RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polypyrimidine tract-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ43_LEIDO

TriTrypDb:

LdBPK_320900.1 , LdCL_320014500 , LDHU3_32.1180

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ43

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.478
CLV_C14_Caspase3-7	384	388	PF00656	0.601
CLV_C14_Caspase3-7	632	636	PF00656	0.529
CLV_C14_Caspase3-7	675	679	PF00656	0.693
CLV_C14_Caspase3-7	680	684	PF00656	0.667
CLV_C14_Caspase3-7	729	733	PF00656	0.659
CLV_NRD_NRD_1	200	202	PF00675	0.649
CLV_NRD_NRD_1	374	376	PF00675	0.669
CLV_NRD_NRD_1	56	58	PF00675	0.560
CLV_NRD_NRD_1	617	619	PF00675	0.324
CLV_PCSK_FUR_1	532	536	PF00082	0.426
CLV_PCSK_KEX2_1	200	202	PF00082	0.649
CLV_PCSK_KEX2_1	373	375	PF00082	0.690
CLV_PCSK_KEX2_1	495	497	PF00082	0.403
CLV_PCSK_KEX2_1	534	536	PF00082	0.443
CLV_PCSK_KEX2_1	56	58	PF00082	0.560
CLV_PCSK_KEX2_1	617	619	PF00082	0.324
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.403
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.443
CLV_PCSK_SKI1_1	20	24	PF00082	0.442
CLV_PCSK_SKI1_1	215	219	PF00082	0.415
CLV_PCSK_SKI1_1	272	276	PF00082	0.431
CLV_PCSK_SKI1_1	746	750	PF00082	0.669
DEG_APCC_DBOX_1	214	222	PF00400	0.415
DEG_COP1_1	735	743	PF00400	0.667
DOC_ANK_TNKS_1	401	408	PF00023	0.730
DOC_CYCLIN_RxL_1	17	27	PF00134	0.429
DOC_MAPK_gen_1	200	206	PF00069	0.514
DOC_MAPK_gen_1	643	652	PF00069	0.529
DOC_MAPK_MEF2A_6	646	654	PF00069	0.529
DOC_PP1_RVXF_1	270	276	PF00149	0.398
DOC_PP1_RVXF_1	649	655	PF00149	0.611
DOC_PP4_FxxP_1	274	277	PF00568	0.445
DOC_PP4_FxxP_1	508	511	PF00568	0.507
DOC_USP7_MATH_1	153	157	PF00917	0.732
DOC_USP7_MATH_1	178	182	PF00917	0.656
DOC_USP7_MATH_1	196	200	PF00917	0.515
DOC_USP7_MATH_1	288	292	PF00917	0.668
DOC_USP7_MATH_1	330	334	PF00917	0.619
DOC_USP7_MATH_1	661	665	PF00917	0.699
DOC_USP7_MATH_1	700	704	PF00917	0.724
DOC_USP7_MATH_1	710	714	PF00917	0.637
DOC_USP7_MATH_1	752	756	PF00917	0.574
DOC_USP7_UBL2_3	602	606	PF12436	0.529
DOC_USP7_UBL2_3	749	753	PF12436	0.648
DOC_WW_Pin1_4	165	170	PF00397	0.688
DOC_WW_Pin1_4	434	439	PF00397	0.651
LIG_14-3-3_CanoR_1	183	192	PF00244	0.507
LIG_14-3-3_CanoR_1	56	60	PF00244	0.542
LIG_14-3-3_CanoR_1	651	655	PF00244	0.500
LIG_Actin_WH2_2	589	604	PF00022	0.529
LIG_AP2alpha_2	369	371	PF02296	0.633
LIG_APCC_ABBA_1	271	276	PF00400	0.471
LIG_APCC_ABBAyCdc20_2	578	584	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_BIR_III_4	334	338	PF00653	0.637
LIG_deltaCOP1_diTrp_1	480	488	PF00928	0.430
LIG_eIF4E_1	479	485	PF01652	0.341
LIG_FHA_1	1	7	PF00498	0.420
LIG_FHA_1	212	218	PF00498	0.418
LIG_FHA_1	239	245	PF00498	0.448
LIG_FHA_1	464	470	PF00498	0.424
LIG_FHA_1	500	506	PF00498	0.439
LIG_FHA_1	591	597	PF00498	0.478
LIG_FHA_2	44	50	PF00498	0.468
LIG_FHA_2	542	548	PF00498	0.564
LIG_FHA_2	630	636	PF00498	0.529
LIG_FHA_2	686	692	PF00498	0.665
LIG_IBAR_NPY_1	321	323	PF08397	0.707
LIG_LIR_Apic_2	302	307	PF02991	0.738
LIG_LIR_Gen_1	276	287	PF02991	0.616
LIG_LIR_Gen_1	480	488	PF02991	0.354
LIG_LIR_Gen_1	647	657	PF02991	0.573
LIG_LIR_Nem_3	276	282	PF02991	0.583
LIG_LIR_Nem_3	434	439	PF02991	0.625
LIG_LIR_Nem_3	480	485	PF02991	0.351
LIG_LIR_Nem_3	486	491	PF02991	0.363
LIG_LIR_Nem_3	647	652	PF02991	0.473
LIG_LIR_Nem_3	653	657	PF02991	0.459
LIG_LYPXL_yS_3	457	460	PF13949	0.526
LIG_NRBOX	480	486	PF00104	0.352
LIG_NRP_CendR_1	756	757	PF00754	0.692
LIG_Pex14_2	275	279	PF04695	0.483
LIG_PTB_Apo_2	264	271	PF02174	0.491
LIG_PTB_Phospho_1	264	270	PF10480	0.500
LIG_REV1ctd_RIR_1	613	619	PF16727	0.495
LIG_SH2_CRK	150	154	PF00017	0.641
LIG_SH2_CRK	304	308	PF00017	0.698
LIG_SH2_NCK_1	150	154	PF00017	0.641
LIG_SH2_NCK_1	323	327	PF00017	0.565
LIG_SH2_PTP2	270	273	PF00017	0.382
LIG_SH2_STAP1	479	483	PF00017	0.343
LIG_SH2_STAT3	157	160	PF00017	0.708
LIG_SH2_STAT3	306	309	PF00017	0.619
LIG_SH2_STAT5	176	179	PF00017	0.623
LIG_SH2_STAT5	270	273	PF00017	0.382
LIG_SH2_STAT5	520	523	PF00017	0.412
LIG_SH2_STAT5	588	591	PF00017	0.529
LIG_SH3_1	281	287	PF00018	0.570
LIG_SH3_1	568	574	PF00018	0.556
LIG_SH3_2	195	200	PF14604	0.600
LIG_SH3_3	152	158	PF00018	0.696
LIG_SH3_3	190	196	PF00018	0.594
LIG_SH3_3	232	238	PF00018	0.496
LIG_SH3_3	281	287	PF00018	0.616
LIG_SH3_3	324	330	PF00018	0.585
LIG_SH3_3	357	363	PF00018	0.608
LIG_SH3_3	435	441	PF00018	0.643
LIG_SH3_3	568	574	PF00018	0.556
LIG_SH3_3	655	661	PF00018	0.498
LIG_SH3_3	69	75	PF00018	0.572
LIG_SH3_3	696	702	PF00018	0.701
LIG_SH3_3	713	719	PF00018	0.652
LIG_SH3_3	93	99	PF00018	0.657
LIG_SUMO_SIM_par_1	2	7	PF11976	0.479
LIG_SUMO_SIM_par_1	227	232	PF11976	0.422
LIG_SUMO_SIM_par_1	465	470	PF11976	0.461
LIG_TRAF2_1	46	49	PF00917	0.484
LIG_TRAF2_1	709	712	PF00917	0.743
LIG_TRAF2_1	720	723	PF00917	0.649
LIG_TRAF2_1	727	730	PF00917	0.574
LIG_UBA3_1	637	643	PF00899	0.460
MOD_CK1_1	172	178	PF00069	0.816
MOD_CK1_1	181	187	PF00069	0.543
MOD_CK1_1	35	41	PF00069	0.564
MOD_CK1_1	352	358	PF00069	0.665
MOD_CK1_1	398	404	PF00069	0.661
MOD_CK2_1	43	49	PF00069	0.472
MOD_CK2_1	434	440	PF00069	0.635
MOD_CK2_1	541	547	PF00069	0.555
MOD_CK2_1	594	600	PF00069	0.473
MOD_CK2_1	685	691	PF00069	0.669
MOD_Cter_Amidation	371	374	PF01082	0.590
MOD_GlcNHglycan	114	117	PF01048	0.693
MOD_GlcNHglycan	186	189	PF01048	0.612
MOD_GlcNHglycan	301	304	PF01048	0.718
MOD_GlcNHglycan	355	358	PF01048	0.726
MOD_GlcNHglycan	383	386	PF01048	0.647
MOD_GlcNHglycan	425	428	PF01048	0.682
MOD_GlcNHglycan	440	444	PF01048	0.758
MOD_GlcNHglycan	536	539	PF01048	0.531
MOD_GlcNHglycan	712	715	PF01048	0.745
MOD_GlcNHglycan	737	740	PF01048	0.634
MOD_GSK3_1	165	172	PF00069	0.734
MOD_GSK3_1	177	184	PF00069	0.584
MOD_GSK3_1	293	300	PF00069	0.669
MOD_GSK3_1	349	356	PF00069	0.653
MOD_GSK3_1	459	466	PF00069	0.523
MOD_GSK3_1	541	548	PF00069	0.602
MOD_GSK3_1	549	556	PF00069	0.491
MOD_GSK3_1	590	597	PF00069	0.490
MOD_N-GLC_1	178	183	PF02516	0.635
MOD_N-GLC_1	472	477	PF02516	0.465
MOD_N-GLC_1	590	595	PF02516	0.275
MOD_N-GLC_2	267	269	PF02516	0.494
MOD_N-GLC_2	463	465	PF02516	0.462
MOD_NEK2_1	24	29	PF00069	0.518
MOD_NEK2_1	526	531	PF00069	0.377
MOD_NEK2_1	560	565	PF00069	0.529
MOD_NEK2_1	587	592	PF00069	0.496
MOD_NEK2_1	650	655	PF00069	0.442
MOD_NEK2_2	40	45	PF00069	0.444
MOD_OFUCOSY	465	471	PF10250	0.417
MOD_PIKK_1	35	41	PF00454	0.489
MOD_PIKK_1	358	364	PF00454	0.710
MOD_PIKK_1	685	691	PF00454	0.674
MOD_PIKK_1	700	706	PF00454	0.578
MOD_PKA_1	534	540	PF00069	0.524
MOD_PKA_2	398	404	PF00069	0.658
MOD_PKA_2	423	429	PF00069	0.668
MOD_PKA_2	526	532	PF00069	0.396
MOD_PKA_2	534	540	PF00069	0.485
MOD_PKA_2	541	547	PF00069	0.555
MOD_PKA_2	55	61	PF00069	0.535
MOD_PKA_2	650	656	PF00069	0.510
MOD_PKA_2	661	667	PF00069	0.521
MOD_Plk_1	472	478	PF00069	0.411
MOD_Plk_2-3	541	547	PF00069	0.555
MOD_Plk_2-3	594	600	PF00069	0.460
MOD_Plk_4	172	178	PF00069	0.653
MOD_Plk_4	463	469	PF00069	0.440
MOD_Plk_4	526	532	PF00069	0.485
MOD_ProDKin_1	165	171	PF00069	0.690
MOD_ProDKin_1	434	440	PF00069	0.650
MOD_SUMO_rev_2	541	551	PF00179	0.599
MOD_SUMO_rev_2	594	604	PF00179	0.529
TRG_DiLeu_BaEn_1	49	54	PF01217	0.444
TRG_ENDOCYTIC_2	126	129	PF00928	0.685
TRG_ENDOCYTIC_2	270	273	PF00928	0.382
TRG_ENDOCYTIC_2	457	460	PF00928	0.544
TRG_ER_diArg_1	200	203	PF00400	0.654
TRG_ER_diArg_1	373	375	PF00400	0.585
TRG_ER_diArg_1	577	580	PF00400	0.600
TRG_ER_diArg_1	616	618	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I1	Leptomonas seymouri	42%	100%
A4HK66	Leishmania braziliensis	73%	99%
A4I7Q1	Leishmania infantum	99%	100%
E9B2K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q5J7	Leishmania major	92%	100%