Glyceraldehyde-3-phosphate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glyceraldehyde 3-phosphate dehydrogenase, cytosolic

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ37_LEIDO

TriTrypDb:

LdBPK_362480.1 , LdCL_360030500 , LDHU3_36.3310

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ37

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	8
GO:0005996	monosaccharide metabolic process	3	8
GO:0006006	glucose metabolic process	5	8
GO:0006082	organic acid metabolic process	3	8
GO:0006090	pyruvate metabolic process	7	8
GO:0006091	generation of precursor metabolites and energy	3	8
GO:0006096	glycolytic process	5	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006163	purine nucleotide metabolic process	5	8
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	8

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	6	8
GO:0005488	binding	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	8
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	8
GO:0036094	small molecule binding	2	8
GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	5	8
GO:0050661	NADP binding	4	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.522
CLV_PCSK_KEX2_1	114	116	PF00082	0.602
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.602
CLV_PCSK_SKI1_1	14	18	PF00082	0.326
CLV_PCSK_SKI1_1	248	252	PF00082	0.329
CLV_PCSK_SKI1_1	268	272	PF00082	0.353
DEG_SCF_FBW7_1	232	238	PF00400	0.540
DOC_CKS1_1	232	237	PF01111	0.540
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.557
DOC_MAPK_MEF2A_6	231	239	PF00069	0.537

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0H3MAB5	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	51%	98%
A0A0N1PDI1	Leptomonas seymouri	88%	100%
A0A0S4IV72	Bodo saltans	54%	92%
A0A0S4JCP6	Bodo saltans	40%	98%
A0A1X0P1G4	Trypanosomatidae	53%	92%
A0A1X0P6C0	Trypanosomatidae	32%	95%
A0A1X0P8Z3	Trypanosomatidae	83%	100%
A0A3Q8IQ62	Leishmania donovani	27%	95%
A0A3R7KES2	Trypanosoma rangeli	52%	92%
A0A3R7LC67	Trypanosoma rangeli	31%	97%

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