LIG_Clathr_ClatBox_1	149	153	PF01394	0.578
LIG_deltaCOP1_diTrp_1	92	98	PF00928	0.504
LIG_EVH1_2	274	278	PF00568	0.664
LIG_FHA_1	19	25	PF00498	0.416
LIG_FHA_1	298	304	PF00498	0.709
LIG_FHA_1	331	337	PF00498	0.553
LIG_FHA_1	407	413	PF00498	0.635
LIG_FHA_1	445	451	PF00498	0.564
LIG_FHA_1	79	85	PF00498	0.537
LIG_FHA_2	198	204	PF00498	0.699
LIG_FHA_2	324	330	PF00498	0.632
LIG_GBD_Chelix_1	150	158	PF00786	0.400
LIG_Integrin_RGD_1	72	74	PF01839	0.384
LIG_LIR_Apic_2	276	281	PF02991	0.776
LIG_LIR_Apic_2	415	421	PF02991	0.620
LIG_LIR_Gen_1	189	199	PF02991	0.503
LIG_LIR_Gen_1	315	321	PF02991	0.627
LIG_LIR_Gen_1	359	368	PF02991	0.530
LIG_LIR_Gen_1	92	103	PF02991	0.518
LIG_LIR_LC3C_4	148	151	PF02991	0.507
LIG_LIR_LC3C_4	348	351	PF02991	0.521
LIG_LIR_Nem_3	189	194	PF02991	0.638
LIG_LIR_Nem_3	315	319	PF02991	0.615
LIG_LIR_Nem_3	359	364	PF02991	0.526
LIG_LIR_Nem_3	397	403	PF02991	0.590
LIG_LIR_Nem_3	408	414	PF02991	0.533
LIG_LIR_Nem_3	65	70	PF02991	0.660
LIG_LIR_Nem_3	92	98	PF02991	0.551
LIG_MYND_1	270	274	PF01753	0.676
LIG_NRBOX	153	159	PF00104	0.596
LIG_PDZ_Class_1	446	451	PF00595	0.592
LIG_Pex14_2	414	418	PF04695	0.613
LIG_Pex14_2	67	71	PF04695	0.577
LIG_SH2_CRK	316	320	PF00017	0.582
LIG_SH2_CRK	361	365	PF00017	0.570
LIG_SH2_GRB2like	142	145	PF00017	0.624
LIG_SH2_SRC	419	422	PF00017	0.568
LIG_SH2_SRC	49	52	PF00017	0.733
LIG_SH2_STAP1	282	286	PF00017	0.653
LIG_SH2_STAT5	115	118	PF00017	0.591
LIG_SH2_STAT5	142	145	PF00017	0.523
LIG_SH2_STAT5	199	202	PF00017	0.738
LIG_SH2_STAT5	316	319	PF00017	0.500
LIG_SH2_STAT5	401	404	PF00017	0.554
LIG_SH2_STAT5	419	422	PF00017	0.497
LIG_SH2_STAT5	434	437	PF00017	0.603
LIG_SH2_STAT5	85	88	PF00017	0.537
LIG_SH3_1	129	135	PF00018	0.569
LIG_SH3_3	128	134	PF00018	0.617
LIG_SH3_3	256	262	PF00018	0.785
LIG_SH3_3	264	270	PF00018	0.681
LIG_SH3_3	291	297	PF00018	0.567
LIG_SH3_3	361	367	PF00018	0.509
LIG_SH3_4	101	108	PF00018	0.535
LIG_SUMO_SIM_anti_2	148	153	PF11976	0.616
LIG_SUMO_SIM_par_1	136	141	PF11976	0.601
LIG_SUMO_SIM_par_1	148	153	PF11976	0.621
LIG_SUMO_SIM_par_1	173	179	PF11976	0.548
LIG_SUMO_SIM_par_1	304	312	PF11976	0.554
MOD_CK1_1	189	195	PF00069	0.410
MOD_CK1_1	205	211	PF00069	0.756
MOD_CK1_1	273	279	PF00069	0.698
MOD_CK1_1	375	381	PF00069	0.624
MOD_CK1_1	39	45	PF00069	0.637
MOD_CK1_1	438	444	PF00069	0.448
MOD_CK2_1	321	327	PF00069	0.519
MOD_GlcNHglycan	109	112	PF01048	0.470
MOD_GlcNHglycan	250	253	PF01048	0.753
MOD_GlcNHglycan	285	289	PF01048	0.676
MOD_GlcNHglycan	354	357	PF01048	0.633
MOD_GlcNHglycan	358	361	PF01048	0.544
MOD_GlcNHglycan	377	380	PF01048	0.382
MOD_GSK3_1	205	212	PF00069	0.511
MOD_GSK3_1	250	257	PF00069	0.771
MOD_GSK3_1	273	280	PF00069	0.738
MOD_GSK3_1	297	304	PF00069	0.527
MOD_GSK3_1	35	42	PF00069	0.693
MOD_GSK3_1	352	359	PF00069	0.555
MOD_GSK3_1	366	373	PF00069	0.431
MOD_N-GLC_1	276	281	PF02516	0.624
MOD_N-GLC_1	321	326	PF02516	0.521
MOD_N-GLC_1	406	411	PF02516	0.548
MOD_N-GLC_1	42	47	PF02516	0.585
MOD_N-GLC_1	436	441	PF02516	0.485
MOD_NEK2_1	138	143	PF00069	0.509
MOD_NEK2_1	176	181	PF00069	0.444
MOD_NEK2_1	236	241	PF00069	0.733
MOD_NEK2_1	446	451	PF00069	0.574
MOD_NEK2_2	186	191	PF00069	0.371
MOD_NEK2_2	429	434	PF00069	0.396
MOD_PIKK_1	207	213	PF00454	0.741
MOD_PIKK_1	406	412	PF00454	0.551
MOD_PKA_1	345	351	PF00069	0.501
MOD_PKA_1	35	41	PF00069	0.575
MOD_PKA_2	168	174	PF00069	0.409
MOD_PKA_2	345	351	PF00069	0.388
MOD_PKA_2	35	41	PF00069	0.630
MOD_PKA_2	429	435	PF00069	0.506
MOD_PKB_1	34	42	PF00069	0.697
MOD_Plk_1	202	208	PF00069	0.578
MOD_Plk_1	370	376	PF00069	0.421
MOD_Plk_1	406	412	PF00069	0.542
MOD_Plk_2-3	366	372	PF00069	0.429
MOD_Plk_4	138	144	PF00069	0.396
MOD_Plk_4	145	151	PF00069	0.453
MOD_Plk_4	186	192	PF00069	0.529
MOD_Plk_4	314	320	PF00069	0.490
MOD_Plk_4	345	351	PF00069	0.466
MOD_Plk_4	387	393	PF00069	0.425
MOD_Plk_4	429	435	PF00069	0.407
MOD_ProDKin_1	18	24	PF00069	0.306
MOD_ProDKin_1	220	226	PF00069	0.653
MOD_ProDKin_1	270	276	PF00069	0.646
MOD_ProDKin_1	277	283	PF00069	0.628
MOD_ProDKin_1	304	310	PF00069	0.431
TRG_DiLeu_BaEn_1	173	178	PF01217	0.423
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.494
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.252
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.306
TRG_ENDOCYTIC_2	316	319	PF00928	0.504
TRG_ENDOCYTIC_2	361	364	PF00928	0.462
TRG_ENDOCYTIC_2	400	403	PF00928	0.443
TRG_ER_diArg_1	34	36	PF00400	0.573
TRG_ER_diArg_1	340	343	PF00400	0.532
TRG_ER_diArg_1	427	430	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL22	Leptomonas seymouri	53%	98%
A0A1X0P7K7	Trypanosomatidae	24%	100%
A0A3R7KBE0	Trypanosoma rangeli	27%	100%
A4HPB1	Leishmania braziliensis	69%	97%
A4ICF1	Leishmania infantum	100%	100%
D0A3C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AT22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1H6	Leishmania major	92%	100%
V5B844	Trypanosoma cruzi	27%	100%