WW domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ47_LEIDO

TriTrypDb:

LdBPK_161180.1 , LdCL_160017000 , LDHU3_16.1450

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IJ47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ47

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	465	467	PF00675	0.365
CLV_NRD_NRD_1	78	80	PF00675	0.513
CLV_PCSK_KEX2_1	465	467	PF00082	0.410
CLV_PCSK_KEX2_1	78	80	PF00082	0.513
CLV_PCSK_SKI1_1	28	32	PF00082	0.620
CLV_PCSK_SKI1_1	53	57	PF00082	0.448
DEG_Kelch_Keap1_1	154	159	PF01344	0.479
DEG_SPOP_SBC_1	340	344	PF00917	0.706
DEG_SPOP_SBC_1	362	366	PF00917	0.763
DOC_CKS1_1	138	143	PF01111	0.544
DOC_CKS1_1	597	602	PF01111	0.594
DOC_CKS1_1	94	99	PF01111	0.518
DOC_CYCLIN_RxL_1	102	110	PF00134	0.532
DOC_CYCLIN_RxL_1	422	434	PF00134	0.505
DOC_CYCLIN_RxL_1	75	84	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	614	620	PF00134	0.341
DOC_MAPK_DCC_7	299	309	PF00069	0.559
DOC_PP1_RVXF_1	51	58	PF00149	0.436
DOC_PP1_RVXF_1	76	83	PF00149	0.499
DOC_PP2B_LxvP_1	271	274	PF13499	0.667
DOC_PP2B_LxvP_1	614	617	PF13499	0.341
DOC_PP4_FxxP_1	272	275	PF00568	0.654
DOC_PP4_MxPP_1	359	362	PF00568	0.531
DOC_USP7_MATH_1	252	256	PF00917	0.751
DOC_USP7_MATH_1	282	286	PF00917	0.685
DOC_USP7_MATH_1	291	295	PF00917	0.609
DOC_USP7_MATH_1	327	331	PF00917	0.598
DOC_USP7_MATH_1	384	388	PF00917	0.413
DOC_USP7_MATH_1	482	486	PF00917	0.602
DOC_USP7_MATH_1	49	53	PF00917	0.492
DOC_USP7_MATH_1	493	497	PF00917	0.634
DOC_USP7_MATH_1	606	610	PF00917	0.708
DOC_WW_Pin1_4	137	142	PF00397	0.543
DOC_WW_Pin1_4	342	347	PF00397	0.617
DOC_WW_Pin1_4	351	356	PF00397	0.588
DOC_WW_Pin1_4	363	368	PF00397	0.634
DOC_WW_Pin1_4	539	544	PF00397	0.686
DOC_WW_Pin1_4	596	601	PF00397	0.806
DOC_WW_Pin1_4	602	607	PF00397	0.734
DOC_WW_Pin1_4	93	98	PF00397	0.509
LIG_14-3-3_CanoR_1	15	22	PF00244	0.562
LIG_14-3-3_CanoR_1	28	37	PF00244	0.412
LIG_14-3-3_CanoR_1	415	421	PF00244	0.552
LIG_14-3-3_CanoR_1	465	469	PF00244	0.371
LIG_14-3-3_CanoR_1	518	524	PF00244	0.297
LIG_14-3-3_CanoR_1	581	586	PF00244	0.482
LIG_14-3-3_CanoR_1	81	90	PF00244	0.581
LIG_FHA_1	102	108	PF00498	0.346
LIG_FHA_1	183	189	PF00498	0.562
LIG_FHA_1	332	338	PF00498	0.754
LIG_FHA_1	363	369	PF00498	0.791
LIG_FHA_1	387	393	PF00498	0.487
LIG_FHA_1	46	52	PF00498	0.579
LIG_FHA_1	465	471	PF00498	0.366
LIG_FHA_1	520	526	PF00498	0.489
LIG_FHA_1	571	577	PF00498	0.379
LIG_FHA_1	627	633	PF00498	0.489
LIG_FHA_1	82	88	PF00498	0.526
LIG_FHA_2	145	151	PF00498	0.576
LIG_FHA_2	15	21	PF00498	0.559
LIG_FHA_2	29	35	PF00498	0.520
LIG_FHA_2	475	481	PF00498	0.341
LIG_FHA_2	530	536	PF00498	0.341
LIG_FHA_2	637	643	PF00498	0.365
LIG_FHA_2	94	100	PF00498	0.615
LIG_LIR_Apic_2	270	275	PF02991	0.658
LIG_LIR_Apic_2	418	423	PF02991	0.457
LIG_LIR_Apic_2	476	482	PF02991	0.303
LIG_LIR_Apic_2	531	537	PF02991	0.372
LIG_LIR_Apic_2	583	588	PF02991	0.393
LIG_LIR_Apic_2	638	644	PF02991	0.301
LIG_LIR_Gen_1	393	401	PF02991	0.498
LIG_LIR_Nem_3	159	165	PF02991	0.592
LIG_LIR_Nem_3	393	397	PF02991	0.518
LIG_Pex14_1	394	398	PF04695	0.379
LIG_SH2_GRB2like	524	527	PF00017	0.335
LIG_SH2_GRB2like	575	578	PF00017	0.393
LIG_SH2_GRB2like	631	634	PF00017	0.300
LIG_SH2_SRC	469	472	PF00017	0.393
LIG_SH2_SRC	524	527	PF00017	0.335
LIG_SH2_SRC	631	634	PF00017	0.300
LIG_SH2_STAT5	144	147	PF00017	0.483
LIG_SH2_STAT5	409	412	PF00017	0.432
LIG_SH2_STAT5	469	472	PF00017	0.321
LIG_SH2_STAT5	524	527	PF00017	0.335
LIG_SH2_STAT5	575	578	PF00017	0.372
LIG_SH2_STAT5	631	634	PF00017	0.335
LIG_SH2_STAT5	9	12	PF00017	0.513
LIG_SH3_2	423	428	PF14604	0.522
LIG_SH3_3	246	252	PF00018	0.667
LIG_SH3_3	257	263	PF00018	0.647
LIG_SH3_3	272	278	PF00018	0.690
LIG_SH3_3	302	308	PF00018	0.694
LIG_SH3_3	420	426	PF00018	0.515
LIG_SH3_3	483	489	PF00018	0.688
LIG_SH3_3	538	544	PF00018	0.548
LIG_SH3_3	589	595	PF00018	0.811
LIG_SH3_3	598	604	PF00018	0.699
LIG_SH3_3	609	615	PF00018	0.520
LIG_SH3_3	91	97	PF00018	0.543
LIG_SH3_4	589	596	PF00018	0.576
LIG_SH3_CIN85_PxpxPR_1	262	267	PF14604	0.531
LIG_TRAF2_1	17	20	PF00917	0.527
MOD_CK1_1	154	160	PF00069	0.494
MOD_CK1_1	224	230	PF00069	0.641
MOD_CK1_1	285	291	PF00069	0.634
MOD_CK1_1	354	360	PF00069	0.702
MOD_CK1_1	366	372	PF00069	0.538
MOD_CK1_1	474	480	PF00069	0.475
MOD_CK1_1	497	503	PF00069	0.692
MOD_CK2_1	14	20	PF00069	0.507
MOD_CK2_1	144	150	PF00069	0.514
MOD_CK2_1	28	34	PF00069	0.482
MOD_CK2_1	327	333	PF00069	0.714
MOD_CK2_1	377	383	PF00069	0.651
MOD_CK2_1	474	480	PF00069	0.341
MOD_CK2_1	529	535	PF00069	0.341
MOD_CK2_1	636	642	PF00069	0.365
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.537
MOD_GlcNHglycan	11	14	PF01048	0.543
MOD_GlcNHglycan	119	122	PF01048	0.684
MOD_GlcNHglycan	123	126	PF01048	0.671
MOD_GlcNHglycan	156	159	PF01048	0.566
MOD_GlcNHglycan	178	181	PF01048	0.502
MOD_GlcNHglycan	223	226	PF01048	0.661
MOD_GlcNHglycan	293	296	PF01048	0.704
MOD_GlcNHglycan	311	314	PF01048	0.714
MOD_GlcNHglycan	356	359	PF01048	0.622
MOD_GlcNHglycan	449	452	PF01048	0.618
MOD_GlcNHglycan	499	502	PF01048	0.790
MOD_GlcNHglycan	550	553	PF01048	0.825
MOD_GlcNHglycan	58	61	PF01048	0.665
MOD_GlcNHglycan	608	611	PF01048	0.588
MOD_GSK3_1	107	114	PF00069	0.539
MOD_GSK3_1	117	124	PF00069	0.645
MOD_GSK3_1	195	202	PF00069	0.606
MOD_GSK3_1	281	288	PF00069	0.649
MOD_GSK3_1	315	322	PF00069	0.718
MOD_GSK3_1	323	330	PF00069	0.794
MOD_GSK3_1	336	343	PF00069	0.603
MOD_GSK3_1	362	369	PF00069	0.687
MOD_GSK3_1	409	416	PF00069	0.448
MOD_GSK3_1	45	52	PF00069	0.545
MOD_GSK3_1	457	464	PF00069	0.341
MOD_GSK3_1	471	478	PF00069	0.314
MOD_GSK3_1	493	500	PF00069	0.754
MOD_GSK3_1	526	533	PF00069	0.323
MOD_GSK3_1	577	584	PF00069	0.393
MOD_GSK3_1	602	609	PF00069	0.569
MOD_GSK3_1	633	640	PF00069	0.342
MOD_N-GLC_1	219	224	PF02516	0.559
MOD_N-GLC_1	289	294	PF02516	0.698
MOD_N-GLC_1	493	498	PF02516	0.637
MOD_NEK2_1	107	112	PF00069	0.640
MOD_NEK2_1	221	226	PF00069	0.632
MOD_NEK2_1	309	314	PF00069	0.566
MOD_NEK2_1	331	336	PF00069	0.678
MOD_NEK2_1	385	390	PF00069	0.522
MOD_NEK2_1	56	61	PF00069	0.504
MOD_NEK2_1	72	77	PF00069	0.471
MOD_PIKK_1	282	288	PF00454	0.637
MOD_PKA_2	14	20	PF00069	0.567
MOD_PKA_2	154	160	PF00069	0.473
MOD_PKA_2	416	422	PF00069	0.472
MOD_PKA_2	464	470	PF00069	0.345
MOD_PKA_2	547	553	PF00069	0.790
MOD_PKA_2	580	586	PF00069	0.341
MOD_PKB_1	79	87	PF00069	0.514
MOD_Plk_1	219	225	PF00069	0.654
MOD_Plk_4	107	113	PF00069	0.587
MOD_Plk_4	195	201	PF00069	0.648
MOD_Plk_4	245	251	PF00069	0.774
MOD_Plk_4	327	333	PF00069	0.736
MOD_ProDKin_1	137	143	PF00069	0.544
MOD_ProDKin_1	342	348	PF00069	0.619
MOD_ProDKin_1	351	357	PF00069	0.585
MOD_ProDKin_1	363	369	PF00069	0.634
MOD_ProDKin_1	539	545	PF00069	0.687
MOD_ProDKin_1	596	602	PF00069	0.810
MOD_ProDKin_1	93	99	PF00069	0.504
MOD_SUMO_rev_2	18	25	PF00179	0.564
MOD_SUMO_rev_2	222	232	PF00179	0.561
TRG_ER_diArg_1	77	79	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ37	Leptomonas seymouri	50%	100%
A0A3R7LE31	Trypanosoma rangeli	34%	99%
A4H8P0	Leishmania braziliensis	72%	93%
A4HX11	Leishmania infantum	98%	100%
C9ZVZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	98%
Q4QEQ3	Leishmania major	93%	99%
V5BML0	Trypanosoma cruzi	36%	100%