Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ25_LEIDO

TriTrypDb:

LdBPK_362290.1 , LdCL_360028600 , LDHU3_36.3050

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005874	microtubule	6	10
GO:0005875	microtubule associated complex	2	10
GO:0030286	dynein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	10
GO:0005868	cytoplasmic dynein complex	4	1

Expansion

Sequence features

A0A3Q8IJ25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ25

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.467
CLV_NRD_NRD_1	67	69	PF00675	0.278
CLV_PCSK_KEX2_1	66	68	PF00082	0.286
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.286
DOC_MAPK_gen_1	18	28	PF00069	0.634
DOC_USP7_MATH_1	108	112	PF00917	0.573
DOC_USP7_MATH_1	117	121	PF00917	0.732
DOC_USP7_UBL2_3	14	18	PF12436	0.590
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_FHA_1	74	80	PF00498	0.508
LIG_FHA_2	34	40	PF00498	0.610
LIG_FHA_2	45	51	PF00498	0.470
LIG_FHA_2	55	61	PF00498	0.491
LIG_FHA_2	88	94	PF00498	0.573
LIG_GBD_Chelix_1	61	69	PF00786	0.291
LIG_HCF-1_HBM_1	55	58	PF13415	0.489
LIG_LIR_Gen_1	76	85	PF02991	0.498
LIG_LIR_Nem_3	55	61	PF02991	0.486
LIG_LIR_Nem_3	76	80	PF02991	0.491
LIG_PCNA_yPIPBox_3	98	110	PF02747	0.573
LIG_SH2_STAP1	7	11	PF00017	0.611
LIG_SH2_STAT5	105	108	PF00017	0.532
LIG_SH3_3	111	117	PF00018	0.564
LIG_TRAF2_1	2	5	PF00917	0.691
LIG_UBA3_1	96	100	PF00899	0.573
MOD_CK2_1	33	39	PF00069	0.554
MOD_GlcNHglycan	110	113	PF01048	0.426
MOD_GlcNHglycan	119	122	PF01048	0.620
MOD_GSK3_1	44	51	PF00069	0.550
MOD_N-GLC_1	33	38	PF02516	0.273
MOD_N-GLC_1	87	92	PF02516	0.301
MOD_Plk_1	33	39	PF00069	0.484
MOD_Plk_1	54	60	PF00069	0.517
MOD_Plk_1	92	98	PF00069	0.610
MOD_Plk_4	44	50	PF00069	0.576
MOD_Plk_4	92	98	PF00069	0.540
TRG_DiLeu_BaEn_4	4	10	PF01217	0.538
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.622
TRG_ENDOCYTIC_2	58	61	PF00928	0.491
TRG_ER_diArg_1	67	69	PF00400	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT5	Leptomonas seymouri	74%	100%
A0A1X0P7U5	Trypanosomatidae	55%	100%
A0A3S5H7R1	Leishmania donovani	34%	100%
A0A422NIV0	Trypanosoma rangeli	56%	100%
A4HK04	Leishmania braziliensis	34%	100%
A4HP85	Leishmania braziliensis	83%	100%
A4I7I7	Leishmania infantum	34%	100%
A4IDJ0	Leishmania infantum	99%	100%
D0A385	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ASZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O02414	Heliocidaris crassispina	32%	100%
Q4Q1K5	Leishmania major	95%	100%
Q4Q5R2	Leishmania major	34%	100%
Q94748	Schistosoma mansoni	37%	100%
Q94758	Schistosoma mansoni	33%	100%