Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

GPI anchor biosynthesis protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ48_LEIDO

TriTrypDb:

LdBPK_361260.1 , LdCL_360017700 , LDHU3_36.1600

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IJ48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ48

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	12
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.331
CLV_NRD_NRD_1	131	133	PF00675	0.332
CLV_NRD_NRD_1	413	415	PF00675	0.329
CLV_NRD_NRD_1	427	429	PF00675	0.310
CLV_NRD_NRD_1	449	451	PF00675	0.465
CLV_NRD_NRD_1	593	595	PF00675	0.581
CLV_PCSK_FUR_1	410	414	PF00082	0.206
CLV_PCSK_KEX2_1	125	127	PF00082	0.329
CLV_PCSK_KEX2_1	131	133	PF00082	0.334
CLV_PCSK_KEX2_1	355	357	PF00082	0.365
CLV_PCSK_KEX2_1	412	414	PF00082	0.324
CLV_PCSK_KEX2_1	427	429	PF00082	0.309
CLV_PCSK_KEX2_1	449	451	PF00082	0.465
CLV_PCSK_KEX2_1	593	595	PF00082	0.593
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.397
CLV_PCSK_PC7_1	351	357	PF00082	0.331
CLV_PCSK_SKI1_1	135	139	PF00082	0.308
CLV_PCSK_SKI1_1	17	21	PF00082	0.471
CLV_PCSK_SKI1_1	239	243	PF00082	0.276
CLV_PCSK_SKI1_1	268	272	PF00082	0.516
CLV_PCSK_SKI1_1	356	360	PF00082	0.396
CLV_PCSK_SKI1_1	427	431	PF00082	0.302
CLV_PCSK_SKI1_1	513	517	PF00082	0.559
CLV_PCSK_SKI1_1	52	56	PF00082	0.526
CLV_PCSK_SKI1_1	554	558	PF00082	0.584
CLV_Separin_Metazoa	555	559	PF03568	0.264
DEG_APCC_DBOX_1	16	24	PF00400	0.406
DEG_APCC_DBOX_1	496	504	PF00400	0.308
DEG_APCC_DBOX_1	553	561	PF00400	0.267
DEG_Nend_UBRbox_2	1	3	PF02207	0.510
DEG_SPOP_SBC_1	141	145	PF00917	0.509
DOC_CDC14_PxL_1	359	367	PF14671	0.395
DOC_CDC14_PxL_1	380	388	PF14671	0.453
DOC_CDC14_PxL_1	76	84	PF14671	0.337
DOC_CKS1_1	270	275	PF01111	0.279
DOC_CKS1_1	476	481	PF01111	0.271
DOC_CYCLIN_RxL_1	236	246	PF00134	0.428
DOC_CYCLIN_RxL_1	424	433	PF00134	0.540
DOC_CYCLIN_yClb1_LxF_4	266	271	PF00134	0.137
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.366
DOC_MAPK_DCC_7	377	387	PF00069	0.265
DOC_MAPK_gen_1	410	420	PF00069	0.532
DOC_MAPK_gen_1	526	536	PF00069	0.411
DOC_MAPK_gen_1	593	599	PF00069	0.322
DOC_MAPK_MEF2A_6	17	25	PF00069	0.370
DOC_MAPK_MEF2A_6	27	34	PF00069	0.293
DOC_MAPK_NFAT4_5	17	25	PF00069	0.443
DOC_MAPK_NFAT4_5	27	35	PF00069	0.409
DOC_PP1_RVXF_1	266	272	PF00149	0.357
DOC_PP1_RVXF_1	375	382	PF00149	0.344
DOC_PP1_RVXF_1	488	494	PF00149	0.368
DOC_PP2B_LxvP_1	418	421	PF13499	0.540
DOC_PP4_FxxP_1	138	141	PF00568	0.503
DOC_PP4_FxxP_1	381	384	PF00568	0.375
DOC_PP4_FxxP_1	77	80	PF00568	0.427
DOC_USP7_MATH_1	13	17	PF00917	0.498
DOC_USP7_MATH_1	141	145	PF00917	0.518
DOC_USP7_MATH_1	419	423	PF00917	0.517
DOC_USP7_MATH_1	621	625	PF00917	0.433
DOC_USP7_MATH_1	67	71	PF00917	0.303
DOC_WW_Pin1_4	153	158	PF00397	0.483
DOC_WW_Pin1_4	269	274	PF00397	0.254
DOC_WW_Pin1_4	36	41	PF00397	0.279
DOC_WW_Pin1_4	475	480	PF00397	0.276
DOC_WW_Pin1_4	614	619	PF00397	0.193
LIG_14-3-3_CanoR_1	135	141	PF00244	0.406
LIG_14-3-3_CanoR_1	213	221	PF00244	0.289
LIG_14-3-3_CanoR_1	27	31	PF00244	0.413
LIG_14-3-3_CanoR_1	412	417	PF00244	0.553
LIG_14-3-3_CanoR_1	427	433	PF00244	0.517
LIG_14-3-3_CanoR_1	513	522	PF00244	0.367
LIG_14-3-3_CanoR_1	57	63	PF00244	0.340
LIG_Actin_WH2_2	390	408	PF00022	0.376
LIG_BRCT_BRCA1_1	186	190	PF00533	0.329
LIG_BRCT_BRCA1_1	338	342	PF00533	0.503
LIG_BRCT_BRCA1_1	436	440	PF00533	0.337
LIG_BRCT_BRCA1_1	69	73	PF00533	0.322
LIG_CSL_BTD_1	313	316	PF09270	0.415
LIG_CSL_BTD_1	615	618	PF09270	0.183
LIG_eIF4E_1	380	386	PF01652	0.415
LIG_FHA_1	154	160	PF00498	0.530
LIG_FHA_1	27	33	PF00498	0.434
LIG_FHA_1	362	368	PF00498	0.406
LIG_FHA_1	397	403	PF00498	0.373
LIG_FHA_1	439	445	PF00498	0.396
LIG_FHA_1	576	582	PF00498	0.376
LIG_FHA_2	143	149	PF00498	0.511
LIG_FHA_2	85	91	PF00498	0.559
LIG_IRF3_LxIS_1	383	390	PF10401	0.376
LIG_LIR_Apic_2	70	74	PF02991	0.391
LIG_LIR_Apic_2	8	13	PF02991	0.474
LIG_LIR_Gen_1	16	26	PF02991	0.278
LIG_LIR_Gen_1	180	189	PF02991	0.311
LIG_LIR_Gen_1	215	226	PF02991	0.387
LIG_LIR_Gen_1	272	282	PF02991	0.345
LIG_LIR_Gen_1	375	386	PF02991	0.315
LIG_LIR_Gen_1	478	488	PF02991	0.291
LIG_LIR_Gen_1	609	618	PF02991	0.334
LIG_LIR_Nem_3	16	21	PF02991	0.430
LIG_LIR_Nem_3	170	174	PF02991	0.285
LIG_LIR_Nem_3	180	184	PF02991	0.274
LIG_LIR_Nem_3	186	192	PF02991	0.309
LIG_LIR_Nem_3	197	202	PF02991	0.210
LIG_LIR_Nem_3	215	221	PF02991	0.318
LIG_LIR_Nem_3	262	266	PF02991	0.278
LIG_LIR_Nem_3	272	277	PF02991	0.269
LIG_LIR_Nem_3	286	291	PF02991	0.206
LIG_LIR_Nem_3	375	381	PF02991	0.316
LIG_LIR_Nem_3	454	459	PF02991	0.315
LIG_LIR_Nem_3	463	469	PF02991	0.340
LIG_LIR_Nem_3	478	484	PF02991	0.299
LIG_LIR_Nem_3	48	54	PF02991	0.254
LIG_LIR_Nem_3	609	615	PF02991	0.401
LIG_LIR_Nem_3	70	76	PF02991	0.317
LIG_MLH1_MIPbox_1	186	190	PF16413	0.329
LIG_NRBOX	18	24	PF00104	0.411
LIG_NRBOX	187	193	PF00104	0.283
LIG_Pex14_2	310	314	PF04695	0.415
LIG_Pex14_2	430	434	PF04695	0.427
LIG_Pex14_2	73	77	PF04695	0.398
LIG_SH2_CRK	181	185	PF00017	0.288
LIG_SH2_CRK	266	270	PF00017	0.340
LIG_SH2_CRK	274	278	PF00017	0.340
LIG_SH2_CRK	476	480	PF00017	0.251
LIG_SH2_CRK	51	55	PF00017	0.279
LIG_SH2_CRK	592	596	PF00017	0.401
LIG_SH2_GRB2like	181	184	PF00017	0.295
LIG_SH2_NCK_1	181	185	PF00017	0.340
LIG_SH2_PTP2	71	74	PF00017	0.415
LIG_SH2_STAT5	263	266	PF00017	0.325
LIG_SH2_STAT5	281	284	PF00017	0.241
LIG_SH2_STAT5	297	300	PF00017	0.266
LIG_SH2_STAT5	380	383	PF00017	0.415
LIG_SH2_STAT5	527	530	PF00017	0.320
LIG_SH2_STAT5	612	615	PF00017	0.360
LIG_SH2_STAT5	71	74	PF00017	0.374
LIG_SH3_3	267	273	PF00018	0.275
LIG_SH3_3	288	294	PF00018	0.296
LIG_SH3_3	296	302	PF00018	0.245
LIG_SH3_3	310	316	PF00018	0.248
LIG_SH3_3	357	363	PF00018	0.446
LIG_SH3_3	563	569	PF00018	0.400
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.427
LIG_SUMO_SIM_anti_2	441	446	PF11976	0.378
LIG_SUMO_SIM_par_1	165	170	PF11976	0.339
LIG_SUMO_SIM_par_1	363	370	PF11976	0.376
LIG_SUMO_SIM_par_1	384	391	PF11976	0.393
LIG_TRAF2_1	604	607	PF00917	0.383
LIG_TRFH_1	380	384	PF08558	0.412
LIG_TYR_ITIM	264	269	PF00017	0.298
LIG_TYR_ITIM	49	54	PF00017	0.254
LIG_UBA3_1	556	562	PF00899	0.272
LIG_UBA3_1	81	85	PF00899	0.453
LIG_WRC_WIRS_1	602	607	PF05994	0.328
MOD_CK1_1	130	136	PF00069	0.551
MOD_CK1_1	144	150	PF00069	0.478
MOD_CK1_1	343	349	PF00069	0.538
MOD_CK1_1	400	406	PF00069	0.555
MOD_CK1_1	617	623	PF00069	0.486
MOD_CK2_1	142	148	PF00069	0.562
MOD_CK2_1	36	42	PF00069	0.257
MOD_CK2_1	366	372	PF00069	0.342
MOD_CK2_1	601	607	PF00069	0.420
MOD_GlcNHglycan	132	135	PF01048	0.335
MOD_GlcNHglycan	138	141	PF01048	0.264
MOD_GlcNHglycan	254	257	PF01048	0.426
MOD_GlcNHglycan	330	333	PF01048	0.341
MOD_GlcNHglycan	342	345	PF01048	0.350
MOD_GlcNHglycan	402	405	PF01048	0.344
MOD_GlcNHglycan	421	424	PF01048	0.229
MOD_GlcNHglycan	436	439	PF01048	0.341
MOD_GlcNHglycan	503	506	PF01048	0.598
MOD_GSK3_1	136	143	PF00069	0.515
MOD_GSK3_1	155	162	PF00069	0.492
MOD_GSK3_1	173	180	PF00069	0.254
MOD_GSK3_1	190	197	PF00069	0.215
MOD_GSK3_1	26	33	PF00069	0.376
MOD_GSK3_1	336	343	PF00069	0.553
MOD_GSK3_1	396	403	PF00069	0.424
MOD_GSK3_1	430	437	PF00069	0.423
MOD_GSK3_1	617	624	PF00069	0.446
MOD_GSK3_1	84	91	PF00069	0.415
MOD_NEK2_1	142	147	PF00069	0.530
MOD_NEK2_1	173	178	PF00069	0.396
MOD_NEK2_1	190	195	PF00069	0.185
MOD_NEK2_1	212	217	PF00069	0.289
MOD_NEK2_1	283	288	PF00069	0.320
MOD_NEK2_1	30	35	PF00069	0.336
MOD_NEK2_1	330	335	PF00069	0.513
MOD_NEK2_1	342	347	PF00069	0.546
MOD_NEK2_1	366	371	PF00069	0.354
MOD_NEK2_1	387	392	PF00069	0.361
MOD_NEK2_1	396	401	PF00069	0.381
MOD_NEK2_1	405	410	PF00069	0.495
MOD_NEK2_1	430	435	PF00069	0.331
MOD_NEK2_1	575	580	PF00069	0.309
MOD_NEK2_1	84	89	PF00069	0.375
MOD_NEK2_2	337	342	PF00069	0.549
MOD_PIKK_1	507	513	PF00454	0.395
MOD_PKA_1	412	418	PF00069	0.406
MOD_PKA_2	130	136	PF00069	0.542
MOD_PKA_2	212	218	PF00069	0.289
MOD_PKA_2	26	32	PF00069	0.376
MOD_PKA_2	412	418	PF00069	0.562
MOD_PKB_1	410	418	PF00069	0.434
MOD_Plk_1	110	116	PF00069	0.540
MOD_Plk_4	110	116	PF00069	0.372
MOD_Plk_4	184	190	PF00069	0.307
MOD_Plk_4	337	343	PF00069	0.559
MOD_Plk_4	361	367	PF00069	0.346
MOD_Plk_4	388	394	PF00069	0.384
MOD_Plk_4	451	457	PF00069	0.324
MOD_Plk_4	91	97	PF00069	0.519
MOD_ProDKin_1	153	159	PF00069	0.483
MOD_ProDKin_1	269	275	PF00069	0.254
MOD_ProDKin_1	36	42	PF00069	0.279
MOD_ProDKin_1	475	481	PF00069	0.276
MOD_ProDKin_1	614	620	PF00069	0.207
MOD_SUMO_for_1	561	564	PF00179	0.332
MOD_SUMO_rev_2	369	376	PF00179	0.411
TRG_DiLeu_BaEn_2	185	191	PF01217	0.298
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.376
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.412
TRG_ENDOCYTIC_2	181	184	PF00928	0.308
TRG_ENDOCYTIC_2	199	202	PF00928	0.265
TRG_ENDOCYTIC_2	266	269	PF00928	0.295
TRG_ENDOCYTIC_2	274	277	PF00928	0.295
TRG_ENDOCYTIC_2	288	291	PF00928	0.223
TRG_ENDOCYTIC_2	295	298	PF00928	0.258
TRG_ENDOCYTIC_2	368	371	PF00928	0.301
TRG_ENDOCYTIC_2	380	383	PF00928	0.276
TRG_ENDOCYTIC_2	51	54	PF00928	0.254
TRG_ENDOCYTIC_2	527	530	PF00928	0.313
TRG_ENDOCYTIC_2	592	595	PF00928	0.331
TRG_ENDOCYTIC_2	612	615	PF00928	0.347
TRG_ER_diArg_1	124	126	PF00400	0.406
TRG_ER_diArg_1	410	413	PF00400	0.510
TRG_ER_diArg_1	426	428	PF00400	0.514
TRG_ER_diArg_1	448	450	PF00400	0.295
TRG_ER_diArg_1	497	500	PF00400	0.424
TRG_ER_diArg_1	592	594	PF00400	0.368
TRG_NES_CRM1_1	489	501	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q8	Leptomonas seymouri	56%	100%
A0A0S4J7A7	Bodo saltans	28%	100%
A0A1X0P926	Trypanosomatidae	33%	100%
A0A422NTW3	Trypanosoma rangeli	32%	100%
A4HNY0	Leishmania braziliensis	70%	100%
A4ICL4	Leishmania infantum	99%	100%
D0A2U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P30777	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P86935	Trypanosoma brucei brucei	34%	100%
P86936	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	34%	100%
Q4Q1V6	Leishmania major	88%	100%
Q4V7R2	Xenopus laevis	24%	100%
Q6CN76	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q6FTY5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q7SXZ1	Danio rerio	25%	100%
Q94A15	Arabidopsis thaliana	25%	100%
Q9JJQ0	Mus musculus	25%	100%
Q9USN0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9VZM5	Drosophila melanogaster	27%	100%
V5DRF7	Trypanosoma cruzi	32%	100%