Casein kinase II subunit beta

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Casein kinase II subunit beta, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ42_LEIDO

TriTrypDb:

LdBPK_365320.1 , LdCL_360060400 , LDHU3_36.7100

Length:

275

Annotations

Annotations by Jardim et al.

Protein kinase, Casein kinase II subunit beta

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005956	protein kinase CK2 complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1902554	serine/threonine protein kinase complex	6	10
GO:1902911	protein kinase complex	5	10
GO:1990234	transferase complex	3	10
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IJ42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ42

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016310	phosphorylation	5	3
GO:0044237	cellular metabolic process	2	3
GO:0010921	regulation of phosphatase activity	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035304	regulation of protein dephosphorylation	7	1
GO:0043666	regulation of phosphoprotein phosphatase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0080163	regulation of protein serine/threonine phosphatase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0019207	kinase regulator activity	3	10
GO:0019887	protein kinase regulator activity	4	10
GO:0030234	enzyme regulator activity	2	10
GO:0098772	molecular function regulator activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.414
CLV_PCSK_KEX2_1	82	84	PF00082	0.221
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.221
CLV_PCSK_SKI1_1	105	109	PF00082	0.165
CLV_PCSK_SKI1_1	99	103	PF00082	0.175
DEG_Nend_UBRbox_2	1	3	PF02207	0.546
DEG_ODPH_VHL_1	52	65	PF01847	0.421
DEG_SCF_FBW7_1	210	216	PF00400	0.355
DEG_SPOP_SBC_1	263	267	PF00917	0.511
DOC_CKS1_1	210	215	PF01111	0.358
DOC_CYCLIN_RxL_1	99	112	PF00134	0.367
DOC_USP7_MATH_1	262	266	PF00917	0.636
DOC_USP7_MATH_2	262	268	PF00917	0.441
DOC_WW_Pin1_4	209	214	PF00397	0.587
DOC_WW_Pin1_4	3	8	PF00397	0.425
LIG_14-3-3_CanoR_1	163	168	PF00244	0.355
LIG_14-3-3_CanoR_1	99	107	PF00244	0.348
LIG_eIF4E_1	14	20	PF01652	0.453
LIG_FHA_1	210	216	PF00498	0.483
LIG_LIR_Gen_1	24	34	PF02991	0.421
LIG_LIR_Nem_3	174	179	PF02991	0.340
LIG_LIR_Nem_3	24	29	PF02991	0.415
LIG_LIR_Nem_3	33	38	PF02991	0.372
LIG_LIR_Nem_3	90	96	PF02991	0.355
LIG_PALB2_WD40_1	21	29	PF16756	0.355
LIG_Pex14_1	172	176	PF04695	0.340
LIG_Pex14_1	22	26	PF04695	0.340
LIG_SH2_CRK	93	97	PF00017	0.355
LIG_SH2_STAP1	61	65	PF00017	0.340
LIG_SH2_STAT5	198	201	PF00017	0.340
LIG_SH3_3	186	192	PF00018	0.426
LIG_SH3_3	204	210	PF00018	0.525
LIG_SH3_3	51	57	PF00018	0.421
LIG_SUMO_SIM_par_1	64	71	PF11976	0.340
LIG_TRAF2_1	219	222	PF00917	0.599
LIG_TYR_ITIM	91	96	PF00017	0.421
MOD_CK1_1	21	27	PF00069	0.421
MOD_CK1_1	265	271	PF00069	0.536
MOD_CK1_1	71	77	PF00069	0.413
MOD_CK2_1	84	90	PF00069	0.385
MOD_CMANNOS	22	25	PF00535	0.140
MOD_GlcNHglycan	227	230	PF01048	0.518
MOD_GlcNHglycan	86	90	PF01048	0.191
MOD_GSK3_1	209	216	PF00069	0.563
MOD_GSK3_1	221	228	PF00069	0.504
MOD_GSK3_1	262	269	PF00069	0.496
MOD_GSK3_1	71	78	PF00069	0.342
MOD_LATS_1	97	103	PF00433	0.340
MOD_N-GLC_1	47	52	PF02516	0.196
MOD_NEK2_1	100	105	PF00069	0.355
MOD_NEK2_1	171	176	PF00069	0.340
MOD_NEK2_1	47	52	PF00069	0.385
MOD_NEK2_1	84	89	PF00069	0.385
MOD_PK_1	142	148	PF00069	0.340
MOD_PK_1	187	193	PF00069	0.363
MOD_PKA_2	141	147	PF00069	0.358
MOD_PKB_1	185	193	PF00069	0.418
MOD_Plk_1	142	148	PF00069	0.340
MOD_Plk_2-3	41	47	PF00069	0.421
MOD_Plk_2-3	68	74	PF00069	0.421
MOD_Plk_4	18	24	PF00069	0.280
MOD_ProDKin_1	209	215	PF00069	0.595
MOD_ProDKin_1	3	9	PF00069	0.427
TRG_DiLeu_BaEn_1	128	133	PF01217	0.421
TRG_DiLeu_BaEn_1	15	20	PF01217	0.448
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.362
TRG_ENDOCYTIC_2	93	96	PF00928	0.355
TRG_ER_diArg_1	162	165	PF00400	0.442
TRG_ER_diArg_1	205	208	PF00400	0.452
TRG_ER_diLys_1	271	275	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH7	Leptomonas seymouri	93%	100%
A0A0S4JSI8	Bodo saltans	54%	84%
A0A1X0NE95	Trypanosomatidae	73%	79%
A0A3S5IQM0	Trypanosoma rangeli	65%	99%
A4HQ25	Leishmania braziliensis	92%	100%
A4IDT1	Leishmania infantum	100%	100%
D0A8U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	94%
E9ATU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O59906	Candida albicans	44%	94%
O76485	Spodoptera frugiperda	53%	100%
O80507	Arabidopsis thaliana	59%	97%
O81275	Arabidopsis thaliana	56%	100%
O94281	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
O96863	Drosophila melanogaster	45%	100%
P08182	Drosophila melanogaster	52%	100%
P28021	Xenopus laevis	54%	100%
P28548	Caenorhabditis elegans	53%	100%
P38930	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P40228	Arabidopsis thaliana	56%	96%
P40229	Arabidopsis thaliana	54%	98%
P40232	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
P43639	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	99%
P67868	Bos taurus	54%	100%
P67869	Gallus gallus	54%	100%
P67870	Homo sapiens	54%	100%
P67871	Mus musculus	54%	100%
P67872	Sus scrofa	54%	100%
P67873	Oryctolagus cuniculus	54%	100%
P67874	Rattus norvegicus	54%	100%
Q24536	Drosophila melanogaster	45%	100%
Q4Q0Q3	Leishmania major	97%	100%
Q54PF1	Dictyostelium discoideum	51%	100%
Q8TG11	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	47%	96%
Q8TG12	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	46%	83%
Q91398	Danio rerio	54%	100%